INHIBITORS, INDUCERS AND SUBSTRATES OF
CYTOCHROME P450 ISOZYMES
remember
inhibitors and substrates INCREASE the effectiveness of another drug metabolized
by that isozyme
inducers DECREASE effectiveness
INHIBITORS INDUCERS SUBSTRATES INHIBITORS INDUCERS SUBSTRATES
CYP1A2 CYP3A4
cimetidine barbiturates amitriptyline olanzapine amiodarone barbiturates alfentanil lovastatin
ciproflxacin carbamazepine caffeine propranolol amprenavir carbamazepine alprazolam methadone
enoxacin charcoal-broiled foods clomipramine riluzole clarithromycin dexamethasone amiodipine midazolam
erythromycin lansoprazole clozapine ropinirole cyclosporine efavirenz amprenavir mirtazapine
***fluvoxamine omeprazole cyclobenzaprine R-warfarin danazol ethosuximide atorvastatin montelukast
grepafloxacin phenytoin grepafloxacin tacrine delavirdine griseofulvin bepridil nefazodone
isoniazid rifampin imipramine theophylline diltazem modafinil buspirone nelfinavir
mexiletine smoking mirtazapine zileuton efavirenz nafcillin carbamazepine nicardipine
norfloxacin erythromycin nevirapine cerivastatin nifedipine
tacrine ethinylestradiol oxcarbazepine cisapride nimodipine
zileuton fluconazole phenytoin citalopram nisoldipine
fluvoxamine primidone clarithromycin paclitaxel
CYP2C9 grapefruit juice rifabutin clomipramine pimozide
amiodarone barbiturates carvedilol montelukast indinavir ***rifampin corticosteroids quetiapine
cimetidine carbamazepine celecoxib naproxen itraconazole rifapentine cyclophosphamide quinidine
cortrimoxazole rifampin diclofenac phenytoin ketoconazole St. John's wort cyclosporine quinine
fluconazole rifapentine flurbiprofen piroxicam nefazodone dapsone repaglinide
***fluvoxamine St. John's wort fluvastatin tolbutamide nelfinavir delavirdine refabutin
isoniazid glimepiride torsemide quinine diazepam ritonavir
ketoconazole ibuprofen S-warfarin ***ritonavir diltiazem saquinavir
metronidazole irbesartan zafirlukast saquinavir disopyramide sertraline
zafirlukast losartan Synercid dofetilide sibutamine
troleandomycin donepezil sildenafil
CYP2C19 verapamil doxorubicin simvastatin
felbamate None amitriptyline lansoprazole zafirlukast efavirenz sirolimus
fluoxetine citalopram phenytoin erythromycin sufentanil
fluvoxamine clomipramine omeprazole ethinylestradiol tacrolimus
modafinil diazepam R-warfarin etoposide tamoxifen
omeprazole imipramine felodipine testosterone
oxcarbazepine fentanyl tolterodine
finasteride toremifene
CYP2D6 ifosfamide triazolam
amiodarone None amitriptyline metoprolol imipramine troleandomycin
chloroquine carvedilol mexiletine indinavir verapamil
cimetidine chlorpromazine mirtazpine isradipine vinblastine
clomipramine clomipramine nortriptyline itraconazole vincristine
diphenhydramine clozapine oxycodone ketoconazole R-warfarin
fluoxetine codeine paroxetine lansoprazole zaleplon
fluphenazine desipramine perphenazine loratadine zileuton
haloperidol dextromethorphan propafenone losartan zolpidem
paroxetine dihydrocodeine propanolol zonisamide
perphenazine donepezil risperidone
propafenone flecainide ritonavir
propoxyphene fluoxetine thoridazine
quinacrine haloperidol timolo
quinidine hydrocodone tolterodine
ritonavir imipramine tramadol
sertaline loratadine trazodone
terbinafine maprotiline venlafaxine
thioridazine methamphetamine
