NEET Molecular Biology Questions
NEET Molecular Biology Questions
2. Purines found both in DNA and RNA are 6. Which one of the following does not follow the
(NEET 20M9) central dogma of molecular biology?
(a) cytosine and thymine (2010)
(b) adenine and thymine (a) Pea
(c) adenine and guanine (b) Mucor
(d) guanine and cytosine. (c) Chlamydomonas
(d) HIV
3. The association of histone H1with a
nucleosome 7. The 3'.5' phosphodiester linkages inside a
indicates that polynucdeotide chain serve to join
(NEET 2017) (Main 2010)
(a) DNA replication is occurring (a) one DNA strand with the other DNA strand
(b) the DNA is condensed into a chromatin fibre (b) one nucleoside with another nucleoside
(c) the DNA double helix is exposed (c) one nucleotide with another nucleotide
(d) transcription is occurring. (d) one nitrogenous base with pentose sugar.
4. In sea urchin DNA, which is double stranded, 8. Which one of the following statements about
the
17% of the bases were shown to be cytosine.
The particular entity is true ?
(Main 2010)
percentages of the other three bases expected
to be (a) Centromere is found in animal cels, which
present in this DNA are produces aster during cell division.
(2015 Cancelled) (b) The gene for producing insulin is present in
(a) G 17%, A 33%, T 33% every body cell.
(b) G 8.5%, A 50%, T 24.5% (c) Nucleosome is formed of nucleotides.
(c) G 34%, A 24.5%, T 24.5% (d) DNA consists of core of eight histones.
(d) G 17%, A 16.5%,T 32.5%.
9. In the DNA molecule,
(a) one strand turns clockwise
(2008)
(b) one strand turns anti-clockwise
(a) the proportion of adenine in relation to
thymine (c) the phosphate groups of two DNA
varies with the organism strands, at heir ends, share the same
(b) there are two strands which run position
antiparallel-one in 5' +3 direction and other (d) the phosphate groups at the start of two
in DNA strands are in opposite position (pole).
3+5'
(c) the total amount of purine nucleotides
13. Which one of the following makes use of RNA
and
template to synthesise DNA?
pyrimidine nucleotides is not always equal (2005)
() there are two strands which run parallel (a) DNA polymerase
in the
5'+3' direction. (b) RNA polymerase
(c) Reverse transcriptase
(d) DNA dependant RNA polymerase
10. Which one of the following pairs of
nitrogenous
bases of nucleic acids, is wrongly matched 14. Which one of the following hydrolyses internal
with the phosphodiester bonds in a polynucleotide chain?
category mentioned against it? (2005)
(2008) (a) Lipase
(a) Guanine, Adenine- Purines (b) Protease
(b) Adenine, Thymine- Purines (c) Endonuclease
(c) Thymine, Uracil - Pyrimidines (d) Exonuclease
(c) Uracil, Cytosine- Pyrimidines
15. In a DNA percentage of thymine is 20% then what
11. One turn of the helix in a B-form DNA is will be percentage of guanine?
approximately (2002)
(2006) (a) 20%
(a) 2 nm (b) 40%
(b) 20 nm (c) 30%
(d) 60%
(c) 0.34 nm
(d) 3.4 nm.
16. Length of one loop of B-DNA
12.Antiparallel strands of a DNA molecule (2000)
means that (a) 3.4 nm
(2006) (b) 0.34 nm
(c) 20 nm
(d) 10 nm.
(b) it should be able to generate its replica
17. The experimental proof for semi-conservative (c) it should be unstable structurally and
replication of DNA was first shown in a chemically
(NEET 2018) (d) it should provide the scope for slow changes
(a) fungus that are required for evolution.
(b) bacterium
(c) plant 22. Transformation was discovered by
() virus.) (a) Meselson and Stahl (b) Hershey and Chase
(c) Griffith
18. Select the correct match.
(d) Watson and Crick.
(NEET 2018)
(2014)
(a) Ribozyme
23. The unequivocal proof of DNA as the genetic
- Nucleic acid material
(b) F2 * Recessive parent- Diybrid cross came from the studies on a
(c) T.H. Morgan (a) bacterium
Transduction
(b) fungus
() G. Mendel (c) viroid
- Transformation
(d) bacterial virus.
(Main 2011)
19. The final proof for DNA as the genetic material 24. Semi-conservative replication of DNA was first
came from the experiments of demonstrated in
(NEET2017)
(a) Escherichia coli
(a) Hershey and Chase
(b) Avery, MacLeod and McCarty (b) Streptococcus pneumoniae
(c) Salmonella typhimurium
(c) Hargobind Khorana
(d) Drosophila melanogaster.
() Griffith.
(2009)
25. Transformation experiment was first performed
20.Taylor conducted the experiments to prove on
semiconservative mode of chromosome which bacteria?
replication on (a) E. coli
(NEET-II 2016)
(a) Vinca rosea (b) Diplococcus pneumoniae
(c) Salmonella
(b) Vicia faba
(c) Drosophila melanogaster (d) Pasteurella pestis
() E. coli. 26. DNA synthesis can be specifically measured by
estimating the incorporation of radio-labelled
21. A molecule that can act as a genetic material (a) thymidine
must (b) deoxyribose sugar
fulfill the traits given below, except (c) uracil
(NEET-I| 2016) () adenine.
