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Structure of Model Membrane

The document outlines the structure and function of cell membranes, emphasizing the plasma membrane's composition of lipids (60%) and proteins (40%). It discusses various membrane models, including the Sandwich model, Unit membrane model, and Fluid mosaic model, highlighting their contributions to understanding membrane permeability and transport. Additionally, it references key historical figures and studies that have shaped the field of cell biology.

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Shamme Huda
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22 views14 pages

Structure of Model Membrane

The document outlines the structure and function of cell membranes, emphasizing the plasma membrane's composition of lipids (60%) and proteins (40%). It discusses various membrane models, including the Sandwich model, Unit membrane model, and Fluid mosaic model, highlighting their contributions to understanding membrane permeability and transport. Additionally, it references key historical figures and studies that have shaped the field of cell biology.

Uploaded by

Shamme Huda
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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MSc Botany, Semester –II, Course code BO2.

2,
Hard Core -2
Cell Biology, Genetics and Plant Breeding

Programme I MSc
Subject Hard core II
Semester II
Session No 1
Topic Structure of model membrane

Created by Nandashree B M
Membrane structure and function
• Cell – Structural and functional unit
• Robert Hooke (1665), Antony von Leeuwenhoek
• MJ Schleiden & T Schwann – cell theory
• It states that,
• All life forms made from one or more cells
• Cell- pre-existing cell
• Smallest form of life
Membrane structure and function
• Plasma membrane:
• Thin, elastic semi permeable membrane
• Nageli in 1855
Membrane structure and function
• Origin of Plasma membrane:
• Self assembly of proteins and lipids
• Chemical composition:
• Consists of lipoproteins
• Lipids 60% & proteins 40%
Membrane structure and function
• Proteins of plasma membrane are of 3 types (on function)
• 1. structural proteins
• 2. Enzymatic proteins
• 3. Carrier proteins
• Proteins of plasma membrane are of 2 types (on position)
• 1. Intrinsic proteins
• 2. Extrinsic proteins
Membrane structure and function
• The lipids of plasma membrane are of 3 types
• 1. Phospholipids
• 2. Glycolipids
• 3. Sterols
• Lipids – hydrophobic tail and hydrophilic head
• Glycerol jelly
Structure of model • Structure of model membrane
membrane • Pfeffer (1877) – Plasma membrane
• Charles Ernest Overton (1895) –
.
properties of oil –lipoids
• Langmuir (1917) – polar head:
water, hydrophobic hydrocarbon: air
phase
• Gorter and Grendel (1925) –bilayer-
polar head: aqueous environment.
Membrane models
• Various models have been produced to explain structure of
plasma membrane
• 1. Sandwich model/ bimolecular leaflet model
• 2. Unit membrane model/ Trilamellar model
• 3. Fluid mosaic model
• Sandwich model
Sandwich model • JR Danielli & H Davson (1935)
• Bimolecular lipid layer between 2
protein layer
• They are 2 types
• 1. Polar hydrophilic head
• 2. Non polar hydrophobic tail
• Explains permeability and transport
across the membrane.
• Unit membrane model
Unit membrane model • JD Robertson (1959) – Trilamellar
. concept.
• Two outer layers -20Å, middle layer-
35Å
• Trilamellar – (protein- lipid-protein)
• Explains specificity of plasma
membrane in addition to permeability
and transport.
Fluid mosaic model • Fluid mosaic model

. • SJ Singer & GL Nicolson (1972)


• Bimolecular lipid layer – proteins
arranged in mosaic patron
• Proteins – 1. Intrinsic proteins
• 2. Extrinsic proteins
• Widely accepted model.
Micellar theory • Micellar theory
• Hilleir & Hoffman
. • Membrane – globular subunits
Revision

• Plasma membrane is a thin, elastic semi permeable


membrane formed of lipids and proteins (Lipids 60% &
proteins 40%)
• Various models have been studied
• 1. Sandwich model/ bimolecular leaflet model
• 2. Unit membrane model/ Trilamellar model
• 3. Fluid mosaic model
References
• References
• Life sciences – Fundamentals and practice I, By – Pranav kumar
and Usha Mina.

• Life sciences – Ashish Nagesh, Prashant Kumar, Quaisher J.


Hossain (Arihant publications).

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