PHARMACOLOGY

Pharmacodynamics what does drug do to the body

Pharmacokinetics what does the body do to the drug
ION CHANNELS
CATION ANION
Potassium IN, Phosphate IN,
Primary PiSo PhIClO
Sodium OUT Chloride OUT
Magnesium IN, Sulfate IN,
Secondary MiCo SulIBiO
Calcium OUT Bicarbonate OUT
ION CAUSING STIMULATORY & INHIBITORY EFFECT
De Ca Na + Depolarization (stimulatory) Calcium & Sodium
Hy K Cl - Hyperpolarization (inhibitory) Potassium and Chloride
TYPES OF RECEPTORS DOSE RESPONSE RELATIONSHIP
Location Onset  Graded-Dose Response
Ionotropic/ Parameters:
I Cell
Ligand-gated Millisecond Maximum achievable
Ion channels
Membrane Efficacy (Ɛ)
response
Metabotropic/ Smallest dose that
Ceiling dose
G-Protein Cell produces the maximum
II Seconds (Dc)
coupled/ Membrane response
Serpentine Doses needed to
Cell Potency (P) achieve 50% of the
III Kinase-linked Minutes
Membrane maximum response
Transciption Degree of changes in
IV Nucleus Hours
linked/ Nuclear Slope response with a change
in dose
FICK’S LAW OF DIFFUSION
Applications:
𝑑𝑄⁄ 𝐷𝑥𝐴𝑥𝐾 1. Efficacy vs. Potency
𝑑𝑡 = (C GI-CP)
ℎ 2. Full, Partial & Inverse Agonist
𝑑𝑄⁄ 3. Competitive Antagonism
Rate of diffusion
𝑑𝑡 4. Noncompetitive Antagonism
D Diffusion coefficient  Quantal Dose Response
A Surface Area Parameters:
K Partition coefficient ED50 Median Effective Dose
1/h Membrane thickness TD50 Median Toxic Dose
(CGI-CP) Concentration gradient Measure of
Therapeutic relative 𝑇𝐷50
DIFFUSION COEFFICIENT Index (I) 𝐼 =
safety 𝐸𝐷50
Particle Size
Determinants:
Lipophilicity Margin of
Partition 𝐶𝑜𝑖𝑙 Safety
Factors: 𝐾 =
coefficient (K) 𝐶𝐻2𝑂 BIOAVAILABILITY (F)
Degree of Dissociation / Ionization Parameters
L Lipophilic H Hydrophilic Maximum drug plasma
U Unionized I Ionized concentration
Cmax
N NonPolar P Polar - measures both rate & extent
A Absorbed E Excretion - most variable
Bioavailability studies: Tmax Time to reach Tmax
Absolute 𝐴𝑈𝐶 𝑛𝑜𝑛𝐼𝑉 - measures the rate of
𝐹𝑎𝑏𝑠 =
bioavailability 𝐴𝑈𝐶 𝐼𝑉 absorption
Relative 𝐴𝑈𝐶 𝐸𝑉 (𝑔𝑒𝑛. ) AUC Area Under the Curve
𝐹𝑟𝑒𝑙 =
bioavailability 𝐴𝑈𝐶 𝐸𝑉 (𝑠𝑡𝑑. ) - measures the extent
𝐷𝑜𝑠𝑒 - most important BA parameter
Volume of Distribution 𝑉𝑑 =
𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛

Module 4 All-around Pharmacist (@GapangPharma)

I. ANS
RECEPTORS Location Response
ADRENERGIC RECEPTORS
Smooth muscle Contraction
Eyes
Radial muscle Mydriasis
Blood vessels Vasoconstriction
Prostate Gland
Alpha-1
Bladder Trigone Urinary Retention
Bladder Sphincter
Pilomotor Goosebumps
Cutaneous Splanchnic BV Gooseflesh
Autoregulation
Presynaptic Vasomotor center (CNS) Central - Sedation, Depression
Alpha-2 Peripheral - Vasodilation
Vascular SM/
Postsynaptic Vasoconstriction
Peripheral BV
(+) inotropism
Heart (+) chronotropism
Beta-1 (+) dromotropism
Renin release in
Kidney
Juxtaglomerular apparatus
Smooth Muscle Relaxation
Bronchial Dilation
Beta-2 Uterus Relaxation/Tocolysis
Vascular SM Dilation
Neuromuscular end plates Contraction (Tremors)
Beta-3 Adipose tissues Lipolysis
Dopamine-1 Renal & Splanchic BV Dilation
Peripheral = GIT  GI Motility
Dopamine 2-4 Altered behaviour, perception,
Central = CNS
Motor activity
Epinephrine B1 = B2 > A1
Norepinephrine B1 > A1
Dopamine D1 > B1 > A1
CHOLINERGIC RECEPTORS
Muscarinic-1 Gastric Nerves  HCl secretion
(-) Inotropism
Muscarinic-2 Heart Nerves Bradycardia
(-) Dromotropism
Exocrine glands Secretion
Eyes Ciliary muscle :  near vision
Circular muscle: Miosis
Muscarinic-3 Smooth
Bronchial Constriction
Muscle
Walls/Detrussor: Contraction Diarrhea
GIT/Urinary
Trigone/Sphincter: Relaxation /Urination
Neural Nicotinic NN Ganglion / CNS Stimulation
Neuromuscular end plates / Contraction
Neural Muscarinic NM
Skeletal Muscle (Para/Sympha)
G-Protein = Receptor
q Alpha-1 q M-1 s D1
i Alpha-2 i M-2 i D2
s Beta-1 q M-3 q H1 / V1
s Beta-2 s H2 / V2
Kiniss si boy, kinick ni girl kasi gusto ng sexs

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 ANS DRUGS
SYMPHATHETIC NERVOUS SYSTEM
SYMPHATHOMIMETIC / ADRENERGIC AGONIST
 DIRECT-ACTING
Epinephrine Dopamine
A. Non-selective
Norepinephrine
B. Selective
Non selective B Isoproterenol Isoprenaline
Selective B1 Dobutamine * partial agonist Penalterol
Salbutamol/ Albuterol Terbutaline
SABA
Metaproterenol Pirbuterol
Salmeterol Bambuterol
Selective B2 LABA
Formoterol Indacaterol
Ritodrine Tertbutaline
Tocolytics
Isoxsuprine
Selective A1 Phenylephrine Tetrahydrozoline Midodrine
PropMethPhen + Methoxamine Oxymetazoline Xylometazoline
-zoline Propyhexedrine Nafazoline
Selective A2 Clonidine Guanfacine
GuaMeth + - Methyldopa Guanabenz
nidine Apraclonidine Brimonidine
Selective D1 Fenoldopam
 INDIRECT-ACTING
Tyramine Ephedrine
A. Releasers
Amphetamine Pseudoephedrine
B. Reuptake Inhibitors Cocaine Reboxetine TCA
 CENTRALLY-ACTING Phen-
Phenylpropanolamine (PPA) Amphetamine/ Methamphetamine Modafenil
Phentermine Methylphenidate/ Mephenidate
Phenmetrazine Pemoline
SYMPATHOLYTICS / ADRENERGIC ANTAGONIST
 ALPHA BLOCKERS
Irreversible Phenoxybenzamine
A. Non-Selective
Reversible Phentolamine + Tolazoline
B. Selective A1 Prazosin Alfuzosin Terazosin
-zosin Doxazosin Tamsulosin Indoramin
C. Selective A2 Yohimbine Rauwolscine (alkaloids)
 BETA BLOCKERS -olol/-lol
A. Non-Selective The rest of -olols & -alols
Celiprolol Acebutolol
Shortest t½: Esmolol
Bisoprolol Metoprolol Longest t½: Nadolol
B. Cardioselective
Betaxolol Nebivolol Most β sel.: Nebivolol
CBEAM + NN
Esmolol Nadolol
Atenolol
C. Instrinsic Symphathomimetic Carteolol Labetalol Pindolol
Activity CLAP Celiprolol Atenolol Penbutolol
D. Membrane Stabilizing Pindolol Acebutolol Metoprolol
Activity PPALM Propranolol Labetalol
Labetalol Medroxalol
E. Mixed A & B
Carvedilol Bucindolol

