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Drug Study: NCM 106 Pharmacology: Patient Monitoring

Cidofovir is an antiviral drug used to treat CMV retinitis in AIDS patients. It works by interfering with the DNA synthesis of CMV, inhibiting viral replication. It has serious potential adverse effects including kidney damage, low white blood cell count, fever, nausea, vomiting, and vision changes. Nurses must closely monitor patients for these adverse effects and educate patients about reporting any side effects or changes in vision immediately.

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0% found this document useful (0 votes)
373 views2 pages

Drug Study: NCM 106 Pharmacology: Patient Monitoring

Cidofovir is an antiviral drug used to treat CMV retinitis in AIDS patients. It works by interfering with the DNA synthesis of CMV, inhibiting viral replication. It has serious potential adverse effects including kidney damage, low white blood cell count, fever, nausea, vomiting, and vision changes. Nurses must closely monitor patients for these adverse effects and educate patients about reporting any side effects or changes in vision immediately.

Uploaded by

poleene de leon
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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DRUG STUDY: NCM 106 PHARMACOLOGY Instructor: _______________________________________ Date: ________________________

NAME: ____________________________________________________________ BLOCK and Year:___________________________Group: ______________________________

DRUG NAME MECHANISM OF INDICATION CONTRAINDICATION ADVERSE EFFECTS NURSING INTERVENTIONS


ACTION
Generic Name: Exerts antiviral effect CMV retinitis in AIDS  Hypersensitivity to drug,  CNS: headache, seizures, Patient monitoring:
cidofovir by interfering with patients probenecid, or other sulfa- coma  Assess white blood cell
DNA synthesis of containing agents  EENT: decreased count and creatinine and
CMV, thereby  Creatininelevelabove1.5mg/ intraocular pressure urine protein levels
inhibiting viral dl, calculated creatinine  GI: nausea, vomiting, within 48 hours of each
replication diarrhea, anorexia, oral dose.
clearance of 55 ml/ minute
candidiasis
Drug Classification: or less, or urine protein  Closely monitor
 GU: proteinuria,
Antiviral level of 100 mg/dl or higher nephrotoxicity intraocular pressure and
 Concurrent use of Hematologic: neutropenia visual acuity.
nephrotoxic drugs  Hepatic: hepatomegaly  Monitor hepatic enzyme
 Metabolic: metabolic levels in patients with
acidosis hepatic disease.
 Musculoskeletal: muscle
contractions Patient teaching:
Available Dosage:  Respiratory: dyspnea,  Tell patient to
CMV retinitis in increased cough immediately report
AIDS patients  Skin: rash, alopecia fever, vision
Adults: 5 mg/kg I.V.  Other: pain, fever, chills, changes, nausea,
infused over 1 hour infection, pain at I.V. site vomiting, rash, or
q week for 2 urinary output
continuous weeks; changes.
then 5 mg/kg I.V.  Instruct patient to
once q 2 weeks as a take probenecid, as
maintenance dose prescribed, before
each dose and to
have regular eye
examinations.
 Urge female patient
of childbearing age
to use effective
contraception during
and for 1 month after
therapy.
 Instruct male
patients to use
barrier contraception
during and for 3
months after therapy.
 As appropriate,
review all other
significant and life-
threatening adverse
reactions and
interactions,
especially those
related to the drugs
and tests mentioned
above.

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