NCM 116 Semifinals Lec
NCM 116 Semifinals Lec
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Huntington:
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By: elel and eya <3 2
GUILLAIN-BARRE - Immune system attacks myelin - Ascending symmetrical Assessment: [No cure but aid in recovery] ● Airway priority! (ABC’s)
SYNDROME sheath = no electrical impulse muscle weakness ● Paresthesias of feet to administered within 2 weeks: ● Eye management
- Georges Guillain = no action potential - Lower extremity weakness hand = tetraplegia ➔ Plasmapheresis ○ Ointment, drops
- Jean Barre - rapid onset; w/ in weeks - Absent deep tendon ● Hyporeflexia and ◆ Filters blood to remove ○ Keep moist
reflexes weakness = Quadriplegia antibodies attacking ● Dysphagia
- Demyelinating disease TYPES: ● Neuromuscular respiratory myelin sheath. ○ Assess swallowing
of the peripheral 1. Acute inflammatory demyelinating Respiratory Failure Early failure ➔ Immunoglobulin Therapy abilities after ensuring
nervous system polyradiculoneuropathy signs: ● Cranial nerve deficit ◆ Stops antibodies that safety
(neurons, cranial - Paresthesia starts from feet then - Inability to cough (II-VII-IX-X) are damaging nerves ○ Risk for aspiration
nerves, spinal cord) ascends (symmetrical) - Inability to lift head and ● Ptosis, diplopia, facial ➔ Continuous ECG ○ Nx: NGT for feeding
2. Miller fisher syndrome
- Affects anyone eyebrows weakness, dysarthria ■ [note residuals]
- triad of symptoms: paralysis all
(gender, race, age) - Shallow respiration ● Sensory dysfunction Medication: ○ Risk for pneumonia
- ophthalmoplegia (paralysis of
eye muscles) - Dyspnea and hypoxia ● Does not affect - Anticholinergic ○ Impaired communication
- Also known as - ataxia (lack of coordination), cognition and LOC (Atropine) ● Monitor bowel sounds
polyradiculoneuritis - areflexia (absence of reflexes), Peripheral Nervous System - Anticoagulant Impaired sphincter
3. Acute motor axonal neuropathy - Somatic: controls If severe, autonomic nervous - Compression socks ○ Nx: catheter
- Causes: EBV, Herpes ● rapid motor nerve degeneration, voluntary functions system can be affected aeb: ● Immobility complications:
Virus, HIV/AIDS, leading to severe muscle - Autonomic: controls - Monitor vitals (note if hypo Collaboration: ○ Blood clots (DVT,
⬇️
Campylobacter jejuni weakness involuntary functions or hyper ) - Physical therapist for Pulmonary emboli)
- Constipation due to rehabilitation in muscle ○ Pressure ulcers
gastric motility recovery ○ Nx: ROM, Turning
Diagnostics: Spinal tap (lumbar puncture) | CSF analysis elevated protein content upto 700 mg/dl | Evoke potential study (Nerve conduction studies) | Electromyography
SPINAL TAP: Before: Empty Bladder | During: Position- Lateral recumbent with knees up to abdomen and chin to chest | After: Supine and encourage hydration to replace CSF loss
MULTIPLE SCLEROSIS ● Immune system attacks myelin - MS- Muscle spasm & Balance exercise with rest Medication: depends on s/s 1. Promotion of ADL’s
- Autoimmune condition
sheaths
○ Leads to inflammation and
Stiffness
s/s depends on location:
AVOID THE 4 Ss= Trigger
Flare-Ups ○ ⬇️
● Beta interferon
relapses and
2. Keep room cool
3. Rx: Prednisone
- Demyelinating disease
of central nervous
system (brain & spinal
○ ⬇️
scarring
nerve signal transmission
● a relapsing-remitting pattern
● Cerebellar
○ Tremors, dysarthria,
ataxia, cognitive
❖ S - Stress (exercise,
surgery, pregnancy)
inflammation
○ S/E: Risk for infection
❖ S - Sun & extreme heat ● Corticosteroids
a. Assess visual acuity
(cataract)
4. Rx: Azathioprine
cord) ● Sensory and motor problems issue ❖ S- Smoking ○ For relapse of s/s a. Monitor WBC