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 PARASYMPHATHETIC NERVOUS SYSTEM
PARASYMPATHOMIMETIC / CHOLINERGIC AGONIST
 DIRECT ACTING
Mixed (M and N)
Carbachol Acetylcholine Metacholine
A. Choline Esters CAM
Muscarinic Bethanechol
Mixed Arecoline
B. Alkaloids Nicotinic only Nicotine Varenicline Lobeline
Muscarinic only Muscarine Pilocarpine
 INDIRECT-ACTING Chemical & DOA
A. Short Acting Edrophonium Aminoalcohol (15-30mins)
Physostigmine/ Eserine
B. Intermediate-acting Carbamates
Pyridostigmine Ambenonium
(-stigmine) (2-8hrs; <24hrs.)
Neostigmine Demecarum
Echothiopate Tabun
Organophosphates
C. Very long-acting Malathion Sarin
(>24hrs.; days to weeks)
Parathion Soman
D. CNS-acting Rivastigmine Donepezil Riva is tact, she’s done
(Alzheimer’s dse.) Tacrine + Galantamine with gala
PARASYMPHATOLYTIC/ CHOLINERGIC ANTAGONIST
 ANTI-MUSCARINIC
A. Atropine
Scopolamine Biperiden
CNS
Trihexyphenidyl Benztropine
Atropine Cyclopentolate
Mydriatic-Cycloplegic
Homatropine Panistropine
-tropine
Scopolamine Tropicamide
Bronchodilator Ipratropium Tiotropium
-tropium Oxytropium
B. Others:
Selective M1-blocker
Pirenzepine Telenzepine
(GIT) -zepine
Methoscopolamine Dicycloverine
Glycopyrrolate Oxybutinin
Selective M3-blocker
Scopolamine Hyoscine-N-butylbromide
(Urinary Bladder)
Dicyclomine Clidinium
Anisotropine Propantheline
 ANTINICOTINIC
A. Nn / Ganglionic Trimetaphan Hexamethonium
Blockers Mecamylamine
Depolarizing NMB Succinylcholine
Isoquinoline Atracurium
B. Nm Blockers (-curium) Mivacurium
Non-Depolarizing NMB
Steroidal Pancuronium
(-curonium) Vecuronium
+ Regenerator Pralidoxime

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II. AUTACOIDS
 Histamines Location Effect
Vascular SM Dilation
Bronchi, GIT Contraction Partial Agonist:
Histaprodifen
H1 Gq Endothelial cells Contraction Partial Antagonist:
Sensory nerve endings Itch and pain Tripolidine
Brain Excitatory Wakefulness
Gastric Glands (parietal cells) Basal Gastric Acid Secretion
H2 Gs
Mast cells Promote Histamine Release
Pre-synaptic:
H3 Gi GIT Contraction
Brain, Myenteric plexus
H4 Gi WBC: Eosinophils, Neutrophils, CD4 T-Lymphocytes
DRUGS
Histamine Betahistine
Imetit R-α methyl histamine
Agonist H3 Partial Agonist
Imepip
H4 Partial Agonist Clozapine
Antagonist Physiologic Epinephrine
1st Gen/ Sedating/ Classical
Diphenhydramine Carbinoxamine
Ethanolamine
Dimenhydrinate Doxylamine
Ethylenediamine Pyrilamine Tripelenamine
Hydroxyzine Cyclizine
Piperazine
Meclizine
H1 Blockers Alkylamine Brompheniramine Chlorpheniramine
Phenothiazine Promethiazine
Piperidine Cyproheptadine
nd
2 Gen./ Non or Less Sedating
Loratidine Fexofenadine
Piperidine (true)
Desloratidine Levocetirizine
Piperazine (less) Cetirizine Acrivastatine
H2 Blockers Cimetidine Famotidine
-tidine Ranitidine Nizatidine
Thioperamide
H3 blockers
Partial Antagonist Indophenpropit Tiprolisant
H4 Antagonist / Partial Agonist Clobenpropit
 Serotonin Happy Hormone; responsible for mood regulation
Effect DRUGS
To inhibit
5HT1A Partial
Gi further Buspirone Repinotan
CNS release Agonist
5HT1B/1D Full Agonist Sumatriptan Zolmitriptan
Gi Constriction
Vascular SM “-triptans” Naratriptan Rizatriptan
Agonist Ergotamine Methylergometrine
5HT2A “Ergot” Ergonovine Dihydroergotamine
Gq Contraction
Uterine SM
Antagonist Methysergide Ketanserin
5HT3 Antagonist Granisetron Ondansetron
Emesis
CTZ “-setron” Dolasetron Palonosetron
Partial
5HT4 Tegaserod Cisapride
Gs Peristalsis Agonist
GIT
Full Agonist Prucalopride

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 Melatonin  N –acetyl-methoxytryptamine
 Diurnal cycle (Sleepwake) MT1 Sleepiness
MT2 Circadian Rhythym
Agonist Ramelteon Agomelatone
 Kalidin  no agent, but its analogues/ drugs can mimic, block or modulate
other autocoids
 Bradykinin
function as an algesic

PROSTAGLANDINS & EICOSANOIDS

 Prostaglandin
Constriction Dilation DRUGS
Vascular Smooth
Muscle PGE1 Alprostadil (PGE1)
TXA2, PGF2
PGI2 Epoprostenol (PGI2)
Spasm Dilation
TXA2
Bronchial PGI2
PGF2
PGE
LT CDE4
Aggregation Inhibitor
Platelet PGI2
TXA2
PGE1
Cytoprotection
GIT Misoprostol (PGE1)
PGE series
Contraction Dysmenorrhea
PGE2 PGE2
Uterine Dinoprostone (PGE2)
PGF2 PGF2
TXA2 PGD
PGF2α Latanoprost (PGF2)
Eyes
PGE Carboprost (PGF2)
 Leukotrienes
Agonist LTB4 LTC4, LTD4
Lipooxygenase inhibitor Zileuton
Antagonist
Leukotriene receptor inhibitors Montelukast Zafirlukast
 Thromboxane TXA2
 Prostacycline PGI2 Epoprostenol Treprostinil (Analogue)

