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Group 1 Reflection: Members: Boh Guias Mangubat Oñate Tayko Verdon

The document discusses recent developments in gene therapy and stem cell treatment. It notes that gene therapy can be somatic or germline, targeting either somatic or reproductive cells. Recent gene therapy research focuses on cerebellar disorders. Stem cell treatments exist but are experimental, with potential to treat conditions like cancer, spinal cord injuries, and muscle damage. Gene therapy may help treat many diseases like cancer, cystic fibrosis, heart disease, and more. Advancing technologies could increase the human lifespan in the next 20 years through anti-aging research.

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Tonette Hatamosa Verdon
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63 views3 pages

Group 1 Reflection: Members: Boh Guias Mangubat Oñate Tayko Verdon

The document discusses recent developments in gene therapy and stem cell treatment. It notes that gene therapy can be somatic or germline, targeting either somatic or reproductive cells. Recent gene therapy research focuses on cerebellar disorders. Stem cell treatments exist but are experimental, with potential to treat conditions like cancer, spinal cord injuries, and muscle damage. Gene therapy may help treat many diseases like cancer, cystic fibrosis, heart disease, and more. Advancing technologies could increase the human lifespan in the next 20 years through anti-aging research.

Uploaded by

Tonette Hatamosa Verdon
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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CHAPTER 11

GROUP 1
REFLECTION

Members:
Boh
Guias
Mangubat
Oñate
Tayko
Verdon
1. Research on the various forms of gene therapy. How are they done?

First is the somatic gene therapy. Somatic gene therapy is the transfer of genes into the
somatic cells of the patient, such as cells of the bone marrow, and hence the new DNA does
not enter the eggs or sperm. The genes transferred are usually normal alleles that could
‘correct’ the mutant or disease alleles of the recipient. The second is the Germline gene
therapy, is when DNA is transferred into the cells that produce reproductive cells, eggs or
sperm, in the body. This type of therapy allows for the correction of disease-
causing gene variants that are certain to be passed down from generation to generation.

2. What are the recent developments in gene therapy?

One of the recent developments in gene therapy is the research targeted to cerebellar
disorders. The cerebellum plays an important role in coordinated movement, motor learning
and vestibular function. Cerebellar damage results in impaired body balance and disturbance
in gait and posture.  The first challenge results from its large size, as the cerebellum is the
second largest component of the central nervous system. The cerebellum can be subdivided
into three main parts: the cerebro cerebellum, the vestibule cerebellum and the spino
cerebellum. Each subdivision in the cerebellum plays a distinct role and, to attain a satisfactory
rescue of the cerebellar function by gene therapy, a therapeutic gene should be delivered
efficiently and extensively into the large cerebellum. The second challenge is to deliver a gene
into specific target cell populations in the cerebellum. In Parkinson's disease, which is caused
by degeneration of nigra-striatal dopaminergic neurons, cell type-specific delivery of a
therapeutic gene is a secondary matter, as the supply of sufficient amounts of dopamine,
irrespective of neurons or glia, in the striatum is most critical for the functional recovery of the
basal ganglia.

3. Stem cell treatment has been a subject of debates since the early 21 st century. What do
you think about the current developments in stem cell treatment?

A number of current stem cell treatments already exists, they are not commonly used because
they tend to be experimental. In the future needs, medical researchers anticipate being able to
use technologies derived from stem cell research to treat cancer, spinal cord injuries, and
muscle damage, amongst a number of other diseases and defects.

4. What health condition do you think urgently needs to be treated by gene therapy?

Gene therapy holds promise for treating a wide range of diseases, such as cancer,
cystic fibrosis, heart disease, diabetes, haemophilia and AIDS.
5. Do you think the average human lifespan will change 20 years from now? Why or why
not?
Because of the advancement of technology that will help the increase of life expectancy
of a human, yes I think that it will change in the future. Because of science like the anti-aging
experiment, it is possible there are also scientists talking seriously about the human lifespan.

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