Republic of the Philippines
CAMARINES SUR POLYTECHNIC COLLEGES
Nabua, Camarines Sur
College of Health Sciences
DRUG STUDY
DRUG ORDER MECHANISM OF INDICATIONS AND SIDE EFFECTS AND NURSING
ACTION CONTRAINDICATION ADVERSE EFFECTS RESPONSIBILITY
S
Generic Name: Trimetazidine inhibits Indications Side Effects o Check for doctor’s
Trimetazidine β-oxidation of fatty This drug is Dizziness, headache, order
acids through inhibition recommended in long abdominal pain,
Brand Name: of long-chain 3- term treatment of dyspepsia, diarrhea, o Monitor blood
Vastarel ketoacyl-CoAthiolase, coronary insufficiency; nausea, vomiting, pruritus, pressure and pulse
which enhances glucose Angina Pectoris rash, urticaria, asthenia rate before and after
Classification: oxidation. It ensures giving the meds.
Anti Angina proper functioning of Contraindications Adverse Effects
ionic pumps and Parkinson's disease, Tachycardia, palpitations, o Notify prescribing
Dosage: 35 mg transmembrane Na-K parkinsonian symptoms, extrasystoles, orthostatic signs of heart failure
flow by preventing tremors, restless leg hypotension, arterial such as swelling of
Frequency: BID decrease in intracellular syndrome and other hypotension, flushing hands and feet or
ATP levels movement related SOB.
Route: Po disorders. Severe renal
impairment (CrCl<30 o Advise patient of the
mL/min). Lactation. adverse effects of the
drug
DRUG STUDY
Name: Cyrene Jasmine P. Cabañes Year and Section: BSN-4B
Clinical Group: Group 1 Subject: NCM-122 RLE
JCI: Ms. Joy A. Tormes Date: February 6, 2023
Republic of the Philippines
CAMARINES SUR POLYTECHNIC COLLEGES
Nabua, Camarines Sur
College of Health Sciences
DRUG ORDER MECHANISM OF INDICATIONS AND SIDE EFFECTS AND NURSING
ACTION CONTRAINDICATION ADVERSE EFFECTS RESPONSIBILITY
S
Generic Name: Carvedilol causes Indications Adverse Effects o WARNING: Do not
carvedilol vasodilation by blocking Hypertension, alone or with Bradycardia, AV block, discontinue drug
the activity of α-blockers, other oral drugs, especially angina pectoris, abruptly after chronic
Brand Name: mainly at alpha-1 diuretics hypervolemia, leucopenia, therapy
Coreg receptors. It exerts Treatment of mild to severe hypotension, peripheral (hypersensitivity to
antihypertensive effect CHF of ischemic or edema, allergy, malaise, fluid catecholamines may
Classification: partly by reducing total cardiomyopathic origin with overload, melena, have developed,
Alpha- and beta- peripheral resistance and digitalis, diuretics, ACE periodontitis, hyperuricemia, causing exacerbation of
adrenergic blocker, vasodilation. It is used in inhibitors hyponatremia, increased angina, MI, and
Antihypertensive patients with renal Left ventricular dysfunction alkaline phosphatase, ventricular
impairment, NIDDM or (LVD) after MI glycosuria, prothrombin arrhythmias); taper
Pregnancy IDDM. Unlabeled uses: Angina time, SGPT and SGOT drug gradually over 2
Category: C (25–50 mg bid) levels, purpura, somnolence, wks. with monitoring.
Absorption: Absorbed impotence, albuminuria,
well from the GI tract Contraindications hypokinesia, nervousness, o Consult with physician
Dosage & Route (oral); peak plasma Hypersensitivity; severe sleep disorder, skin reaction, about withdrawing
Oral
concentrations after 1-2 chronic heart failure, tinnitus, dry mouth, anemia, drug if patient is to
hypertension
hr. bronchial asthma or related sweating, fatigue, arthralgia, undergo surgery
Adult: Initially, 12.5
Distribution: Enters bronchospastic conditions; aggravation, dizziness. (withdrawal is
mg once daily
breast milk. Protein- severe hepatic impairment. Diarrhea, nausea, vomiting, controversial).
increased to 25 mg
binding: >98%. Patients with NYHA class insomnia,
once daily after 2
IV cardiac failure, 2nd or hypercholesterolemia, weight o Give with food to
days. Alternatively,
Metabolism: Hepatic: 3rd ° AV block, sick sinus gain, abnormal vision, decrease orthostatic
initial dose of 6.25
Considerable first-pass syndrome (unless a rhinitis, pharyngitis and hypotension and
mg bid increased to
effect. permanent pacemaker is in hypertriglyceridemia. adverse effects.
12.5 mg bid after 1-2
wk, increased further place), cardiogenic shock or
Excretion: Via bile (as severe bradycardia. o Monitor for orthostatic
if necessary to 50 mg
metabolites); 6-10 hr Lactation. hypotension and
once daily or in
Name: Cyrene Jasmine P. Cabañes Year and Section: BSN-4B
Clinical Group: Group 1 Subject: NCM-122 RLE
JCI: Ms. Joy A. Tormes Date: February 6, 2023
Republic of the Philippines
CAMARINES SUR POLYTECHNIC COLLEGES
Nabua, Camarines Sur
College of Health Sciences
divided doses. (elimination half-life). provide safety
Elderly: 12.5 mg precautions.
once daily.
o Monitor diabetic
Angina pectoris patient closely; drug
Adult: Initially, 12.5 may mask
mg bid increased to hypoglycemia or
25 mg bid after 2 worsen hyperglycemia.
days.
o WARNING: Monitor
Heart failure Adult: patient for any sign of
Initially, 3.125 mg hepatic impairment
bid, doubled to 6.25 (pruritus, dark urine or
mg bid after 2 wks. if stools, anorexia,
tolerated, then jaundice, pain); arrange
gradually increased for LFTs and
to the max dose the discontinue drug if
patient can tolerate at tests indicate liver
intervals of not <2 injury. Do not restart
wk. Max dose: >85 carvedilol.
kg: 50 mg bid; <85
kg: 25 mg bid.
Left ventricular
dysfunction post
myocardial
infarction
Adult: Initially: 6.25
mg bid, if tolerated,
after 3-10 days,
increase to 12.5 mg
bid and then to a
Name: Cyrene Jasmine P. Cabañes Year and Section: BSN-4B
Clinical Group: Group 1 Subject: NCM-122 RLE
JCI: Ms. Joy A. Tormes Date: February 6, 2023
Republic of the Philippines
CAMARINES SUR POLYTECHNIC COLLEGES
Nabua, Camarines Sur
College of Health Sciences
target dose of 25 mg
bid.
Name: Cyrene Jasmine P. Cabañes Year and Section: BSN-4B
Clinical Group: Group 1 Subject: NCM-122 RLE
JCI: Ms. Joy A. Tormes Date: February 6, 2023
