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Inflam 200 mg
Tablet
Ibuprofen
Synovia Pharma PLC
MRP ৳ 0.88 8% Off
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Medicine English
overview
Indications of Inflam 200 mg
Inflam 200 mg oral dosage form is indicated
in Rheumatoid arthritis, Osteoarthritis, Gouty
arthritis, Juvenile polyarthritis, Ankylosing
spondylitis, Synovitis, Low back pain,
Dysmenorrhoea, Fever, Migraine, Soft tissue
injuries, Pain & Inflammation in dental and
musculoskeletal origin ... Read moreInflam
200 mg oral dosage form is indicated in
Rheumatoid arthritis, Osteoarthritis, Gouty
arthritis, Juvenile polyarthritis, Ankylosing
spondylitis, Synovitis, Low back pain,
Dysmenorrhoea, Fever, Migraine, Soft tissue
injuries, Pain & Inflammation in dental and
musculoskeletal origin.Inflam 200 mg topical
gel contains Inflam 200 mg and belongs to a
group of medicines called non-steroid anti-
inflammatory drugs (NSAIDs). These
medicines reduce pain and inflammation
and bring down a high temperature. Inflam
200 mg 5% gel is used to treat a number of
painful conditions affecting the joints and
muscles, such as backache, rheumatic and
muscular pain, sprains, strains and sports
injuries. It is also used to treat pain from non-
serious arthritic conditions and nerve pain
(neuralgia).
Theropeutic Class
Drugs for Osteoarthritis, Drugs used for
Rheumatoid Arthritis, Non-steroidal Anti-
inflammatory Drugs (NSAIDs)
Pharmacology
Inflam 200 mg is a non-selective inhibitor of
cyclooxygenase, an enzyme invovled in
prostaglandin synthesis via the arachidonic
acid pathway. Its pharmacological effects
are believed to be due to inhibition
cylooxygenase-2 (COX-2) which decreases
the synthesis of prostaglandins involved in
mediating inflammation, pain, fever and
swelling. Antipyretic effects may be due to
action on the hypothalamus, resulting in an
increased peripheral blood flow, vasodilation,
and subsequent heat dissipation. Inhibition of
COX-1 is thought to cause some of the side
effects of Inflam 200 mg including GI
ulceration. Inflam 200 mg is administered as
a racemic mixture. The R-enantiomer
undergoes extensive interconversion to the S-
enantiomer in vivo. The S-enantiomer is
believed to be the more pharmacologically
active enantiomer.
Dosage & Administration of Inflam 200 mg
Oral Administrations- For Children: 20 mg per
kg body weight daily in divided doses. In
children weighing less than 30 kg the total
daily dosage should not exceed 500 mg. If
gastrointestinal disturbances occur Inflam
200 mg should be given with food or milk. 1-2
years: 1/2 tea spoonful (2.5 ml) 3-4 times
daily 3-7 years: 1 tea spoonful (5 ml) 3-4
times daily 8-12 years: 2 tea spoonful (10 ml)
3-4 times daily Inflam 200 mg is not
recommended for children under 1 year. For
adult: For arthritic pain: The dosage range is
from 0.9 to 2.4 g per day. The usual dose is
400 mg, 3-4 times per day, preferably after
food. The dose may be raised to a maximum
of 2.4 g daily depending on the severity of
symptom at the time of initiating drug
therapy or as patients fail to respond. After a
satisfactory response has been achieved the
patients dose should be reviewed and
adjusted as required and tapered gradually.
For mild to moderate pain: 400 mg 6 hourly or
as demanded by the condition. For
dysmenorrhoea: 400 mg every 4 hours or as
demanded by the condition. Topical
Administrations- Pain and inflammation
associated with musculoskeletal and joint
disorder: As 5% cream, foam, gel, spray soln
or 10% gel: Apply onto affected area.
