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Dopamine Cardiac Output: Levophed

Dobutamine is a synthetic catecholamine drug that stimulates beta-1 receptors in the heart, causing it to contract more forcefully and increase cardiac output. Unlike other catecholamines, it has minimal effects on heart rate and blood pressure. The initial dosage for adults is 0.5 to 1 microgram per kilogram of body weight per minute by intravenous infusion, up to a maximum of 40 micrograms per kilogram per minute.

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56 views2 pages

Dopamine Cardiac Output: Levophed

Dobutamine is a synthetic catecholamine drug that stimulates beta-1 receptors in the heart, causing it to contract more forcefully and increase cardiac output. Unlike other catecholamines, it has minimal effects on heart rate and blood pressure. The initial dosage for adults is 0.5 to 1 microgram per kilogram of body weight per minute by intravenous infusion, up to a maximum of 40 micrograms per kilogram per minute.

Uploaded by

Noelle Harrison
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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HOW DOES DOBUTAMINE WORK?

 Dobutamine is a synthetic drug that stimulates receptors (beta-1


receptors) on the heart. It is classified as a catecholamine. Other
catecholamines include epinephrine, dopamine, and isoproterenol.
Stimulating beta-1 receptors receptor causes an increase in the force of
the heart's contraction, therefore increasing cardiac output which is the
amount of blood pumped by the heart. Unlike other catecholamines,
dobutamine has minimal effects on heart rate, which helps to decrease
the chance of irregular heartbeats. Dobutamine does not have significant
effects on blood pressure.

DOSAGE

The initial dose for adults is based on the indication and severity of heart
failure.

 Dosing is 0.5 to 1 micrograms per kilogram body weight per minute


followed by an intravenous infusion of 2 to 20 micrograms per kilogram
body weight per minute.
 Maximum dose is 40 micrograms per kilogram per minute.

LEVOPHED
Levophed is a peripheral vasoconstrictor and an inotropic stimulator. It works by
making the blood vessels narrower, which increases blood pressure. It also helps
the heart work better.

LEVOPHED should be used with extreme caution in patients receiving


monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or
imipramine types, because severe, prolonged hypertension may result.

The following reactions can occur:

Body As A Whole: Ischemic injury due to potent vasoconstrictor action and tissue


hypoxia.
Cardiovascular System: Bradycardia, probably as a reflex result of a rise in blood
pressure, arrhythmias.
Nervous System: Anxiety, transient headache.
Respiratory System: Respiratory difficulty.
Skin and Appendages: Extravasation necrosis at injection site.

[weight-based dosing]
Dose: 0.02-1 mcg/kg/min IV; Start: 0.1-0.5 mcg/kg/min IV, then titrate to
effect;

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