SAFETY DATA SHEET Version 6.
4
Revision Date 28.06.2020
according to Regulation (EC) No. 1907/2006 Print Date 12.08.2020
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers
Product name : Sodium azide
Product Number : S2002
Brand : Sigma-Aldrich
Index-No. : 011-004-00-7
REACH No. : A registration number is not available for this substance as the
substance or its uses are exempted from registration, the
annual tonnage does not require a registration or the
registration is envisaged for a later registration deadline.
CAS-No. : 26628-22-8
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Merck Life Science UK Limited
New Road
The Old Brickyard
GILLINGHAM
Dorset
SP8 4XT
UNITED KINGDOM
Telephone : +44 (0)1747 833-000
Fax : +44 (0)1747 833-313
1.4 Emergency telephone
Emergency Phone # : +44 (0)870 8200418 (CHEMTREC)
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 2), H300
Acute toxicity, Inhalation (Category 2), H330
Acute toxicity, Dermal (Category 1), H310
Specific target organ toxicity - repeated exposure, Oral (Category 2), Brain, H373
Short-term (acute) aquatic hazard (Category 1), H400
Long-term (chronic) aquatic hazard (Category 1), H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
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2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Danger
Hazard statement(s)
H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled.
H373 May cause damage to organs (Brain) through prolonged or
repeated exposure if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P262 Do not get in eyes, on skin, or on clothing.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing.
P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
Rinse mouth.
P302 + P352 + P310 IF ON SKIN: Wash with plenty of water. Immediately call a
POISON CENTER/ doctor.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/ doctor.
Supplemental Hazard information (EU)
EUH032 Contact with acids liberates very toxic gas.
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
Sodium Azide may react with lead and copper plumbing to form highly explosive metal
azides., Rapidly absorbed through skin.
SECTION 3: Composition/information on ingredients
3.1 Substances
Formula : N3Na
Molecular weight : 65.01 g/mol
CAS-No. : 26628-22-8
EC-No. : 247-852-1
Index-No. : 011-004-00-7
Component Classification Concentration
sodium azide
Acute Tox. 2; Acute Tox. <= 100 %
1; STOT RE 2; Aquatic
Acute 1; Aquatic Chronic
1; H300, H330, H310,
H373, H400, H410
M-Factor - Aquatic Acute:
1
M-Factor - Aquatic
Chronic: 1
For the full text of the H-Statements mentioned in this Section, see Section 16.
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SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a
physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult
a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Dry powder Dry sand
5.2 Special hazards arising from the substance or mixture
Sodium oxides
Combustible.
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas.
Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
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6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Do not flush
with water. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Store in cool place.
Never allow product to get in contact with water during storage. Do not store near acids.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
Component CAS-No. Value Control Basis
parameters
sodium azide 26628-22- TWA 0.1 mg/m3 Europe. Commission Directive
8 2000/39/EC establishing a first
list of indicative occupational
exposure limit values
Remarks Identifies the possibility of significant uptake through the
skin
Indicative
STEL 0.3 mg/m3 Europe. Commission Directive
2000/39/EC establishing a first
list of indicative occupational
exposure limit values
Identifies the possibility of significant uptake through the
skin
Indicative
TWA 0.1 mg/m3 UK. EH40 WEL - Workplace
Exposure Limits
Can be absorbed through the skin. The assigned substances
are those for which there are concerns that dermal
absorption will lead to systemic toxicity.
STEL 0.3 mg/m3 UK. EH40 WEL - Workplace
Exposure Limits
Can be absorbed through the skin. The assigned substances
are those for which there are concerns that dermal
absorption will lead to systemic toxicity.
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately
after handling the product.