● Relapsing-remitting multiple ● Optic ❖ S- Sickness or sepsis ○ Methylprednisolone, b. Normal S/E: Gingival
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- Cause: Female (20-40 sclerosis (RRMS): ○ Blurry vision, (infection) prednisone hyperplasia (Gums)
yrs old), infection, vit D ○ s/s come and go blindness in one eye, ● Anticholinergic c.No live vaccines
deficiency ● Sensory problems diplopia, nystagmus, Diagnostics: ○ For overactive bladder d.Avoid crowds
○ Lhermitte’s sign: electric dark spots, pain ● MRI [3-4mm sclerotic brain [prevents contractions] e.No pregnancy
- Descending paralysis shock sensation when when moving eye plaques] ○ oxybutynin f.Report signs of
moving head or neck ● Elimination: ● CT scan ● Cholinergic: helps empty infection and bleeding
Early s/s of MS: ○ Romberg’s sign: unaware of ○ Overactive bladder ● Lumbar spinal puncture: bladder by contracting 5. Passive exercise only
- vision issues, tingling body position when eyes are ■ nocturia ○ assess for oligoclonal ● CNS stimulant for fatigue 6. Encourage assistive device
numbness, weakness, closed [swaying when ○ Retaining urine bands (if +) means ○ Amantidine 7. Hydration and high fiber
dizziness, balance standing with eyes closed] ■ risk for UTI and inflammation in CNS ○ Modafinil a. 1-2L of water
issues, bladder renal stones ● Evoked potential studies: ● Baclofen for spasm b. Stool softeners
problems, cognitive Uhtoff’s sign: symptoms get worse ○ Bowel: sens e-signals to CNS and (muscle relaxants)
issue…issues due to heat or physical exercise constipation/diarrhea evaluate response ○ diazepam Collaboration:
speaking, weakness, or incontinence ○ Normal: 60-70mv ● Beta-blocker for tremors 1. Physical therapist
spasms Affects emotion and cognition: ○ Propranolol 2. Speech-Language
fatigue, depressed, mood swings, ○ isoniazid Pathologist
can’t concentrate
Note: No cure, just for the symptoms. Irreversible | Demyelination: loss of myelin sheath | EXACERBATIONS: new s/s appear and old ones worsen | REMISSIONS: s/s decrease or disappear |
RELAPSES: assoc. w/ periods of emotional and physical stress | Depression | FOR TYPES: Refer to pings note
MYASTHENIA GRAVIS In Neuromuscular junction Hallmark: muscle weakness ● Edrophonium (Tensilon test) Myasthenic Crisis: 1. If myasthenic crisis,
- Acetylcholine can’t bind to becomes worse with activity esp. ○ s/s temporarily improve - Sudden onset of acute intubate. Monitor for
Mys = muscle Nicotinic Acetylcholine Receptors With repetitive activity, but as it prevents respiratory distress and respiratory failure
Asthenia = weakness (NaChRs) = no muscle improves after resting: breakdown of ACh inability to swallow or 2. Maintain suction and
Weak in neck, face, & extremities speak
Gravis = grave contraction = weakness ○ To differentiate MC and emergency equipment
Eyelid drooping (PTOSIS) - Result from: progression
Appearance: mask-like- no expression CC 3. Assess muscle status
of disease, emotional
Worse than MS Causes: Keeps choking/gag (dysphagia) ○ If pt is with CC s/s will upset, wrong dosage in 4. Instruct the client to avoid
No energy, fatigue all day worsen, administer medications, trauma stress, infection, fatigue,
Autoimmune disorders 1. B cells makes antibodies that Extraocular muscle (strabismus) atropine Cholinergic Crisis and over-the counter
that affect voluntary
muscle. Results in ⬇️
impaired transmission of
attacks the receptors of ACh
a. Type II Hypersensitivity:
cytotoxic injury
Slurred speech
Short breath
● MRI
● Serum analysis for ACh
receptor
- Overmedication with
cholinergic or
anticholinesterase drugs
medications.
