BIOAKTIVITAS

NAMA SENYAWA
NO ANTI BACTERIAL
KIMIA
(%)

1 (+)-Catechin 32

2 (-)-Epicatechin 32

3 (+)-Epicatechin 32

4 Mitraphylline 18,5

5 Roxburghine B -

6 Catechol 32,1

7 Gallic acid 41,8

8 Cinchonain Ia 33,5

9 Gambiriin C 31,9

10 Gambiriin A1 22

11 Gambiriin A3 31,1

12 Gambiriin B1 25,3

13 Gambiriin B3 28,7

14 Procyanidin B3 31,9

15 Procyanidin B1 31,9

16 Uncarine B 18,5

17 Gambiriin A2 22

18 Gambiriin B2 25,3
 FREE RADICAL
ANTIOXIDANT (%) NO
SCAVENGER (%)

81 84,2 1

81 84,2 2

81 84,2 3

- - 4

- - 5

50,1 41,3 6

52 57 7

58,6 71,6 8

80,3 79,8 9

64,7 79,2 10

80,2 80,8 11

70,3 81,5 12

72,7 74,2 13

80,3 79,8 14

80,3 79,8 15

- - 16

64,7 79,2 17

70,3 81,5 18
NAMA SENYAWA TP53 EXPRESSION ANTICARCINOGE CHEMOPREVENTI
KIMIA ENHANCER (%) NIC (%) VE (%)

(+)-Catechin 95,9 79,5 78,8

(-)-Epicatechin 95,9 79,5 78,8

(+)-Epicatechin 95,9 79,5 78,8

Mitraphylline 73,1 - -

Roxburghine B - - -

Catechol 73,1 35,7 30,4

Gallic acid 71,8 39,5 40,6

Cinchonain Ia 85,7 70,2 72

Gambiriin C 95,4 75,5 83

Gambiriin A1 83,5 68,5 75,7

Gambiriin A3 80 69,5 78,3

Gambiriin B1 91 67,9 73,7

Gambiriin B3 88,6 65 75,5

Procyanidin B3 95,4 75,5 83

Procyanidin B1 95,4 75,5 83

Uncarine B - - -

Gambiriin A2 83,5 68,5 75,7

Gambiriin B2 91 67,9 73,7

 BIOAKTIVITAS
NAMA SENYAWA
NO ANTI BACTERIAL
KIMIA
(%)

(Z,Z,Z)-3,6,9-
1 50,4
Dodecatrien-1-ol

2 (Z)-Jasmone 42,7

3 (+-)-Linalool 38,5

4 E-beta-farnesene 41,5

5 Nerolidol 46,2

(+)-8-
6 -
Hydroxypinoresinol

7 Oleoside 71,3

8 (-)-alpha-Cadinol 44,4

9 Benzenemethanol 46,7

10 Benzaldehyde 52,3

11 Oleoside 11-methyl ester 67,5

12 Linalyl benzoate 30,6

13 3-Methylcyclopentene 61,4

14 Sambacolignoside 64,7

15 Phenethyl primeveroside 50,6

16 Sambacin 67,9

2,2,3,4-
17 41,4
Tetramethylpentane

18 Sambacoside E -

19 Sambacoside F -

20 Sambacoside A -
21 Molihuaside A 73,6

22 Molihuaside C 72,6

23 Molihuaside D 70,7

24 Molihuaside E 70,7

25 Molihuaside B -
 FREE RADICAL
ANTIOXIDANT (%) NO
SCAVENGER (%)

39,8 - 1

48,2 - 2

38 - 3

49,7 41,6 4

43,1 31 5

37,2 52,8 6

95,8 52,3 7

- - 8

2-1,9 30,5 9

- - 10

95 48,8 11

- - 12

- - 13

89,5 72,2 14

68,7 78,3 15

57,6 - 16

- - 17

- - 18

- - 19

- - 20
83,4 - 21

82,1 - 22

83,2 - 23

83,2 - 24

- - 25
 NAMA SENYAWA TP53 EXPRESSION ANTICARCINOGE CHEMOPREVENTI
KIMIA ENHANCER(%) NIC (%) VE (%)

