Cebu Normal University
College of Nursing
Osmeña Blvd. Cebu City 6000
DRUG STUDY
Name of Patient Age Height
Diagnosis Sex Weight
Doctor Date of Body
Admission Build
Drug Data Classification Mechanism of Action Indication
Generic Name Therapeutic class: Pharmacodynamics General Indications:
Gentamicin Sulfate *Anti infectives Chemical Effect: Parenteral use
Inhibits protein synthesis in bacteria at the level of the restricted to
Trade Name Pharmacologic class: 30S ribosome. treatment of serious
Garamycin, Garamycin *Aminoglycosides infections of GI,
Ophthalmic, Genoptic Therapeutic Effect: respiratory, and
Pregnancy Category Bactericidal action urinary tracts, CNS,
Minimum Dose *D bone, skin, and soft
Pharmacokinetics tissue (including
Maximum Dose * A – well absorbed after IM administration. IV burns) when other
administration results in complete less toxic
Availability and Color: bioavailability. Some absorption follows antimicrobial agents
Cream: 0.1%; administration by other routes. are ineffective or are
Injection: 10 mg/mL, 40 contraindicated. Has
mg/mL; Ointment: 1%; * D – widely distributed throughout extracellular been used in
Ophthalmic ointment: 3 fluid’ crosses the placenta; small amounts combination with
mg/g; Ophthalmic Solution: 3 enter breast milk. Poor penetration into CSF. other antibiotics. Also
mg/mL * M and E – Excretion is >90% renal used topically for
primary and
ROUTE ONSET PEAK DURATIO secondary skin
N infections and for
IV Rapid unknow 45 mins superficial infections
n of external eye and its
IM Rapid unknow 3 hrs adnexa.
n
Patients Actual
Half- Life: 2-4 hours Indication:
Source: Source: Springhouse Nurse’s Drug Source: Springhouse Nurse’s Drug Guide, 7th Edition. Source: Springhouse
http://www.healthdigest.org/t Guide, 7th Edition. Lippincott Williams Lippincott Williams and Wilkins, 2006 Nurse’s Drug Guide,
opics/category/1271- and Wilkins. 2006 7th Edition. Lippincott
gentamicin-sulfate-dosage- Williams and Wilkins,
interactions-side-effects-how- 2006
to-use
Drug Data Contraindications Adverse Reaction Nursing Responsibilities
Routes of administration: History of hypersensitivity to Special Senses: Ototoxicity (vestibular Before:
aminoglycoside; pregnancy; hepatic disturbances, impaired hearing), optic neuritis. 1. Do hand washing
IM impairment, perforated ear drum. before and after
IV CNS: neuromuscular blockade: skeletal muscle medication administration.
TOPICAL SPECIAL PRECAUTIONS weakness, apnea, respiratory paralysis (high 2. Throw away any
OPHTH Concurrent use of neuromuscular doses); arachnoiditis (intrathecal use). unused medicine after the
blocking agents; myasthenia gravis, expiration date.
3. Use with caution in
parkinsonism; conditions predisposing CV: hypotension or hypertension.
premature infants and
to ototoxicity and nephrotoxicity;
neonates. Ophthalmic
lactation. Monitor plasma GI: Nausea, vomiting, transient increase in AST, ointments may retard
concentrations of gentamicin in ALT, and serum LDH and bilirubin; corneal epithelial healing.
patients receiving high doses or hepatomegaly, splenomegaly.
prolonged courses, in infants, elderly, During:
patients with renal impairment, cystic Hematologic: Increased or decreased
fibrosis or significant obesity. Monitor reticulocyte counts; granulocytopenia,
1. Retract the neonate’s
eye carefully for proper
auditory and renal functions. thrombocytopenia (fever, bleeding tendency), administration of
thrombocytopenic purpura, anemia. medication.
DRUG-DRUG INTERACTIONS: 2. Apply medication from
Synergistic with ampicillin, Body as a Whole: Hypersensitivity (rash, the inner to the outer
benzylpenicillin and other β-lactam pruritus, urticaria, exfoliative dermatitis, canthus of the eye.
antibiotics. Increased risk of severe eosinophilia, burning sensation of skin, drug 3. Do not touch the tip of
respiratory depression when used fever, joint pains, laryngeal edema, the medication on the
concurrently with anaesthetics or anaphylaxis). patient’s eyes to prevent
opioids. May reduce renal clearance of spread of infection.
zalcitabine and induce hypocalcaemia Urogenital: Nephrotoxicity: proteinuria, tubular 4. Do recap medication
when used with biphosphonates. Not necrosis, cells or casts in urine, hematuria, after using.
to be used with agalsidase alfa or beta rising BUN, nonprotein nitrogen, serum 5. Monitor for adverse
as it may inhibit α-galactosidase creatinine; decreased creatinine clearance. reactions/
activity. drug interactions.
Other: Local irritation and pain following IM use;
After:
Potentially Fatal: Increased thrombophlebitis, abscess, superinfections,
1. Store medication
incidence of ototoxicity when syndrome of hypocalcemia (tetany, weakness,
between 2 and 30
combined with ethacrynic acid and hypokalemia, hypomagnesemia). degrees C (36 and 86
furosemide. Cephalosporins, degrees F). Do not freeze.
ciclosporin, cisplatin, vancomycin, 2. Return medication to cord
hydrocortisone and indometacin dress basket.
potentiate nephrotoxicity. Potentiates 3. Observe proper
neuromuscular blocking agents. documentation.
Source:
http://www.healthdigest.org/t
opics/category/1271-
gentamicin-sulfate-dosage-
interactions-side-effects-how-
to-use
Source: http://nursingcrib.com/drug-study/drug-
study-gentamicin-sulfate/
Source:
http://www.mims.com/Page.aspx?
Source: Springhouse Nurse’s
menuid=mng&name=gentamicin
Drug Guide, 7th Edition.
Lippincott Williams and
Wilkins, 2006
