Printed on: Fri Jan 05 2024, 09:13:55 PM(EST) Status: Currently Official on 06-Jan-2024 DocId: GUID-9BB0AA10-FEF6-4425-9735-F7A36245AC46_2_en-US
Printed by: USP NF Official Date: Official as of 01-Jun-2023 Document Type: USP @2024 USPC
Do Not Distribute DOI Ref: s2ebo DOI: https://doi.org/10.31003/USPNF_M9780_02_01
1
Bismuth Subnitrate Change to read:
▲
Arsenic á211ñ, Procedures, Procedure 1▲ (CN 1-Jun-2023)—Mix
Bi5O(OH)9(NO3)4 1461.99 375 mg with 5 mL of water, cautiously add 2 mL of sulfuric
Bismuth hydroxide nitrate oxide Bi5O(OH)9(NO3)4. acid, and heat the mixture until fumes of sulfur trioxide are
Bismuth hydroxide nitrate oxide Bi5O(OH)9(NO3)4 CAS RN®: copiously evolved. Cool, cautiously add 10 mL of water, and
1304-85-4; UNII: H19J064BA5. again evaporate to strong fuming, repeating, if necessary, to
remove any trace of nitric acid. The limit is 8 ppm.
Copper—To a 5-mL portion of the test liquid retained in the
» Bismuth Subnitrate is a basic salt that contains the test for Carbonate add a slight excess of 6 N ammonium
equivalent of not less than 79.0 percent of bismuth hydroxide: the liquid does not exhibit a bluish color.
trioxide (Bi2O3), calculated on the dried basis. Lead—Mix a 5-mL portion of the test liquid retained in the
test for Carbonate with an equal volume of 2 N sulfuric acid:
Packaging and storage—Preserve in well-closed the liquid does not become cloudy.
containers. Silver—To a 5-mL portion of the test liquid retained in the test
Identification—It responds to the tests for Bismuth á191ñ and for Carbonate add hydrochloric acid, dropwise: no precipitate
for Nitrate á191ñ. is formed that is insoluble in a slight excess of hydrochloric
Loss on drying á731ñ—Dry it at 105° for 2 hours: it loses not acid, but that is soluble in 6 N ammonium hydroxide.
more than 3.0% of its weight. Limit of alkalies and alkaline earths—Boil 1.0 g with
Carbonate—Add 3 g to 3 mL of warm nitric acid: no 20 mL of a mixture of equal volumes of 6 N acetic acid and
effervescence occurs. Pour the solution into 100 mL of water: a water, cool, and filter. Add 2 mL of 3 N hydrochloric acid,
white precipitate forms. Filter, evaporate the filtrate on a steam precipitate the bismuth by the addition of hydrogen sulfide,
al
bath to 30 mL, again filter the liquid, divide the latter filtrate boil the mixture, and filter it. Add 5 drops of sulfuric acid to
into portions of 5 mL each, and use these several portions in the filtrate, evaporate to dryness, and ignite to constant
the tests for Chloride, Sulfate, Copper, Lead, and Silver. weight: the weight of the residue does not exceed 5 mg
Chloride á221ñ—A 10-mL portion of the test liquid retained in (0.5%).
the test for Carbonate shows no more chloride than Assay—Transfer about 400 mg of Bismuth Subnitrate,
corresponds to 0.50 mL of 0.020 N hydrochloric acid accurately weighed, to a 250-mL beaker. Add 5 mL of water,
(0.035%).
Sulfate á221ñ—To a 5-mL portion of the test liquid retained in
the test for Carbonate add 5 drops of barium nitrate TS: no
ci then add 2 mL of nitric acid, and warm, if necessary, to effect
solution. Dilute with water to 100 mL, add 0.3 mL of xylenol
orange TS, and titrate with 0.05 M edetate disodium VS to a
turbidity is produced immediately. yellow endpoint. Each mL of 0.05 M edetate disodium is
Limit of ammonium salts—Boil about 100 mg with 5 mL equivalent to 11.65 mg of Bi2O3.
ffi
of 1 N sodium hydroxide: the vapor does not turn moistened
red litmus paper blue.
O
https://online.uspnf.com/uspnf/document/1_GUID-9BB0AA10-FEF6-4425-9735-F7A36245AC46_2_en-US 1/1
