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Pyruvate Dehydrogenase Complex Overview

The document summarizes key aspects of the citric acid cycle and pyruvate dehydrogenase complex. It describes how the pyruvate dehydrogenase complex, composed of three enzymes, catalyzes the oxidative decarboxylation of pyruvic acid to produce acetyl-CoA. It then discusses the citric acid cycle, noting the 10 steps where citric acid is synthesized and undergoes oxidation, decarboxylation, hydration, and other reactions to generate NADH and FADH2 for use in the electron transport chain to produce ATP. Regulation of the pyruvate dehydrogenase complex by phosphorylation is also mentioned.

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Sofi Amalia
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77 views28 pages

Pyruvate Dehydrogenase Complex Overview

The document summarizes key aspects of the citric acid cycle and pyruvate dehydrogenase complex. It describes how the pyruvate dehydrogenase complex, composed of three enzymes, catalyzes the oxidative decarboxylation of pyruvic acid to produce acetyl-CoA. It then discusses the citric acid cycle, noting the 10 steps where citric acid is synthesized and undergoes oxidation, decarboxylation, hydration, and other reactions to generate NADH and FADH2 for use in the electron transport chain to produce ATP. Regulation of the pyruvate dehydrogenase complex by phosphorylation is also mentioned.

Uploaded by

Sofi Amalia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Citric Acid Cycle

Citric Acid Cycle


Overview of the reactions of the pyruvate dehydrogenase complex.

-Reaksi yg dikatalisis: oksidatif


dekarboksilasi
-Bersifat irreversibel. Menghilangkan
gugus karboksi piruvat
-Memerlukan 3 enzim dan 5 koenzim
-Dihasilkan NADH → 3 ATP

Asupan
vitamin
B

Tina Dewi Rosahdi – SAINTEK, UIN SGD BDG


Enzim piruvat dehidrogenase kompleks terdiri dari 3 enzim yaitu:
1. Pyruvate dehidrogenas (E1)
2. Dihidrolipoil tranasetilasi (E2)
3. Dihidrolipoil dehidrogenase (E3)
Tina Dewi Rosahdi – SAINTEK, UIN SGD BDG
Tina Dewi Rosahdi – SAINTEK, UIN SGD BDG
Pyruvic Acid to Acetyl CoA
Mechanisms of the pyruvate dehydrogenase complex.

Senyawa intermediet
yang dihasilkan dalam
reaksi ini tetap
menempel pada
enzimnya

Tina Dewi Rosahdi – SAINTEK, UIN SGD BDG


Regulation of the pyruvate dehydrogenase complex by modification
of E1.

Tina Dewi Rosahdi – SAINTEK, UIN SGD BDG


Citric Acid Cycle
Citric Acid Cycle
Citric Acid Cycle
Citric Acid Cycle
1.
Synthesis
of citric
acid
2.
Dehydra-
tion
3.
Hydration
Citric Acid Cycle 4.
Oxidation
NAD+ to
electron
transport
5.
Decar-
boxy-
lation
Remove
CO2
Citric Acid Cycle 6.
Oxidation
NAD+ to
electron
transport
Decar-
boxy-
lation
Thiol
synthesis
Citric Acid Cycle 7.
Hydrol-
ysis
Make
ATP
8.
Oxidation
9.
Hydration
10.
Oxidation
Citric Acid Cycle Summary
• Link to vchembook - ATP calculation
Citric Acid Cycle
Citric Acid Cycle
ATP Electron Transport
ATP from glucose
ATP
ATP
ATP
ATP
Hormone Regulation of Carbo- Metabolism
Hormone Regulation of Carbo- Metabolism
• Insulin - high glucose |||| Glucagon - low glucose
Response to muscle activity
Cori Cycle

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