Code No.

G-13100/PCI

FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, March 2025
Subject: Medicinal Chemistry - III

Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1
1. Write the mechanism of action of Pencillins?

70
2. Write the structure and uses of Chlortetracycline?
3. What are Macrolides, give few examples?
4. Give the applications of Prodrugs?

-1
5. Write the structure and uses of Ciprofloxacin?
6. Write the mechanism of action of Acyclovir?
7. What are folate reductase inhibitors, give few examples?
8. Give the structure and uses of metronidazole?
U
9. Write the applications of combinatorial chemistry?
10. Define Partition coefficient, Hansch analysis?
O
PART – B
Note: Answer any two questions. (2 x 10 = 20 Marks)
1
70

11. (a) Define antibiotics? Write the classification and SAR of Cephalosporins?
(b) Write the synthesis and uses of Chloramphenicol?
12. (a) Give the classification of antiviral agents with examples?
-1

(b) Write the synthesis and uses of Nitrofurantion?

13. (a) Write the classification and SAR of Sulphonamides?
(b) Give the synthesis and mode of action of Diethylcarbamazine citrate?
U

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
O

14. Give a note on epimerization of Tetracyclines?

15. Write a note on β-Lactamase inhibitors?
16. Write the synthesis, mode of action and uses of Chloramphenicol?
17. Give the classification of Antimalarial agents with examples (write any one structure for each
class)?
18. Write the synthesis, MOA and uses of Isoniazid?
19. What are antifungal agents? Write the synthesis of Miconazole?
20. Give a note on combinatorial chemistry?
21. Write the classification of Anti-protozoal agents? Write the structure and uses of Tinidazole and
Ornidazole?
22. Write the structure, synthesis and uses of Dapsone?

***

Library,G.Pulla Reddy College of Pharmacy,Hyderabad

 Code No. G-13104/PCI

FACULTY OF PHARMACY
B. Pharmacy (PCI) VI - Semester (Backlog) Examination, March 2025
Subject: Pharmaceutical Biotechnology

Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1
1. Define biosensors. Write the main components of biosensors.

70
2. Write a brief note on penicillinase.
3. Write about types of aerators in Fermenter.

-1
4. What is protein engineering?
5. Differentiate exonucleases and endonucleases.
6. Describe the importance linkers and adapters.
7. Differentiate between exotoxins and endotoxins.
8. Define the following:
a. Cosmid b. Toxoid. U
O
9. Write a note on DNA ligase.
10. What are monoclonal antibodies? Mention its uses.
1

PART – B
70

Note: Answer any two questions. (2 x 10 = 20 Marks)

-1

11. Write the significance of microbial biotransformation, Explain various methods of

biotransformation.
12. Discuss the production of Penicillin by fermentation process.
13. Discuss the preparation & purification of Dextran, Plasma substitute.
U
O

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Discuss about PCR.

15. Describe in brief about cloning vectors.
16. Discuss type II Hypersensitivity and type III Hypersensitivity reactions.
17. Explain basic principles of genetic engineering.
18. What are mutations? Explain the types of mutations.
19. Write about IgG and IgE antibodies.
20. Describe the process of conjugation.
21. Explain the preparation of dried human plasma.
22. Explain the methods for immobilization of enzymes.

***

Library,G.Pulla Reddy College of Pharmacy,Hyderabad

 Code No. G-13103/PCI
FACULTY OF PHARMACY
B. Pharmacy (PCI) VI - Semester (Backlog) Examination, March 2025
Subject: Biopharmaceutics and Pharmacokinetics

Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. List the mechanisms of drug absorption through GIT.

2. Describe blood brain barrier for permeation of drugs.

1
3. Differentiate Phase I and Phase II metabolic pathways.

70
4. What are the objectives of bioavailability?
5. Explain Glomerular filtration rate and its clinical significance.

-1
6. Define Pharmacokinetics.
7. Describe AUC calculation by Trapezoid method.
8. If dose administered in IV bolus is 500mg and plasma concentration is (Co) is 2.5µg/ml, calculate
Vd in litres.
U
9. Write the equation for calculating peak plasma/serum concentration (Cp)max in extravascular
O
administration.
10. Write Michaelis Menten equation.
PART – B
1

Note: Answer any two questions. (2 x 10 = 20 Marks)

70

11. Describe non-renal routes of excretion of drugs.

12. Discuss about factors influencing drug absorption through GIT.
-1

13. A dose of 500 mg of drug was given intravenously to a patient and following blood data was
obtained. Assuming that the drug follows one compartment open model. Calculate all possible
pharmacokinetic parameters.
U

Time (Hrs) 2 4 6 8 10 12 16 20
O

Plasma Concentration (µg/ml) 1.8311.0100.5800.3300.1800.1000.031 0.012

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Describe kinetics of protein binding.

15. Write a note on Carrier mediated transport.
16. Explain methods to enhance bioavailability of poorly soluble drugs.
17. Explain the various methods for assessment of bioavailability.
18. A drug whose KE= 0.02hr-1 and Vd=20Lts is infused to a patient at a rate of 3mg/hr for 8hrs. What
is the concentration of the drug in the body 2 hrs after the cessation of the infusion?
19. Explain factors affecting renal excretion of drugs.
20. A dose of 100mg of a drug is administered by rapid intravenous injection to a 70kg healthy adult
male. Assume that the drug follows a two-compartment model and can be described by the
following equation C=30 e-1.5t + 10 e-0.15t where c=µg/ml; t=hr. Calculate K12; K21; K13; VC; C0.
21. Write a note on non-linear pharmacokinetics.
22. Write the significance of different
Library,G.Pulla volumes
Reddy of distribution
College in two compartment open model.
of Pharmacy,Hyderabad
***
 Code No: G-13102/PCI

FACULTY OF PHARMACY
B. Pharmacy (PCI) VI - Semester (Backlog) Examination, March 2025
Subject: Herbal Drug Technology

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1
1. What are the objectives of IPR?

70
2. Define the term Nutraceuticals.
3. What are antioxidants and give their importance.
4. Write the significance of natural excipient.

-1
5. Define Aristas and Asawas.
6. List the plant based the research institutes in India.
7. What are the advantages of Farmers rights?
8. Give the source and health benefits of Amla
9. Give the source and interactions of Pepper. U
O
10. Write a note on Authentication of plants.
PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)
1

11. Explain the Good Agricultural practices in cultivation of Medicinal plants.

70

12. Elaborate the health benefits and role of Nutraceuticals in management of Diabetes.
13. List the skin care products. Explain the raw materials of herbal origin used in skin care
-1

products.

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U

14. Define the term patent. Give its objectives and criteria for patent award.
O

15. What are the objectives of Schedule T. Write a note on Infrastructural requirements?
16. Write a note on patenting aspects of Traditional knowledge.
17. Classify the Excipients. Write the advantages and disadvantages of herbal Excipients.
18. Explain the Curcumin case study.
19. Give an informative note on scope and future prospects of Herbal Industry.
20. Write the health benefits of Spirulina and Honey.
21. Describe the role of colorants. Elaborate different colorants of natural origin.
22. Give the sources and sode effects and interactions of Hypercium.

******

Library,G.Pulla Reddy College of Pharmacy,Hyderabad

 Code No: F-7342/PCI

FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination, October 2024
Subject: Biopharmaceutics and Pharmacokinetics
Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define apparent volume of distribution.

2. Mention factors affecting the absorption.
3. Differentiate Passive transport and Active transports.

1
4. Define Absolute bioavailability and relative bioavailability.

70
5. Write a note on excretion of drugs through skin.
6. Write a note on enterohepatic circulation.
7. Define Cmax, tmax and AUC.

-1
8. Write the equation for calculating steady state drug concentration for one compartment open
model.
9. What is protein binding? How it affects bio availability
10. What are the factors for cause of non-linear kinetics?
U
PART - B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Write methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.
1

12. Derive Michaelis - Menten equation and estimate Km and Vmax.

70

13. Discuss about factors influencing absorption of drug in GIT.

-1

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Write a note on factors influencing absorption of drugs.

U

15. Describe about the physiological barriers to the distribution of drugs.

O

16. Explain the biliary excretion of drugs.

17. Explain the various methods for assessment of bioavailability.
18. Discuss in-Vitro-in-Vivo correlation
19. Explain Phase-II metabolic pathways of metabolism.
20. Write in detail about compartment models.
21. Write a note on non-linear pharmacokinetics.
22. Explain methods of adjustment of dose and dosage regimen in patients with renal and
hepatic failure.

******
 Code No. F-7341/PCI

FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination, September 2024
Subject: Herbal Drug Technology

Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define the terms ‘patent’ and ‘IPR’.

2. What are bio pesticides? Write their advantages?

1
3. Define excipients. Write about any two diluents used in herbal formulations.

70
4. What are the principles of the siddha system of medicine?
5. What are the various sources of herbs?
6. Write features of asavas and lehyas.

-1
7. Ashwagandha is a health food. Justify.
8. List the plant-based research institutes in India.
9. Give any three marketed herbal nutraceuticals useful in management of diabetes.
10. Write drug interactions of spirulina.
U
PART – B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Write about stability testing of herbal drugs.

1

12. Describe the good agricultural practices in the cultivation of medicinal plants.
70

13. Describe the components of Good Manufacturing Practices (Schedulre-T) for Indian system
of medicine.
-1

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Write a note on selection and authentication of herbs.

U

15. Give the preparation and standardization of ghutika/vati.

16. Give an overview of any three plant based industries.
O

17. Write in detail about pest management methods.

18. Write the present scope and future prospects of herbal drug industry.
19. Describe the herb-drug interactions of pepper and garlic.
20. What are Phytosomes? Write the preparation and applications of phytosomes.
21. Elaborate on the herbal materials used in formulation of oral hygiene products.
22. Give a detailed account of patenting issues of neem.

***
 Code No: F-7340/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination, September 2024
Subject: Pharmacology – III
Time: 3 Hours Max.Marks:75

PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Differentiate between expectorants and antitussives.

2. What are nasal decongestants?
3. Define and classify purgatives.

1
4. What is ulcer and explain the mechanism of action of proton pump inhibitors?