(Z,Z,Z)-3,6,9-
59,7 36,1 -
Dodecatrien-1-ol

(Z)-Jasmone 58,7 44,2 40,8

(+-)-Linalool 71,9 43,9 46,8

E-beta-farnesene 61,8 39,6 44,7

Nerolidol 70,3 50,5 54,5

(+)-8-
52,8 49,3 60,6
Hydroxypinoresinol

Oleoside 52,7 48 46,8

(-)-alpha-Cadinol 35,2 - -

Benzenemethanol 63,6 34,2 -

Benzaldehyde 50,3 - -

Oleoside 11-methyl ester 48,7 43,9 48,9

Linalyl benzoate 56,3 34,9 39,4

3-Methylcyclopentene 52,1 - -

Sambacolignoside 43,7 65 85,5

Phenethyl primeveroside 38,7 79,2 73

Sambacin 39,9 38,5 63,6

2,2,3,4-
54,7 - -
Tetramethylpentane

Sambacoside E - - -

Sambacoside F - - -

Sambacoside A - - 34,5
Molihuaside A - - 36,5

Molihuaside C - - -

Molihuaside D - - -

Molihuaside E - - -

Molihuaside B - - -
 BIOAKTIVITAS
NAMA SENYAWA
NO ANTI BACTERIAL ANTIOXIDANT (%)
KIMIA
(%)

1 Vanillin 49,5 -

2 Vanillic acid 58,2 -

3 Umbelliferone 53,6 56,3

4 Tonghaosu 36,9 -

5 Syringic acid 61,7 40,33

6 Skimmin - -

7 Sinapic acid - -

8 Salicylic acid 65,9 -

9 Quercetin 3-rutinoside 67,7 -

10 Pentadecanoic acid 25,1 -

11 Patuletin 7-glucoside 53,4 -

12 Patuletin - -

13 Palmitic acid 25,1 -

14 p-Coumaric acid 13,9 55,3

15 Nerolidol 46,2 43,1

N1,N5,N10-Tris-trans-p-
16 26,2 -
coumaroylspermine
N1,N5,N10,N14-Tetra-
17 trans-p- 63,8 18,9
coumaroylspermine
18 Methyl hexadecanoate 44 -

19 Matricin 54,2 -
20 Matricarin 57,3 -

Luteolin 3'-methyl ether

21 - -
7-rutinoside

22 Linoleic acid 49,9 -

23 Hyperin - -

24 Herniarin - -

25 Guaiazulene - -

26 Gallic acid - -

27 Ferulic acid 33,3 -

28 Espatulenol 40,8 -

29 Elixene - -

30 E-beta-farnesene 41,5 -

31 Daphnin 61,9 -

32 Daphnetin 57,4 -

33 chamomillol - -

34 Chamolol 56,1 -

35 Casticin 36,7 -

36 Camazulene 35,9 -

37 Caffeic acid - -

38 beta-Caryophyllene 43,7 -

39 Axillarin - -

40 Astragalin - -

Apigenin 7-O-beta-D-
41 - -
glucopyranoside
 Apigenin 7-(6''-
42 61 -
acetylglucoside)
Apigenin 7-(3'',4''-
43 65,5 -
diacetylglucoside)
Apigenin 7-(2''-
44 65 73,2
acetylglucoside)
Apigenin 7-(2'',3''-
45 - -
diacetylglucoside)

46 alpha-Bisabolol oxide C - -

47 alpha-Bisabolol oxide B - -

48 alpha-Bisabolol - -

9,12-Octadecadienoic
49 - -
acid, methyl ester

50 6-Methoxykaempferol - -

5,7,3',4'-
51 - -
Tetrahydroxyflavone

52 4-hydroxybenzoic acid - -

53 3-O-Caffeoylquinic acid - -

54 3,5-Caffeoyl quinic acid - -

3,4-Dihydroxybenzoic
55 - -
acid
(-)-alpha-Bisabolol oxide
56 - -
A

57 (-)-alpha-Bisabolol - -

58 (+)-alpha-Bisabolol 34,5 -
 FREE RADICAL NAMA SENYAWA TP53 EXPRESSION
NO
SCAVENGER (%) KIMIA ENHANCER(%)

- 1 Vanillin -

- 2 Vanillic acid -

67,1 3 Umbelliferone -

- 4 Tonghaosu -

- 5 Syringic acid -

- 6 Skimmin -

- 7 Sinapic acid -

- 8 Salicylic acid -

- 9 Quercetin 3-rutinoside -

- 10 Pentadecanoic acid -

- 11 Patuletin 7-glucoside -

- 12 Patuletin -

- 13 Palmitic acid -

62,7 14 p-Coumaric acid -

- 15 Nerolidol -

N1,N5,N10-Tris-trans-p-
- 16 -
coumaroylspermine
N1,N5,N10,N14-Tetra-
49,4 17 trans-p- 31,3
coumaroylspermine
- 18 Methyl hexadecanoate -

