Drug

Acid Lowering Agents

PPI H2RA
HIV ARV Cheat Sheet
Rilpivirine Avoid Separate Dosing ARVs & Oral Contraceptives Renal Adjustments For ARVs
Atazanavir Avoid Separate Dosing Lower Contraceptive Levels Drug CrCl (mL/min) Notes
Fosamprenavir Okay Separate Dosing Use Second/Alternate Method
Zidovudine 15 / HD
ARVs Safe in Pregnancy Nevirapine
Didanosine 60 Weight based dosing
Drug Note Darunavir
Emtricitabine 50
Abacavir Lopinavir/r
Lamivudine 50
Emtricitabine Nelfinavir
Stavudine 50 Weight based dosing
Lamivudine Saquinvir
Tenofovir Disoproxil Fumarate 50 <70 w/ Cobicistat
Tenofovir Tipranavir
Tenofovir Alefenamide 30
Zidovudine Elvitegravir
Nevirapine 20 / HD
NNRTIs EFV: Preg D 1st trimester Lower ARV Levels
Do Not Use Rilpivirine Severe / HD Monitor
IIs DTG: some concerns with NTD
PIs LPV/r commonly used Fosamprenavir Atazanavir HD ARV-naïve

Class Class-Wide Adverse Effects Considerations Lopinavir HD

NRTIs Lactic Acidosis/Hepatic Steatosis Dolutegravir Severe Caution

NNRTIs Rash/Hepatitis Drug Interactions Maraviroc 30 / HD

PIs Metabolic/LFTs Drug Interactions Cobicistat 70
IIs Separate 2+ Cations (Mg/Al/Ca) Combination agents use lower cutoff

Drug Adverse Effects/Notes (Likely To Be Tested)

Abacavir Rash / Hypersensitivity (Test HLA*B-5701) / Avoid in Viral Load >100K Unless with DTG
Atazanavir PR Prolongation / Cholelithiasis / May Increase Bilirubin / Boost if in Combination with Tenofovir
Darunavir Caution w/ Sulfa Allergy / Always Boost w/ Ritonavir or Cobicistat
Didanosine Peripheral Neuropathy / Pancreatitis
Efavirenz Pregnancy D 1 Trimester / Somnolence / Abnormal Dreams / Suicidal Ideation / Depression
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Fosamprenavir Caution w/ Sulfa Allergy

Indinavir May Increase Bilirubin
Lopinavir PR Prolongation / Always Boost w/ Ritonavir or Cobicistat
Maraviroc CCR5 Only (Must Check To Confirm Virus is CCR5 Binding, Not CXCR4 or Mixed)
Nevirapine Rash / Hypersensitivity Highest in NNRTIs / Autoinducer / Hepatotoxicity Higher with pre-ART CD4 ♀>250, ♂>400
Raltegravir Increased CPK
Rilpivirine QT Prolongation / Depression / Suicidal Ideation / Avoid if pre-Treatment Viral Load >100k, CD4 <200
Saquinavir PR Prolongation / QT Prolongation / Always Boost w/ Ritonavir or Cobicistat
Stavudine Peripheral Neuropathy / Pancreatitis
Tenofovir Decreased Bone Density / Fanconi / Acute Renal Failure
Tipranavir Intracranial Hemorrhage / Caution w/ Sulfa Allergy / Always Boost w/ Ritonavir or Cobicistat
Zidovudine Bone Marrow Suppression

Statin Interactions ARVs & Food

Statin Protease Inhibitors Cobicistat Note Take With Food Take on Empty Stomach
Etravirine Didanosine
Simvastatin Contraindicated Contraindicated Not even once.
Rilpivirine Efavirenz
Lovastatin Contraindicated Contraindicated Not even once.
Atazanavir
Fluvastatin No Data No Data ¯\_(ツ)_/¯
Darunavir
Pitavastatin Okay No Data
Nelfinavir
Pravastatin Okay (See Note) No Data ATV/DRV: Monitor Saquinavir
Rosuvastatin Okay (See Note) Okay Start Low -> Go Slow Elvitegravir
Atorvastatin Okay Except TPV/r Okay Start Low -> Go Slow Cobicistat
This resource was last updated February 2020. New agents are continually in development, and guidelines change over time.