70
5. Explain the mechanism of action and adverse effects of penicillin’s.
6. What is amoebiasis and mention any four drugs used in the treatment of amoebiasis?

-1
7. What are the causative organisms of syphilis and gonorrhea?
8. What is teratogenicity and give examples of drugs casusing teratogenic effects?
9. Write the applications of biosimilars.
10. Define Chronotherapy and write its applications.
U
PART - B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Classify antiviral drugs. Write the pharmacology of reverse transcriptase inhibitors.
1

12. What is bronchial asthma? Classify anti-asthmatic drugs. Explain the pharmacology of
70

two drugs.
13. Classify anticancer agents and explain in detail about the mechanism of action,
-1

therapeutic uses and adverse effects of antimetabolites.

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U

14. Write the pharmacology of respiration stimulants.

O

15. Write short notes on the pharmacology of H2 receptor blockers.

16. What is clotrimoxazole and mention advantages?
17. Write the classification of anti-tubercular agents and write MOA and adverse effects of
Isoniazid.
18. Classify antifungal agents and write the MOA and adverse effects of amphotericin B.
19. Write about the treatment for Urinary tract infections.
20. What are immunosuppressants? Classify them.
21. Define toxicology and explain the types of toxicity studies.
22. What are the different types of rhythms? Explain about circadian rhythm with examples.

*********
 Code No: F-7339/PCI

FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination, September 2024
Subject: Medicinal Chemistry-III
Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Write the mechanism of action of Pencillins.

2. Write the MOA and uses of Streptomycin & Sulbactam.

1
3. Give the MOA and uses of Erythromycin.

70
4. Write the structure and uses of Chloroquine.
5. Write the structure and uses of Isoniazid.
6. Give the MOA and uses of chloramphenicol.

-1
7. Write the structure and uses of Trimithoprim.
8. Give the MOA and uses of Fluconazole.
9. Define combinatorial chemistry.
U
10. Define Partition coefficient and Hammet’s electronic parameter.
O
PART – B
Note: Answer any two questions. (2 x 10 = 20 Marks)
1

11. Define Beta lactam antibiotics and explain the classification, SAR and chemical
70

degradation of Cephalosporins?
12. Write the chemical classification of antituberculer agents. Write the synthesis, mode of
action and uses of Para amino salicylic acid?
-1

13. Explain mechanism of action and SAR of Sulphonamides and Write the synthesis of
Sulfacetamide?
U

PART – C
O

Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Write the chemical degradation of Pencillins?

15. Give the structure, SAR and epimerization of Tetracyclines.
16. Write the structure, synthesis and uses of Pamaquine.
17. Give a note on Prodrugs?
18. Explain the structure, synthesis and uses of Tolnaftate?
19. Write the structure, synthesis and uses of Dapsone?
20. Write a note on SAR of Quinolines?
21. Write the structure, synthesis and uses of Metronidazole?
22. Give the structure, synthesis and uses of Mebendazole?

*********
 Code No. F-7344/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination, October 2024
Subject: Quality Assurance

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define the term TQM.

2. What is QbD?

1
3. Mention different records in a Pharmaceutical Industry.

70
4. List out the contents of a purchase specification.
5. Name different secondary packing materials.
6. Mention the equipment in quality control laboratory.

-1
7. Write different methods to give a complaint to an industry.
8. What is SOP?
9. Why calibration of instruments is required?
U
10. Give types of validation.
O
PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)
1

11. Explain principles and procedure involved in NABL accreditation.

70

12. Discuss about different aspects of premises for a pharmaceutical company.

13. Discuss about all provisions of GLP in brief.
-1

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U
O

14. Write short notes on QA

15. Explain the steps for ISO9000 registration.
16. Write a note on personnel responsibilities in QA department.
17. Discuss quality control of secondary packing material
18. How a complaint is evaluated in Pharmaceutical Industry?
19. Explain the contents of a master formula record.
20. Explain calibration of pH meter.
21. Discuss on general principles of analytical method validation.
22. Give informative notes on warehousing practices.

***
 Code No: F-7343/PCI

FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination, October 2024
Subject: Pharmaceutical Biotechnology

Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define vaccines. Mention the differences between attenuated and killed vaccines.
2. What are nucleases? Explain the type of nucleases.

1
3. Write a note on transposons.

70
4. Define mutants and write a brief note on mutants.
5. What are foam controlling materials?

-1
6. What are toxins? Explain the method of conversion of toxin to toxoid.
7. What are vectors? Write the ideal properties of vectors.
8. Differentiate between prokaryotic and eukaryotic organisms.
9. Write the preparation and uses of human fibrinogen.
U
10. Enlist applications of biotechnology to pharmaceutical industry.
O

PART-B
Note: Answer any two questions. (2 x 10 = 20 Marks)
1

11. What is Hybridoma technology? Explain the steps involved in the production of monoclonal
70

antibodies and applications.

12. Explain the typical structure of Immunoglobulin with neat labelled diagram and add a note
-1

on types and functions of Antibodies.

13. Explain the production of insulin by rDNA technology.

U

PART-C
O

Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Explain the stability of official vaccines.

15. Explain the collection, processing and storage of whole human blood.
16. Describe fermenter with a neat labelled diagram.
17. Write in detail about enzyme linked immunosorbent assay.
18. Explain type I and type II hypersensitivity reactions.
19. Write the applications of genetic Engineering in medicine.
20. Explain pBR322 and pUC vectors.
21. Discuss about PCR.
22. Describe protein engineering.
******
 Code No: F-7190/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, April 2024
Subject: Quality Assurance

Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define the term quality assurance.

2. Mention different ICH guidelines.

1
3. Give the list of different designations of personnel in QA department.

70
4. List out the contents of a purchase specification.
5. Name different secondary packing materials.
6. What are the benefits of NABL accreditation?

-1
7. Write different methods to give a complaint to an industry.
8. What is quality audit?
9. Write the significance of calibration.
U
10. Mention different distribution records?
O
PART-B
Note: Answer any two questions (2 x 10 = 20 Marks)
1

11. Explain total quality management system (TQM) in detail.

70

12. Discuss about different aspects of premises for a pharmaceutical company.

13. What is validation? Write its significance and explain different types of validation in brief.
-1

PART-C
Note: Answer any seven questions (7 x 5 = 35 Marks)
U

14. Write short notes on QbD.

15. Explain the steps for ISO9000 registration.
O

16. Discuss quality control of rubber closures.

17. Write notes on general provisions required to maintain GLP.
18. What is SOP? Write the general contents of an SOP.
19. Explain recalling procedure for a pharmaceutical product.
20. Write calibration of pH meter.
21. Discuss on qualification of UV-Visible spectrophotometer.
22. Give informative notes on warehousing practices.

*********
Library
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: F-7187/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, April 2024
Subject: Herbal Drug Technology

Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Give the composition and functions of ASU DTAB.

2. What is Biopiracy and give its disadvantages.
3. Define Excipients and give ideal properties of excipients.

1
4. Give the principles of Siddha system of medicine.

70
5. List the principles of Homeopathy system of medicine.
6. Define the terms Herbal medicine and Traditional medicine.
7. What are Biopesticides and give their advantages.

-1
8. Give the health benefits of Ashwagandha
9. List the plant based research Institutes.
10. What are colorants and list the herbal colorants.
PART-B
U
Note: Answer any two questions. (2 x 10 = 20 Marks)
O
11. Define the evaluation of drugs. Describe the WHO guidelines for evaluation of drugs.
12. Describe the good agricultural practices in cultivation of medicinal plants.
1

13. Describe the components of Good Manufacturing Practices (Schedule-T).

70

PART-C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
-1

14. Write note on selection and authentication of herbs.

15. Give the preparation of Aristas and Asawas.
16. What are Nutraceuticals? Give the classification and scope of Nutraceuticals.
U

17. Write the health benefits of Spirulina and Alfaalfa.

O

18. Define patent. Write the criteria, objective and advantages of patent.
19. Describe the herb- drug interactions of Pepper and Garlic.
20. What are Phytosomes. Write the preparation and applications of phytosomes.
21. Write the importance and methods of stability testing of herbal drugs.
22. List the hair care products. Write the importance of raw materials used in Hair care
products.

******

Library
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: F-7186/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, March 2024
Subject: Pharmacology-III
Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)
1. Define the terms malignancy and poision.
2. What are decongestants and anti tussives? Give examples.
3. Give the adverse drug reactions of Aminoglycosides.
4. What is teratogenecity? Give examples.
5. Differentiate between narrow spectrum and broad spectrum antibiotics with examples.
6. Write the uses of Laxatives.

1
7. Write the mechanism of monoclonal antibodies.

70
8. What is HAART?
9. Write the mechanism of action of Methylxanthines.
10. What is genotoxicity?

-1
PART-B
Note: Answer any two questions. (2 x 10 = 20 Marks)
U
11. Classify anti cancer drugs with examples. Write the mechanism, pharmacokinetics, uses and
adverse drug reactions of antimetabolites.
O

12. Write the general principle measures of treatment of poisioning and explain
organophosphorus poisioning.
1

13. Classify anti viral drugs with examples. Write the mechanism of action, Pharmacokinetics,
70

advere drug reactions and uses of NRTI’s.

PART-C
-1

Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Classify anti asthmatics with examples. Write a detail note on bronchodilators in the treatment
of asthma.
U

15. Classify anti leprotic drugs with examples and explain pharmacology of dapsone.
O

16. Write in brief about the circadian rhythm and its impact on pharmacological therapy with
examples.
17. Briefly write about acute, sub acute and chronic toxicity studies.

18. Classify anti tussives with examples. Write their mechanism and uses.

19. Write the mechanisms of antibiotic resistance development.

20. Classify anti-fungal drugs with examples. Write about azoles.

21. What are alkylating agents? Classify them. Write mechanism and Adverse drug reaction
of them.
22. Briefly write about the role of Calcineurin inhibitors as immuno suppressants
Library
*********
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: F-7189/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, April 2024
Subject: Pharmaceutical Biotechnology

Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Write a brief note on plasmids.

2. Explain restriction endonucelases.
3. Write about types of aerators in Fermenter.

1
4. Mention the applications of Hybridoma technology.