5. Encourage smaller meals,
easy to chew food
nerve impulses in 2. Thymus stores antibodies that Rx: NO CURE! ● Electromyography - (+) muscle weakness, 6. Thicken liquids for swallowing
myoneural junction = no attacks NaChRs due to tumor ● Anticholinesterase: respiratory depression, GI 7. Pt usually feels better on
contractions. 3. Acetylcholinesterase: an pyridostigmine [relieve symptoms, sweating, the morning then gradually
enzyme that breaks down ACh hypersalivation, and becomes fatigue
only]
bradycardia, pupil throughout (do hard tasks in
Affects: women: 20-30’s a. [Rx is focused on stopping ● Thymectomy/ corticosteroid
By: elel and eya <3 4
Men: 60-70’s the breakdown of ACh] ● Plasmapheresis w/ IVG constriction the morning)
TRIGEMINAL - chronic pain disorder that ● sudden, excruciating, ● Assess for pain and SURGERY Medication:
NEURALGIA involves sudden attacks of sharp, pain, similar to an triggering factors for ❖ Microvascular ● Anticonvulsant agents,
severe facial pain. electric shock pain Decompression of the (carbamazepine)
Aka “tic douloureux” - affects the trigeminal nerve, ● pain is unilateral Trigeminal Nerve ○ is taken with
(5th cranial nerve) ○ involves the lower face ➢ relieve the contact between meals
Common age: 50-60’s - which provides ○ from the corner of the the cerebral vessel and the ○ Monitor for
feeling and nerve mouth to the jaw trigeminal nerve root entry. toxicity
signaling to parts of ❖ Radiofrequency
the head and face. ● TRIGGER:chewing, Thermal Coagulation
brushing the teeth, ➢ produces a thermal lesion
on the trigeminal nerve
shaving, or even just
❖ Percutaneous Balloon
smiling
Microcompression
● ONSET:pain occurs in
➢ disrupts large myelinated
paroxysmal attacks that fibers in all three branches
generally last from a few of the trigeminal nerve.
seconds up to 2 minutes ➢ The balloon compresses
the nerve root for 1 minute
to provide decompression
BELL’S PALSY - causes sudden weakness in “BELLS P” 1. Eye Care ● Corneal ulcers Corticosteroid therapy
the muscles on one side of ● Cover eye with a ● Blindness (prednisone) may be
the face ● Blink reflect abnormal protective shield at night. ● Impaired nutrition initiated to reduce
- MAIN CAUSE: inflammation ● Earache/Eye rolls up ● Apply eye ointment to inflammation
● Lower corner of mouth & keep eyelids closed during
affecting the body's immune
eyelid sleep.
system. ● Loss of taste & brow Analgesic Agents
● Close the paralyzed eyelid
- Cranial nerve VII, or the movements manually before going to To control facial pain
facial nerve, is the nerve ● Sudden Onset sleep.
involved in Bell palsy. ● Wear wraparound
sunglasses or goggles to
decrease normal
evaporation from the eye.
2. Diet & Nutrition
● chew on the unaffected
side of his mouth.
● Soft foods.
● Eliminate hot fluids and
By: elel and eya <3 5
foods.
● Give frequent mouth
care, being particularly
careful to remove
residues of food that
collects between the
cheeks and gums.
PERIPHERAL - distal nerves of the hands ● Numbness or reduced ● sensory alterations that Medications: ● Skin biopsy
NEUROPATHIES and feet are damaged and ability to feel pain or are often progressive, ● Anti-seizure ● MRI scan
unable to transmit messages temperature changes. including sensory loss, medications ● Blood scan
- CAUSE: GBS, correctly ● Tingling or burning feeling. numbness, pain, or ○ pregabalin, ● Physical examination
rheumatoid arthritis, - (peripheral nerves are ● Sharp pains or cramps. burning sensations in a gabapentin and ● electromyography
hepatitis B and C, tumors, DAMAGED) ● Muscle weakness. “stocking and glove” tegretol.
hypothyroidism ● Extreme sensitivity to touch distribution of the ○ It block the
— for some people, even a extremities transmission of pain
bedsheet's weight can be signals.
painful. ● Antidepressants
● Serious foot problems, ○ decrease pain in
such as ulcers, infections, peripheral neuropathy
and bone and joint
damage.