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III. ANALGESICS
 COX INHIBITORS
NON-SELECTIVE
Aspirin Mg choline salicylate Salicylsalicylate
Salicylates
Diflunisal Na salicylate Methylsalicylate
Phenylbutazone Sulfinpyrazone Apazone
Pyrazolone
Oxyphenbutazone Dipyrone
Sulindac Alcofenac Etodolac
Phenylacetic acid
Diclofenac Ketorolac Nabumetone
Fenamates Mefenamic acid Flufenamic acid Meclofenic acid
Propionic acid Ibuprofen Flubiprofen
-pro/-profen Ketoprofen Naproxen
Indole Indomethacin
Pyrole-alkanoic acid Tolmetin
Oxicam Piroxicam
Selective COX-2 Meloxicam
Specific COX-2 -coxib Celecoxib Enterocoxib
 NON-NARCOTIC
Para-aminophenol Acetaminophen/ Paracetamol Phenacetin
 NARCOTIC
Natural Opium Morphine Codeine Thebaine
Heroin Hydromorphone Hydrocodone
Semi-synthetic
Apomorphine Oxymorphone Oxycodone
Methadone Loperamide Alfentanil
Synthetic Meperidine Tramadol Sulfentanil
Diphenoxylate Fentanyl Dofentanil
CLASSIFICATION BY DYNAMICS
Strong Agonist Morphine Oxymorphone Hydromorphone
“Morphine +L” Meperidine Fentanyl Levorphanol
Antagonist Naloxone Naltrexone
“Nal + L” Nalorphine Levalorphan
Partial Agonist Pentazocine Buprenorphine Codeine
“PNB” Butorphanol Nalbuphine Hydrocodone
Mixed agonist-antagonist Buprenorphine Nalbuphine
Miscellaneous Codeine Loperamide Tramadol

DRUGS FOR GOUTY ARTHRITIS

Colchicine Glucocorticoids: Methylprednisone
A. Acute Gout
NSAID
Colchicine Penicillamine
Prednisone Mathylprednisolone
Glucocorticoid
Triamcinolone
Uricosuric Agents Probenecid Sulfinpyrazone
B. Chronic Gout
Xanthine Oxidase
Allopurinol Febuxostat
Inhibitor
Urate Oxidase
Pegloticase Rasburicase
Analog

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 DRUGS FOR RHEUMATIC DISORDERS
 NSAIDS except Aspirin, Tolmetin
 DMARDS (DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS)
1. Non-biologics / Classical / Traditional
A. Methotrexate
B. Anti-malarial Agents Chloroquin Hydroxychloroquin
C. Sulfasalazine Sulfapyridine
Leflunomide Cyclosporine
D. Immunosuppresants
Azathioprine Mycophenolate mofetil
and Cytotoxic Drugs
Cyclophosphamide
2. Biologics
Adalimumab Etanercept Golimumab
TNF α blocking agents
Infiximab Certolizumab
IL-1-neutralizing agents Anakinra
B-cell depleting agent Rituximab
T-cell activation inhibitor Abatacept
Anti-IL-6 receptor antibody Tocilizumab
Aurothioglucose
 Gold Compounds Auranofin oral parenteral
Aurothiomalate
 Penicillamine
 Glucocorticoids

IV. Drugs for COAGULATION Disorder

ANTITHROMBOTICS
 Anticoagulants
A. Direct Thrombin Hirudin / Lepirudin Bivalirudin
Inhibitor Dabigatran etexilate mesylate Argatroban
B. Indirect Thrombin Heparin Warfarin
Inhibitor Regular Unfractioned Heparin Dicumarol
Apixaban Fondaparinux Danaparoid
Low Molecular Weight/
Enoxaparin Tinzaparin Fraxiparin
Fractioned Heparin
Dalteparin Fraxiparin Danaparoid
 Antiplatelet
A. TXA2 Inhibitors Aspirin
B. ADP Inhibitor Clopidogrel Prasugrel Ticlopidin
3 Dipyridamol 5 Sildenafil
C. Phosphodiesterase Inhibitor
4 Raftumilast Cilostazol
Abciximab Eptifibatide
D. Glycoprotein IIb/IIIa Inhibitors
Tirofiban
 Fibrinolytics/ Thrombolytics (-kinase, -teplase)
A. Streptokinase
B. APSAC Anistreplase
C. Tissue Plasminogen Natural Alteplase
Activator Recombinant Reteplase Tenecteplase
D. Urokinase
PROTHROMBOTICS
Vitamin K1 Phytomenadione Vitamin K3 Menadione
A. Vitamin K
Vitamin K2 Menaquinone
B. Antiplasmin Epsilon-aminocaproic acid Tranexamic acid
C. Serine Protease Inhibitor Aprotinin

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V. Drugs For LIPID Disorder
 Statins ( Cholesterol)
Fluvastatin Pravastatin
A. SHORT-ACTING
Simvastatin Lovastatin
B. LONG-ACTING Atorvastatin Rosuvastatin
 Fenofibrates Gemfibrozil Clofibrate
( Triglycerides) Fenofibrate Bezafibrate
 Nicotinic Acid Vit. B3 (Niacin)
 NPCILI-Like Transporter
Ezetimibe
Inhibitor
Colestipol Colesevelam
 Bile Acid Binding Resin
Cholestyramin
 Cholesteryl Ester Transfer
Anacetrapib Dalcetrapib
Protein Inhibitors

VI. Cardiovascular drugs

DRUGS FOR HYPERTENSION
 Diuretics
A. Carbonic Anhydrase Acetazolamide Dorzolamide
Inhibitors “-zolamide” Brinzolamide Dichlorphenamide
B. Osmotic Diuretic Mannitol
Sulfonamide Furosemide Bumetanide
C. Loop Diuretics Sulfonyurea Torsemide
Phenoxyacetate Ethacrynic acid
Hydrochlorothiazide Chlorthalidone Metalazone
D. Thiazide Diuretic
Chlorthiazide Indapamide
E. Potassium-Sparring Aldosterone Antagonist Spirinolactone Epterenone
Diuretic Direct Na-Cl transporter Amiloride Triamterene
ADH Agonist “-pressin” Desmopressin Terlipressin
F. Other Diuretics ADH Antagonist Convaptan Demeclocycline
“-vaptan” Lixivaptan
 Sympathoplegics
Clonidine Guanfacine
A. Centrally Acting
Methyldopa Guanabenz
B. Peripherally-Acting Reserpine Guanadrel Guanethidine
C. Ganglionic Blockers
D. Alpha Blockers
E. Beta Blockers
 Vasodilators
A. Arteriolar Vasodilators Hydralazine Minoxidil Diazoxide
B. Mixed Arteriolar & Venous
Na nitroprusside Organic Nitrates
Dilators
 Calcium Channel Blockers
Nifedipine Amlodipine
A. Dihydropyridine “-dipine”
Nimodipine Felodipine
B. Non-Dihydropyridine Verapamil Diltiazem
BASED ON DURATION OF ACTION
Intrinsically short-acting Intrinsically-long acting Modified-Long acting
NonDHP CCBS Lacidipine Plendal ER
All DHP CCBS except “L,A” Lercanidipine Versant SR
Amlodipine Verapamil SR