(a) it should be able to express itself in the form of (1997)
'Mendelian characters'
31. Name the enzyme that facilitates opening of
DNA
27. Which one of the following is not applicable to helix during transcription.
RNA?
(NEET 2020)
(2015)
(a) Heterocyclic nitrogenous bases (a) DNA ligase
(b) DNA helicase
(b) Chargaff 's rule
(c) Complementary base paiing (c) DNA polymerase
(d) 5' phosphoryl and 3' hydroxyl ends () RNA polymerase
28.Similarity in DNA and RNA is that 32. What will be the sequence of mRNA
(2000) produced by
the following stretch of DNA?
(a) both are polymer of nucleotides
(b) both have similar pyrimidine (Odisha NEET 2019)
3ATGCATGCATGCATG5TEMPLATE STRAND
(c) both have similar sugar
(d) both are genetic material. 5' TACGTACGTACGTAC3' CODING STRAND
(a) 3'AUGCAUGCAUGCAUGS'
(b) 5'UACGUACGUACGUAC 3
29. During DNA replication, Okazaki fragments are (c) 3' UACGUACGUACGUAC 5'
used to elongate (d) 5' AUGCAUGCAUGCAUG 3'
(NEET 2017) 33. Select the correct statement.
(a) the lagging strand towards replication fork (NEET 2018)
(b) the leading strand away from replication fork (a) Franklin Stahl coined the term "linkage".
(c) the lagging strand away from the replication fork (b) Punnett square was developed by a British
scientist.
(d) the leading strand towards replication fork.
(c) Spliceosomes take part in translation.
30. During replication of a bacterial chromosome (d) Transduction was discovered by S. Altman.
DNA
synthesis starts from a replication origin site and 34. AGGTATCGCAT is a sequence from the coding
(2004) strand of a gene. What will be the corresponding
(a) RNA primers are involved sequence of the transcribed mRNA?
(b) is facilitated by telomerase (NEET 2018)
(c) moves in one direction of the site (a) AGGUAUCGCAU (b) UGGTUTCGCAT
(d) moves in bidirectional way. (c) ACCUAUGCGAU(d) UCCAUAGCGUA
78. Out of 64 codons, 61 codons code for 20 types 83.A complex of ribosomes attached to a single
strand
amino acid. It is called of RNA is known as
(2002)
(a) degeneracy of genetic code (NEET-I 2016)
(b) overlapping of gene (a) polypeptide
(c) wobbling of codon (b) Okazaki fragment
(d) universility of codons. (c) polysome
(d) polymer.
79. Change in sequence of nucleotide in DNA is
called
(2002)
84.Amino acid sequence, in protein synthesis is
87. Match the following genes of the Lac operon with
decided
their respective products.
by the sequence of (A) i gene (i) B-galactosidase
(2006) (B) Zgene (ii) Permease
(a) rRNA (C) a gene (ii) Repressor
(b) tRNA (D) y gene (iv) Transacetylase
(c) mRNA Select the correct option.
(d) cDNA. (A) (B) (C) (D)
(a) (iüi) (iv) (i) (ii)
(b) () (iüi) (ii) (iv)
85. Using imprints from a plate with complete (c) (iii) (i) (ii) (iv)
medium (NEET 2019)
(d) (iüi) (i) (iv) (i)
and carrying bacterial colonies, you can select
streptomycin resistant mutants and prove that 88.All of the following are part of an operon
such
except
mutations do not originate as adaptation. (NEET 2018)
These
(a) an operator
imprints need to be used (b) structural genes
(2005) (c) an enhancer
(a) on plates with and without streptomycin (d) a promoter.
(b) on plates with minimal medium
(c) only on plates with streptomycin 89. Which of the following is required as
() only on plates without streptomycin. inducer(s) for
the expression of Lac operon?
86.Protein synthesis in an animal cell occurs (NEET-1 2016)
(2005) (a) Lactose
(a) only on the ribosomes present in cytosol (b) Lactose and galactose
(b) only on ribosome attached to the nucdear (c) Glucose
envelope and endoplasmic reticulum (d) Galactose
(c) on ribosome present in the nucleolus as
well as
90.Gene regulation governing lactose operon of
in cytoplasm E.coli
() on ribosomes present in cytoplasm as well that involves the lac I gene product is
as in
(2015 Cancelled)
mitochondria. (a) negative and repressible because repressor
protein prevents transcription
(b) feedback inhibition because excess of
B-galactosidase can switch off transcription
94.The lac operon consists of
(c) positive and inducible because it can be induced (Main 2010)
by lactose (a) four regulatory genes only
(d) negative and inducible because repressor (b) one regulatory gene and three structural
protein prevents transcription. genes
(c) two regulatory genes and two structural
genes
91. Which one of the following is wrongly matched? (d) three regulatory genes and three structural
(a) Transcription - Writing information from DNA genes.
to tRNA.