By: elel and eya <3 6
Ping’s: for MS! RR: acute attacks with full recovery | PP: without plateaus or remission | SP: initial
RR - valuable rate + occasional relapse and minor lapses | PR: with or without recovery
By: elel and eya <3 7
DEGENERATIVE DISEASES
COGNITIVE| DEMENTIA: group of symptoms, not a specific disease | DELIRIUM: short term impairment | ALZHEMER: decline of function long term
PARKINSON'S ● the body produces low or ● Progressively slow - Encourage exercise Medications: ● low heel shoes and
DISEASE has stopped dopamine movements (Passive ROM), 1. Benztropine myslate avoid rubber soles
production. ● Rigidity or freezing breaking swear to 2. Ropinirole “Requip”: ● For balance: move
- 4th most ● It is not about the body while walking release dopamine stimulates dopamine receptors slowly when changing
neurodegenerative attacking itself like that of ● Shuffling gait - Foods rich in - helps with improving position
disease MS or MG. ● Balance problems Antioxidants (green movement ● Education on how to
● .The dopaminergic neurons ● Tremors improves with tea & veggies) 3. Carbidopa/Levodopa deal with freezing
in the brain called movement Pill-rolling: ● adds more dopamine to the episodes:
substantia nigra have ○ Pill rolling is brain ○ Try to change
started to die. tremors of the ● Takes 3 wks to decrease direction of
○ This part controls hands and fingers symp. movement
movements. ○ looks like the ● Normal if body fluids turn to ○ DON’T push
patient is rolling a a dark color through the
pill between ● after long term usage the freeze up.
fingers and hands. drug may wear off before ○ Consciously
● Expressionless face next dose and cause signs lift the legs
● Stiffness of extremities and symptoms (as in
(arms DON’T swing ○ Entacapone “Comtan”: marching)
with gait)…. Akinesia: a COMT can be with each
○ Shuffling of gait prescribed to help step or
(extremities can decrease this from pretend they
freeze while happening are walking
walking) - NO TO: over an
○ Cogwheel - ↑ amounts of food w/ Vit object.
rigidity: when B6: decreases ○ Use cane or
moving the effectiveness walker with a
patient’s arms - w/ MAO inhibitors = laser
passively toward hypertensive crisis!! ● Diet: Avoid taking
the body they jerk - ↑ protein foods like antiparkinson’s
or push back cheese, milk, meat etc medication
slightly (Carbidopa/Levodopa
○ Bradykinesia: ) with a high protein
movements are meal
slow, difficulty ● Prevent constipation:
swallowing drink plenty of fluids 2
(drooling), Face L per day
mask-like:
expressionless
By: elel and eya <3 9
DISORDER DEFINITION CLINICAL MANIFESTATION ASSESSMENT MANAGEMENT NURSING MGT
HUNTINGTON'S ❖ Transmitted as an autosomal characterized by: ➔ Neurological exams ● Antipsychotics. to control DIET:
CHOREA DISEASE genetic disorder: - uncontrolled ◆ Assess: motor, agitation, anxiety, and ❖ Choose soft,
- Inherited chromosome #4 movements sensory, psychiatric psychosis. easy-to-chew and
disease of the ❖ Glutamine in Nucleus + C#4 - loss of intellectual ➔ Neuropsychological ● Antidepressants for easy-to-swallow foods
nervous system contain Huntington abilities, which are testing depression and anxiety (aim for the
resulting in ❖ caused by extra repeats of often accompanied by ➔ Brain imaging and disorders. consistency of
involuntary the behavioral changes. function tests ● Anti-anxiety medications porridge).
choreiform cytosine-adenine-guanine - Depression, memory ➔ Genetic counseling such as benzodiazepines ❖ AVOID MILK:
- Chorea = dance (CAG) amino acid group in loss, emotional lability (e.g., Valium) to treat produces milk
the huntingtin gene and impulsiveness severe anxiety episodes.
