BCQ Test for Batch-36

1)- A BOND MAY BE HIGH ENERGY DUE TO:

(A) Produce of its cleavage are more resonance stabilized than the original compound.
(B) The bond is unusually stable, requiring a large energy input to cleave it.
(C) Electrostatic repulsion is relieved when the bond is cleaved.
(D) A cleavage product may be unstable, tautomerizing to a more stable form.
(E) The bond may be strained.

2)- AT WHICH OF THE FOLLOWING ENZYME –CATALYZED STEPS OF THE

TRICARBOXLYLIC ACID CYCLE, DO(ES) NET INCORPORATION OF WATER INTO AN
INTERMEDIATE OF THE CYCLE OCCUR:

(A) Citrate synthase.

(B) Succinyl CoA sythase.
(C) Malate Dehydrogenase.
(D) Aconitase.
(E) α – ketoglutarate D.H.

3)- THE FREELY REVERSIBLE REACTION OF THE TRICARBOXYLIC ACID CYCLE

INCLUDE:

(A) The citrate synthase reaction.

(B) The isocitrate dehydeogenase reaction.
(C) The α – ketoglutarate dehydrogenase reaction.
(D) The succinyl CoA synthase reaction.
(E) The pyruvate D.H reaction.

4)- WHICH OF THE FOLLOWING TRICARBOXYLIC ACID CYCLE INTERMEDIATES MAY

BE ADDED OR REMOVED BY OTHER METABOLIC PATHWAY:

(A) Oxalosuccinate.
(B) α - ketoglutarate.
(C) Isocitrate.
(D) Oxloacetate.
(E) Citrate.

5)- THE MITOCHONDRIAL MEMBRANE CONTAINS A TRANSPORTER FOR:

(A) NADH .
(B) Acetyl CoA.
(C) GTP.
(D) ATP.
(E) Cyclic AMP.

6)- ADP CAN RECEIVE A PHOSPHATE GROUP FROM:

(A) Fructose -6-phosphate.

(B) Glycerol-3-Phosphate.
(C) Creatine phosphate.
(D) Glusoce-6-Phosphate.
(E) 1-3-bisphosphoglycerate.

7)- THE HIGHEST GROUP TRANSFER POTENTIAL IS PRESENT AMONGST THE

FOLLOWING IN:

(A) 1.3-Biphospholglycerate.
(B) Creatine phosphate.
(C) Carbamoyl phosphate.
(D) Phosphoenol pyruvate.
(E) Glucose-6-P.
8)- THE COMPOUND HAVING THE LOWEST REDOX POTENTIAL AMONGST THE
FOLLOWING IS:

(A) Hydrogen.
(B) NAD.
(C) Cytochrome b.
(D) Cytochrome a.
(E) Cytochrome c.

9)- WHEN REDUCING EQUIVALENTS ENTER THE RESPIRATORY CHAIN THROUGH

NAD, THE P:O RATIO IS:

(A) 1:2 .
(B) 2:1.
(C) 1:3.
(D) 3:1.
(E) 2:2.

10)- A COPPER CONTAING CYTOCHRONE IS

(A) Cytochrone c.
(B) Cytochrome P - 450.
(C) Cytochrome b.
(D) Cytochrome oxidase.
(E) Cytocheome c1.

11)- CYTOCHROME P450 IS A MEMBER OF WHICH FAMILY OF OXIDOREDUCTASES?

(A) Catalase.
(B) Hydeoperoxidase.
(C) Oxidase.
(D) Oxygenase.
(E) Dehydrogenases.

12)- THE CONVERSION OF GLUCOSE TO GLUCOSE-6-PHOSPHATE TAKE PLACE IN THE

CELL BECAUSE:

(A) The reaction has a positive Δ G0`.

(B) The reaction has a negative Δ G0`.
(C) Glucose-6-phosphate is unstable.
(D) There is no enzyme capable of catalyzing this reaction.
(E) G-6-P is a functional compound.
13)- WHICH OF THE FOLLOWING ENZYMES ALLOWS THE HIGH –ENERGY PHOSPHATE
PF ADP TO BE USED IN THE SYNTHESIS OF ATP ?

(A) Adenyly kinase.

(B) ATPase.
(C) Inorganic pyrophosohatase.
(D) Nucleoside diphosphate kinase.
(E) Nucleotide diphosphate kinase.

