Q1 Module 3 in Biotechnology
Q1 Module 3 in Biotechnology
Biotechnology
Quarter 1 – Module 3:
Different Cell Functions
Week 5-6
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Introductory Message
For the facilitator:
This learning resource hopes to engage the learners into guided and independent
learning activities at their own pace and time. Furthermore, this also aims to help
learners acquire the needed 21st century skills while taking into consideration
their needs and circumstances.
In addition to the material in the main text, you will also see this box in the body of
the module:
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For the learner:
The hand is one of the most symbolized part of the human body. It is often used to
depict skill, action and purpose. Through our hands we may learn, create and
accomplish. Hence, the hand in this learning resource signifies that you as a
learner is capable and empowered to successfully achieve the relevant
competencies and skills at your own pace and time. Your academic success lies in
your own hands!
This module was designed to provide you with fun and meaningful opportunities
for guided and independent learning at your own pace and time. You will be
enabled to process the contents of the learning resource while being an active
learner.
What I Need to Know This will give you an idea of the skills or
competencies you are expected to learn in
the module.
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skill into real life situations or concerns.
1. Use the module with care. Do not put unnecessary mark/s on any part of
the module. Use a separate sheet of paper in answering the exercises.
2. Don’t forget to answer What I Know before moving on to the other activities
included in the module.
3. Read the instruction carefully before doing each task.
4. Observe honesty and integrity in doing the tasks and checking your answers.
5. Finish the task at hand before proceeding to the next.
6. Return this module to your teacher/facilitator once you are through with it.
If you encounter any difficulty in answering the tasks in this module, do not
hesitate to consult your teacher or facilitator. Always bear in mind that you are
not alone.
We hope that through this material, you will experience meaningful learning
and gain deep understanding of the relevant competencies. You can do it!
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What I Need to Know
This module was designed and written with you in mind. It is here to help you
master the nature of Biology. The scope of this module permits it to be used in
many different learning situations. The language used recognizes the diverse
vocabulary level of students. The lessons are arranged to follow the standard
sequence of the course. But the order in which you read them can be changed to
correspond with the textbook you are now using.
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What I Know
Choose the letter of the best answer. Write the chosen letter on a separate sheet of
paper.
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Lesson
1 Cellular Reproduction
What’s In
When you look at your parents, you can see features that you share with
them, such as the shape of the eye, the presence of dimples, or even the hand you
use when you write. The sharing of features can be explained by heredity, where
traits are passed on from parents to offspring. Yet when you look at your brothers
and sisters, even if you share the same parents, each on of you can be considered
unique based on the combination of traits each possesses. That is variation, which
demonstrates differences among individuals.
Genetics is the study of heredity and variation. It aims to understand how
traits can be passed on to the next generation and how variation arises.
Every living thing undergoes reproduction. The nutrients taken by an
individual will provide for energy for metabolic processes, for growth and
development, repair as well as reproduction. The cellular level of reproduction, in
the form of cell division, provides for the backdrop for the organismal level of
reproduction.
In the previous module, you have learned about the different cell structure
and its specific functions, as well as the movement of molecules across the cell
membrane. In this lesson , you will earn about cellular reproduction and
differentiate the two types of cell division, mitosis and meiosis.
What’s New
The Chromosome
All living things contain what we call the genetic material that serves as the
set of instructions that direct the activities and functions of the cells. These genetic
materials, also known as the deoxyribonucleic acid or DNA, are passed on from one
generation to the next to ensure the continuity of life. In eukaryotic cells (cells with
organelles), the DNA are bound with proteins and are organized as beads on strings
to form chromosomes.
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Figure 1. Chromosome
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What is It
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the next cell division or M (mitosis or meiosis) phase. G2 represents period of rapid
cell growth to prepare for cell division.
During interphase, the nucleus is clearly visible as a distinct membrane-
bound organelle. In stained cells, this membrane can be clearly seen under the
light microscope. One or more nucleoli are visible inside the nucleus. On the other
hand, the chromosomes cannot be clearly seen. They appear as an irregular mass
that is grainy in appearance because the DNA they contain are stretched out thinly
in the nucleus. This facilitates the replication of DNA during the S phase.
1. Mitosis
This type of cell division produces two identical cells with the same number
of chromosomes. Mitosis is divided into four stages.