Juvenile Huntingtons: ❖ associated with decreased - Facial grimaces, ● Anticonvulsants to prevent
- Behavioral serotonin and GABA. protrusion of the seizures.
changes ❖ GABA: ↓ GABA causes ↑ tongue, jerky
- Frequent falls dopamine and presents as movements of the
or clumsiness chorea, which is defined by arms and legs
- Seizures excessive and abnormal - Gait disturbances,
involuntary movements. patient at risk for falls
❖ Serotonin: affect memory and -
learning abilities.
By: elel and eya <3 10
By: elel and eya <3 11
MOTOR NEURON DISORDER
Amyotrophic Lateral ● A nervous system disease Common: ➔ Electromyography ➢ Symptomatic and ● Provide intellectual
Sclerosis that affects brain and spinal ● Fatigue | cramps ◆ studies of affected rehabilitative stimulating activities,
cord ● Progressive muscle weakness muscles indicate ■ To improve quality of life because the client typically
“Lou Gehrig’s Disease” ● Gets worse over time! | twitching reduction in the number ➢ Baclofen (Lioresal) | experiences no cognitive
● Incoordination deficits and retains mental
after the baseball ● The leading theory held by of functioning motor Diazepam (Valium) |
abilities.
player diagnosed with it researchers is that units Dantrolene Sodium ● Provide client and family
over-excitation of nerve cells Cranial Nerves ➔ MRI (Dantrium)
● Difficulty talking, swallowing, teaching and measures to
- Risk factor: by the neurotransmitter ◆ may show high signal ■ Management of spasticity enhance body image.
breathing
- Autoimmune glutamate leads to cell injury ● Muscle weakness, soft palate intensity in the ➢ Enteral feeding ● Maximize functional
- Free radical and neuronal degeneration. and upper esophageal corticospinal tracts ■ If pt is presented with abilities and Prevent
damage weakness difficulty in swallowing complications of immobility
- Oxidative stress ● Weakness on the tongue ➢ Mechanical ● Prevent respiratory
- smoking ● s/s depends on the location of ➢ no specific therapy! ventilation complications
the affected neuron Interventions is ■ Use: negative-pressure if ● Promote measures to
Bulbar Muscles
maintain adequate airway
● Difficulty in speaking and focused on alveolar hypoventilation
● Promote measures to
swallowing management of develops enhance gas exchange,
● Compromised respiratory symptoms and ➢ Patients are such as oxygen therapy
function function of body encouraged to and ventilator assistance.
● Articulation and speech effects complete an advance ● Promote measures to
directive or “living will” prevent respiratory
to preserve their infection
autonomy in decision
making.