70
5. What are vectors? Write the ideal properties of vectors.
6. Describe the importance of linkers and adapters.

-1
7. Differentiate between exotoxins and endotoxins.
8. What are the organisms responsible for the production of amylases and lipases?
9. Write a note on DNA ligase.
10. What is genetic engineering?
U
PART-B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. What are plasma substitutes? Discuss in detail about the preparation of dextran.
1

12. Discuss the production of Penicillin by fermentation process.

70

13. Discuss the structure and function of Major Histocompatability Complex.

-1

PART-C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U

14. Explain the southern blotting technique.

15. Explain the preparation of dried human plasma and dried human serum.
O

16. Differentiate between ‘type II Hypersensitivity’ and ‘type III Hypersensitivity’ reactions.
17. Write short note on vitamin B12 Production by fermentation.
18. What are mutations? Explain the types of mutations.
19. Write about IgG and IgE antibodies.
20. Describe the process of transduction.
21. Discuss the applications of biosensors.
22. Explain protein engineering.
******

Library
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: F-7188/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, April 2024
Subject: Biopharmaceutics and Pharmacokinetics

Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define absorption.
2. Define Noyes and Whitney equation and its application.
3. What is plasma protein-drug binding and tissue drug binding.

1
4. Define bioavailability.

70
5. Write a note on Volume of distribution.
6. What are the different methods used to calculate the AUC?
7. Write the objectives of bioavailability studies.

-1
8. Define Absolute bioavailability and Relative bioavailability.
9. Write a note on steady state.
10. Describe hepatic clearance.
U
PART-B
Note: Answer any two questions. (2 x 10 = 20 Marks)
O

11. Explain mechanisms of drug absorption with diagram.

12. Describe Bioequivalence study protocols.
1

13. Derive Michaelis - Menten equation and estimate Km and Vmax.

70

PART-C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
-1

14. Write in detail about pH partition hypothesis and its limitation.

15. Explain Phase-I reactions of metabolism.
16. Write the factors and significance of protein drug binding.
U

17. Describe about physiological barriers to the distribution of drugs.

18. Describe renal excretion of drugs.
O

19. Write the factors causing Non-Linearity.

20. Write methods to enhance the bioavailability of poorly soluble drugs.
21. Write different methods for Assessment of Bioavailability.
22. Explain methods of adjustment of dose and dosage regimen in patients with hepatic
failure.

******

Library
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: F-7185/PCI

FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Backlog) Examination, March 2024
Subject: Medicinal Chemistry-III
Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define & classify antibiotics?

2. Write the MOA and uses of Ampicillin & Tetracycline?
3. Give the structure and uses of Mefloquine?

1
4. Write the MOA and uses of Clindamycin & Azithromycin?

70
5. Write the structure of Ethambutol & Ciprofloxacin?
6. Give the structure and uses of para amino salicylic acid.

-1
7. What are folate reductase inhibitors?
8. Give the structure and uses of Mebendazole?
9. Write the applications of prodrugs?
10. Define Taft’s steric parameter and Hammet’s electronic parameter?
U
PART – B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Define Beta lactam antibiotics and explain the classification, SAR and chemical
1

degradation of Penicillins?
70

12. Give the chemical classification of antiviral drugs. Write the synthesis, mode of action and
uses of any one antiviral drug.
-1

13. Write the chemical classification of antifungal agents. Write the synthesis, mode of action
and uses of Miconozole?

PART – C
U

Note: Answer any seven questions. (7 x 5 = 35 Marks)

O

14. Classify Beta lactam antibiotics with examples?

15. Write the structure, SAR and uses of Tetracyclines?
16. Write the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Give a short note on Prodrugs?
18. Explain the structure, synthesis and uses of Chloroquine?
19. Write the structure, synthesis and uses of Dapsone?
20. Give the concept and applications of combinatorial chemistry?
21. Write the structure, synthesis and uses of Sulfmethoxazole?
22. Give the structure, synthesis and uses of Isoniazid?
Library
***********
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: E-12419/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main& Backlog) Examination, October 2023
Subject: Pharmaceutical Biotechnology

Time: 3 Hours Max.Marks:75

PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Classify the Immunoglobulins.

2. Give a brief note on DNA ligase.

4
3. Write the difference between toxoid and anti-toxin.

70
4. Describe in brief about restriction endonucleases.
5. Describe in brief about transposons.
6. Write about storage condition of vaccines.

-1
7. Define Mutation. What are the various types of mutagenic agents?
8. Describe the spargers used in fermentation technology.
9. Give the examples for Class I MHC antigens.
U
10. Draw the general structure of bacteriophage.
O
PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)
4

11. What is recombinant DNA technology, Explain the production of Insulin by r-DNA
70

Technology?
12. Write the significance of microbial biotransformation, Explain various methods of
biotransformation.
-1

13. Describe fermentative production of Pencillin.

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U
O

14. Explain basic principles of genetic engineering.

15. Explain production and uses of Pencillinase enzyme.
16. Explain in brief about the significance of polymerase chain reaction.
17. Explain in brief about cloning vectors.
18. Explain the structure of any one immunoglobulin.
19. What is hybridoma technology and write its applications.
20. Write in-detail about biosensors used in pharmaceutical industry.
21. Write in detail about preparation of Toxoids.
22. Explain about various plasma substitutes.

*********

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: E-12416/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Main & Backlog) Examination, October 2023
Subject: Pharmacology - III
Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all the questions. (10 x 2 = 20 marks)

1. What are antiemetics?

2. What are expectorants?
3. Define poisoning and list the antidotes used for poisoning.

4
4. Explain cell cycle.

70
5. What are the causative organisms of syphilis and gonorrhoea?
6. Define acute and sub-acute toxicity.
7. What are respiratory stimulants?

-1
8. Write about biosimilars.
9. What are causes and symptoms of tuberculosis?
10. Define and classify purgatives.
PART - B
U
Note: Answer any two questions. (2 x 10 = 20 Marks)
O
11. What are immunosuppressants? Write the MOA, therapeutic uses and adverse effects
of inhibitors of cytokine production or action.
4

12. Discuss the symptoms and treatment of

70

(a) Barbiturate poisoning (b) organophosphorous poisoning

13. Classify the agents used in treatment of peptic ulcer disease. Write about the
-1

pharmacological actions and therapeutic uses of Ranitidine and Omeprazole.

PART - C
U

Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Write a note on cephalosporin antibiotics.
O

15. Describe the symptoms and treatment of lead poisoning.

16. Explain the disease pathology and therapeutic agents for COPD.
17. Write short notes on urinary tract infections.
18. Mention the MOA, therapeutic uses and adverse effects of Isoniazid.
19. Explain the causes and therapy of peptic ulcer.
20. Write short notes on monoclonal antibodies.
21. List the sexually transmitted diseases and explain any one of them.
22. Discuss the therapy for cough.

******
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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: E-12415/PCI
FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Main & Backlog) Examination, October 2023
Subject: Medical Chemistry-III

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)
1. What are Monobactams?
2. Write the uses of Neomycin & Oxytetracycline.
3. Write the uses of Clindamycin.

4
4. Write the uses of Erythromycin & Pyrimethamine.

70
5. Write the uses of Cycloserine & Ciprofloxacin.
6. Give the uses of Miconazole and Mebendazole.
7. What are folate reductase inhibitors?

-1
8. Write the mechanism of action of Macrolides.
9. Write the applications of prodrugs.
10. Define Partition coefficient, Hammet’s electronic parameter.
U
PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)
O

11. (a) Write a note on β-lactam antibiotics.

(b) Write the synthesis and uses of Chloramphenicol.
4

12. Give the chemical classification of antitubercular drugs. Write the synthesis, mode of
70

action and uses of Isoniazid.

13. Explain mechanism of action and SAR of Sulphonamides and Write the synthesis of
-1

Sulfacetamide.

PART - C
Note: Answer any seven questions (7 x 5 = 35 Marks)
U

14. Give a note on chemical degradation of cephalosporins.

O

15. Write the structure, SAR and uses of Streptomycin.

16. Write the structure, synthesis, mode of action and uses of Dapsone.
17. Give a short note on Prodrugs.
18. Write the structure, synthesis and uses of Chloroquine.
19. Write the structure, synthesis, mode of action and uses of Acyclovir.
20. Give the concept and applications of combinatorial chemistry.
21. Write the structure, synthesis, mode of action and uses of Diethylcarbamazine citrate.
22. Give the structure, synthesis and uses of Metronidazole.

*********

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G.Pulla Reddy College of Pharmacy
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 Code No: E-12417/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, October 2023
Subject: Herbal Drug Technology
Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all the questions. (10 x 2 = 20 marks)

1. Define Herb and Herbal medicine.

2. Classify nutraceuticals with examples.
3. Differentiate Asava and Arista preparations with examples.

4
4. Give various parameters involved in the evaluation of Churna,
5. Give the significance of authentication of plant material.

70
6. Explain Fenugreek as health food
7. Give the composition and functions of ASU DCC.
8. What are the objectives of Schedule Z for ASU drugs?

-1
9. Explain raw material of herbal origin used in skin care products
10. Write about natural sweeteners.
PART - B
U
Note: Answer any two questions. (2 x 10 = 20 Marks)
O
11. Explain WHO and ICH guidelines for the evaluation of herbal drugs.
12. Describe the role of Ashwagandha and Ginger as a nutraceuticals.
13. Explain the sources and processing of herbal raw materials.
4

PART - C
70

Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Write a note on organic forming.

-1

15. Explain the role of nutraceuticals in CVS disorders.

16. Explain herb-drug interactions of Hypericum and Garlic.
17. Describe biopiracy case of Neem.
U

18. Explain in detail about bioprospecting.

19. Explain the methods of preparation and standardization of Bhasma.
O

20. Give the composition and functions of ASU DTAB.

21. Explain the authentication of herbal material.
22. Explain the principle involved in Ayurveda system of medicine.

******

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G.Pulla Reddy College of Pharmacy
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 Code No: E-12418/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, October 2023
Subject: Bio-pharmaceutics and Pharmacokinetics
Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Write any three differences between active absorption and passive absorption.
2. Describe any three factors affecting distribution of drugs.
3. Define renal clearance.
4. Write a note on excretion of drugs through lungs.
5. Define absolute bioavailability and relative bioavailability.

