MOLECULAR PHYSICAL PHARMACY 7.
5 HP
Course Content:
• Self-assembly of amphiphilic molecules in pharmaceutical and
biological systems (3 Lectures)
• Macromolecules, biopolymers and gels in pharmaceutical and
biological systems (2 Lectures)
• Transport and release of drug molecules (2 Lectures)
• Classical molecular simulations for relevant systems in
pharmaceutics (2 Lectures)
• Introduction to scattering techniques for structural
characterization of pharmaceutical and biological systems (2
Lectures)
MOLECULAR PHYSICAL PHARMACY
LEARNING OUTCOMES
On completion of the course, the student should be able to:
• apply knowledge dealing with thermodynamic principles and models for the self-assembly of amphiphilic molecules
• apply knowledge dealing with models based on bending elasticity and spontaneous curvature to understand the formation of
micelles, membranes and microemulsions
• account for assumptions and restrictions in different theories for macromolecules
• apply knowledge dealing with the thermodynamic driving forces that underlies swelling of polymer coils and gels, phase separation
in polymer solutions and formation of complexes in systems of oppositely charged polyelectrolytes
• apply knowledge dealing with different transport mechanisms and their relevance for the release of drugs from different
pharmaceutical formulations
• account for how the structure of materials influence the effective transport properties, in particular with respect to diffusion
• use molecular dynamics simulations as a tool for simulations of pharmaceutically relevant molecules, for example peptides
• analyze structural and dynamic properties of the simulated systems
• apply knowledge how different levels of coarse-graining are applicable in different circumstances.
• apply knowledge dealing with basic principles of the experimental techniques static and dynamic light scattering, small-angle x-ray
and neutron scattering
• perform simple analysis of experimental light scattering and small-angle scattering data
• apply analytic methods to solve quantitative problems
MOLECULAR PHYSICAL PHARMACY
Content Date Teacher
I Course introduction 30/8, 9-10 Magnus Bergström
L1 Introduction to self-assembly of surfactants and phospholipids 30/8, 10-12 Magnus Bergström
Schedule L2
L3
Thermodynamics of self-assembly
Curvature properties of micelles, bilayers and microemulsions.
Surfactants as solubilization agents.
31/9, 10-12
1/9, 10-12
Magnus Bergström
Magnus Bergström
L4 Macromolecules and biopolymers 1 2/9, 10-12 Per Hansson
S1 Self-assembly of surfactants and phospholipids 3/9, 10-12 Magnus Bergström
L = Lecture L5
S2
Macromolecules and biopolymers 2
Macromolecules and biopolymers
6/9, 10-12
8/9, 10-12
Per Hansson
Per Hansson
S = Supervision L6
L7
Introduction to transport properties and drug release processes
Mathematical modelling of drug release
9/9, 10-12
10/9, 10-12
Göran Frenning
Göran Frenning
E = Exercise S3
L8
Transport properties and drug release
Molecular dynamics 1
14/9, 10-12
15/9, 10-12
Göran Frenning
Per Larsson
L9 Molecular dynamics 2 16/9, 10-12 Per Larsson
L10 Introduction to scattering techniques 17/9, 10-12 Magnus Bergström
TEACHERS L11 SLS, SAXS, SANS 17/9, 13-15 Magnus Bergström
Magnus Bergström [email protected]
Per Hansson [email protected] S4 Molecular dynamics 20/9, 10-12 Per Larsson
Göran Frenning [email protected] E1 Molecular dynamics computer exercise 21-22/9, 8-17 Per Larsson
Per Larsson [email protected]
Magnus Bergström
E2 SLS and SAXS experimental exercise 21-22/9, 8-17
Per Hansson
MOLECULAR PHYSICAL PHARMACY
Electronic Examination on Inspera:
4 exercises, 15 p each
1. Self-assembly of amphiphilic molecules
2. Macromolecules
3. Transport and release
4. Molecular simulations
36 p required for passing the exam with the grade approved (G)
48 p required for the grade well approved (VG)
MOLECULAR PHYSICAL PHARMACY
Home Tasks and Bonus:
Exercises will be handed out for each subject.
Approved home tasks will each give maximum
5 points that is added to each exercise on the
examine.
MOLECULAR PHYSICAL PHARMACY
Laboratory exercises:
1. Molecular Dynamics
21-22 Sep
2. Scattering Techniques (SLS and SAXS)
21-22 Sep at D3:4, BMC
MOLECULAR PHYSICAL PHARMACY
Course literature:
Recommended Literature
• Surfactants – In Solution, at Interfaces and Colloidal Dispersions
(Aveyard), Oxford Graduate Texts, 2019, ISBN 978-0-19-882860-0
• Biophysical Chemistry (Kalsi and Mahanta), New Academic Science,
2014, ISBN 978-1-78-183003-1
MOLECULAR PHYSICAL PHARMACY
Why mathematics?
MOLECULAR PHYSICAL PHARMACY
Course administration located at A5:3
Course administrators:
Sandra Bratt
William Lozancic
E-mail: [email protected]
MOLECULAR PHYSICAL PHARMACY
Don’t forget to fill in the
course evaluation!
BMC planned actions due to the pandemic
Access card required to enter BMC, A11 entrance open 08:00-15:00 during
the start of the semester
Follow the recommendations issued by the Public Health Agency of Sweden,
Folkhälsomyndigheten
Dual info desks with access card handling active during start of the semester
Information screens showing recommendations regarding handwash, physical
distance etc.
Floor markers reminding about keeping 2 metres distance
Limitations in central dish facility, info desk and goods reception
Divided corridor next to the restaurant to grant easy passage
Maps showing the closest entrance to minimize the risk of crowds inside BMC
