Quiz Module 7
True or False
1. Naive B lymphocytes recognize antigens but do not secrete antibodies.
T
2. T cell responses to different antigens are classified as T-dependent or
T-independent, based on the requirement for T cell help. F
3. The antibodies secreted in response to an antigen have the same
specificity as the surface receptors on naive T cells that recognize that
antigen to initiate the response. F
4. Primary response is usually a heightened IgG titer. F
5. Membrane IgM and IgG, the antigen receptors of naive B lymphocytes,
are membrane bound antibodies and therefore have highly variable
extracellular antigen-binding regions. F
6. B lymphocytes express a receptor for C3d called CD21. T
7. In the absence of CD40 or CD40L, B cells secrete only IgG and fail to
switch to other isotypes, indicating the essential role of this ligand-
receptor pair in isotype switching. F
8. Thymus-independent antigen have a strong affinity maturation. T
9. The cytoplasmic domain of B cell FcyRIIB contains an ITAM that binds
enzymes that inhibit antigen receptor–mediated B cell activation. F
10. During their differentiation, some B cells may begin to produce
antibodies of different heavy-chain isotypes (or classes), which
mediate different effector functions and are specialized to combat
different types of microbes. T
Quiz Module 8
True or False
1. The Fc portions of immunoglobulin (Ig) molecules, made up of the
light-chain constant regions, contain the binding sites for Fc receptors
on phagocytes and for complement proteins. F
2. The progressive decrease in antibody affinity with repeated stimulation
of B cells is
one of the reasons for the recommended practice of giving multiple
rounds of immunizations with the same antigen. F
3. CD32 works for Antibody dependent cellular cytotoxicity. F
4. CD32 allows feedback inhibition of B cells. T
5. NK cells express an Fc receptor called CD16, which is one of several
kinds of NK cell–activating receptors. T
6. Factor D is the active enzyme of C3 and C5 convertases. F
7. Factor D cleaves factor B when is bound to C5b. F
8. MBL initiates lectin pathway. T
9. C6 binds C5b and accepts C7.
10. Vaccination is the process of stimulating protective adaptive
immune responses against microbes by exposure to pathogenic forms
or components of the microbes. F
