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This review discusses the advancements in hydroxyapatite–polymer biocomposites for bone regeneration, highlighting their effectiveness as alternatives to traditional grafts. Hydroxyapatite is noted for its bioactivity and compatibility but is limited by its brittleness, which biocomposites aim to overcome. The article summarizes the evolution of these biocomposite implants as ideal scaffolds for promoting bone healing.

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16 views1 page

Anoth

This review discusses the advancements in hydroxyapatite–polymer biocomposites for bone regeneration, highlighting their effectiveness as alternatives to traditional grafts. Hydroxyapatite is noted for its bioactivity and compatibility but is limited by its brittleness, which biocomposites aim to overcome. The article summarizes the evolution of these biocomposite implants as ideal scaffolds for promoting bone healing.

Uploaded by

colbyabuhoff
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© © All Rights Reserved
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TY - JOUR

AU - Ramesh, Niranjan
AU - Moratti, Stephen C.
AU - Dias, George J.
TI - Hydroxyapatite–polymer biocomposites for bone regeneration: A review of
current trends
JO - Journal of Biomedical Materials Research Part B: Applied Biomaterials
JA - J. Biomed. Mater. Res.
VL - 106
IS - 5
SN - 1552-4973
UR - https://doi.org/10.1002/jbm.b.33950
DO - https://doi.org/10.1002/jbm.b.33950
SP - 2046
EP - 2057
KW - bone
KW - biomaterials
KW - hydroxyapatite
KW - polymers
KW - biocomposites
PY - 2018
AB - Abstract Bone tissue engineering has emerged as one of the most indispensable
approaches to address bone trauma in the past few decades. This approach offers an
efficient and a risk-free alternative to autografts and allografts by employing a
combination of biomaterials and cells to promote bone regeneration. Hydroxyapatite
(HA) is a ceramic biomaterial that mimics the mineral composition of bones and
teeth in vertebrates. HA, commonly produced via several synthetic routes over the
years has been found to exhibit good bioactivity, biocompatibility, and
osteoconductivity under both in vitro and in vivo conditions. However, the brittle
nature of HA restricts its usage for load bearing applications. To address this
problem, HA has been used in combination with several polymers in the form of
biocomposite implants to primarily improve its mechanical properties and also
enhance the implants' overall performance by simultaneously exploiting the positive
effects of both HA and the polymer involved in making the biocomposite. This review
article summarizes the past and recent developments in the evolution of HA?polymer
biocomposite implants as an ?ideal? biomaterial scaffold for bone regeneration. ?
2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2046?
2057, 2018.
ER -

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