- 19 Matricin -
 - 20 Matricarin -

Luteolin 3'-methyl ether

-- 21 -
7-rutinoside

- 22 Linoleic acid -

- 23 Hyperin -

- 24 Herniarin -

- 25 Guaiazulene -

- 26 Gallic acid -

- 27 Ferulic acid -

- 28 Espatulenol -

- 29 Elixene -

- 30 E-beta-farnesene -

- 31 Daphnin -

- 32 Daphnetin -

- 33 chamomillol -

- 34 Chamolol -

- 35 Casticin -

24,4 36 Camazulene 59,9

- 37 Caffeic acid -

- 38 beta-Caryophyllene -

- 39 Axillarin -

- 40 Astragalin -

Apigenin 7-O-beta-D-
- 41 -
glucopyranoside
 Apigenin 7-(6''-
- 42 -
acetylglucoside)
Apigenin 7-(3'',4''-
- 43 -
diacetylglucoside)
Apigenin 7-(2''-
- 44 -
acetylglucoside)
Apigenin 7-(2'',3''-
- 45 -
diacetylglucoside)

- 46 alpha-Bisabolol oxide C -

- 47 alpha-Bisabolol oxide B -

- 48 alpha-Bisabolol -

9,12-Octadecadienoic
- 49 -
acid, methyl ester

- 50 6-Methoxykaempferol 93,1

5,7,3',4'-
- 51 -
Tetrahydroxyflavone

- 52 4-hydroxybenzoic acid -

- 53 3-O-Caffeoylquinic acid -

- 54 3,5-Caffeoyl quinic acid -

3,4-Dihydroxybenzoic
- 55 -
acid
(-)-alpha-Bisabolol oxide
- 56 -
A

- 57 (-)-alpha-Bisabolol 50,8

- 58 (+)-alpha-Bisabolol -
 CHEMOPREVENTI
VE
ANTICARCINOGE
NIC (%)
(%)

38,8 36,4

- -

53,4 51

- -

- -

- -

- -

- -

- -

- -

93,6 -

- -

- -

- -

- -

- -

49,1 40

- -

- -
- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -

- -
 - -

- -

- -

- -

- -

- -

- -

- -

73,8 -

- -

- -

- -

- -

- -

- -

- -

- 66
 BIOAKTIVITAS
NAMA SENYAWA
NO ANTI BACTERIAL ANTIOXIDANT (%)
KIMIA
(%)

1 Gibberellin A1 - -

2 Gibberellin A19 30,1 -

3 Gibberellin A20 20,6 -

4 Gibberellin A53 30,2 14,1

5 Tigogenin 46 18,4

Kaempferol 3,4'-
6 55 91,8
dixyloside

7 Agamenoside F 69,8 43,6

8 Polianthoside B 68 46,4

9 Polianthoside C 66 43,1

10 Polianthoside D 66,2 62,6

11 Polianthoside E - -

12 Polianthoside F - -

13 Polianthoside G - -

14 Uttroside B 64,1 66,8

 FREE RADICAL NAMA SENYAWA TP53 EXPRESSION
NO
SCAVENGER (%) KIMIA ENHANCER (%)

- 1 Gibberellin A1 -

- 2 Gibberellin A19 -

- 3 Gibberellin A20 -

- 4 Gibberellin A53

- 5 Tigogenin 26,3

Kaempferol 3,4'-
- 6 80,6
dixyloside

27,5 7 Agamenoside F -

29,9 8 Polianthoside B -

24 9 Polianthoside C -

89,5 10 Polianthoside D -

- 11 Polianthoside E -

- 12 Polianthoside F -

- 13 Polianthoside G -

91,2 14 Uttroside B -
ANTICARCINOGE CHEMOPREVENTI
NIC (%) VE(%)

- 37,1

- 66,7

- 32,4

17 62,3

76,9 85,5

91,5 91,5

97,9 98,3

97,4 98,7

94,6 97,5

99,2 84,9

- -

- -

- -

99,1 87
 NAMA SENYAWA ANTI BACTERIAL
NO ANTIOXIDANT (%)
KIMIA (%)

1 beta-Carotene 29,3 77,5

2 Cyanidin 3-O-glucoside - -

3 Antirrhinin - -

4 Cyanin - -

5 Pelargonin - -

6 Pyrogallol 54,6 65,5

7 Eugeniin 57,4 82,2

8 Tellimagrandin I 54,4 76,3

9 Antheraxanth 29 82,7

10 Flavoxanthin 59,3 49,1

11 Juglanin 60,1 90,5

12 Callistephin - -

13 Cyanidin 3-sophoroside - -

14 Peonidin 3-rutinoside - -

15 Petunin - -

16 Hyacinthin - -

Peonidin 3-(6''-p-
17 - -
coumarylglucoside)