4
6. Define Cmax, tmax and AUC?
If equation of the curve is C=30.e-0.46t for a drug administered by IV route and following

70
7.
one compartment open model, then calculate its biological half-life.
8. Write Michaelis menten equation.

-1
9. Write formulas for calculating loading dose and maintenance dose.
10. Describe the cause of non-linearity in absorption.U
PART-B
Note: Answer any two questions. (2 x 10 = 20 Marks)
O

11. A 50kg woman was given a single IV dose of an antibacterial drug at a dose level of 6mg/kg.
Blood samples were taken at various time intervals. The concentration of the drug was
4

determined in the plasma fraction of each blood sample and the following data was obtained.
Assume that it follows one compartment open model. Calculate all possible
70

Pharmacokinetic parameters.
Time (Hrs) 0.25 0.5 1.0 3 6 12 18
-1

Plasma Concentration (mg/ml) 8.21 7.87 7.23 5.15 3.09 1.11 0.4

12. Describe factors influencing distribution of drugs.

13. Describe methods to enhance dissolution rate of drugs.
U
O

PART-C
Note: Answer any seven questions (7 x 5 = 35 Marks)

14. Discuss about dosage form factors affecting absorption of drugs.

15. Describe tissue permeability of drugs.
16. Explain briefly factors affecting protein-drug binding.
17. Explain conjugation reactions in metabolism of drugs.
18. Discuss about in-vitro dissolution models.
19. Describe estimation of Km and Vmax in non-linear kinetics.
20. Derive kinetic parameters for IV bolus administration in Two compartment open model.
21. Describe factors causing non-linearity.
22. A 650mg I.V.dose of a drug is administered to a 65kg subject, the plasma drug concentration
was found to decline biexponentially. TheLibrary
equation that best describes the drug kinetics C=67.e-
14t+ 33.e-3t; C is in mg/lt Calculate the different volumes of
G.Pulla Reddy College of Pharmacy
distribution Vc,Vp, Vdβ, Vdarea, Vdss.
Hyderabad
*********
 Code No: E-12399/PCI

FACULTY OF PHARMACY
B. Pharmacy II Semester (PCI) (Main & Backlog) Examination, October 2023
Subject: Computer Application in Pharmacy
Time: 2 Hours Max. Marks: 50

PART – A
Note: Answer any two questions from following. (2 x 10 = 20 Marks)

1. Define number system. Explain the conversion process from binary to octal and binary

4
to hexadecimal.

70
2. (i) Explain different generations of programming languages.
(ii) How Barcode Labels will Work?

-1
3. (i) Explain the impact of bioinformatics on vaccine design and development.
(ii) Write a note on LIMS (Laboratory Information Management Systems)
U
PART – B
O

Note: Answer any five questions from following. (6 x 5 = 30 Marks)

4. Explain the process for binary addition and binary subtraction.

4
70

5. Write different types of Cascading Style Sheets with examples.

-1

6. What is a database? Explain about MySQL Components.

7. Explain about Mathematical modelling in drug design.

U

8. Explain different types of Databases in Bioinformatics.

O

9. Write note on CDS (Chromatographic data systems).

10. Explain the process of planning and managing the project.

11. How does Pharma information system works?

*********

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: E-12420/PCI
FACULTY OF PHARMACY
B. Pharm VI-Semester (PCI) (Main & Backlog) Examination, November 2023

Subject: Quality Assurance

Time: 3 Hours Max. Marks: 75

PART-A
Note: Answer all the questions. (10 x 2 = 20 Marks)

4
70
1. Write any three parameters each for GMP and TQM.
2. Define the term quality control.
3. Mention different personal records.

-1
4. What is the importance of a specification for any activity?
5. List different secondary packing materials.
6. What is GLP?
7.
U
Mention different methods to give complaint to an industry.
O
8. What is SOP?
9. Define the term calibration.
10. Write the scope of validation.
4

PART-B
70

Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Discuss the details of QbD.

-1

12. Explain the various aspects of premises of a pharmaceutical industry.

13. Write the calibration procedure of a PH meter.
U

PART-C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
O

14. Write short notes on ICH guidelines.

15. Give informative notes on ISO9000 series.
16. Write about maintenance of stores for raw materials.
17. Explain quality control tests for rubber closures.
18. What are the general provisions for GLP?
19. Write about recalling and waste disposal procedures.
20. Explain the contents of master formula record.
21. Discuss on general principles of analytical method validation.
22. Explain good warehousing practice of a Pharmaceutical industry.

*********
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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No. D-8252/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main &Backlog) Examination, August 2022

Subject: Pharmacology-III
Time: 3 Hours Max. Marks: 75
PART- A
Note: Answer all the questions. (10 x 2 = 20 Marks)
1. Differentiate between expectorants and antitussives.
2. What are antiemetics?
3. What is ulcer and explain the mechanism of action of proton pump inhibitors?
4. What is teratogenicity and give examples of drugs causing teratogenic effects.
5. What are fluoroquinolones? Give examples.

1
6. Write about the treatment for organophosphorous poisoning.
7. Define Chronotherapy and write its applications.

70
8. Write a note on carminatives.
9. Define monoclonal antibodies and write their applications.

-1
10. What is amoebiasis and mention any four drugs used in the treatment of
amoebiasis?
PART- B
Note: Answer any two questions. (2 x 10 = 20 Marks)
U
11. Classify anticancer agents and explain in detail about the mechanism of action,
O
therapeutic uses and adverse effects of antimetabolites.
12. What is bronchial asthma? Classify anti-asthmatic drugs. Explain the
1

pharmacology of any two drugs.

70

13. Classify antiviral drugs. Write the pharmacology of reverse transcriptase inhibitors.
PART- C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
-1

14. Write short notes on the pharmacology of H2 receptor blockers.

15. Explain the MOA and adverse effects of tetracyclines and penicillins.
U

16. Explain the general principles of treatment of poisoning.

O

17. Classify antifungal agents and write the MOA and adverse effects of amphotericin
B.
18. Write short note on immunostimulants.
19. Write about the treatment for urinary tract infections.
20. Define toxicology and explain the types of toxicity studies.
21. Discuss the clinical symptoms and management of morphine poisoning.
22. What is clotrimoxazole and mention its advantages?
**

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: D-8256/PCI
FACULTY OF PHARMACY
B. Pharmacy VI - Semester (PCI) (Main & Backlog) Examination,
September 2022
Subject: Quality Assurance

Time: 3Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1) What is SOP.? Explain.

2) What is Warehousing? Explain.
3) Explain of specification.
4) What is Sources of impurities? Explain.

1
5) What is short note on Batch Formula Record.

70
6) Define ISO 14000
7) Define Quality by design (QbD)
8) Define Quality Assurance.

-1
9) Define GMP.
10) Explain of trend (OOT)
PART – B
U
Note: Answer any two questions. (2 x 10 = 20 Marks)
O
11) Write briefly about Quality control test for Containers, rubber closures.
12) Define ICH. Explain about ICH Guidelines.
13) Write briefly about importance, scope of validation and types of validation.
1
70

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
-1

14) Write a short note on ISO 9000 series?

U

15) Write a short note on Total Quality Management (TQM)

16) List out what are the different analytical instrumentation used in the estimation of
O

impurities.
17) Explain about validation master plan.
18) Explain about Personnel responsibilities, training, and hygiene.
19) Describe SOP, Quality audit and Quality Review.
20) Explain about Equipment selection, purchase specifications and maintenance.
21) Explain ISO certification procedure and its advantages?
22) Explain about calibration, qualification & validation.
*******

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G.Pulla Reddy College of Pharmacy
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 Code No: D-8251/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, August - 2022

Subject: Medicinal Chemistry - III

Time: 3 Hours Max. Marks: 75

Note: Answer All Questions from Part –A, Any two Questions from Part-B.
and Any seven Questions from Part-C
PART – A (10 X 2 = 20 Marks)
1. Write the synthesis, mechanism of action and uses of Metronidazole.
2. Mention any six Quinoline drugs.

1
3. What are Monobactams? Give examples with one structure.

70
4. Mention any six ant tubercular agents.
5. Write about the chemical degradation of Penicillins.

-1
6. Mention any six antiviral drugs.
7. What is Cotrimoxazole? Give its uses.
U
8. Give examples of antifungal antibiotics.
9. What are Macrolides? Give examples.
O

10. Mention any six anti protozoal agents

1

PART- B (2 X 10 = 20 Marks)
70

11. Classify antibiotics based on chemical structure with examples.

12. Write a note on anti tubercular drugs.
-1

13. Classify anti-malarial agents with examples. Give the synthesis, MOA and uses of any
one drug.
U

PART - C (7 X 5 = 35 Marks)
O

14. Write the synthesis, mode of action and therapeutic uses of Para amino salicylic
acid and isoniazid.
15.Discuss the SAR of quinolones.
16. Give the synthesis, MOA and uses of any two anti fungal agents.
17. What are sulfonamides? Give their importance in chemotherapy.
18. Write about antiviral drugs.
19. Give the applications of Prodrugs with examples.
20. Classify anti-tubercular drugs with examples.
21. Write about solid phase synthesis in combinatorial chemistry.
22. Write a note on anthelmintics.
Library
G.Pulla Reddy College
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 Code No: D-8255/PCI
FACULTY OF PHARMACY
B. Pharmacy VI – Semester (PCI) (Main & Backlog) Examination,
September 2022
Subject: Pharmaceutical Biotechnology
Time: 3Hours Max. Marks: 75
PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1) Define Immobilization. What are the types of immobilization?

2) What is protein engineering?
3) What are DNA ligases.
4) What are nucleases? Explain the types of nucleases.
5) What are vaccines? Enlist types of vaccines.

1
6) What are Plasma substitutes.
7) What are mutants? Types of mutants.

70
8) What are foam controlling materials
9) What are transposons.

-1
10) Write the organisms responsible for the production of Amylases and Lipases.

