P-annotatePDF-v12

INSTRUCTIONS ON THE ANNOTATION OF PDF FILES

To view, print and annotate your content you will need Adobe Reader version 9 (or higher). This program is freely
available for a whole series of platforms that include PC, Mac, and UNIX and can be downloaded from
http://get.adobe.com/reader/. The exact system requirements are given at the Adobe site:
http://www.adobe.com/products/reader/tech-specs.html.

Note: Please do NOT make direct edits to the PDF using the editing tools as doing so could lead us to overlook your
desired changes. Rather, please request corrections by using the tools in the Comment pane to annotate the PDF and
call out the changes you are requesting. If you opt to annotate the file with software other than Adobe Reader then
please also highlight the appropriate place in the PDF file.

PDF ANNOTATIONS
Adobe Reader version 9 Adobe Reader version X and XI
When you open the PDF file using Adobe Reader, the To make annotations in the PDF file, open the PDF file using
Commenting tool bar should be displayed automatically; if Adobe Reader XI, click on ‘Comment’.
not, click on ‘Tools’, select ‘Comment & Markup’, then click
on ‘Show Comment & Markup tool bar’ (or ‘Show If this option is not available in your Adobe Reader menus
Commenting bar’ on the Mac). If these options are not then it is possible that your Adobe Acrobat version is lower
available in your Adobe Reader menus then it is possible than XI or the PDF has not been prepared properly.
that your Adobe Acrobat version is lower than 9 or the PDF
has not been prepared properly.

This opens a task pane and, below that, a list of all

(Mac) Comments in the text. These comments initially show all
PDF ANNOTATIONS (Adobe Reader version 9) the changes made by our copyeditor to your file.

The default for the Commenting tool bar is set to ‘off’ in

version 9. To change this setting select ‘Edit | Preferences’,
then ‘Documents’ (at left under ‘Categories’), then select
the option ‘Never’ for ‘PDF/A View Mode’.

(Changing the default setting, Adobe version 9)

 HOW TO...
Action Adobe Reader version 9 Adobe Reader version X and XI
Insert text
Click the ‘Text Edits’ button on the Click the ‘Insert Text’ icon on the Comment
Commenting tool bar. Click to set the cursor tool bar. Click to set the cursor location in the text
location in the text and simply start typing. The and simply start typing. The text will appear in a
text will appear in a commenting box. You may commenting box. You may also cut‐and‐paste text
also cut‐and‐paste text from another file into the from another file into the commenting box. Close
commenting box. Close the box by clicking on ‘x’ in
the top right‐hand corner. the box by clicking on ‘_’ in the top right‐hand
corner. Replace text
Replace text
Click the ‘Text Edits’ button on the Click the ‘Replace (Ins)’ icon on the
Commenting tool bar. To highlight the text to be Comment tool bar. To highlight the text to be
replaced, click and drag the cursor over the text. replaced, click and drag the cursor over the text.
Then simply type in the replacement text. The Then simply type in the replacement text. The
replacement text will appear in a commenting box. replacement text will appear in a commenting box.
You may also cut‐and‐paste text from another file You may also cut‐and‐paste text from another file
into this box. To replace formatted text (an into this box. To replace formatted text (an
equation for example) please Attach a file (see equation for example) please Attach a file (see
below). below).
Remove text
Click the ‘Text Edits’ button on the Click the ‘Strikethrough (Del)’ icon on the
Commenting tool bar. Click and drag over the text Comment tool bar. Click and drag over the text to
to be deleted. Then press the delete button on be deleted. Then press the delete button on your
your keyboard. The text to be deleted will then be keyboard. The text to be deleted will then be
struck through. struck through.
Highlight text/
make a Click on the ‘Highlight’ button on the Click on the ‘Highlight Text’ icon on the
comment Commenting tool bar. Click and drag over the text. Comment tool bar. Click and drag over the text. To
To make a comment, double click on the make a comment, double click on the highlighted
highlighted text and simply start typing. text and simply start typing.
Attach a file
Click on the ‘Attach a File’ button on the Click on the ‘Attach File’ icon on the
Commenting tool bar. Click on the figure, table or Comment tool bar. Click on the figure, table or
formatted text to be replaced. A window will formatted text to be replaced. A window will
automatically open allowing you to attach the file. automatically open allowing you to attach the file.
To make a comment, go to ‘General’ in the A graphic will appear indicating the insertion of a
‘Properties’ window, and then ‘Description’. A file.
graphic will appear in the PDF file indicating the
insertion of a file.
Leave a note/
comment Click on the ‘Note Tool’ button on Click on the ‘Add Sticky Note’ icon on the
the Commenting tool bar. Click to set the location Comment tool bar. Click to set the location of the
of the note on the document and simply start note on the document and simply start typing. Do
typing. Do not use this feature to make text edits. not use this feature to make text edits.
 HOW TO...
Action Adobe Reader version 9 Adobe Reader version X and XI
Review To review your changes, click on the ‘Show’ button Your changes will appear automatically in a list
below the Comment tool bar. Navigate by clicking
on the Commenting tool bar. on a correction in the list. Alternatively, double
Choose ‘Show Comments List’. Navigate by clicking click on any mark‐up to open the commenting box.
on a correction in the list. Alternatively, double
click on any mark‐up to open the commenting box.
Undo/delete To undo any changes made, use the right click To undo any changes made, use the right click
change button on your mouse (for PCs, Ctrl‐Click for the button on your mouse (for PCs, Ctrl‐Click for the
Mac). Alternatively click on ‘Edit’ in the main Mac). Alternatively click on ‘Edit’ in the main
Adobe menu and then ‘Undo’. You can also delete Adobe menu and then ‘Undo’. You can also delete
edits using the right click (Ctrl‐click on the Mac) edits using the right click (Ctrl‐click on the Mac)
and selecting ‘Delete’. and selecting ‘Delete’.

