¢ fu Homewosk bls: Meheli- Pj # IM Iso 51S | Qa a Joms of Mesrailline onc leomy of calUWanie axel 4 potent intiater | CF B Lathan Were Yeeoncitiuesl In leoml of Aenke ates Fey ee ' s covey %o pine %e patien Ts - . eines ot the Ave isa P pet agers “i See rare ae Told aca Wenn ‘oie pine mi | } Hele Voge ran ZI b 2 FA |e con, _of seayolbne at o cey = es (ea er aha aus Cy 2s. (ee a C44 Lose) ) We erie erin W = TET Yoo eo: CP. 0.9 Chm) wg JL JST mie a = loowys/min _ 4 ( Core ea as we 0-693 i = BBzeng/mm (pe ¥ = 6 673K Vise! kes =_1o0 |cpie = % B25 on “wy i) 3 = 2.2% Ms bmi ng { 11:3 | Plasma Sevel a. ¢ttearceillln a ee of (nguoon. | a (ess (eco) t pete cottmin' z\¥ormn) ! ce = co = Es (EK) ju ae 30) Pie 4 ROS oa eo =H 1LI mglt| |volune of chictvils nites ot Chevilarve cei Cir = KaNd “vet 8 yd = Zool wip! 0-643 He Nila Deatbe wil = 11, 31heng 2-643 fi su]Fatbe Talal amount of Hearciplin eliminated dung the Zoxnin WNpUsion. Abtiminated) = Ajo) — Alosds) i Lpyvel a ie Nd = Cr/ A = 2571 2\s.\ | Nd too zi 2.0844 Eres [m4 |

$34 mg/L Total, amauat—of-—diyy bn s AO ae se UA = sho. 1h, So wneand Goheue the Creat orate Di) Cpa CPS qf ai}OQ) MLL QA The Lherageutic plosma cons. of — dyvg 15. Upto ISmy/b » Vou Nave cleeiwed! attain q lavyeh cone, of \emg/b tvnndial anol mainhary the Cone, ILWe. The dug he tS bY WAN wengl and metoboalid clearance o¢ Sand f gg LI wy : Kespee\ively Ane pk hac an rdeal. bad. bt of $04 , AAA Callenbcde the foadiay close Cbollus) ancl_mainhain vale of -Inglt\ sf sb Dat tant Sh rnasy | Tei ES Aaah glove = Di = Cory y of Maintenance dose Dw = COSS¥4 CLT -—___— tpg Cle 601g — + S*b-SSz WSSt4 Inn vey Wyo ke vde i EDD 2iessy yy ot : ctisisils , Ce Nis CY, ots ok > i ‘ Ce be Nido bain ail ke 2his. Then = a y ma G Ou= \ex\oo eS Dr =looe my b | Ome tort Ea SNS Sema / hs Bp , ‘dlose) ig the voode of _inpuk 16 _cletidlea a Arnl/ min > | No = 4 > : Vol. °F Sol = 12 omg 7 ; Concendvohion € Amount > 4 . : Nal ot ! ’ tenes To . ee Tega a em | a ROT ON 4. -) dime to¥en Uy speed Aine Seng a ri ‘ t 5 au —y Vw any he Shy =» = Tin. a3§ sl held ah a aco | fe ts Poti) le t= orto ONS pore end ee ee a |13-Se llega cone. “Stopped ck Ake PDateau Devel of lorng/ I. Opes Coe thy Z Cox bhs Lb ond rhe attr ke Cissy é [Pine =, 30 ry i] onssed C Pb = lo’ ne Inguston Was the COs [ine = 2.5 myA| —cleveDeps acute renal gailare ond the venal cleat ance (AS Xedued 40 ar/hr. Wher bolus Joading dose ond maintenence sé erve $e the pt aa ~ —vunon—gahe—olol—you—_tecovnmmensl_4e achieve the cps — ‘Phe Mev of Jomy/L 2 Assume Roem eur oeeron and the SHAS 3 3 | Oy - Co sal rr= r+ (0m =1U+bess @ DE= fox\oo [eps eS LL Dine looomy a Coane : CLE leo = coe cey fox Gg ss [ee = 85crq/ir] RECC Ease y ee ot i | Usinolion emenstrots symptom const uit UTI. The | [UEC , on