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 Angiotensin Modifiers
Sulfhydryl Captopril
A. Angiotensin-Converting
Phosphinyl Fosinopril
Enzyme (ACE) Inhibitors
Lisinopril Enalaprilat
“-pril” Carboxyl
Enalaprilat Perindopril
B. Angiotensin Receptor Losartan Valsartan
Blocker (ARBS) “-sartan” Candesartan
C. Renin Inhibitor Aliskerin

DRUGS FOR ANGINA PECTORIS

 Nitrovasodilators
A. Very Short Acting (Lasts 5-10mins) Amyl nitrate
B. Short Acting (Lasts 10-30mins) Isosorbide Dinitrate Nitroglycerin SL
C. Intermediate Acting (5-8hrs) Isosorbide Dinitrate PO Nitroglycerin -SR
Isosorbide
D. Long Acting (5-8hrs) Isosorbide Dinitrate -SR
Mononitrate
 Beta Blockers
 Calcium Channel Blockers
A. NON-DHP Alternative for CSAP ++ SILDENAFIL
B. LONG-ACTING Alternative for CSAP * do not take w/ Nitrates
C. SHORT-ACTING For Prinzmetal Angina  Lethal Hypotension
DRUGS FOR HEART FAILURE
Digoxin Digitoxin
A. Inotropics
Digitalis
 INOTROPICS
B. B1 Agonist Dobutamine Dopamine
C. PDEInhibitors Amrinone Milrinone
A. ACE Inhibitors
Furosemide
B. Diuretics
Spirinolactone + Eplerenone
C. Vasodilators ISDN + Hydralazine
 UNLOADERS Carvedilol Labetalol
D. Betablockers Bisoprolol Nebivolol
Metoprolol
E. Brain Natriuretic
Neseritide
Peptide Analogue
ANTI-ARRHYTMIC DRUGS
Class Effects on AP
Procainamide Disopyramide “Proclamation of the
A Prolong
Quinidine Quin in the Pyramide”
I. Na
Tocainide Mexilitine “Tomato Lettuce at
Channel B Shorten
Lidocaine Phenytoin Mayo Po”
Blockers
Moracizine Profenone “More Fried Please,
C No effect
Flecainide Encainide Enrico”
Propranolol Acebutolol Propranolol
II. Beta Blockers No effect
Esmolol Timolol Sotalol
Amiodarone Ibutelide Vernakalant
III. K Channel
Prolong Sotalol Dofetilide
Blocker
Bretylium Dronedarone
IV. Ca channel
No effect Verapamil Diltizaem
blockers
V. Miscellaneous Adenosine K ion
agents Mg ion
Module 4 All-around Pharmacist (@GapangPharma)
VII. ENDOCRINE DRUGS
Hypothalamic Hormone Anterior-P.H Target Organ Hormone
Thyroxine
Thyrotrophin RH
Thyrotropin (TSH) Thyroid Gland Triiodothyronine
(TRH)
T4 & T3
Corticotropin/
Corticotropin RH Adrenal
Adrenocorticotropin Cortisol only
(CRH) Cortex
(ACTH)
Gonadotropin RH Estrogen (FSH),
Gonadotropin = LH Ovaries &
(GnRH)/ Lutenising Progesterone (LH),
& FSH Testes
Hormone RH (LHRH) Testosterone (LH)
Somatomedin-C
Growth Hormone RH Growth Hormone
Liver Insulin-like Growth
(GHRH) (Somatotropin)
Factor-1 (IGF-1)
Growth Hormone Somatomedin-C
Inhibitory Hormone Somatostatin Liver Insulin-like Growth
(GHIH) Factor-1 (IGF-1)

HYPOTHALAMIC-PITUITARY HORMONE
 Anterior Pituitary Hormone
GROWTH HORMONE
A. GH deficiency Growth Hormone Agonist
A. Cadaveric Somatotropin
I. Growth Hormone
B. Recombinant Somatropin Somatrem
II. Mecasermin
III. Growth Hormone
Sermorelin
Releasing Hormone
B. GH excess Growth Hormone Antagonist
I. Growth Hormone III. GH receptor
Somatostatin Pegvisomant
Inhibiting Hormone Antagonist
II. Somatostatin Ocreotide Lanreotide IV. Dopamine Bromocriptine
Analogue -reotide Pasireotide Vapreotide Agonist Cabergolide
GONADOTROPIN FSH & LH and HCG
Gonadotropin Preparation
I. Mixed LH & FSH Menotropin
II. FSH Follitropin α & β Urofollitropin
III. LH Lutropin alpha
IV. Human Chronic
hCG purified IM rhCG subQ
Gonadotropin
Gonadotropin-releasing hormone (GnRH) & Analogs
A. Gonadorelin
GnRH Agonist Leuprolide Nafarelin
-relin B. Synthetic Nasal spray
Goserelin SQ Buserelin
Analogs
Histrelin Triptorelin IM depot
GnRH Antagonist Ganirelix Degarelix
-relix Cetorelix Abarelix
 Posterior Pituitary Hormone
1. Vasopressin
A. ADH deficiency ADH Agonist (-pressin) Vasopressin Desmopressin
ADH Antagonist (-vaptan) Conivaptan Tolvaptan
B. ADH excess
Other Drugs: Demeclocycline
2. Oxytocin
Oxytocin antagonist Atosiban

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 ADRENOCORTICAL HORMONES
Zones of Adrenal Cortex Hormones
Zona Glomerulosa Mineralocorticoid “Go Find Rex,
Zona Fasciculata Glucocorticoid Make Good Sex”
Zona Reticularis Adrenal Sex Hormone
I. Glucocorticoids
Cortisol / Hydrocortisone Prednisolone
A. Short-Acting To
Cortisone Methylprednisolone
Medium (8-12)
Prednisone
B. Intermediate Fluprednisolone Paramethasone
(12-36) Triamcinolone
C. Long-Acting (>36) Betamethasone Dexamethasone
II. Mineralocorticoid
A. Endogenous Aldosterone Desoxycorticosterone acetate
B. Synthetic Fludrocortisone
III. Antagonist
Ketoconazole Metyrapone Abiraterone
Synthetic Inhibitors
Aminoglutethimide Trilostane Mitotane
Glucocorticoid
Mifepristone
Receptor Antagonist
Mineralocorticoid
Spirinolactone Eplerenone
Receptor Antagonist
IV. Sex Hormones ++++
Estrogen
Natural, steroidal Estradiol (E2) Estriol (E3) Estrone (E1)
Synthethic, steroidal Ethinyl estradiol Mestranol Quinestrol
Synthethic, non steroidal Diethylsilbestrol Chlorotrianisene Methallenestril
ANTIESTROGEN
Selective Estrogen Tamoxifen Raloxifene
Receptor Modulator Toremifene Clomiphene
Receptor Antagonist Fulvestrant
Aromatase Inhibitor Anastrozole Letrozole Exemestane
Antiprogestin Mifepristone
Progestin
Natural Progesterone
Synthethic
Hydroxyprogesterone
Medroxyprogesterone acetate
Progesterone deriv caproate
Megestrol acetate
Testosterone deriv Dimethisterone
Levonorgestrel Norethynodrel
19 Nor Testosterone
Norethindrone Lynesterol
deriv
Ethynodiol diacetate
13 Ethyl Nor Norgestimate Desogestrel
Testosterone deriv Gestodone
Androgens
Testosterone Nandrolone
Methyltestosterone Menotropin
Danazol
ANTIANDROGENS
A. 5-Reductase Inhibitor Finasteride Dutasteride
B. Receptor Antagonist Flutamide Bicalutamide Spirinolactone
Module 4 All-around Pharmacist (@GapangPharma)
  HORMONAL CONTRACEPTIVES
Combination Oral Contraceptives Estrogen + Progesterone
Monophasic Constant amount
Biphasic D1-D14; D15-D28 2conc. / pill
Triphasic D1-D7; D8-D14; D15-D22 3 or more conc. / pill
Transdermal Patch Ethinyl estradiol + Progestin
Vaginal ring Ethinyl estradiol + Etonogestrel
Progestin-only pills Ethindrone or Norgestrel “Minipill”
Norimplant 216mg of Norgestrel
Progestin implant
Implanon 68mg of Etonogestrel
Progestine
Impregnated IUD Levorgestrel
Intrauterine Device
Post-coital pills Morning after pills  dose of Progesterone
Injectable Methoxy progesterone acetate
Fertility Drug Clomiphene citrate