STAGE A: Prophase. The nuclear membrane and nucleoli may still be present. The
chromosomes are thicker and shorter because of repeated coiling. At this stage,
each chromosome is made up of two identical sister chromatids as a consequence
of replication of DNA during the S phase. The two chromatids produced from one
chromosome are still attached at one point, called the centromere. The centromere
may divide the chromosome into the shorter arms, also calles the p arms (petite)
and the longer q arms. If the chromosomes are stained using Giemsa, alternating
dark and light regions will appear. These are the heterochromatin and euchromatin,
respectively. The heterochromatin is more coiled than the eurochromatin.
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STAGE B: Metaphase. The nuclear membrane has disappeared while the highly
coiled chromosomes align at the metaphase plate, an imaginary plane equidistant
between the cell’s two poles. Spindle fibers are also formed. Each fiber binds to a
protein called the kinetochore at the centromere of each sister chromatid of the
chromosome.
STAGE D: Telophase. The chromosomes are now at the opposite poles of the spindle.
They start to uncoil and become indistinct under the light microscope. A new
nuclear membrane forms around them while the spindle fibers disappear. There is
also cytokinesis or the division of the cytoplasm to form two separate daughter cells
immediately after mitosis.
2. Meiosis
The number of chromosomes normally remains the same within the species.
It does not double or triple for every generation. This suggests that a different kind
of cell division must take place in an individual. This kind of cell division is called
meiosis, from a Greek word which means “to make smaller:. Meiosis reduces the
chromosome number in half. It takes place in plants and animals whenever
gametes, or sex cells, are formed through the process called gametogenesis.
Meiosis is a special type of cell division wehere the cell undergoes two
rounds of cell division to produce four daughter cells, each with half the
chromosome number as the original parent cell and with a unique set of genetic
material as a result of exchange of chromosome segments during the process of
crossing over.
The first round of meiotic division, also known as meiosis I, consists of four
stages: prophase I, metaphase I, anaphase I, and telophase I. Prophase I of meiosis
I, unlike its counterpart in mitosis, is more elaborate and should be understood
well in order to grasp the mechanisms of heredity.
STAGE A. Prophase I. Meiosis starts with this stage and includes the following sub-
stages:
Leptotene. Each chromosome is made up of two long threads of sister chromatids
as a result of replication during the S phase of the cell cycle.
Zygotene. The chromosomes begin to pair off. Pairs of chromosomes are called
homologous chromosomes, and this pairing process is exact.
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Pachytene. The chromosomes contract due to repeated coiling. Crossing over takes
place during this stage where a segment of a sister chromatid of one chromosome
is exchanged with the same segment of the sister chromatid of the homologous
chromosome through the formation of a cross-linkage of the segments called
chiasma. After crossing over, the sister chromatids of each chromosome may no
longer be identical with each other based on the genetic material they contain.
STAGE C: Anaphase I. Spindle fibers form and attach to the centromeres of the
chromosomes. The homologous chromosomes separate from each other completely
and start their movement toward the poles of the cells as they are pulled by the
spindle fibers. As the centromere of eacg chromosome does not divide, the sister
chromatids remain together.
STAGE D: Telophase I. This is the stage when the chromosomes each their
respective poles. Cytokinesis follows and two daughter cells are formed. Each cell
now has only half the chromosome number because only one chromosome from
each pair goes to the daughter cell. This is called the haploid condition, in contrast
to the diploid condition at the beginning of the meiosis I where each chromosome
pair is intact. Telophase I is followed by interphase II.
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Note that each chromosome still has two sister chromatids; it is therefore,
necessary for the cells to undergo another round of division.
The second meiotic division, also known as meiosis II, is mitotic in nature
and consists of the following stages: prophase II, metaphase II, anaphase II and
telophase II; these stages are identical with the mitotic stage. The results are four
cells, two from each daughter cell from meiosis I, with one half the diploid
chromosome number and with only one sister chromatid for each chromosome.
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The Role of Meiosis in Gametogenesis
Sperm cells are produced in the testes of male animals. Meiosis produces
four cells which are very small but of similar size. These cells become spermatozoa
(singular form is spermatozoon) or sperms. The nucleus is found in the head of the
sperm; mitochondria are found at the midpiece that connects the head to the tail.
These mitochondria provide the energy for the movement of the sperm’s tail.