14)- WHICH OF THE FOLLOWING REACTIONS GENERATES ATP ?

(A) Glucose-6-phosphate to fructose-6-phosphate.

(B) Glucose to glucose-6-phosphate.
(C) Fructose-6-phosphate to fructose-1,6-disphosphate
(D) Phospoenolpyruvate to pyruvate .
(E) Pyruvate to lactate.
15)- WHICH OF THE FOLLOWING ENZYMES CATALYZES HIGH-ENERGY
PHOSPHORYLATION OF SUBSTRATE DURING GLYCOLYSIS?

(A) Pyruvate kinase.

(B) Phosphoglycerate kinase.
(C) Triose phosphate isomerase.
(D) Aldolase.
(E) Glyceraldehyde-3-phosphate dehyrogenase.

16)- CITRIC ACID CYCLE IS REGULATED BY:

(A) High glucose concentration.

(B) Low glucose Conc:.
(C) High Conc: of Acetyl CoA.
(D) Hormones.
(E) Cirtrate and ATP / AMP ratio.

17)- INORGANIC PHOSPHATE IS INCORPORATED IN THE SUBSTRATE BY:

(A) Glyceraldehde-3-phosphate dehydrogenase.

(B) Phosphoglycerate kinase.
(C) Pyruvate kinase.
(D) Enolase.
(E) Aldolase.

18)- BIPHOSPHOGLYCERATE MUTASE IS PRESENT IN

(A) Liver.
(B) Muscles.
(C) Brain.
(D) Erythrocytes.
(E) Heart.

19)- GLUCOSE-6-PHOSPHATE DEHYDROGENASE IS INDUCED BY:

(A) 6-Phosphogluconolactone.
(B) Glucose-6-phosphate.
(C) Ribose-5-phosphate.
(D) Insulin.
(E) Glucogon.

20)- THE FIRST PENTOSE FORMED IN HMP SHUNT IS:

(A) Ribose-5-phosphate.
(B) Ribulose-5-phosphate.
(C) Xylose-5-phosphate.
(D) Xylulose-5-phosphate.
(E) PRPP.
 Questions of Sir Arjan Das

1)- GLUCOKINASE

(A) Formed in all tissues.

(B) Km is low hence high affinity for glucose.
(C) Specific for all carbohydrate.
(D) Active in hypoglyemia.
(E) Active during high intake of CHO diet.

2)- HER’S DISEASE (GLYCOGEN STORAGE DISEASE TYPE-VI ) OCCURS DUE TO THE
DEFECTIONS OF:

(A) Acid maltase.

(B) Muscle phosphorylase.
(C) Liver phosphosrylase.
(D) Glucose 6-phosphatase.
(E) Branching enzyme.

3)- WHICH MONOSACHRIDES IS ABSORBED EARLIER:

(A) Fructose.
(B) Mannose.
(C) Xylose.
(D) Glucose.
(E) Galatose.

4)- THE ACTIVE SITE FOR ABSORPTION FOR CARBOHYDRATE IS:

(A) Stomach.
(B) Jejunum.
(C) Dudenum.
(D) Ileum.
(E) Large intestine.

5)- RENIN IS

(A) Proteolytic enzyme present in gastric juice.

(B) Convert aniotensinogen to angiotensin I.
(C) Causes increased blood pressure.
(D) Proteolytic enzyme present in pancreatic juice.
(E) Converts angiotensin II to angiotensin I.
 Questions of Sir Hanif Shaikh

1)- SALIVA

(A) Saliva from parotid gland is mucus.

(B) Saliva from sublingual gland is serous.
(C) Increase secretion b/c of vesodilation of parasympathtic stimulation.
(D) Vasodilation is due to secretion of histamine.
(E) pH is almost acidic.

2)- GASTRIC JUICE:

(A) Chief cells secrete Hcl.

(B) Parietal cells secrete pepsinogen.
(C) Pepsmogen is activated by enteriokinase.
(D) pH is highly acidic due to weak acid like Hcl.
(E) Main organic coustituent is enzymes and intrinsic factor.

3)- REGULATION OF JUICE

(A) Increase secretion due to bradykinin by entrance of fatty food.

(B) Decrease by entrance of CHO.
(C) Cephelic phase is stimulated by entrance of food in stomach.
(D) Gastric phase is started when stimulation like smell, sight and taste.
(E) Gastrin increase the secretion.