Degenerative Disk - Degeneration of the lumbar ● Neck and back pain ● CT scan or MRI ➔ Physical Therapy ● HOT AND COLD
Disease disk is when your spinal discs ● Numbness or tingling in ● Nerve function: use of a ➔ Medications: NSAIDS, THERAPY:
Intervertebral disk wear down. extremities reflex hammer to check steroid injections, ○ Alternate ice packs
degeneration - Spinal disks are rubbery ● Pain worse when sitting, reaction. (+) if no reaction ➔ radiofrequency and heat pad
Causes: Age(40 ⬆️
),
obesity, sex (women),
cushions between
vertebrae (bones in your
spinal column)
your bending, or lifting
● Weakness and atrophy or
muscle
= damaged/compressed
nerve
neurotomy: use of electric
currents to burn sensory
nerves and prevent pain
every 10-15mins
● Encourage passive
exercise
smoking - Loss of elasticity, flexibility, signals from reaching brain ○ Stretching, yoga,
and ability to absorb shock. passive ROM
Dry out: disks have a Surgical Management:
soft core that contains ● Adult scoliosis, where the ● Diskectomy: remove part
mostly water. In adult, spine curves. of spinal disk to relieve
By: elel and eya <3 12
water decreases = disk ● Herniated disk, also called pressure in nerves
gets thinner a bulged, slipped or ruptured ● Foraminotomy: remove
disk. tissue and bone to
● Spinal stenosis, when the expand opening of nerve
spaces around your spine roots
narrow. ● Laminectomy: take out a
● Spondylolisthesis, when small portion of bone from
vertebrae move in and out of lower spine (lamina)
place ● Spinal fusion: connects
two or more vertebrae to
improve stability
Herniation of a - Between the vertebrae are ➔ Herniated lumbar disk - MRI, CT, X-Ray ● Rest - Assist in using
cervical intervertebral spongy cushions called ◆ Sciatic nerve pain - Myelogram: injection of ● OTC pain relievers proper lifting
disk cervical disks. It stabilize the ➔ Herniated cervical disk dye to reveal narrowing of ● Ice and cold therapy techniques
neck and allow it to turn ◆ Pain near shoulder spinal canal (spinal ● Spinal injection - Encourage healthy
Causes: Age (30-50yo), smoothly from side to side blades that travels to stenosis) and location of ● Surgery: spinal diet
affects men twice as and bend forward to back arm and hand/finger herniated disk decompression surgery - Advise practicing
women, obesity, sitting - A herniated disk happens ◆ Neck pain especially in - Electromyogram: placing to relieve pressure good posture
for long periods, lifting when the inner “jelly” the back and on sides of small needles in muscles - Avoid wearing
heavy objects substance pushes through neck to evaluate function of high-heeled shoes
the crack. The leaked ◆ Pain increases during nerves
material may press on bending or turning
nearby spinal nerves. ◆ Numbness and tingling
of arms
By: elel and eya <3 13
Muscular Dystrophies Duchenne muscluar dystrophy (DMD). most common, affects ● Muscle weakness ● Neurological exam ● Physical and
heart and lungs as it progresses (atrophy) ● Creatine kinase blood test occupational therapy
Genetic (inherited) - Frequent falls, difficulty rising after lying or sitting, waddling ● Difficulty walking, ○ Muscles release CK when ● Corticosteroids
conditions that affects gait, walking on toes, large calf muscles, delayed growth climbing stairs, or damaged = elevated (prednisone and
the functioning of running indicates muscle damage deflazacort) to delay
muscles. Becker (BMD). second most common, affects AMAB but AFAB ● Irregular walking gait ● Genetic tests muscle weakness and
have milder symptoms. (waddling and using toe ● Muscle biopsy improve lung function
A disorder of the in walking) ● Electromyography ● Mobility aids
skeletal muscle Myotonic. Inability to relax muscles after contractions. Individuals ● Stiff or loose joints ○ Canes and walker
have long, thin faces, drooping eyelids, and swan-like necks. (depends on your type) ● Surgery to relieve
A(F/M)AB: assigned Also affects endocrine = thyroid disease & DM ● Spasticity tension in scoliosis
fe/male at birth ● Muscle pain ● Heart care
Emery-Dreifuss (EDMD): causes muscle weakness in your ● Fatigue ○ Rx: ACE and beta
Due to: mutations in shoulders, upper arms and shins. ● Dysphagia blockers
genes ● Heart problems ● Speech therapy
Facioscapulohumeral (FSHMD): affects muscles in your face, ● Curved spine (scoliosis) ○ For those with
shoulders and upper arms. Symptoms tend to appear before age ● Learning disorder difficulty
20. ● Intellectual disabilities swallowing
● Respiratory care
Limb-girdle (LGMD): affects the muscles in your upper arms, ○ tracheostomy
upper legs, shoulders and hips. It affects people of all ages
FOR DMD:
Oculopharyngeal (OPMD): weakens muscles in your eyelids and ● Meds: eteplirsen
throat. Symptoms, such as droopy eyelids (ptosis) and difficulty and golodirsen
swallowing (dysphagia)
By: elel and eya <3 14