DRUGS FOR THYROID DISORDER

A. TH deficiency = Hypothyroidism THYROID PREPARATIONS
Synthethic Levothyroxine (LT4) Levothyronine (LT3) Liotrix (T4 & T3)
Animal Origin
B. TH excess = Hyperthyroidism
Classification MOA Drugs
Inhibiting peroxidase (Blocks Methimazole
Propylthiouracil
Thioamide peroxidation, organification &
(PTU) Carbimazole
coupling)
Inorganic anions Inhibit Iodine uptake Perchlorate Thiocyanate
Lugol’s solution Saturated
(Strong Iodine solution of
Iodides <10-14 days
solution) 5% I2 Potassium
KI, H2O Iodide (SSKI)
Radiocontrast Inhibit peripheral conversion
Iopanate Ipodate
Dyes & proteolysis
Dexamethasone Inhibit peripheral conversion
Control Hypersymphathetic
Beta Blocker s/sx + Inhibition of Peripheral Propranolol
Conversion
Taken up by thyroid cells &
causes destruction &
Radioactive
oxidative damage by
Iodine (I131)
emission of high energy β
radiation

Module 4 All-around Pharmacist (@GapangPharma)

 PANCREATIC HORMONES
I. Insulin
A. Ultra rapid-acting Insulin Lispro Insulin Aspart Insulin Glulisine
B. Short-acting Regular Insulin
C. Intermediate-acting Isophane Insulin Lente insulin
Insulin Detemir Insuline Glargine
D. Long-acting
Insulin Levemir Ultra-lente insulin
70-30 (NPH-Regular/Ultra-rapid acting)
E. Mixed insulin
60-40 (NPH-Regular)
II. Insulin Secretagogues
Chlorpropamide Acetohexamide
1st Gen “-amide”
Tolbutamide Tolazamide
A. Sulfonylurea
Glibenclamide Gliclazide Glyburide
2nd Gen “Gly-, Gli-”
Glipizide Glimepiride
B. Meglinitide Repaglinide Nateglinide
III. INSULIN SENSITIZER
A. Biguanides Metformin Phenformin
B. Thiazolidinedione Rosiglitazone Pioglitazone Traglitazone
IV. ALPHA-GLUCOSIDASE Acarbose Liraglutide
INHIBITOR Voglibose Miglitol
V. INCRETIN-ACTING DRUGS
A. GLP-1 Analogue
Exenatide Liraglutide
(GLUCAGON-LIKE PEPTIDE 1)
B. DPP-IV INHIBITOR Sitagliptin Linagliptin
(DIPEPTIDE PEPTIDASE IV) Saxagliptin
VI. AMYLIN ANALOGUE Pramlitide
VII. GLUCAGON
DRUGS FOR OSTEOPOROSIS
1. Calcium Carbonate
Alendronate Ibandronate
2. Biphosphonate “-dronate”
Risedronate Zoledronic acid
3. SERM Raloxifene
4. Calcitonin
5. Estrogen & Hormonal
Therapy
6. Phystoestrogen
7. Testosterone & Anabolic
Oral Methyltestosterone Testosterone Implants
Steroids
8. Parathyroid Hormone Terparatide

Module 4 All-around Pharmacist (@GapangPharma)

VIII. CNS Drugs
 Psychosis (Schizoprenia)  Dopamine, 5-HT, Glutamate
ANTIPSYCHOTICS / NEUROLEPTICS / MAJOR TRANQUILIZER
I. First Gen. / Typical / Classical / Traditional
Aliphatic “-promazine” Chlorpromazine
Fluphenazine +Prochlorperazine
A. Phenothiazine
Piperazine “phenazine” Perphenazine +Trifluoroperazine
“-azine”
Trifluphenazine
Piperidine “-ridazine” Mesoridazine Thioridazine
B. Butyrphenone “-peridol” Haloperidol Droperidol
C. Thioxantene “-thix” Thiothixene
II. Atypical/Second Gen “-zapine”, “-xapine”, “-peridone”
Aripripazole Paliperidone Molindone
Clozapine Risperidone Loxapine
Olanzapine Ziprasidone Ziprasidone
Quetiapine
 Mood Regulation 5-HT, NE, Dopamine
Bipolar disease Mania + Major depression
Cyclothymia Hypomania + Dysthymia
DRUGS FOR MOOD DISORDER
A. Antidepressants
Amitriptyline + Trimipramine
I. Tricyclic Antidepressants
Nortriptyline + Clomipramine
-triptiline (Ami,Nor-)
Desipramine + Dosulepine / Dothiepin
-pramine (Desi-,Imi-)
Imipramine + Nortryptyline
Doxepine
Doxepine + Protriptyline
Mianserin Maprotiline
II. Tetracyclic Antidepressants
Amoxapine
Phenelzine Isocarboxazid
III. Non-Selective MAO Inhibitor
Tranylcypramine
IV. Atypical Antidepressants
Trazodone Nefazodone
-zodone
V. Selective Serotonin Fluoxetine Fluvoxamine
Reuptake Inhibitor (SSRI) Sertraline Paroxetine
Flu-Flu, Paro-Ser,CC Citalopram Escitalopram
VI. Serotonin-Norepinephrine Duloxetine Desvenlafaxine
Reuptake Inhibitors (SNRI) Venlafaxine
VII. Noradrenergic & Selective “Nasan si Mirta,
Serotonin Antidepressants Mirtazepine pampagana pero
(NASSA) papatulugin”
VIII. Noradrenaline Reuptake
Reboxetine
Inhibitor (NARI)
IX. Reversible Inhibitor of MAOA Moclobemide
X. NE-Dopamine Reuptake
Bupropion
Inhibitor
+ Selective Serotonin Reuptake
Tianeptine
Enhancer SSRE
B. Anti-Mania / Drugs for Bipolar Disorder
Lithium Carbamazepine + Lamotrigine
Valproic acid Atypical Antipyschotic Drug
Depression Antidepressant + Anti Mania
When treating:
Mania Anti-Mania