Dosage of Inflam 200 mg
Oral dosage form:Adults: The dose is initially,
400 mg 3 times daily. A dose of 2400 mg daily
should not be exceeded.Children: 3-6 months
(body-weight over 5 kg): ½ tsp (2.5 ml) 3
times daily; max. 30 mg/kg daily in 3-4
divided doses. 6 months-1 year: ½ tsp (2.5 ml)
3-4 times daily; max. 30 mg/kg daily in 3-4
divided doses. 1-4 years: 1 tsp (5 ml) 3 times
daily; max. 30 mg/kg daily in 3-4 divided
doses. 4-7 years: 1½ tsp (7.5 ml) 3 times daily;
max. 30 mg/kg daily in 3-4 divided doses. 7-
10 years: 2 tsp (10 ml) 3 times daily; upto 30
mg/kg (max. 2.4 gm) daily in 3-4 divided
doses. 10-12 years: 3 tsp (15 ml) 3 times daily;
upto 30 mg/kg (max. 2.4 gm) daily in 3-4
divided doses. children weighing less than 5
kg: Not recommended for children weighing
less than 5 kg. In juvenile rheumatoid arthritis:
up to 30-40 mg/kg of body weight daily in 3-
4 divided doses may be taken or as directed
by the physician.Topical gel:Adults: Squeeze 4
to 10cm (i.e. 1.6 to 4 inches) of gel from the
tube on affected area. Massage until
absorbed. This dose should not be repeated
more frequently than every four hours and no
more than four times a day in any 24 hour
period. The amount of gel squeezed would be
equivalent to 50 to 125 mg of Inflam 200 mg.
Inflam 200 mg 5% gel should only be used on
healthy, unbroken skin. Do not use it on or
near cuts or grazes or under dressings such
as plasters. Also, do not use it on the genital
area. Do not let any gel come in contact with
your eyes. If it does, rinse your eyes with cold
water and consult your doctor. Hands should
be washed after applying Inflam 200 mg 5%
gel, unless they are the site of treatment. If the
condition does not improve after two weeks
use, or becomes worse at any time, speak to
your doctor or pharmacist.Use in children:
Inflam 200 mg 5% gel is not recommended
for use in children under 12 years.
Interaction of Inflam 200 mg
Increased risk of GI bleeding with warfarin,
corticosteroids, SSRIs and aspirin. May reduce
the natriuretic effects of diuretics. Reduced
antihypertensive effect of ACE inhibitors and
angiotensin II receptor antagonists. May
increase toxicity of lithium and methotrexate.
Increased nephrotoxicity with ciclosporin and
tacrolimus.
Contraindications
Inflam 200 mg is contraindicated in patients
who have shown the previous hypersensitivity
to Inflam 200 mg, and in patients with severe
or active peptic ulceration.
Side Effects of Inflam 200 mg
Upset stomach, vomiting, heartburn, nausea
may occur.
Pregnancy & Lactation
Inflam 200 mg is not recommended during
pregnancy or for use in nursing mothers.
Precautions & Warnings
Inflam 200 mg should be used with caution
and the lowest effective doses should be
given if there is a history of gastrointestinal
hemorrhage or ulcer. Patients on long-term
therapy with Inflam 200 mg require ocular
monitoring at regular intervals, as changes in
ocular function have been reported. Patients
with systemic lupus erythematosus are more
likely than others to develop hypersensitivity
to Inflam 200 mg. Inflam 200 mg should be
prescribed with caution in patients with
asthma and in patients with a history of
hypersensitivity to other nonsteroidal anti-
inflammatory agents.
Overdose Effects of Inflam 200 mg
Gastric lavage, correction of blood
electrolytes (if necessary). There is no specific
antidote for Inflam 200 mg
Storage Conditions
Keep all medicines out of reach of children.
Store in a cool and dry place, protected from
light.
Drug Classes
Drugs for Osteoarthritis, Drugs used for
Rheumatoid Arthritis, Non-steroidal Anti-
inflammatory Drugs (NSAIDs)
Mode Of Action
Inflam 200 mg has a high level of anti-
inflammatory, anti-pyretic, and analgesic
activity. The analgesic effects of Inflam 200
mg are due to both a peripheral and a
central effect. Inflam 200 mg is a potent
inhibitor of the enzyme cyclooxygenase,
which thus results in a marked reduction in
prostaglandin synthesis. Inflam 200 mg also
inhibits the synthesis of some lipo-oxygenase
products. Inflam 200 mg thus quickly relieves
pain and stiffness, reduces swelling, and
improves the movement of different joints of
arthritis sufferers.
Pregnancy
Adverse effects of Inflam 200 mg on the
developing fetus cannot be fully excluded.
Inflam 200 mg should not be used during
pregnancy and for nursing mothers unless
the potential benefits to the mothers
outweigh the potential risks.
Disclaimer
The information provided is accurate to our best
practices, but it does not replace professional
medical advice. We cannot guarantee its
completeness or accuracy. The absence of
specific information about a drug should not be
seen as an endorsement. We are not responsible
for any consequences resulting from this
information, so consult a healthcare professional
for any concerns or questions.
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