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Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
[email protected], test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the EC approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must
be selected according to the concentration and amount of the dangerous substance
at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as
a backup to engineering controls. If the respirator is the sole means of protection,
use a full-face supplied air respirator. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN
(EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
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SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odor odorless
c) Odor Threshold No data available
d) pH 10.0 at 65.0 g/l at 25.0 °C
e) Melting Melting point/range: 370 - 425 °C - ASTM E 537-76 -
point/freezing point Decomposition
f) Initial boiling point 300 °C - (rigorous decomposition)
and boiling range
g) Flash point 300.0 °C - open cup
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits
k) Vapor pressure 0.01 hPa at 20.0 °C
l) Vapor density No data available
m) Relative density 1.85 g/cm3 at 20.0 °C
n) Water solubility 408 g/l at 20 °C
o) Partition coefficient: Not applicable for inorganic substances
n-octanol/water
p) Autoignition 309 °C
temperature - Relative self-ignition temperature for solids
q) Decomposition 370 - 425 °C, 0.8 kJ/kg -
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available
SECTION 10: Stability and reactivity
10.1 Reactivity
Contact with acids liberates very toxic gas.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
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10.4 Conditions to avoid
An explosion occurred when a mixture of sodium azide, methylene chloride, dimethyl
sulfoxide, and sulfuric acid were being concentrated on a rotary evaporator.
Strong heating (decomposition).
Exposure to moisture.
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Sodium oxides
Other decomposition products - No data available
In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 27 mg/kg
Remarks: (RTECS)
LC50 Inhalation - Rat - male and female - 4 h - 0.054 - 0.52 mg/l
(US-EPA)
LD50 Dermal - Rabbit - 20 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
Skin - In vitro study
Result: No skin irritation
(OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - Bovine cornea
Result: No eye irritation - 4 h
(OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative
(OECD Test Guideline 429)
Germ cell mutagenicity
No data available
Mutagenicity (mammal cell test): chromosome aberration.
Chinese hamster ovary cells
Result: negative
unscheduled DNA synthesis assay
Chinese hamster lung cells
Result: negative
sister chromatid exchange assay
Chinese hamster ovary cells
Result: negative
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
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Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
Oral - May cause damage to organs through prolonged or repeated exposure. - Brain
Aspiration hazard
No data available
Additional Information
RTECS: VY8050000
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Nausea, Headache, Vomiting, Laboratory experiments in animals have shown sodium azide
to produce a profound hypotensive effect, demyelination of myelinated nerve fibers in the
central nervous system, testicular damage, blindness, attacks of rigidity, and hepatic and
cerebral effects., To the best of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
SECTION 12: Ecological information
12.1 Toxicity
Toxicity to fish flow-through test LC50 - Oncorhynchus mykiss (rainbow trout) - 2.84
mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - 0.35 mg/l - 96 h
(OECD Test Guideline 201)
Toxicity to bacteria
12.2 Persistence and degradability
The methods for determining the biological degradability are not applicable to inorganic
substances.
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Very toxic to aquatic life with long lasting effects.
No data available
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or
mix the material with a combustible solvent and burn in a chemical incinerator equipped
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with an afterburner and scrubber. Waste material must be disposed of in accordance with
the Directive on waste 2008/98/EC as well as other national and local regulations. Leave
chemicals in original containers. No mixing with other waste. Handle uncleaned containers
like the product itself.
Contaminated packaging
Dispose of as unused product.
SECTION 14: Transport information
14.1 UN number
ADR/RID: 1687 IMDG: 1687 IATA: 1687
14.2 UN proper shipping name
ADR/RID: SODIUM AZIDE
IMDG: SODIUM AZIDE
IATA: Sodium azide
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
14.6 Special precautions for user
No data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
EUH032 Contact with acids liberates very toxic gas.
H300 Fatal if swallowed.
H300 + H310 + Fatal if swallowed, in contact with skin or if inhaled.
H330
H310 Fatal in contact with skin.
H330 Fatal if inhaled.
H373 May cause damage to organs through prolonged or repeated exposure if
swallowed.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
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Further information
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.
The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact [email protected].
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