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 Anxiety Overstimulation of excitatory neurons
Types of Generalized Anxiety Disorder Post-Traumatic Stress Syndrome
Anxiety Obssesive-Compulsive Disorder Social Phobia
Disorder Panic Disorder
ANXIOLYTIC / MINOR TRANQUILIZER
Chlordiazepoxide Chlorazepate
Short Acting MT-zolam Midazolam Triazolam
1. Benzodiazepines Intermediate-acting Lorazepam Oxazepam
-zepam, -zolam LTO-zepam, A-zolam Temazepam Alprazolam
except CC Long-acting The rest
Without Active Clonazepam Lorazepam
Metabolites “COLA” Oxazepam Alprazolam
Ultra-short acting Thipental Methohexital
“S, sulfur/Thio Thiamylal
Short-acting Pentobarbital Secobarbital
5-6-7 barbital Hexobarbita
2. Barbiturates
Intermediate-acting
-barbital, -bital,
Amo-buta, intermediate, Amobarbital Bitabarbital
-tal
hypnotic
Long-acting
May Forever kay Pheno Phenobarbital Barbital
& Barbi
3. Buspirone
4. Other Anxiolytics Zolpidem, Zaltreonam
5. TCA’s

Abnormal electrical activity in the brain; firing neurons

Inhibitory NT =  Excitatory NT
Seizure
Inhibitory NT NE, Epi, Dopa, Glutamate, Aspartate
Excitatory NT Glycine, GABA
SEIZURES W/ DOCs & ALTERNATIVES
Types of Seizure DOC Alternative
Simple Lamotrigine
1. Partial / Focal Carbamazepine
Oxacarbazepine
Seizure Complex Phenytoin
Valproic acid
Generalized Tonic- Topiramate
Valproic acid
Clonic (Grandmal) Lamotrigine
Absence (Petitmal) Ethosuximide Valproic acid
2. Generalized Valproic acid
Atonic Clonazepam Topiramate
Lamotrigine
Myoclonic Valproic acid
3. Status Lorazepam
Epilepticus Clonazepam
4. Acute Diazepam
ANTI-CONVULSANT ++++
1. Cyclic Ureides Phenytoin Phenobarbital Ethosuximide
2. Tricyclics Carbamazepine
3. Benzodiazepine Diazepam Lorazepam Clonazepam
4. GABA deriv Gabapentin Pregabalin Vigabatin
Valproic acid Topiramate Leveliracetam
5. Miscellaneous Divalproex Na Tiagabine Zonisamide
Lamotrigine Magnesium Sulfate

Module 4 All-around Pharmacist (@GapangPharma)

 Parkinson’s Dse Dopamine =  Acetylcholine; Progressive Movement disorder
ANTIPARKINSONISM
1. Levodopa + Carbidopa
2. COMT Inhibitors Entacapone Tolcapone
Ideal Triple Theory Levodopa + Carbidopa + Entacapone
Bromocriptine Pramipexole
3. D2 agonist Ergot Cabergolide Non-Ergot Rupinirole
Pergolide
4. Selective MAOB Inhibitors Selegiline Rasegiline
5. Amantadine
6. Apomorphine
Biperiden Trihexyphenidyl
7. Anticholinergic agents
Benztropine
DRUGS FOR OTHER MOVEMENT DISORDER
Tetrabenazine Haloperidol
Huntington’s Disease
Reserpine
Tourette’s Syndrome Clonidine Haloperidol

IX. ANESTHETHICS
I Analgesia III Anesthesia
Stages of Anesthesia
II Excitatory/Delirium IV Medullary Depression
 General Anesthesia
1. Inhalational anesthethics
N Nitrous Oxide I Isoflurane M Methoxyflurane
D Desflurane E Enflurane N Nitrous Oxide
S Sevoflurane H Halothane
2. Intravenous Anesthethic
Ultra-short acting BB Thiopental Methiohexital Thiamylal
Benzodiazepines Midazolam Triazolam
Propofol
Ketamine
Opioids Morphine Sulfentanil Fentanyl
Muscle relaxant Succinylcholine
Droperidol + Fentanyl Neurolept analgesia
Combined Therapy
Droperidol + Fentanyl + NO2 Neurolept anesthesia
 Local Anesthesia
Ester type “i" Cocaine, Procaine Amide type “ii” Lidocaine, Prilocaine

DRUGS OF ABUSE
I. CNS Stimulant
Caffeine Theobromine
A. Xanthine
Theophylline
Nicotine Polacrilex gum Bupropion
B. Nicotine
Clonidine Vareniclenin
Methylphenidate Phentermine
C. Amphetamine Methamphetamine Bangkok Pills
Ecstacy
D. Cocaine
Ethanol/ Ethyl alcohol Opioids (Heroin,Morphine)
II. CNS Depressant
Benzodiazepine
Phencyclidine Marijuana
III. Hallucinogens
Lysegic acid Diethylamide

Module 4 All-around Pharmacist (@GapangPharma)

 DRUGS USE TO TREAT DEPENDENCE & ADDICTION
Opioid Antagonist Naloxone, Naltrexone
Synthetic Opioid Methadone
Partial-receptor agonist Buprenorphine
N-receptor partial agonist Varenicline
Benzodiazepine Oxazepam, Lorazepam
NMDA receptor antagonist Acamprosate
Cannabinoid receptor agonist Rimonabant

X. RESPIRATORY DISORDERS
Drugs for Colds
A. Common Colds
Nasal Decongestants A1 agonist Phenylephrine
Nasay Spray
B. Allergic Colds Antihistamine w/ Nasal Decongestant
Drugs for Cough
A. Mucoregulators Ambroxol Bromhexine Carbocisteine
B. Mucolytic N-acetylcysteine
C. Expectorant Guiafenesin (Glycerol guiacolate)
D. Antitussive
Peripheral-acting Levodropropizine
Non-narcotic Butamirate citrate
Centrally-acting
Narcotic Codeine Dextromethorphan Noscapine
Drugs For Bronchospastic Disorders
A. BRONCHODILATORS
SABA LABA
1. B2 Agonist Salbutamol/ Albuterol Metoproterenol Salmeterol Bambuterol
Tertbutaline Picoterol Formoterol Indacaterol
B. METHYLXANTHINE Theophylline Aminophylline
C. ANTICHOLINERGICS/ANTIMUSCARINIC
Short-acting Ipratropium
Long-acting Tiotropium Glycopyrronium
II. MAST CELL STABILIZER “-crom”
Nedocromil Cromolyn Sodium / Na Cromoglycate
III. ANTI-INFLAMMATORY AGENTS
A. LEUKOTRIENE MODIFIERS
Lipooxygenase Inhibitor Zilueton
LTD4 Receptor Blocker Montelukast Zafirlukast
B. GLUCOCORTICOIDS
Inhaled Budesonide Fluticasone Triamcinolone
Systemic Oral Prednisone Prednisolone Methylprednisolone
Systemic Parenteral Hydrocortisone IV Methylpresnisolone IV

Module 4 All-around Pharmacist (@GapangPharma)