In female animals, egg cells are produced in the ovary. When a cell in the
ovary undergoes meiosis, new cells which differ in size are produced. After meiosis I,
two cells - one big and one small - are produced. Meiosis II produces one big and
one small cell from the first big cell. The small cell produced from meiosis I may or
may not divide. If it does, two small cells are produced. The big cell becomes the
egg cell; the small cells disintegrate. The egg cell contains a lot of stored food which
is used by the growing embryo at the start of its development. In fertilization, the
tiny sperm cell only contributes its genetic material found in the head.
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What’s More
4. What is the first stage of interphase and what happens during this stage?
___________________________________________________________________________
___________________________________________________________________________
___________________________________________________________________________
5. What are the stages of Mitosis?
___________________________________________________________________________
___________________________________________________________________________
___________________________________________________________________________
___________________________________________________________________________
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What I Have Learned
I have learned that the two stages of the cell cycle are ____________________________
__________________________________________________________________________________
__________________________________________________________________________________
I have learned that there are two types of cell division which are __________________
_________________________________________________________________________________
_________________________________________________________________________________
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What I Can Do
Directions: Draw the different stages of mitosis and meiosis and explain what
happens during these stages.
Score/ 10 9 8 7
Criteria
Neatness of Neat and Presentable with Quit Poor color
work attractive with good color presentable combination
exceptional combination. with acceptable and messy.
color color
combination. combination
and a little bit
messy.
Content and Written work Written work has Written work Written
information has an interesting performance work has no
extraordinary style. Provided was done in style.
style. Provided informative and little style. Provided few
informative & organized ideas. Essay lacked information.
well-organized some
ideas. information.
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Lesson
Cellular Respiration and
2 Photosynthesis
What’s In
What’s New
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6. Light Dependent Reaction uses energy (ATP & NADPH) from light reaction to
make sugar.
FACT BLUFF
7. Cellular Respiration is a process that uses oxygen and break up sugars into a
form that the cell can use.
FACT BLUFF
8. The breakdown of glucose has three stages; Glycolysis, Krebs Cycle & Electron
Transport Chain.
FACT BLUFF
9. The formula for Cellular Respiration is C6H12 + 6O2 → 6CO2 + 6H2O + Energy
(ATP).
FACT BLUFF
10. Organisms released stored energy in food through the process of respiration.
FACT BLUFF
What is It
Photosynthesis
Plants are great providers. Why do you think they are called great providers?
As you go through this lesson, you will understand how plants provide food and
help to make the flow of energy in the ecosystem possible.
Photosynthesis is a process of food making done by plants and ither
autotrophic organisms. The presence of chlorophyll enables these organisms to
make their own food. Autotrophic organisms require light energy, carbon dioxide
(CO2), and water (H2O) to make food (sugar).
In plants, photosynthesis primarily takes place in the leaves and little or
none in the stems depending on the presence of chlorophyll. The typical parts of
the leaves include the upper and lower epidermis, mesophyll, spongy layer,
vascular bundles, and stomates. The upper and lower epidermis protects the leaves
and has nothing to do with photosynthetic processes. Mesophyll has the most
number of chloroplasts that contain chlorophyll. They are important in trapping
light energy from the sun. Vascular bundles - phloem and xylem serve as
transporting vessels of manufactured food and water. Carbon dioxide and oxygen
were collected in the spongy layer and enters and exits the leaf through the
stomata.
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Figure 1. Leaf Anatomy
The are two steps of photosynthesis: (a) Light-dependen→t Reaction and (b)
Calvin Cycle (dark reaction). Light-dependent reaction happens in the presence of
light. It occurs in thylakoid membrane and converts light energy to chemical energy.
Water is one of the raw materials of photosynthesis and is utilized during this stage
and facilitates the formation of free electrons and oxygen.The energy harvested
during this stage is stored in the form of ATP (Adenosine Triphosphate) and NADPH
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(Nicotinamide Adenine Dinucleotide Phosphate Hydrogen). These products will be
needed in the next stage to complete photosynthetic process.
Chlorophyll
Carbon Dioxide + Water Glucose + Oxygen
(CO2) (H2O) Sunlight (C6H12O6) (O2)
The factors that affect the rate of photosynthesis are temperature, carbon
dioxide, water , and light. Providing the plant with the right amount of these
materials will ensure good quality and quantity of the harvest.
Cellular Respiration
All heterotrophic organisms including man, depend directly or indirectly on
plants and other photosynthetic organisms for food. Why do we need food?
Organisms need food as the main source of energy. All organisms need energy to
perform essential life processes.