(b) Translatio 95.Expressed Sequence Tags (ESTs) refers to
(2014)n- Using information in mRNA to (a) novel DNA sequences
make protein. (NEET 2019)
(c) Repressor protein - Binds to operator to stop (b) genes expressed as RNA
enzyme synthesis.
(c) polypeptide expression
(d) Operon - Structural genes, operator and () DNA polymorphism.
promoter.
96.ldentify the correct order of organisation of
92.Which enzyme will be produced in a cell if there genetic
is a material from largest to smallest.
nonsense mutation in the lacY gene? (2015)
(NEET 2013) (a) Genome, chromosome, gene, nucleotide
(a) Transacetylase (b) Chromosome, genome, nucleotide, gene
(b) Lactose permease and transacetylase (c) Chromosome, gene, genome, nucleotide
(c) B-galactosidase (d) Genome, chromosome, nucleotide, gene
(d) Lactose permease
97. Satelite DNA is important because it
93.In an inducible operon, the genes are (2015)
(Karnataka NEET 2013) (a) does not code for proteins and is same in
all
(a) usually not expressed unless a signal turns
them"on". members of the population
(b) usually expressed unless a signal turns them (b) codes for enzymes needed for DNA
"off. replication
(c) never expressed (c) codes for proteins needed in cell cycle
(d) always expresser. (d) shows high degree of polymorphism in
population
and also the same degree of polymorphism in
an
106.The lac operon is an example of E. coli and proposed operon concept. Operon
concept
(1995)
is applicable for
(a) repressible operon
(b) overlapping genes (2002)
(c) arabinose operon (a) all prokaryotes
(d) inducible operon. (b) all prokaryotes and some eukaryotes
(c) all prokaryotes and all eukaryotes
107.An environmental agent, which triggers (d) all prokaryotes and some protozoans.
transcription
from an operon, isa 111.in E. coli, during lactose metabolism repressor
binds to
(1995)
(a) depressor (2002)
(b) controlling element (a) regulator gene
(c) regulator (b) operator gene
(d) inducer. (c) structural gene
(d) promoter gene.
108. Lac operon' in E. coli, is induced by
(1994) 112.In negative operon,
(a) "' gene (2001)
(b) promnoter gene (a) co-repressor binds with repressor
(c) B-galactosidase (b) co-repressor does not bind with repressor
(d) lactose. (c) co-repressor binds with inducer
(d) CAMP have negative effect on lac operon.
116.The codons causing chain termination are
113.Khorana first deciphered the triplet codons (1997)
of
(a) AGT, TAG, UGA
(1992)
(a) serine and isoleucine (b) UAG, UGA, UAA
(c) TAG, TAA, TGA
(b) cysteine and valine
(d) GAT, AAT, AGT.
(c) tyrosine and tryptophan
(d) phenylalanine and methinonine.
117.Which of the following serves as a terminal
codon?
114.In the genetic dictionary, there are 64
(1996)
codons as
(a) UAG
(1990) (b) AGA
(a) 64 amino acids are to be coded
(c) AUG
(b) 64 types of tRNAS are present
(d) GCG
(c) there are 44 nonsense codons and 20 sense
codons 118.If the DNA codons are ATG ATG ATG and a
(d) genetic code is triplet. cytosine
base is inserted at the beginning, then which of
115.Genetic code consists of
the
(1988) following will result?
(a) adenine and guanine (1995)
(b) cytosine and uracil (a) CAT GAT GAT G (b) A non-sense mutation
(c) cytosine and guanine (c) CATGATG ATG (d) CA TGA TGA TG
(d) all of these.
119.Anticodon is an unpaired triplet of bases in
an
exposed position of
(1995)
(a) tRNA
(b) mRNA
(c) rRNA
(d) both (b) and (c).
120.Initiation codon of protein synthesis (in
eukaryotes)
is
(1993)
(a) GUA
(b) GCA
(c) CCA
(d) AUG.
1.A 31.D 61.D 91.A.D
2.C 32.B 62.C 92.C
3.B 33.B 63.A 93.A
4.A 34.A 64.D 94.B
5.C 35.D 65.B 95.B
6.D 36.C 66.C 96.A
7.C 37.B 67.B 97.D
8.B 38.C 68.B 98.D
9.B 39.A 69.D 99.A
10.B 40.D 70.D 100.D
11.D 41.B 71.D 101.A
12.D 42.A 72.A 102.B
13.C 43.A 73.C 103.C
14.C 44.A 74.A 104.C
15.C 45.D 75.C 105.C
16.A 46.B 76.D 106.D
17.B 47.A 77.C 107.D
18.A 48.C 78.A 108.C
19.A 49.B 79.B 109.A
20.C 50.D 80.C 110.C
21.C 51.C 81.C 111.B
22.C 52.A 82.A 112.A
23.D 53.C 83.C 113.B
24.A 54.A 84.C 114.D
25.B 55.A 85.C 115.D
26.A 56.C 86.D 116.B
27.B 57.C 87.D 117.A
28.A 58.A 88.C 118.A
29.C 59.A 89.A 119.A
30.D 60.D 90.D 120.D