XI. DRUGS FOR GI DISORDER
GASTROESOPHAGEAL REFLUX DISEASE
▪ Lifestyle modification
Mild cases
▪ Over the counter antisecretory agents
Cimetidine Famotidine
H2 blockers
Moderate To Severe Ranitidine Nizatidine
Cases Omeprazole Pantoprazole
Proton pump inhibitors
Lansoprazole Rabeprazole
PEPTIC ULCER DISEASE AND RELATED CONDITIONS
AlOH + MgOH NaHCO3 + CaCO3 + Na alginate
1. Antacid AlOH + MgOH + Dimethicone NaHCO3
AlOH + MgOH + Simethicone
2. H2 Receptor Antagonist
Omeprazole Esomeprazole Rabeprazole
3. Proton Pump Inhibitor
Lansoprazole Pantoprazole
4. Prostaglandin Misoprostol
5. Mucosal Protectant Sucralfate Colloidal Bismuth Subcitrate
Triple Drug Therapy vs. H.pylori
 Omeprazole + Clarithromycin + Metronidazole/Amoxicillin
 Bismuth subsalicylated + Metronidazole + Tetracycline
 Ranitidine/Bismuth subcitrate + tetracycline + Clarithromycin + Metronidazole
Quadruple Drug Therapy vs. H.pylori
 Omeprazole + Bismyth subsalicylate + Metronidazole + Tetracycline

DRUGS FOR DIARRHEA

1. Oral Rehydration Salts / Oral Glucose- Electrolyte Solution
Diphenoxylate Opium Tincture
2. Antimotility Agents Loperamide Difenoxin
Paregoric
Kaolin-Pectin Tincture Attapulgite
3. Adsorbents
Polycarbophil
Bismuth subsalicylate Bacterial Replacement
4. Antisecretory
Enzymes
5. Ocreotide

DRUGS FOR CONSTIPATION

Fibers (fruits, vegetables) Psyllium
1. Bulk-Forming Laxative
Bran Methyl Cellulose
Lactulose Mg OH/Citrate/SO4
2. Osmotic / Saline Laxative Sorbitol Glycerin
Na PO4
Bisacodyl Sennoside
3. Stimulant / Irritant Laxative Phenolphthalein Casanthrol
Cascara Sagrada Castor oil
4. Stool Softener / Emollient Docusate Na
Mineral oil (Emollient)
Laxative (Stool softener)
PEG

Module 4 All-around Pharmacist (@GapangPharma)

 DRUGS FOR VOMITING
Prochlorperazine Promethazine
1. Dopamine Antagonist
Chlorpromazine Metoclopramide
2. Selective Serotonin Receptor Ondansetron Dolasetron
Inhibitor Granisetron Palonosetron
3. Antihistamine-Anticholinergic Dimenhydrinate Dimenhydrinate
Agents Diphenhydramine Diphenhydramine
Marijuana Dronabinol
4. Cannabinoids
Nabilone
5. Corticosteroid Dexamethasone
6. Benzodiazepine Lorazepam
7. Substance P/ Neurokinin 1
Aprepitant
Receptor Antagonist
8. Pyridoxime

INFLAMMATORY BOWEL DISEASE

1. 5-aminosalicylate 3. Biological agents (TNF α inhibitor)
2. Glucocorticoids Adalimumab Infliximab

Module 4 All-around Pharmacist (@GapangPharma)

X. CHEMOTHERAPEUTIC DRUGS
ONCOTIC DRUGS
I. CYTOTOXIC AGENTS
A. Direct DNA Interacting
 Akylating Agents
1. Merchlorethamine
2. Cyclophosphamide Ifosfamide
3. Platinum Analogs -platin Cisplatin Oxiplatin Carboplatin
4. Nitrosureas -mustine Lamustine Carmustine
5. Procarbazine Dacarbazine
6. Busulfan
7. Chlorambucil
 Topoisomerase Inhibitors
1. Antibiotics antineoplastic -mycin Dactinomycin Bleomycin Mitomycin
Daunorubicin Idarubicin
2. Anthracycline derivative -rubicin
Doxorubicin Epirubicin
3. Podophyllotoxin derivative -poside Etoposide Tenoposide
4. Camptothecin -tecan Irinotecan Topotecan
B. Indirect DNA-Interacting
 Antimetabolites
1. Methotrexate
2. Antipyrimidine/ Pyrimidine Analogue 5-Fluorouracil (5-FU)
3. Antipurine/ Purine Analogue 6-Mercaptopurine 6-Thioguanine
 Antimitotic
1. Taxanes -taxel Paclitaxel Cabazitaxel Docetaxel
2. Vinca alkaloids Vincristine Vinblastine
II. HORMONES AND ANTAGONIST
Adrenocortical steroid
For ER (+) Tamoxifen
cancer Aromatase Inhibitor Anastrazole Exemestane Letrozole
Androgen receptor
Prostate cancer Flutamide Bicalutamide
antagonist –tamide
III. MISCELLANEOUS AGENT Hydroxyurea
1. Bevacizumab 3. -nib
Targeted therapy 2. Cetuximab Sorafenib Sunitinib
Erlotinib Gefitinib

Module 4 All-around Pharmacist (@GapangPharma)

 ANTIBIOTICS
I. Cell Wall Synthesis Inhibitors
A. Penicillins
Natural Penicillins Pen G Benzylpenicillin Pen V Phenoxymethylpenicillin
Beta-Lactamase Methicillins Nafcillin
resistant Cloxacillin
Ampicillin
Aminopenicillin Amoxicillin + Sulbactam
Bacampicillin + Clavulanic acid
Extended Ticarcillin
spectrum Carboxypenicillin Take Care of your Carbs
Carbenicillin
penicillin
Mezlocillin
Ureidopenicillin Azlocillin MAP of Ukreine
Piperacillin
B. Cephalosporins Except Coverage
1 Gen “Ceph-”
st
Cefadroxil Cefazolin Staph, Streph
Cefmetazole Loracarbef CAP, G(+), G(-)
2nd Gen “Cef-vowel”
Cefprozil
Cefixime Moxalactam Cross BBB
3rd Gen “Cef-consonant”
Cefotaxime
Pseudomonas, MRSA,
4th Gen “pi” Cefepime Cefpirome
Enterobacter
5 Gen “ro”
th
Ceftaroline Ceftibiprole Pseudomonas, MRSA
C. Other Beta Lactam
Monobactam Aztreonam
Doripenem Meropenem
Carbapenem
Imipenem + Cilastatin Ertapenem
Glycopeptide antibiotics Vancomycin Bacitracin
II. Protein Synthesis Inhibitors
Doxycycline Tigercycline
1. Tetracycline
Minocycline Demeclocycline
2. Aminoglycoside
Streptomyces “-mycin” Streptomycin Tobramycin Kanamycin
Micromonospora “-micin” Amikacin Netilmicin Gentamicin
3. Macrolide Erythromycin Clarithromycin Azithromycin
4. Chloramphenicol 6. Linezolid
5. Lincosamide 7. Streptogramins
III. Nucleic Acid Synthesis Inhibitors
Sulfonamide
Co-trimoxazole
Trimetophrim
1st Gen Nalidixic acid
2nd Gen Ciprofloxacin Ofloxacin Enoxacin
CLONE Lomefloxacin Norfloxacin
Quinolones 3rd
Levofloxacin Gatifloxacin Sparfloxacin
LeGS
4th
Trovafloxacin Moxifloxacin
TM