4)- SECRETION OF GASTRIC JUICE IS DECREASED BY:

(A) Histamine.
(B) Cholcystokin pancreozymin.
(C) Proteins.
(D) Alkalies.
(E) Acids.

5)- PANCREATIC JUICE

(A) It is mucoid in nature.

(B) Organic costitunet is mainly HCo3.
(C) pH is alkaline due to excessive amount of enzymes.
(D) Secretion is increased in fasting.
(E) Trysine is main proteolytic enzyme.

6)- REGULATION OF PANCREATIC SECRETION

(A) Decreases its secretion.

(B) Sympathetic stimulation increases its secretion.
(C) CCKPZ secretion increased in response to CHO.
(D) CCK PZ increased its secretion.
(E) Increased in response to enzyme.

7)- BILE JUICE:

(A) Biliverdin is major bile pigment.

(B) Increase amino acid absorption increases bile secretion.
(C) Glycine is only amino acid that form bile acids.
(D) Fatty meal increase the formation of bile salts.
(E) Carbohydrates increase the formation of bile salts .
8)- CARBOHYDRATES DIGESTION ABSORPTION:

(A) α – amylase is activated in acidic medium .

(B) glucose require insulin for uptake in enteryoytes.
(C) fructose is easily transported than glucose.
(D) Galactose are more digestive form of CHO for absorption.
(E) CHO is only absorbed in small intestine.

9)- PROTEIN DIGESTION AND ABSORPTION:

(A) Pepsinopen is necessary for digestion of protein .

(B) Elastase is spectic for elastin.
(C) Collagenase is specific for collegen.
(D) One amino acids can not inhibit absorption of another amino acids.
(E) Chymotrypsinogen is activated by Hcl.

10)- FAT DIGESTION AND ABSORPTION:

(A) More than 30 % fat is digested in mouth by lingual lipase.

(B) Gastric lipase hydrolyse the TAG.
(C) Glycerol is only form of absorption.
(D) Vitamin D help the fat for absorption.
(E) Bile Salts help the absorption of cholesterol.

11)- THYROID HORMONES:

(A) Acts by decreased in tracellular cyclic AMP.

(B) Mobilize Ca+ ions from bones.
(C) Is transported in blood by globulins.
(D) Deficiency in intracuterrine life leads to myxedema.
(E) Decreases protein systhesis by transcription.

12)- REGARDING HORMONE ACTION:

(A) Steroid hormones involve structure gene transcription.

(B) Insulin in muscles decrease cyclic AMP activity .
(C) Thyroxine acts in the cytoplasmic mitochondrial enzymes.
(D) Catecholamins act through cyclic AMP .
(E) The Receptors of growth hormones are present in E.R.

13)- THYROID HORMONES:

(A) Receptors are locate in cytosol of targets cells.

(B) Supress the expression of specific genes.
(C) In low dose uncouple the oxidative phosphrylation.
(D) Increase oxygen utilization by mitochondria.
(E) Are dehydrogenated in liver and kidneys.

14)- GLUCOGON:

(A) Promote glycogenesis.

(B) Is composed of two polypeptide chain.
(C) Supress cyclic AMP formation in liver .
(D) Decrease fatty acids in blood.
(E) Is Secreted in response to hypoglycemia.
15)- INSULIN:

(A) Having two alpha and two gamma polypetede chains.

(B) Decrease uptake of amino acids by the cells.
(C) Increase ketogenesis in liver.
(D) Decrease gluconeogensis.
(E) Increase fatty acids synthesis

16)- HORMONES RECEPTORS OF:

(A) Epinephrine are on the cell memberane.

(B) Calcitonin on golgi apparatus.
(C) Thyroxine are in mitochondria.
(D) Glucogon in ER.
(E) Parathroid are in cytoplasm.

17)- REGARDING CRETINISM:

(A) Is due to deficiency of prothyroid hormones

(B) Is disease of adult.
(C) Diarrhoea is constant feature.
(D) The hands and feet are enlarge.
(E) Tongue is enlarger

18)- ANABOLIC HORMONES IS:

(A) cortisol.
(B) Thyroxine.
(C) Glucogan.
(D) Testosterone.
(E) Adrenaline.

19)- HYPOGLYCEMIA MAY SEEN IN:

(A) Acromegaly.
(B) Cushing syndrome.
(C) Glycogen storage disease.
(D) Insulinoma.
(E) Over dose of insulin.