alkaline Urey PL, ond epithelrad od. Ay f oB th, of elimnedren = Any. Apperent Volume et clistloutien a Fa Sr SNe ane la ak tes ih oe oe ML aR ps et ee Neon ond endleal at BN heap hOrDS Pebermone “are follviny oe He greek Se bo 2 ort CP= Ko & \2.30Rm. The theony) BRRERRLE; DZ x O's) Cp < O4 Sy : ) = » © 648 yoy a | C Obst Yom /L “ ————- Bi Uns ena a i "} CP = Cpe + aspire S . Veoh a RoR uile sle le Bay ATidabnynundis carl Ai naire Soe 6" de ge RE Concent edion = Atsnousits he J “ aos Lay Bol cid mal allie ea gin. —0. 613 40,8 Aids = Co-ux2u) + o.o12e. q e > AN2.40 Any , LAv ne = 4 Uys} QTSs 1g: the toteh amauint of dhe shrug tnguredl over Ah. Were losamy » ond the phosima Concertrabion at hes end of the infunon Yas aa lenin tol c . : Ain = Cone ¥ Volume » eo ingusson if Khe aeparert Vodume of attvilbulion of. dros 1s [yeh ‘Cilgann Aekimineted = Arorah — Apilesme : : = 1 Aroral= looms J Ne: Adkimina\ed | » O: tbe Ae the vasa “ap edu Cea RA norma ‘enna vohd inPuyeD Over’ oles,’ Whol vould be the Yate of y > Rore o¢ inguwencs) Coneineml «> : et eA J arene olny Scehts = foomim ss! , lo = 4 =aGitrs ip the desived steady. stote pllasme concentyatron of y 1879.1 Ie the CPs of 9Sme JL. tora dtus vere_achvevedl ith 44 | RMON, ate of tomyn’ Unt Woulsh be the Steady State te dus 1s comglL, its total bedy ch ke loty ond it Hy IS any wha is the plosma concendrsron uy offer Stork of Incusren 7 (ea ost Nee {Seas - a¥ the Same ug7 Co= Ke t x tp || & we ci = piel pe pp ee eal cP ~ DS L Grau en | co = ks ° 2 Camas COeCieaeil 0 __inpution wal owslh hos oceveel 2 Coss’ of lame Wher (s .ANe Yate of element whi Seedy tated 2 bt pt Shea : ower 1S -ecveven|—the—ingunsy 6 Botte is? exval’ te the’ Yaie “ANN 0 Bee S| Se Bo of elimination ak steady tale 1 enryal do Qpz_kt (att) Lae a ¥ [et iste sei ys RE —2oxt CP nae Ge RA) Wy edo0ny | REL het 2 + — tae obey tie hy ox ; ees Ce en 13 Ne ae p 1, xf V # Jou Aneropamie Index divy te contvel cardioe RT : The dh 3 dows. on the fick ob a os on ae Hissk dog of ANectment > Ane iN WOE UHoM Starches & Stovied at \2r00 Noon and ended at oop» The aa 2 four), » | l2hep 40 4 os hes ! ae ae. ai ai orn eat {ss eheda Yo Nore ty, Yemin, On = 4. of lo- Demy) L- cacubele” the Fo owing, | fo A d ° AeA PD esa ene. Ob “Toms, = _- Corer eae Clee) pe far epee _—__} coetaes oT ee ] ND =Yos of Koby k= 0.693 ie 3 Si = $2) = ae Fi Te} —— eei calli 6. 4b oy) Coram = _Soe ci-e 9.469722 : JeRtem= 19 ty) 214.2: Plowne Cont. ok 12 noo ———————— AO . 