Module 4 All-around Pharmacist (@GapangPharma)

 ANTI-TB & LEPROSY DRUGS
Rifampicin Ethambutol
1st line
Isoniazid Streptomycin
RIPES
Pyrazinamide
Anti-TB
Flouroquinolones Linezolid
2nd line
Aminoglycosides Rifabutin
FACLR
Cycloserine
Dapsone
Tuberculoid 6 mos.
Rifampicin
Anti-Leprosy Rifampicin
Lepromatous Dapsone 24 mos.
Clofazamine

ANTIFUNGAL
1. Polyenes Amphotericin B
Imidazole Ketoconazole Miconazole Cotrimoxazole
2. Azoles Fluconazole Itraconazole
Triazole
Posaconazole Variconazole
3. Terbinafines
4. Echinocandins
Caspofungin Micafungin Onidulafungin
“-fungin”
5. Flucytosine
6. Griseofulvin

ANTIVIRAL DRUGS
Oseltamivir Amantadine Ribavirin
I. Respiratory
Zanamivir Rimantadine
II. Hepatic Interferon Alpha Lamivudine Adefovir
Acyclovir Ganciclovir Cidofovir
III. Herpes and CMV
Foscarnet Trifluridine
Zidovudine AZT Lamivudine 3TC
Nucleotide Reverse
Stavudine d4T Emtricitabine FTC
Transcriptase
Didanosine ddl Abacavir ABC
Inhibitors (NRTIs)
Tenofovir TDF
Non-nucleoside Nevirapine NVP Etravirine ETR
reverse transcriptase Delavirdine DLV Rilpivirine RPV
Inhibitors (NNRTI) Efavirenz EFV
IV. HIV
Ritonavir RTV Nelfinavir NFV
Fosamprenavir
Protease Inhibitors Saquinavir SQV
FPV
Indinavir IDV
Entry Inhibitors Enfuvirtide Maraviroe
Raltegravir Dolutegravir
Integrase Inhibitors
Elvigravir

Module 4 All-around Pharmacist (@GapangPharma)

 ANTIPROTOZOAL
Drugs for:
A. Mixed Amebicide Metronidazole Tinidazole
A. Amebiasis B. Luminal Amebicide Iodoquinol Paromycin
C. Systemic Amebicide Chloroquine Dehydroemetine
Primaquine Chloroquine Atovaquine-proguanil
B. Malaria Mefloquine Quinine Artemisin
Pyrimethamine
Albendazole Mebendazole Thiabendazole
Diethylcarbamazine Ivermectin Metrifonate
C. Anthelmintics:
Niclosamiide Piperazine Praziquantel
Pyrantel Pamoate

Ovarian & Advanced Breast Peklitaxel “pekpek” =

Paclitaxel
Cancer ovarian
Docetaxel Advances Breast Cancer Docetaxel pang dodo
Monocytic leukemia, testicular
Etoposide
cancer, Lung cancer
Teniposide Lymphoma
Metastatic ovarian cancer and
Topotecan Topovary
Cisplatin-resistant neoplasm
Irinotecan Colon & Rectal Cancer Iri sa pwet
Breast, ovarian, thyroid, lung
Doxorubicin Doxo for dodo rin
cancer & acute leukemia
Daunorubicin & Acute Leukemia
Down Low, Daun leu
Idarubicin
Pediatric Sarcoma; Wilm’s
Dactinomycin Dac=duckling=pediatric
Tumor
Testicular cancer, reverse
Plicamycin cancer-associated
hypercalcemia
nd
2 ine agent for metastatic
Mitomycin
colon cancer
Bleomycin Neck, Cervical carcinoma
Chlorambucil Chronic Lymphocytic Leukemia
Mercaptopurine Childhood Acute Leukemia MerCALtopurine

BCS CLASSIFICATION
Class Solubility Permeability DRUGS
Diltiazem, Verapamil, Metoprolol,
I   DVMP
Propranolol
Phenytoin, Bicalutamide,
Pheny- Ibuprofen, NSAID, Glibenclamide,
II  
BINGED Ezetamibe,
DHP Ca Channel Blockers

Neomycin B, Cimetidine, Atenolol,

III   Neo-CARE
Ranitidine, Enalaprilat

Furosemide, Hydroclorothiazide,
IV   Furo-HBC
Bifonazole, Cefuroxime

Module 4 All-around Pharmacist (@GapangPharma)

TOXICOLOGY
TOXICANTS AFFECT SYSTEMIC TERATOGENIC AGENTS
M Methanol, Metabolic acidosis Thalidomide Phocomelia/Amelia
U Uremia Warfarin Hypoplatic nose
D Diabetic Ketoacidosis Tetracycline Teeth discoloration
P Paraldehyde Lithium Ebstein anomaly
I Iron, Isoniazid ACEi Renal dysgenesis
L Lactic acidosis DES CC CA for cervix & vagina
E Ethylene glycol Methimazole Aplasia cutis
S Salicylates Carbamazepine Neural tube defect
ANS Valproic acid Spina bifida
Parasymphatomimetics: Phenytoin Fetal Hydantoin syndrome
Organophosphates Alcohol Fetal Alcohol syndrome
D Diarrhea ANTIDOTES
U Urination Anticholinergics Neostigmine
M Miosis, muscle fasciculation Cholinesterase Inhibitors Atropine
Bronchoconstriction, Organophosphates Pralidoxime
B
Bradycardia BZD or Zolpidem Flumazenil
E Emesis Carbon Monoxide Oxygen
L Lacrimation Cyanide Hydroxycobalamin
S Salivation, Sweating Digoxin Digoxin antibodies
Symphatomimetics: Flouride, CCBS Calcium
Amphetamine Warfarin Vit.K
M Mydriasis Heparin Protamine sulfate
A Agitation Iron Deferoxamine
T Tachycardia Hypoglycemics Glucose
H Hypertension Beta-blockers Glucagon
S Seizure, sweating Paracetamol N-acetylcysteine
Methanol/ Ethylene glycol Ethanol/Fomepizole
Opioids Naloxone

GENERAL MANAGEMENT OF POISOINED PX

INITIAL ASSESMENT / PRIMARY SECONDARY SURVEY
A Airway M Medications
B Breathing A Allergy
C Circulation P Past Medical History/ Pregnancy
Glasgow coma scale
L Last meal
(15)
Degree of
D Eye opening 4 Events/ Environment related to
disability E
Verbal response 5 injury
Motor response 6 HEMODIALYSIS INDICATION
S Substance A Acidosis (Severe)
A Amount Electrolytes
E Exposure E
T Time (Refractory hyperkalemia)
S Symptoms Intoxication
NICOTINIC STIMULATION I (Salicylates, Lithium, Methanol,
M Muscle weakness Ethylene Glycol)
A Adrenal Medulla O Overlad volume
T Tachycardia
Uremia
C Cramps U
(Encephalopathy, Bleeding)
H Hypertension

Module 4 All-around Pharmacist (@GapangPharma)