PART – B
U
Note: Answer any two questions. (2 x 10 = 20 Marks)
O
11) Explain the production of insulin by rDNA technology
12) Explain the production of penicillin by fermentation technology
13) What is hybridoma technology? Explain the production of monoclonal antibodies.
1

PART – C
70

Note: Answer any seven questions. (7 x 5 = 35 Marks)

-1

14) Explain pBR322 and pUC vectors

15) Write the applications of genetic Engineering in medicine
U

16) Explain the stability of official vaccines

O

17) Explain Enzyme linked immunosorbent Assay.

18) What is recombination? Explain general mechanism of recombination.
19) Explain the collection, processing and storage of whole human blood.
20) Explain the preparation of dried human plasma and dried human serum.
21) Explain type I and type II hypersensitivity reactions.
22) Write about IgG and IgE antibodies.

*******

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G.Pulla Reddy College of Pharmacy
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 Code No. D-8260/PCI

FACULTY OF PHARMACY
B. Pharmacy VII - Semester (PCI) (Backlog) Examination, September 2022
Subject: Novel Drug Delivery Systems
Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all questions. (10 x 2 = 20 Marks)

1. Define terms sustained, controlled and targeted release dosage forms.

2. Write ideal characters suitable for selection of drug for controlled drug delivery
system.
3. Explain about inflatable systems.

1
4. Explain the Nasal and Pulmonary routes of drug delivery.
5. Write the advantages and disadvantages of gastroretentive drug delivery system.

70
6. Explain various coating materials used in microencapsulation.
7. Write a note on transmucosal permeability.

-1
8. What is floating time and floating lag time.
9. Write the applications of monoclonal antibodies.
10. Compare and contrast liposomes and niosomes.
U
PART – B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Explain in detail physiochemical and biological factors affecting controlled release
1

formulations.
12. Explain in detail coacervation phase separation method with suitable examples.
70

13. Discuss about advantages and disadvantages and development of intra uterine
devices and applications.
-1

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U

14. Discuss the classification and applications of polymers used in controlled drug
delivery system.
O

15. Explain the theories of mucoadhesion.

16. Explain about factors affecting permeation in transdermal drug delivery system.
17. Discuss the approaches used in development of gastroretentive drug delivery
system.
18. Explain about nasal sprays and nebulizers.
19. Explain about osmotic pump.
20. Discuss the ocusert with neat sketch.
21. Explain the preparation methods of nanoparticles.
22. Explain dry powder and metered dose inhalers.

***

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G.Pulla Reddy College of Pharmacy
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 Code No. D-8253/PCI
FACULTY OF PHARMACY
B. Pharmacy VI -Semester (Main & Backlog) Examination, September 2022
Subject: Herbal Drug Technology
Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define and exemplify Ayurvedic product and herbal drug preparation.

2. Write principle of Unani system of medicine.
3. Write about Breeder’s right.
4. Write composition and functions of ASUDTAB.

1
5. Write about spirulina as health food.

70
6. Define asavas and arishtas. Give two examples each.
7. Write about health foods.
8. What is traditional knowledge? Give examples.

-1
9. Write about any two natural binders.
10. Classify nutraceuticals giving examples.
PART – B
U
Note: Answer any two questions. (2 x 10 = 20 Marks)
O
11. Write about principles of integrated pest management. Give a detailed account of
biopesticides.
12. Elaborate on the WHO guidelines for assessment of herbal drugs.
1

13. Write a note on: a) Phytosomes b) Herbal disintegrants.

70

PART – C
-1

Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Explain about the methods for identification and authentication of herbs.
15. Write a note on preparation and evaluation of bhasmas.
U

16. Discuss the role of nutraceuticals in the prevention, therapy and management of
cancer.
O

17. Write the role of antioxidants in herbal formulations. Give a brief account of these
materials.
18. Write a short note on schedule Z.
19. What is bioprospecting policy? Give an overview of the process of bioprospecting
herbs as medicines.
20. Give a brief account of herbal hair dyes.
21. Write a detailed note on herb drug interactions.
22. List objectives of Schedule T.

*****

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G.Pulla Reddy College of Pharmacy
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 Code No. D-8180/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Backlog) Examination, February / March 2022

Subject: Pharmaceutical Biotechnology

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. What are mutants? Types of mutants.

1
2. Define Immobilization. What are the types of immobilization?

70
3. Write the differences between Exonucleases and Endonucleases.
4. What are vectors? Write the ideal properties of vectors.
5. Write few applications of hybridoma technology.

-1
6. What are toxins? Explain the method of conversion of toxin to toxoid.
7. Write the preparation and uses of human fibrinogen.
8. Write about types of aerators in Fermentor.
9. What is protein engineering?
U
10. Differentiate between prokaryotic and Eukaryotic organisms.
O
PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)
1

11. Write differences between HLA and MHC. Discuss the structure and function
of MHC.
70

12. Explain the typical structure of Immunoglobulin with neat labeled diagram and
types and functions of Antibodies.
-1

13. What are plasma substitutes? Explain the manufacturing of plasma substitutes
and standardization.
U

PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)
O

14. Write a brief notes on Protein Engineering.

15. Explain the working process of polymerase chain reaction.
16. Explain pBR322 and pUC vectors.
17. Discuss the general methods of preparation of vaccines.
18. Explain southern blotting technique.
19. Explain in detail direct and indirect methods of ELISA.
20. What are mutations? Explain the types of mutations.
21. Explain the preparation of dried human plasma and dries human serum.
22. Explain type I and type II hypersensitivity reactions.

*****

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: D-8179/PCI
FACULTY OF PHARMACY
B. Pharmacy VI– Semester (PCI) (Backlog) Examination, February / March 2022
Subject: Bio pharmaceutics and Pharmacokinetics
Time: 3 Hours Max.Marks:75
Note: Answer all questions from Part - A, Any two questions from Part - B.
And any seven questions from Part - C
PART – A (10 x 2 = 20 Marks)
1. Write Noyes Whitney equation. And explain the terms.
2. Describe the absorption of a drug on rectal administration.
3. Define apparent volume of distribution.
4. Write a note on excretion of drugs through skin.

1
5. Define absolute bioavailability and relative bioavailability.

70
6. Define Cmax, tmax and AUC?
7. If equatin of the curve is C=15.e-0.23t for a drug administered by IV route and

-1
following one compartment open model, then calculate its biological half – life.
8. Write Michaelis menten equation.
U
9. Describe hepatic clearance.
10. What are the factors for cause of non-linear kinetics?
O

PART – B (2x10 = 20 Marks)

11. A dose of 500mg of drug was given intravenously to a patient and following blood
1

data was obtained. Assuming that the drug follows one compartment open model.
70

Calculate all possible pharmacokinetic parameters.

Time (Hrs) 2 4 6 8 10 12 16 20
-1

asma Concentration 1.83 1.01 0.58 0.33 0.18 0.10 0.031 0.012
(g/ml)

12. Describe factors influencing absorption of drugs.

U

13. Describe renal excretion of drugs.

O

PART – C (7 X 5 = 35Marks)
14. Discuss about pH-partition hypothesis.
15. Describe the absorption of drugs from extravascular routes.
16. Explain briefly about Kinetics of protein binding.
17. Explain biliary excretion of drugs.
18. Discuss about methods to enhance bioavailability of poorly soluble drugs.
19. Describe estimation of Km and Vmax in non-linear kinetics.
20. Derive kinetic parameters for IV bolus administration in Two compartment open
model.
21. How do you determine absorption rate constant, Ka by Wagner nelson method?
22. A 650mg I.V. dose of a drug is administered to a 65kg subject, the plasma drug
concentration was found to decline biexponentially. The equation that best
describes.
The drug kinetics C=67.e-14t + 33.e-3t; C is in mg/it Calculate the different volumes
Library,
of distribution Vc, Vp, Ddβ, Vdarea, Vdss.
G.Pulla Reddy College of Pharmacy
Hyderabad
*******
 Code No. D-8178/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (BACKLOG) Examination,
February / March 2022

Subject: Herbal Drug Technology

Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all questions. (10 x 2 = 20 Marks)

1 Define herbal medicine and herbs.

2 Define bio pesticide bio insecticide.
3 Write the scope of Nutraceuticals.
4 Define herbal drug interaction with suitable examples.
5 Define herbal formulation with example.

1
6 Define Phytosomes and Microspheres.

70
7 Define Bio piracy and patent.
8 Write the constitution of ASU DTAB.
9 Write the scope and future prospectus of herbal drug industry.

-1
10 Define schedule T and write objectives of schedule T.

PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)
U
11 Write an elaborate note on processing of herbal raw materials.
O

12 Explain in detail about the scope and type of Nutraceutical products available
market.
1

13 Discuss WHO and ICH guidelines for the assessments of herbal drugs.
70

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
-1

14 Explain the sources of herbs.

U

15 Write a brief note on organic farming.

O

16 Write a note on herb drug interactions with suitable exaples.

17 Explain about the side effects and interactions of Hypericum and Kava-Kava.

18 Write a brief note on flavours in herbal preparations.

19 Write a note on Phytosomes.

20 Explain in detail about Patent and IPR.

21 Give a brief note on Schedule Z.

22 Write a brief note on plant based industries and institutions.

Library,
****
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: D-8177/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Backlog) Examination, February 2022
Subject: Pharmacology - III
Time: 3 Hours Max. Marks: 75
Note: Answer all questions from PART-A, and two questions from PART-B,
and any seven questions from PART-C.
PART - A (10 x 2 = 20 Marks)
1) What is Circardian thythm?
2) What is carcinogenicity give examples of drugs causing it?
3) What is the treatment for morphine poisoning?

1
4) What are the adverse effects of tetracyclins.

70
5) Define laxative. Give examples.
6) What are expectorants? Give examples.
7) Write about appetite suppressant drugs.

-1
8) What are mucolytics. Give examples.
9) What are the adverse effects of penicillins.
10) Define Digestant. Give two examples.
U
O
PART - B (2 x 10 = 20 Marks)
11) Write about antibiotics used in cancer.
1

12) Write about anti tubercular drugs.

13) Classify Antiulcer agents? Write the pharmacology of H2 antagonists.
70

PART - C (7 x 5 = 35 Marks)
-1

14) What is biological clock? With some examples explain chronotherapy.

