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Drug Dosage Mechanism of Action Indications & Contraindications Side Effects & Adverse Effects Nursing Responsibility

Piperacillin-tazobactam (brand name Piptaz) is administered as 2.25g IV every 6 hours. It works by interfering with bacterial cell wall synthesis and promoting membrane damage, killing the organism. It is indicated for nosocomial pneumonia but is contraindicated in those with a history of allergy to penicillins, cephalosporins, or beta-lactamase inhibitors. Common side effects include diarrhea, nausea, vomiting, agitation, bruising, and cough. Nurses should obtain an allergy history, monitor for signs of hypersensitivity, and check hematologic status with prolonged use.

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506 views1 page

Drug Dosage Mechanism of Action Indications & Contraindications Side Effects & Adverse Effects Nursing Responsibility

Piperacillin-tazobactam (brand name Piptaz) is administered as 2.25g IV every 6 hours. It works by interfering with bacterial cell wall synthesis and promoting membrane damage, killing the organism. It is indicated for nosocomial pneumonia but is contraindicated in those with a history of allergy to penicillins, cephalosporins, or beta-lactamase inhibitors. Common side effects include diarrhea, nausea, vomiting, agitation, bruising, and cough. Nurses should obtain an allergy history, monitor for signs of hypersensitivity, and check hematologic status with prolonged use.

Uploaded by

Athena Saturday
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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DRUG DOSAGE MECHANISM OF INDICATIONS & SIDE EFFECTS & NURSING RESPONSIBILITY

ACTION CONTRAINDICATIONS ADVERSE EFFECTS


Generic Name: 2.25g TIV It is similar to that of Indication: Side Effects: - Obtain history of
Piperacillin QID (q6) other penicillins. - Nosocomial - Diarrhea hypersensitivity to
Tazobactam Interfere with bacterial Pneumonia - Nausea penicillins,
cell wall synthesis Contraindication: - Vomiting cephalosporins, or
Brand Name: promotes loss of - History of allergic other drugs prior to
Piptaz membrane integrity reactions to any of Adverse Effects: administration.
and leads to death of the penicillins, - Agitation
Functional Class: the organism. cephalosporins, or - Bruising - Lab tests: C&S prior to
Antiinfective β-lactamase - Cough first dose of the drug;
Tazobactam is an inhibitors. start drug pending
Chemical Class: inhibitor of a wide results.
Penicillin variety of bacterial
beta–lactamases. It - Monitor hematologic
has little antibacterial status with prolonged
activity itself; therapy (Hct and Hgb,
however, in CBC with differential
combination with and platelet count).
piperacillin, it extends
the spectrum of - Monitor patient
bacteria that are carefully during the first
susceptible to 30 min after initiation of
piperacillin. Two-drug the infusion for signs of
combination has hypersensitivity.
antibiotic activity
against an extremely
broad spectrum of
gram-positive, gram-
negative and
anaerobic bacteria.

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