18 DMNT 45,7 61,4

19 Cyclotetradecane 58 -
 FREE RADICAL NAMA SENYAWA TP53 EXPRESSION
NO
SCAVENGER (%) KIMIA ENHANCER (%)

30,6 1 beta-Carotene 92,5

- 2 Cyanidin 3-O-glucoside -

- 3 Antirrhinin -

- 4 Cyanin -

-- 5 Pelargonin -

45,7 6 Pyrogallol 74,4

88,6 7 Eugeniin 92,6

87,8 8 Tellimagrandin I 92,6

53,8 9 Antheraxanthin 78,8

16 10 Flavoxanthin 49,9

96,3 11 Juglanin 96,3

- 12 Callistephin -

- 13 Cyanidin 3-sophoroside -

- 14 Peonidin 3-rutinoside -

- 15 Petunin -

- 16 Hyacinthin -

Peonidin 3-(6''-p-
- 17 -
coumarylglucoside)

48,3 18 DMNT 73,1

24,2 19 Cyclotetradecane 62,5

ANTICARCINOGE CHEMOPREVENTI
NIC (%) VE (%)

69 69,4

- -

- -

- -

- -

38,1 33,7

73,8 79,5

66,6 73,3

91,4 95,5

35,8 78,5

94,1 93,3

- -

- -

- -

- -

- -

- -

51,2 49,8

27,2 21,7
 BIOAKTIVITAS
NAMA SENYAWA
NO ANTI BACTERIAL ANTIOXIDANT (%)
KIMIA
(%)

1 Lycopene 58.7 81.2

2 Syringic acid 61.7 40.3

3 Arvensoside A 55.2 66.6

4 Calenduloside E 51.6 58.3

5 beta-Stigmasterol - 21.5

6 Mutatochrome 35.4 49.5

7 Rubixanthin 50.1 84.7

8 Violaxanthin 35.8 74.9

9 Hirsutrin 59.9 91.3

Quercetin 3-O-
10 68.4 91
neohesperidoside

11 Quercetin 3-rutinoside 67.7 92.3

12 Manghaslin 70.2 93.4

Isorhamnetin 3-O-beta-
13 59.7 88.2
D-glucopyranoside
Isorhamnetin 3-O-
14 67.1 87.8
neohesperidoside
Isorhamnetin 3-O-
15 66.3 89.6
rutinoside
Isorhamnetin 3-
16 rhamnosyl-(1->2)- 65.6 89.9
rhamnoside
17 Typhaneoside 69.1 91.2

18 5alpha-ergostanol 37.1 17.8

19 5alpha-campestanol 37.1 17.8

20 Icariside C3 59.8 57.2

21 Oleanolic acid 26.9 36.1

22 Erythrodiol 17.8 35.3

23 Maniladiol - 41.8

(3beta,5alpha)-
24 36.8 17.4
Stigmastan-3-ol

25 Calendasaponin A 62.6 65.9

26 Calendasaponin B 6.21 61.8

27 Calendasaponin C 55.1 67.6

28 Calendasaponin D 6.14 69.4

29 Calenduloside D 55.9 70.7

30 Calenduloside G 54.9 60.5

31 Officinoside A 66.8 43.5

32 Officinoside B 66.8 43.5

33 Officinoside C 58.8 50.9

34 Officinoside D 65.1 44.4

35 Moronic acid 28.6 22.6

36 Pseudotaraxasterol 35.6 34.1

37 Calendulaglycoside A 58.1 70.8

Calendulaglycoside A
38 53.7 66.3
6'-O-methyl ester

39 Calendulaglycoside B 55.6 64.7

40 Calendulaglycoside C 57.5 66.9

Calenduloside F 6'-O-n-
41 49.1 57.7
butyl ester
42 Longispinogenin - 36.5

43 Machaerinic acid - 18

Calendulaglycoside A
44 52.2 62.6
6'-butyl ester
Calendulaglycoside C
45 51.5 59.3
6'-butyl ester