15) Explain the pharmacology of Co-trimoxazole.
U

16) Write a note on symptoms and treatment of arsenic poisoning.

17) Write the pharmacology of any one class of antibiotics.
O

18) Write a note on Urinary antiseptics.

19) Classify antiamoebic agents. Add a note on Metronidazole.
20) Classify Anti-tussives. Add a note on Anti-histaminics.
21) Write a note on Bronchodilators.
22) What is an antiemetic? Classify antiemetics.

*******

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No. D8176/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Backlog) Examination, February / March 2022

Subject: Medicinal Chemistry - III

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. Define & classify -lactam antibiotics?

1
2. Write the structure of Sulbactam & Monobactam?

70
3. Give the structure and uses of Neomycin?
4. Write the structure of Pyrazinamide & Isoniazid?
5. Write the structure and uses of Dapsone?

-1
6. Define Partition coefficient, Tafts steric parameter?
7. Write the mechanism of action of Tetracyclines?
8. Write the mechanism of action of Macrolides?
9. Define prodrugs?
U
10. Write the structure and uses of Clindamycin?
O
PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)
1

11. Write the various classes of antitubercular drugs. Write the synthesis & mode of
action of Para amino salicylic acid?
70

12. Write the life cycle of malaria parasite and Write the synthesis and mode of action
of the Chloroquine?
-1

13. Write the mode of action and SAR of Sulphonamides and Write the synthesis of
Sulfacetamide?

PART - C
U

Note: Answer any seven questions: (7 x 5 = 35 Marks)

O

14. Write the chemical degradation of Pencillins?

15. Explain the mode of action, SAR and uses of Cephalosporins?
16. Give the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Write a note of Prodrugs?
18. Give the various classes of Antifungal agents & write the synthesis of Miconazole?
19. Write the synthesis, mode of action and uses Diethylcarbamazine citrate?
20. Give a note on liquid phase synthesis in combinatorial chemistry?
21. Write the structure, synthesis and uses of Tolnaftate?
22. Give the various classes of Anti-protozoal agents & write the synthesis of
Metronidazole?
*****

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No. D8176/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Backlog) Examination, February / March 2022

Subject: Medicinal Chemistry - III

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. Define & classify -lactam antibiotics?

1
2. Write the structure of Sulbactam & Monobactam?

70
3. Give the structure and uses of Neomycin?
4. Write the structure of Pyrazinamide & Isoniazid?
5. Write the structure and uses of Dapsone?

-1
6. Define Partition coefficient, Tafts steric parameter?
7. Write the mechanism of action of Tetracyclines?
8. Write the mechanism of action of Macrolides?
9. Define prodrugs?
U
10. Write the structure and uses of Clindamycin?
O
PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)
1

11. Write the various classes of antitubercular drugs. Write the synthesis & mode of
action of Para amino salicylic acid?
70

12. Write the life cycle of malaria parasite and Write the synthesis and mode of action
of the Chloroquine?
-1

13. Write the mode of action and SAR of Sulphonamides and Write the synthesis of
Sulfacetamide?

PART - C
U

Note: Answer any seven questions: (7 x 5 = 35 Marks)

O

14. Write the chemical degradation of Pencillins?

15. Explain the mode of action, SAR and uses of Cephalosporins?
16. Give the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Write a note of Prodrugs?
18. Give the various classes of Antifungal agents & write the synthesis of Miconazole?
19. Write the synthesis, mode of action and uses Diethylcarbamazine citrate?
20. Give a note on liquid phase synthesis in combinatorial chemistry?
21. Write the structure, synthesis and uses of Tolnaftate?
22. Give the various classes of Anti-protozoal agents & write the synthesis of
Metronidazole?
*****

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: 12285/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main &Backlog) Examination, September 2021
Subject: Medicinal Chemistry-III
Time: 2 Hours Max. Marks: 75
Note: Answer any seven questions from Part –A, Any one questions from Part-
B and Any five questions from Part-C
PART – A (7X3 = 21 Marks)
1. Define & classify  - lactam antibiotics?
2. Write the structure of Benzly pencillin & Chlortetracycline?

1
3. Write the structure and uses of Strptomycin?

70
4. Write the structure of Isoniazid & Para amino salicylic acid?
5. Write the structure and uses of Dapsone?

-1
6. Define Partition coefficient, Hammet’s electronic parameter?
7. Write the mechanism of action of Tetracyline?
U
8. Write the mechanism of action of Macrolides?
O
9. Define prodrugs?
10. Write the  - Lactamase inhibitors?
1

PART- B (1 X 14 = 14 Marks)
11. Enumerate the various classes of antitubercular drugs. Write the synthesis & mode
70

of action of Isoniazid?
12. Define Beta lactam antibiotics and explain the classification, SAR and mode faction
-1

of cephalosporins?
13. Write the life cycle of malaria parasite and Write the synthesis and mode of action
of the Chloroquine?
U

PART - C (5 X 8 = 40 Marks)
O

14. Write the chemical degradation of pencillin?

15. Write the SAR and uses of Tetracycline?
16. Write the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Write a note on Prodrugs?
18. Write the structure, synthesis, mode of action and uses of Nitrofurantion?
19. Write the mode of action and SAR of Sulphonamides?
20. Write a short note on combinatorial chemistry?
21. Write the structure, synthesis, mode of action and uses of Miconazole?
22. Write the structure, synthesis, mode of action and uses of Mebendazole?
*******
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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No. 12286 / PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, September 2021

Subject: Pharmacology - III

Time: 2 Hours Max. Marks: 75

Note: Answer any seven questions Part – A, any one question from Part – B
and any five questions from Part – C.

PART – A (7 x 3 = 21 Marks)

1
1 What are antiemetics?

70
2 What are nasal decongestants?
3 Differentiate between purgatives and laxatives.
4 Define the following terms

-1
a. Circadian rhythm b. circannual rhythm
5 What are fluoroquinolones? Give examples.
6 Enumerate various antidotes available.
7 Define Chronotherapy and write its applications.
U
8 Write a note on appetite suppressants.
9 What are the cholinesterase reactivators? Give examples.
O
10 How do carminatives act?

PART- B (1 x 14 = 14 Marks)
1

11 Classify the agents used in treatment of peptic ulcer disease. Write about the
70

pharmacological actions and therapeutic uses of Ranitidine and Omeprazole.

12 Write the MOA, adverse effects and therapeutic uses of Reverse transcriptase
inhibitors and cisplastin.
-1

13 Explain the cell cycle. What are fluoroquinolones? Explain their MOA,
therapeutic uses and adverse effects.

PART- C (5 x 8 = 40 Marks)
U

14 Explain the MOA and adverse effects of aminoglycosides and penicillins.

15 Write short notes on the pharmacology of H2 receptor blockers.
O

16 Discuss the symptoms and treatment of heavy metal poisoning.

17 Write a note on antimalarial drugs.
18 What are protein based drugs? Write short notes on them.
19 Write about urinary tract infections.
20 Classify antifungal drugs. Write the MOA and adverse effects of amphotericin.
21 Discuss the symptoms and treatment of barbiturate poisoning.
22 What are immunosuppressants? Classify them.

*****

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: 12287/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (Main & Backlog) Examination, September 2021
Subject: Herbal Drug Technology
Time: 2 Hours Max. Marks: 75

Note: Answer any seven questions from Part-A, any one question from
Part-B and any five questions from Part-C.

Part – A (7 x 3 = 21 Marks)

1 Define “IPR” and “Bioprospecting”

1
2 Write about curcumin

70
3 Explain soxhlet extraction
4 Differentiate conventional and organic farming
5 Write about any two microbial pesticides

-1
6 Write composition and functions of ASUDCC
7 What are churnas & bhasmas
8 Write about guar gum and saffron
9 Write the underlying principle of homeopathy
U
10 What are the methods for authentication of a herb
O
Part – B (1 x 14 = 14 Marks)

11 Write a detailed account of the guidelines for stability testing of herbal

1

drugs.
70

12 Write a note on: (a) Vitamins as antioxidants (b) Schedule Z.

13 Write a short note on (a) Herbal drug industry (b) Traditional Knowledge
-1

Part – C (5 x 8 = 40 Marks)

14 Write a note on the role of nutraceuticals in the prevention and management of

cardiovascular diseases.
U

15 Write about pharmacokinetic herb drug interactions with examples.

16 Present an overview of good agricultural practices.
O

17 Write an account of plant based research institutes in India.

18 What is bio piracy? Discuss any three bio piracy cases in India.
19 Classify herbal excipients. Write in detail about naturally derived thickening
agents.
20. Write the method of preparation and standardization of churnas.
21. Discuss various methods used for processing of herbal materials.
22. Write a note on omega fatty acids and resveratrol.

*****

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: 12288/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, September 2021
Subject: Biopharmaceutics and Pharmacokinetics
Time: 2Hours Max. Marks: 75
Note: Answer any Seven Questions from Part –A, Any One Questions
from Part-B.and Any Five Questions from Part-C
PART – A (7X3 = 21 Marks)
1) Define biopharmaceutics
2) Mention factors affecting Ahsorption
3) Differentiate Passive transport and Active transports.

1
4) Define Absolute bioavailability and relative bioavailability.

70
5) List the factors affecting elimination of drugs.
6) Explain Flip-flop method in Extra vascular administration.

-1
7) What is apparent volume of drug distribution
8) Write the equation for calculating steady state drug concentration for one
compartment open model.
U
9) What is proties binding. How it affects bio availability
O
10)Expand the terms: i. AUC, ii. Vd iii. t1/2 iv. Ka v. Kθ vi. CLR
Part - B (1 x 14 = 14 Marks)
1

11) Write about in-vitro drug dissolution models.

12) How do you estimate the pharmacokinetics parameters (K max and V max) by
70

using Michaelis – Menton equation.

13)Discuss about factors influencing absorption of drug in GIT

-1

Part - C (5 x 8 = 40 Marks)
14) Write a note on Carrier mediated transport.
U

15) Describe about the physiological barriers to the distribution of drugs. Any three.
O

16) Explain the biliary excretion of drugs.