5 4 | CENT pans in’ CaN Orn Tosa? 5) 2 anc a wipes, aaa Leos Plasmse Con. a+ 4 en —— 2 | CP.ar = CPin pm ao ‘yl =y9ure— ie Sia ory al ——a CPsan = 0 16\2 Gees gd 16:4: Le. | pnd merndain_o Sealy a aga ono mf days. | Drs cps xvd = IFS Dr = W4omy Tren t pegs Shas eye Vo = Ce xOX o a SWS FousrFZy feore Oo V4 oy Thy [Men 2 8-b4 my sie! | Shae = Ope [Mi gH 146 by IV tngusten. Adzoediey to the Literature , the ly —of —d V4} -1S——phys—ondAppownt— body wh. The Pk st Ais dsvy o\umes Git} ondey Process. qe @ dxu Haw Dong otter tre Shavh_of Ls) Ingusorr vould |} Take to weadh 40% OF the CK? a v iene 18 lous/mt}. Ve Cree a = |- eda * la COS sbLy 9h a . , Psy = tee KT a = er lao fy 6902 2 0.4 whit y Br IE \2- x 0-04 | a oeRon Inpusion vate i Atoms? el 2 twhar te the Preapen Doadin dloet pay the antt-lototic? %: Ino oy [ee 0. oft hy! \ a at Yes ae ach ie Bee 0 Ce Vo2 997.04 65 ky = ToxT4ae > 02% xb S000 RS reg] ee Role oF infunen = Ko= ae Z Eo= 0 oft 714.40 (0 ols Total bed clearances scarey ccippre Naot spin. tpl LV pEAL [leo = lusg-my pal} Cir = Vde K SS yee 03 44 is ee ais!) 6 | To estabfuln ¢ ane) Ose will lake 30.2 ¢hy Hoverer A Bi lo th fave fora anew CO bo be esteblicheel as thed- OS) of the Cex ig a eealonabole wit Donserr in wo 4 fauve ogg 2 22) ele lp ee 0 senal paiduve, Whar nav Ireutigh. Yate worllel ysu Kecamme A Bluey 2 Ba = Se ean ; ke, w eee el a ; + fin Anstcqnndsca slg fiona tha abide |ii Single Tv dese Comonk TN Ingugioyy Cis Uae) Co-zmy/teg ey Wow wo \o a 2. 67 43 Meg i tal | balk A —|— Cm, f in ee am 8 pee i io a eo Lo : dos 1135 php alt 6 saith. Veet laiapic? ALS ad! Nie les \g | | ot Qu 44 whok 1: -State a 1a fom _grefh “the cecalt hate plas me comnts _Lomy land L What 1s the btne for 40% Steady = Shot. — e Yee 9 | t- ae tee Indeter ee eI rae ett AC) fr aey =o SC o-2erhy" TET] ar _c)| What te th, _= Schecter eee Ie ely= Vadete 5 te ety bt tee oto anc cae Lee = 90d wn fkyh > Aimy key | be snpusiovn — -Cnpurise olin desl ape +24 ne) —— boa al Tam eo - [ud= tsowl Bill Cpt2 Cyend &! Chend = Cos = 4-4uymn! age COSS = 4.4 omg Jen yor = uw Hugmil | a manavain cps of leug/mb 2= 0.2m ley ha! 4 Ky) ox % = 1 f 1 bo- Waid y Cm as / —_}_= 0-202 4. 1San vows 4 : phate. a = 15 Sou, we! eg [Re F 16-15 mph) 14 " : 4 Whar ts Ane pllaame cleus ¢one. Uhy og kr an Tv oleg, { 6|- Lmmy jeg Pabloved by A Conthent Inguiten of O-25 yal hy Ite equmen alec ' — Agi Wie. Wier. 2 ‘, oe = apie Pe vme Done of Sunyl Yet date SY ue Jat PDorrne ans at Conlon’. T-v wagers SS 4, Loa Eons an se Le BED a1 \ ev) yng | Cprarah _srcpcre! a Coos Uaz"™S = coc - Loy Am hein | a Sere 2smyim diy aobukien be given io 164 odidt made Jet ko nce an“ inpusson Yate Bhony Jes Jing 2 APYsVON Bares dmg /leg/hy Fors ej aos pat ty ¥F 2 ems HW! o Ouy cod. Contain - 2S my/mb TS eny in im AM Jems im qe = 0 25 So -Patsent is siven smith 2m) per Wows | | fon —ects-lorohe—chruy_ts 4 oan odul} mabe pCa SY) by Tv infuiion. “The voy ty suopied in gente vial 6 drag 5 BOS 17 ond Ave Sivninotiow LE as AAS sas Vd i Contes) Gol OF WHE ondi-biehe SolwNen at of autre vine 5, 5 4 Concentra en Petrens Ao obiin & O85 of Joust 7 Wher teading Vals a4 — Hine hed faei Ave Phe Of bone — compariment, oFt% mode. Vne Appovent Vd o¢ ths Of wtvon= Ma C Nd= 0'Shvg! yIevy - i rtRal of Ingunon = 2ow) mi. 1 0:23\Mr 4 27.5) | : _£ 2oxfo "4 0.2 Ns iTS + ——"..