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The food must be digested to simple forms such as glucose, amino acids,
and trigylcerides. These are then transported to the cells. The immediate energy
source of the cells is glucose, Glucose inside the cell is broken down to release the
stored energy. This stored energy is harvested in the form of adenosine
triphosphate (ATP). ATP is a high-energy molecule needed by working cells.
Glycolysis
In glycolysis, the 6-carbon sugar, glucose, is broken down into two
molecules of a 3-carbon molecule called pyruvate. This change is
accompanied by a net gain of 2 ATP molecules and 2 NADPH molecules.
Krebs Cycle
The Krebs Cycle occurs in the mitochondrial matrix and generates a
pool of chemical energy (ATP, NADPH, and FADH2) from the oxidation of
pyruvate, the end product of glycolysis.
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Pyruvate is transported into the mitochondria and loses carbob
dioxide to form acetyl-CoA, a 2-carbon molecule. When acetyl-CoA is
oxidized to carbon dioxide in the krebs Cycle, chemical energy is released
and captured in the form of NADPH, FADH2 and ATP.
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What’s More
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What I Have Learned
I have learned that the two major stages of photosynthesis are ____________________
__________________________________________________________________________________
__________________________________________________________________________________
__________________________________________________________________________________
__________________________________________________________________________________
I have learned that the three major stages of cellular respiration are _______________
__________________________________________________________________________________
__________________________________________________________________________________
__________________________________________________________________________________
__________________________________________________________________________________
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What I Can Do
materials
3. End product
4. Energy equipment
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Assessment
Multiple Choice. Choose the letter of the best answer. Write the chosen letter on a
separate sheet of paper.
1. The process of cell division that produces two identical cells with the same
number of chromosomes is
A. cancer B. centromere C. mitosis D. spindle
2. What is the longest phase of the cell cycle?
A. interphase B. metaphase C. mitosis D. prophase
3. What process occurs in the gonads to produce gametes?
A. interphase B. meiosis C. metaphase D. mitosis
4. What is cellular respiration?
A. the breakdown of glucose to release ATP
B. the breakdown of glucose to release NADH
C. the breakdown of glucose to release FADH
D. the breakdown of glucose to release carbon
5. What is the main goal of cellular respiration?
A. make water B. make ATP C. make glucose D. make oxygen
Directions:Study illustration below and answer the following questions.
What are the three things that is needed for photosynthesis to takes place?
6.
7.
8.
What are the by-products of photosynthesis?
9.
10.
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Additional Activities
Below are links to the different topics in this module. For additional information,
watch the following videos and learn more about the different lessons. Use the links
below.
1. https://www.youtube.com/watch?v=f-ldPgEfAHI
2. https://www.youtube.com/watch?v=VzDMG7ke69g
3. https://www.youtube.com/watch?v=zrKdz93WlVk&t=46s
4. https://www.youtube.com/watch?v=sQK3Yr4Sc_k
5. https://www.youtube.com/watch?v=00jbG_cfGuQ
Answer Key
References
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bWcQAzoCCAA6BAgAEB46BggAEAUQHjoGCAAQCBAeULRMWN6BAWCVgwFoAXA
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bWcQAzoCCAA6BAgAEB46BggAEAUQHjoGCAAQCBAeULRMWN6BAWCVgwFoAXA
AeACAAWSIAZYUkgEEMjguMZgBAKABAaoBC2d3cy13aXotaW1nwAEB&sclient=im
g&ei=um2XX5L1JOHHmAXC-bjwDA&bih=821&biw=1707#imgrc=srNe-
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BCxAxBDMgoIABCxAxCDARBDMgQIABBDMgQIABBDMgQIABBDMgcIABCxAxBD
MgQIABBDMgQIABBDOgUIABCxAzoCCABQ_D9YskdgllloAHAAeACAAZEBiAGLBZI
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m=isch&ved=2ahUKEwjfk9SWydjsAhXKIaYKHTGaCgkQ2-
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DICCAAyAggAMgIIADICCAAyAggAMgIIADIECAAQHjIGCAAQBRAeMgYIABAIEB46B
wgAELEDEEM6BAgAEENQlKoFWN-
zBWDY0AVoAHAAeACAAVqIAZUFkgEBOJgBAKABAaoBC2d3cy13aXotaW1nwAEB
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Science 8 Learner’s Module (2014). Department of Education. Republic of the
Philippines
Science 9 Learner’s Module (2014). Department of Education. Republic of the
Philippines
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