17) Explain the various methods for assessment of bioavailability.
18. Discuss in-Vitro-in-Vivo correlation
19. Explain kinetics of protion binding
20. Write in detail about compartment models.
21) Write a note on non-linear pharmacokinetics.
22) Explain methods of adjustment of dose and dosage regimen in patients with
hepatic failure
*******

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: 12289/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, September 2021
Subject: Pharmaceutical Biotechnology
Time: 2 Hours Max. Marks: 75
Note: Answer any Seven Questions from Part –A, Any One Questions from
Part-B. and Any Five Questions from Part-C
PART – A (7X3 = 21 Marks)
1. Define the following:
i) Biotechnology ii) Enzyme immobilization
2. Write the components of Biosensors
3. Write significance of enzyme acting on DNA

1
i) Restriction end nucleases ii) S1 nuclease

70
4. Enumerate types of cloning vectors. Add a note on COSMID as vector
5. What is active immunity?

-1
6. Write stability tests defined for official vaccines
7. Give applications involved in Southern blotting technique
U
8. How will you transfer gene by conjugation method
9. How to control foam during fermentation?
O

10. Mention six enzymes

PART- B (1 X 14 = 14 Marks)
1

11. Give the principle of rDNA technology along with significance of enzymes. Enlist
70

and explain various methods of screening the recombinants.

12. Define vaccine. Write the method of preparation and quality control of bacterial
-1

vaccine
13. Discuss production of Penicillin by fermentation process.

PART - C (5 X 8 = 40 Marks)
U

14. Enlist methods of immobilization of enzymes. Add a note on applications of enzyme

O

Immobilization
15. Explain the applications of Biosensors
16. Write a brief account on production of insulin by rDNA technology
17. Differentiate between ‘type II Hypersensitivity’ the ‘type III Hypersensitivity’.
18. Give role of HAT medium in monoclonal antibody production
19. Write short notes on ELISA technique
20. Differentiate between prokaryote and Eukaryote
21. Describe components and working of fermentor
22. Write short note on vitamin B12 Production by fermentation
Library
*******
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No:12007/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021

Subject : Medicinal Chemistry-III

Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
and Any Five Questions from Part-C

PART – A (7 X 3 = 21 Marks)
1) Define &classify antibiotics?
2) Write the structure of Sulbactam & Monobactam?

1
3) Write the structure and uses of Strptomycin?

70
4) Write the structure of Chloroquine & Ethambutol?
5) Write the structure and uses of Dapsone?

-1
6) Define Partition coefficient, Tafts steric parameter?
7) Write the mechanism of action of Aminoglycosides?
8) Write the mechanism of action of Macrolides?
U
9) Define prodrugs?
O
10) Write the mode of action of anti-fungal agents?
1

Part - B (1 x 14 = 14 Marks)
70

11) Write the various classes of antitubercular drugs. Write the synthesis & mode of action of Isoniazid?

12) Define Beta lactam antibiotics and explain the classification, SAR and mode faction of Pencillins?
-1

13) Write the mode of action and SAR of Sulphonamides and Write the synthesis of
Sulfamethoxaole?
U

Part - C (5x8 = 40 Marks)

O

14) Write the chemical degradation of Cephalosporins?

15) Write the SAR and uses of Tetracycline?
16) Write the structure, synthesis, mode of action and uses of Chloramphenicol?
17) Write a note on Prodrugs?
18) Write the structure, synthesis, mode of action and uses of Ciprofloxacin?
19) Write the structure, synthesis, mode of action and uses Trimethoprim?
20) Write a short note on combinatorial chemistry?
21) Write the structure, synthesis, mode of action and uses of Tolnaftate?
22) Write the structure, synthesis, mode of action and uses of Mebendazole?

Library
*******
G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: 12012/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021
Subject : Quality Assurance
Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
and Any Five Questions from Part-C
PART – A (7 X 3 = 21 Marks)
1 Define ISO 14000
2 Define Quality by design (QbD)
3 Define Quality Assurance.
4 Define GMP.

1
5 Explain out of trend (OOT)?

70
6 What is Warehousing? Explain.
7 Explain on out of specification.

-1
8 What is Sources of impurities? Explain.
9 What is calibration. Why it should be bone for equipment
10 What is SOP.? Explain.
U
Part - B (1x 14 = 14 Marks)
O
11 Write briefly about Quality control test for secondary packing materials.
12 Define ICH. Explain about ICH Guidelines.
13 Write briefly about importance, scope of validation and types of validation.
1

Part - C (5x 8 = 40 Marks)

70

14 Describe SOP, Quality audit and Quality Review.

15 Write a short note on Total Quality Management (TQM)
-1

16 List out what are the different analytical instrumentation used in the estimation of
impurities.
17 Explain about validation master plan.
U

18 Explain about Personnel responsibilities, training, and hygiene

O

19 Write a short note on ISO 9000 series?

20 Explain about Equipment selection, purchase specifications and maintenance
21 Explain ISO certification procedure and its advantages?
22 Write briefly about Quality control test for containers.
*******

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G.Pulla Reddy College of Pharmacy
Hyderabad
 Code No: 12011/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021
Subject : Pharmaceutical Biotechnology
Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
and Any Five Questions from Part-C
PART – A (7 X 3 = 21 Marks)
1 What is biosensor? Write the main components used in biosensor.
2 What is genetic engineering?
3 Explain restriction endonucelases.
4 What are vectors? Write the ideal properties of vectors.

1
5 Write few applications of hybridoma technology.

70
6 What are toxins? Explain the method of conversion of toxin to toxoid.
7 Write the preparation and uses of human fibrinogen.

-1
8 Write about types of aerators in Fermentor.
9 Write a brief note on plasmids.
U
10 Differentiate between prokaryotic and Eukaryotic organisms.
O
Part - B (1 x 14 = 14 Marks)
11 Discuss the structure and function of Major Histocompatability Complex.
12 Explain the typical structure of Immunoglobulin and types of Antibodies.
1
70

13 What are plasma substitutes? Explain the manufacturing of plasma substitutes and
standardization.
Part - C (5x 8= 40 Marks)
-1

14 Write a brief notes on Protein Engineering

15 Explain the steps involved in PCR.
16 Explain insertion and replacement vectors (Bacteriophage vector)
U

17 Discuss the general methods of preparation of vaccines.

O

18 Explain Southern blotting technique.

19 Explain generalized transduction and specialized transduction.
20 What are mutations? Explain the types of mutations.
21 Draw a neat labeled diagram of a typical fermentor.
22 Explain the aeration and agitation process in fermentation.
*******

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G.Pulla Reddy College of Pharmacy
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 Code No. 12010 / PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021

Subject : Biopharmaceutics & Pharmacokinetics

Time : 2 Hours Max. Marks: 75

Note: Answer any seven questions Part – A, any one questions from Part – B
and any five question from Part – C.

PART – A (7x3=21 Marks)

1 Define Noyes and Whitney equation and its application.
2 What is Lipinskis rule of five?
3 Differentiate between plasma protein-drug binding and tissue drug binding.
4 Define Microconstants and Hybrid constants and write relationship between them.
5 What is Flip-Flop Phenomenon and how it is useful in method of residual?

1
6 What are the different methods used to calculate the AUC?

70
7 Define orange book and objectives of bioavailability studies.
8 Difference between Absolute bioavailability and Relative bioavailability.
9 Define Creatinine and how to calculate the Creatinine Clearance

-1
10 If Vd of thiopental is 2000ml.Calculate the amount of drug in the body when plasma
concentration is 2µg/ml.
PART- B (1x14=14 Marks)
U
11 Define absorption. Write in detail about mechanism of drug absorption with diagram.
12 Explain in detail about Bioequivalence study protocols.
O
13 Derive Michaelis-Menten equation and how do you estimate Km and Vmax.

PART- C (5x8=40 Marks)

14 Write in detail about pH partition hypothesis and its limitation.
1

15 Write about Gastric emptying rate and Volume of distribution.

70

16 Significance and kinetics of protein drug binding.

17 What are the factor causing Non-Linearity?
18 How do you calculate absorption rate constant, Ka by using Wagner Nelson method?
-1

19 Explain the pharmacokinetic parameters of a drug which follows one compartment open
model when given by intravenous bolus with relevant mathematical equations.
20 What are the different methods for Assessment of Bioavailability?
21 Explain various cross over designs in Bioequivalence studies.
U

22 A 60 kg male received 2mg/kg of a drug orally. The following plasma concentration vs time
data is obtained. Assume the drug follows one compartment open model and it is
O

completely absorbed. Calculate all possible pharmacokinetic parameters.

Time(hr) 1 2 3 4 5 6 8 10 12 14
Plasma Conc. (µg/ml) 3.2 7.3 9.1 9.7 9.7 9.2 7.1 5.3 4.0 3.0

*****

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G.Pulla Reddy College of Pharmacy
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 Code No: 12009/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021

Subject : Herbal Drug Technology

Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
and Any Five Questions from Part-C

PART – A (7 X 3 = 21 Marks)
1 What is Tridosha
2 What are Biopesticides
3 Define the term nutraceuticals

1
4 Write the health benefits of Amla.

70
5 What are advantages of Herbal Excipients.
6 Define the term Cosmetics.

-1
7 Define the term patent and farmers right
8 What do you mean by evaluation of drugs?
U
9 List plant based government research institutes in India.
10 Write a note on Biopiracy.
O

Part - B (1x 14 = 14 Marks)

1

11 Briefly explain good agricultural practices in cultivation of medicinal plants.

70

12 What is traditional knowledge. Explain patenting aspects of Traditional knowledge

and natural products.
-1

13 Briefly explain the objectives and components of Schedule-T.

Part - C (5x 8 = 40 Marks)

U

14 List the Ayurvedic formulations and write the preparation of Bhasma.

O

15 Explain the principles of Siddha system of medicine.

16 Discuss the future prospects of Herbal drug industry.
17 Write a detailed account of case study of Neem and Curcuma.
18 Write the methods of stability testing of herbal drugs.
19 Write note on herbal binders and diluents.
20 Write the possible side effects and interactions of garlic and pepper.
21 Write the role of Honey and Alfa alfa as health food.
22 Write about pest management in medicinal plants.
*******

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G.Pulla Reddy College of Pharmacy
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 Code:6226/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main) Examination, December 2020
Subject: Quality Assurance
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer any Seven questions. (7 x3=21 Marks)
1. Define TQM
2. Give difference between Quality Assurance & Quality Control.