46 Calenduloside B 54.9 63.7

Calenduloside H methyl
47 53 62.6
ester

48 Coflotriol 16.7 30.7

49 Calendic acid 52.1 34.1

50 Calendulasterolide 47 20.4

51 Coflodiol 24.2 33

52 Arvensoside D 54.7 63.4

Calendulaglycoside B
53 50.9 57
6'-butyl ester

54 Calendulaglycoside E 54.7 58

55 Calenduloside A 53.8 56.7

Calenduloside G methyl
56 51.9 56.6
ester
 FREE RADICAL NAMA SENYAWA TP53 EXPRESSION
NO
SCAVENGER (%) KIMIA ENHANCER (%)

44.6 1 Lycopene 76.6

61.9 2 Syringic acid 71.2

24.5 3 Arvensoside A 53.6

23 4 Calenduloside E 45.3

- 5 beta-Stigmasterol 58.7

16.1 6 Mutatochrome 80.8

58.5 7 Rubixanthin 90.8

6 8 Violaxanthin 72.5

97.8 9 Hirsutrin 95.9

Quercetin 3-O-
98.8 10 95.7
neohesperidoside

98.8 11 Quercetin 3-rutinoside 89.3

99.2 12 Manghaslin 88

Isorhamnetin 3-O-beta-
98.7 13 96.3
D-glucopyranoside
Isorhamnetin 3-O-
99.3 14 96.2
neohesperidoside
Isorhamnetin 3-O-
99.3 15 90.1
rutinoside
Isorhamnetin 3-
98.9 16 rhamnosyl-(1->2)- 92.6
rhamnoside
99.5 17 Typhaneoside 89

- 18 5alpha-ergostanol 39.5

- 19 5alpha-campestanol 39.5
51.9 20 Icariside C3 78.4

- 21 Oleanolic acid 49.8

- 22 Erythrodiol 56.6

- 23 Maniladiol 54

(3beta,5alpha)-
- 24 34.5
Stigmastan-3-ol

41.8 25 Calendasaponin A 28.1

37.9 26 Calendasaponin B 32.9

26.8 27 Calendasaponin C 35.1

26.4 28 Calendasaponin D -

26.7 29 Calenduloside D 49.6

3 30 Calenduloside G 51.8

46.3 31 Officinoside A 54.9

46.3 32 Officinoside B 54.9

26.9 33 Officinoside C 52

30.4 34 Officinoside D 33.7

- 35 Moronic acid 35.4

- 36 Pseudotaraxasterol 34.3

33.8 37 Calendulaglycoside A 37.3

Calendulaglycoside A
27 38 36.3
6'-O-methyl ester

33.1 39 Calendulaglycoside B 47.6

30.6 40 Calendulaglycoside C 42,6

Calenduloside F 6'-O-n-
18.4 41 41.3
butyl ester
 - 42 Longispinogenin 55

- 43 Machaerinic acid -

Calendulaglycoside A
21.7 44 30.9
6'-butyl ester
Calendulaglycoside C
20.1 45 36
6'-butyl ester

20.2 46 Calenduloside B 53.6

Calenduloside H methyl
24.8 47 41.6
ester

- 48 Coflotriol 47.2

39.7 49 Calendic acid 75.6

- 50 Calendulasterolide 29.7

- 51 Coflodiol 46

27.4 52 Arvensoside D 55.6

Calendulaglycoside B
22.2 53 38.8
6'-butyl ester

24.5 54 Calendulaglycoside E 51.8

20.7 55 Calenduloside A 59.3

Calenduloside G methyl
25.4 56 49.1
ester
ANTICARCINOGE CHEMOPREVENTI
NIC (%) VE (%)

54.3 52.5

41.3 45.2

69.8 99.2

69 99.1

38.8 82.7

47.6 61.3

88.3 91.9

85.7 87.4

96.5 95.6

98.8 97.2

98.3 96.8

99 97.6

97.4 86.8

99 98.3

98.7 97.9

97.3 96.8

99.1 98.6

37.9 79.5

37.9 79.5
85 90.7

33.1 93.7

36.1 85.2

38.3 85.4

38.1 80.6

78.7 97.8

76 97.3

79.6 99.6

78.2 99.5

73.4 99.4

76.5 99.5

65.6 61.4

65.6 61.4

77 78.1

58.5 61.3

21.5 74

34.7 74.9

78.7 99.6

70.7 99.5

79.1 99.6

76 99.5

68.9 98
37.1 85.5

- 37.9

68.6 98.8

64.7 98.4

76.6 98.8

67.1 99.4

36.8 67

43 33.3

- 30.3

34.8 66.8

73.8 99.5

69.1 99

81.5 99.3

76.9 98.9

67.6 99.5