Laboratory Report
Name: Kris Anne Balaba
Lab Partner(s): None
Lab Experiment: Determination of Aspirin Using Back Titration, E16
State Standard:
Lab Date: October 7, 2021
Class: Analytical Chemistry
Period: CHEM 21/L – Analytical Chemistry (1:00 – 4:30) Monday and Thursday
Introduction:
A titration is a procedure for determining the concentration of a solution (the
analyte) by allowing a carefully measured volume of this solution to react with another
solution whose concentration is known (the titrant). The point in the titration where
enough of the titrant has been added to react exactly with the analyte is called the
equivalence point, and occurs when moles of titrant equals moles of analyte according
to the balanced equation.
The aim of this laboratory experiment is to determine the mass of aspirin using
back titration and compare it to the mass of aspirin labelled in a manufacturer’s
specification.
Hypothesis:
If the mass of aspirin in a tablet using back titration match the manufacturer
specification then the process validates the mass of the Aspirin.
If the mass of aspirin in a tablet using back titration does not match the
manufacturer specification then errors are found in the process.
Materials:
Below are the listed materials and equipment that are needed to conduct this
experiment:
• Balance
• Flask
• Burettes
• Aspirin Tablets (300mg tablet for commercial aspirin)
• Phenolphthalein indicator
• 0.1 M Sodium Hydroxide Solution
• DNase water
Procedures:
(1) Get a large conical flask then put and tare it on the balance. Put some aspirin
tablets (approx. 1.5 g). Record the measurement of the two tablets.
(2) Measured about 25 M of methoxide having the PFC wash out pipette. Then you
have a whole sample of sodium hydroxide add the sodium hydroxide to the
aspirin. Next, put a 25 cubic centimeters of DNase water.
(3) After mixing put it on a hot plate, then let that simmer gently for about 30
minutes.
(4) Let the reaction cool down. The standard flask will rely on equal solution being
around about 20° centigrade. Transfer the mixture to 250g flask, wash then
transfer it into flask, do it for two times.
(5) Mix now the mixture. Then wash of the 25ml pipette with some aspirin solution,
then transfer a 25ml through the conical flask.
(6) Add two or three drops of phenolphthalein indicator, then you begin to get a
pinkish color of alkaline solutions.
(7) Get the initial reading of the titration. Then continue doing the titration as you get
the endpoint as it becomes a cloudy white color. Then record all the volumes of
the process.
Data Recording:
No. of Aspirin Tablets: 1.21 g (2 tablets)
Volume of Sulphuric acid used: 13.3 cm3
Titre Rough 1 2
Starting Volume
1.0 15.0 28.3
(cm3)
Final Volume (cm3) 15.0 28.3 41.6
Volume used (cm3) 14.0 13.3 13.3
Analysis:
As the results presented above, the professor shows that we have first two
accurate occasions that both volume give us the 13.3 cm 3 which result to the volume of
Sulphuric acid. This volume will used to calculate the mass of the aspirin in one tablet.
So for initial calculation, we have to solve first for the moles sodium hydroxide that we
used to start the experiment.
No. of moles of sodium hydroxide = 1 mole × 0.025 = 0.025 moles
To solve for the final volume, we’re going to work out for how many moles will left
on the sodium hydroxide. For this we will use the result we have from the initial
calculation that use titration.
No. of moles in sulphuric acid = 0.05 × 0.0133 = 6.65 × 10 -4 mol
No. of moles of sodium hydroxide = (6.65 × 10 -4 mol) × 2 = 1.33 × 10-3 mol
As we got the initial and final calculations, we will now calculate for the mass of
Aspirin. Since we have 1.21 g of Aspirin in two tablets, we will now divide the reacted
results in two to get the aspirin mass in one tablet.
No. of moles in sodium hydroxide = 0.025 – 0.0133 = 0.0117 mol
No. of moles in Aspirin = 0.0117/2 = 5.85 × 10 -3 mol
Mass of the aspirin = 5.85 × 10-3 mol (180) = 1.053 g in two tablets of aspirin
Mass of aspirin in one tablet = 0.5265g or 527 mg
Discussion:
As we define titration, it is a process use to determine the concentration of a
solution by allowing a measured volume solution to react with another solution. In this
case, the laboratory scientist doesn’t have the purist aspirin as the main material to use
for this experiment, for him to get an accurate data.
As a lack of materials, he used a commercial aspirin for the process. Since he
doesn’t have a purist aspirin, he jump to determination of aspirin which he use a back
titration. At first, he measure the aspirin which he use two tablets for the basis. He used
sodium hydroxide for the mixing solution. Until titration process are made at the end of
the experiment.
As he gets the data in the process of doing the experiment, he calculates to get
the mass of aspirin to compare with the manufacturer’s specification mass. With the
result, he saw some errors that encounter for measuring volumes of some suplhuric
acid that should add some more to react with the solution. Another factor that affects is
that he use a commercial aspirin that he doesn’t able to have a control experimeny.
Conclusion:
We conclude that a commercial aspirin has big difference in using a purist aspirin
in getting the result. Since titration is strict when it comes to measuring volume of a
solution to have an accurate measurement in the results, we encounter errors. For the
mass of aspirin that reacted with the sodium hydroxide solution is 527 mg, while the
manufacturer’s specification is 300 mg and that is lower than the mass that we got.
Therefore, we determine that the mass of aspirin using back titration does not
match with the manufacturer’s specification then we encounter some errors, as I
mentioned above.
Reference:
Exp 11 Determination of Aspirin
https://www.youtube.com/watch?v=oHVSCrZ3Aj4