1
70
3. State the purpose of ICH.
4. Name Quality Control tests for glass containers.

-1
5. Name different parameters of Analytical method validation.
6. Name any four responsibilities of Quality control people.
7. Mention classification of Recall.
8. What is qualification and validation . U
O
9. Enlist the scope for validation.
10.Give the principles of NABL accreditation.
1

PART – B
70

Note: Answer One question. (1 x14=14 Marks)

11. a) Define Quality by Design.
b) Write in detail note on QbD.
-1

12. Write a short note on plant layout with example.

13. Explain Good Warehousing practices.
PART - C
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Note: Answer any Five questions. (5x8=40 Marks)

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14. Write in detail Equipment Validation.

15. Draw cause and effect diagram for tablet manufacturing process.
16. Write in detail parameters to be checked in Quality Audit.
17. Write short note on ISO 9000.
18. Explain in short Good Laboratory practices.
19. Explain steps involved in complain handling.
20. Explain the term “validation Master Plan”.
21. What is forced degradation stability study? Explain in short.
22. Write a note on Quality Management System.
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G.Pulla Reddy College of Pharmacy, Hyderabad
 Code No: 6225/PCI
FACULTY OF PHARMACY
B.Pharmacy VI-Semester (PCI) (Main) Examination, November 2020
Subject : Pharmaceutical Biotechnology
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer any Seven questions. (7 x3=21 Marks)

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1. Enlist applications of biotechnology to pharmaceutical industry.

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2. Describe the terms biosensor and bioreactor.
3. Write significance of enzyme acting on DNA.

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i) Polymerase ii) Ligase
4. Describe the importance linkers and adapters.
5. What is toxoid. Give examples
6. What are plasma substitutes? U
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7. Define the following :
i) Immunoblotting ii) Immuno suppression.
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8. How will you transfer gene by transduction method?

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9. Define fermentation.
10. Write six enzymes.
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PART – B
Note: Answer One question. (1 x14=14 Marks)
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11. Explain benefits of recombinant DNA products. Write a detailed account on human
insulin production by rDNA technology
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12. What is Hybridoma technology? Explain the steps involved in the production of
monoclonal antibodies and applications.
13. Describe Microbial biotransformation and its pharmaceutical applications.

PART - C
Note: Answer any Five questions. (5x8=40 Marks)
14. Explain the concept of enzyme immobilization. Comment on its applicability with
suitable examples.
15. Write short notes on production of amylase.
16. Write short notes on interferon production by rDNA technology.
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 Code No: 6225/PCI
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17. Write a short note on PCR.
18. Differentiate between humoral mediated immunity and cell mediated immunity.
19. Give an account of collection, processing & storage of whole human blood.
20. What is solthern blotting? Give details of southern blotting and application.
21. Enlist various criteria to be considered in designing of a fermentor, Draw a neat

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schematic labelled diagram of fermentor.

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22. Write short notes on antibiotic production by fermentation with suitable example.
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G.Pulla Reddy College of Pharmacy, Hyderabad
 Code No: 6221/PCI
FACULTY OF PHARMACY
B.Pharmacy VI-Semester (PCI) (Main) Examination, November 2020
Subject : Medicinal Chemistry - III
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer Seven Questions. (7 X 3 = 21 Marks)

1
1. Write the general synthesis of sulfonamides.

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2. What are folate reductase inhibitors?
3. Give the mechanism of action of Trimethoprim.

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4. Mention any six quinolone drugs.
5. What are Monobactams?

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6. Classify antitubercular agents with examples.
7. Mention any six sulfonamide drugs
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8. Mention any six antifungal agents
9. Mention any six antiviral drugs.
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10. Mention any six antiprotozoal agents?

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PART – B
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Note: Answer One Question. (1X14 = 14 Marks)

11. a) Write a note on B-lactam antibiotics
b) Write a note on tetracyclines.
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12. a) Write the classification of antifungal agents

b) Give the synthesis, mechanism of action and uses of any one antifungal drug.
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13. a) Write a note on Tetracyclines.

b) Write a note on Anti-protozoal agents.

PART – C
Note: Answer Five Question. (5X8 = 40 Marks)
14. Discuss the SAR of semi-synthetic Penicillins.
15. What are prodrugs? Write the classification of Prodrugs based on functional groups.
16. Write the synthesis and mechanism of any two sulfa drugs.
17. Give a note on Artemisinin derivatives.
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 Code No: 6221/PCI
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18. Write the synthesis, mode of action and therapeutic uses of Isoniazid and
Para amino salicylic acid
19. Write a note on Anti-HIV drugs.
20. Write the synthesis and mechanism of Diethylcarbamazine citrate and
Metronidazole.

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21. Write about Quinoline antibiotics.

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22. What are β– lactam antibiotics? Write their mechanism of action.

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G.Pulla Reddy College of Pharmacy, Hyderabad
 Code No: 6224/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main) Examination, November 2020
Subject : Biopharmaceutics and Pharmacokinetics
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer Seven Questions. (7 X 3 = 21 Marks)

1
1) Mention the factors effecting elimination of drugs

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2) List the factors influencing absorption of drugs through GIT
3) Differentiate tissue binding and protein binding.

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4) Write the markers used in renal clearance.
5) Define Bioavailability.
6) Expand the terms i. A  C ii. t 1 , iii. Vd
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iv. IV v. Ka vi. E E
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7) What is t1 what is its importance

2

8) Write the equation for calculating loading dose.

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9) What is apparent volume of distribution and its importance

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10) What are the factors for cause of non-linear kinetics.

PART – B
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Note: Answer One Question. (1X14 = 14 Marks)

11) Write about in - vitro drug dissolution models
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12) Derive mathematical equations used to calculate Pharmaco-Kinetic parameters

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following IV bolus administration blood data, assuming that the drug follows two
compartment open model.

13)Discuss about protein binding and various factors affecting drug-protein binding.

PART – C
Note: Answer Five Question. (5X8 = 40 Marks)
14) Discuss the mechanism of Active diffusion in absorption of drugs.
15) How the organ size and perfusion rate influence the drug distribution?
16) Explain briefly about Kinetics of protein binding.
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 Code No: 6224/PCI
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17) Explain factors affecting the renal excretion of drugs.

18) Discuss about in vitro-in vivo correlations
19) A drug has a volume of distribution of 12Lts and elimination rate constant of 0.18hr -1
A steady state concentration of 12g/ml is desired. Assuming one compartment

1
kinetics, calculate time required to reach 99% of Css and infusion rate to achieve

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desired steady state.

20) Write the significance of different volumes of distribution in two compartment model.

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21) Write a note on non-linear pharmacokinetics and Michaelis Mention equation.
22) How do you determine absorption rate constant, Ka by Wagner nelson method.

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G.Pulla Reddy College of Pharmacy, Hyderabad
 Code No:6223/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main) Examination, November 2020
Subject : Herbal Drug Technology
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer Seven Questions. (7 X 3 = 21 Marks)
1) What is Organic farming.
2) Define the term Herbal medicine as per WHO.
3) Mention any six names of Aycervedic preparations (formulations)
4) What is significance of Herbal excipients

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5) Write the health benefits of herbal medicines.

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6) Define the term Nutraceuticals
7) List the parameters for evaluation of herbal tablets.

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8) Define the term patent and IPR.
9) What is schedule T
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10) What are antioxidants and give examples.
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PART – B
Note: Answer One Question. (1X14 = 14 Marks)
1

11) Briefly explain the objectives and components of Schedule-T

12) List the Ayurvedic formulations and write the preparation of any three.
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13)Explain the WHO guidelines for the assessment of herbal drugs.

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PART – C
Note: Answer Five Question. (5X8 = 40 Marks)
14) How will you perform selection and identification of herbal materials?
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15) Briefly explain the principles of Homeopathic system of Medicine.

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16) Write a note on Functional foods and Dietary supplements.

17) Give informative note on Health benefits of nutraceuticals in management of
diabetes.
18) What are excipients and give its classification with examples.
19) What are phytosomes? Give its method of preparation.
20) Give a detailed account of case study of neem and curcumin.
21) Explain the objectives and functions of ASU and DCC.
22) Give an informative note on future prospects of herbal drug industry.
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G.Pulla Reddy College of Pharmacy, Hyderabad
 Code No: 6222/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main) Examination, November 2020
Subject : Pharamacology - III
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer Seven Questions. (7 X 3 = 21 Marks)
1) What is asthma. Give four examples of drugs used in Asthma

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2) What is ulcer. Give four examples of drugs used in ulcer.

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3) What is the treatment for organophosphorus poisoning?
4) What is teratogenicity and give examples of drugs causing teratogenic effects.

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5) Define Chronopharmacology.
6) What are the uses of sulfa drugs mention any four sulfa drugs.
7) What is amoebiasis Give any four examples of drugs.
8) What is BCG? What for it is used U
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9) Give two examples for Bronchiodilators and explain how they work?
10) Define Expectorant. Give two examples.
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PART – B
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Note: Answer One Question. (1X14 = 14 Marks)

11) Classify anticancer agents. Add a note on antimetabolites.
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12) Write the symptoms and management of Heavy metal poisoning.

13) Explain the pharmacological role of H1 and H2 antihistaminics.
PART – C
U

Note: Answer Five Question. (5X8 = 40 Marks)

14) Write a note on sulfanamides.
O

15) Explain about Proton pump Inhibitors.

16) Write a note on Immunosuppressant’s.
17) Explain the chemotherapy of Anti-TB drug.
18) Write a note on Penicillins.
19) Write a note on ant tubercular agents.
20) Write a note on antimalarial drugs.
21) Write the pharmacology of respirations stimulants
22) What are the different types of rhythms. Explain about circardian rhythm with
examples.
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G.Pulla Reddy College of Pharmacy, Hyderabad