- ~ - ~~ — STEER Bl Qexy : eral pee ere = c ete) alae = 405 y\"3 26 125 136 ce ° 21-39bmh | We = 139 hme dns | oa mrecOS a Css aivel SS Doughent 2S) : " {a = Se mg QS) Accorclwy ty the sManwfotdurer, Cpss \A meatuxee! P| when cmbroire , Ceplmmine Wes shoes by es ingusion to 4 Adwlh) “ae Gh p a) Calediede Sota body Ceexence Cor ANS on Romie ya Get 4 mg (ah hx’ Cree eae ESetreer a Css = = k cor 2 SOO la cate, C2 etna 19% mi! 7 Yee 2L-25 mLhs Dyer they inpaiow was —chiseontinued , the ceplrvadine serum” cone deereered exponentially, decline +e US my )mr__at_6-$ hy at s Tapky We Ghovt of Ingution Geleudere the diminaton t¥2. la e Coy = Cp 6 kohe-sey = 24ny 2 =| ROS) 2 Weare US my wl! = 1m me _e eta \Sompeat a beasts) 11 yy wit i : ea —t 0- OS eae 7 e , gq = = 2S Ing =o AZNB ie £2:5¥ ee 2.43 eas] 2 Z gOS: oy race * orm6 fam the infarc, cee the Lp sol O.4ty hy Me ee Ee. TY hy ah kes kuNoly Css ¥ eee Uk =e Boe HY * Ree pS =a LN Serre een = pt Sik) Riana 5 Ba ersby -Wwhy_p¥obenad 1c_ftven wii _Ceph¥ochime? 4 ~ Tit St sete aan oe — 1 as ~__Q-:b| pa TV iMfusen ak | Yate of Zomg/ he The Css is ae it * ethene cst. Une Budd the. PES orn hea | pean, an: exoreon Bate fox Xba > - Cse = a — as : . 7 & kvd=_ Yo & Go i Metres to men) a Stok} Katee * tompnit — _ Yamgha Tees mu! Css Cen) - Cre may = tong ht rym " oe - Lf tet = Olas iad . At Seedy Were, vole of ‘obyarghen = Ne of ehminetion te be ideas pees | 4 smilardy New ellminedan take = new chorPhion male - £ = Harms bt & ~ Q.1| Cov Dare wep feerme ta Shoxfeh chap tts decening @-s- a a) Wher inguin veld im ing h er ee ae BP fee AMO LL ie ‘. | o i pallaS aI 0 18 oy aly Era _ : aray5~ Soacliny dose ould oe Recommend pox tht Ch By het spoude 3 When? Di c Jol Ou Doviamy » \\2-5 Li x : » [os sTeeF 5 T we Ne Lecdiny_al pose 6 given. by J Ty halve 8 Sig jocn cA Shak f Lv _iipusvar, | ee) ay Showld_« Daadiny dose be vecamendest +— S jet Acad Slate Concent tation as cards pitas pasalose ee Acrexding to the menugacturer, 4 Yoke we \Smi lh. Oo yeu agree With ahs Yecommended inguron | ~ a +_cede_Fox a Sean fe— foe eae ~p | Me 2 \44. $8 m/v “~~ ism, iM Sek S$ S's os ge ee a MUS asin V2ml Sa We = IQwal/hy ~~ The 1 comensleel injvyan roate (imi pe) 1S dare eachuel ei (ranb/igl — ae co y ’ HS ak Ox = \eo . \mL/Wy > 225m5]/hy Coss DAS Mp WE Lo otf [The Areoredscnd c65 Sabre 16 dover ra Khe eenmmenileg ca We free tate hf BA by bye Gently Gade din Cont. of 4 Cechalasparin after conchatt + infusion ef _2Sasmel hy ts. He fet ae zl sored la Cir o pal Coy a ——=rsemsit > se