SEND YOUR ANNOTATED PDF FILE BACK TO ELSEVIER

Save the annotations to your file and return as instructed by Elsevier. Before returning, please ensure you have
answered any questions raised on the Query Form and that you have inserted all corrections: later inclusion of any
subsequent corrections cannot be guaranteed.
FURTHER POINTS
 Any (grey) halftones (photographs, micrographs, etc.) are best viewed on screen, for which they are optimized,
and your local printer may not be able to output the greys correctly.
 If the PDF files contain colour images, and if you do have a local colour printer available, then it will be likely that
you will not be able to correctly reproduce the colours on it, as local variations can occur.
 If you print the PDF file attached, and notice some ‘non‐standard’ output, please check if the problem is also
present on screen. If the correct printer driver for your printer is not installed on your PC, the printed output
will be distorted.
Our reference: AJOGMF101600

AUTHOR QUERY FORM

Journal: AJOGMF Please e-mail your responses and any corrections to:

Article Number: 101600 E-mail: [email protected]

Dear Author,

Please check your proof carefully and mark all corrections at the appropriate place in the proof (e.g., by using on-screen anno-
tation in the PDF file) or compile them in a separate list. Note: if you opt to annotate the file with software other than Adobe
Reader then please also highlight the appropriate place in the PDF file. To ensure fast publication of your paper please return
your corrections within 48 hours.

Your article is registered as a regular item and is being processed for inclusion in a regular issue of the journal. If this is NOT
correct and your article belongs to a Special Issue/Collection please contact [email protected] immediately prior to
returning your corrections.

For correction or revision of any artwork, please consult http://www.elsevier.com/artworkinstructions

Any queries or remarks that have arisen during the processing of your manuscript are listed below and highlighted by flags in
the proof. Click on the ‘Q’ link to go to the location in the proof.

Location Query / Remark: click on the Q link to go

in article Please insert your reply or correction at the corresponding line in the proof

Q1 Please review and confirm whether “Letter to the editor regarding” should be removed from the article
title and changed to “The preeclampsia and hypertension target treatment study: a multicenter prospec-
tive study to evaluate the effectiveness of the antihypertensive therapy based on maternal hemodynamic
findings.”
Q2 Per Journal style, the term “Caucasian” has been changed to “White.” Please review and confirm the
change.
Q3 In the sentence beginning with “Furthermore, the article provided no method to. . .,” the author name
for reference 4 was revised as per reference list. Please review.
Q4 Sentence beginning “In conclusion, to improve the effectiveness. . .” okay as edited?
Q5 There is no mention of an ethical statement in the style guide. Therefore, please review and confirm
whether the ethical statement section should be removed from the article or presented as article title
footnotes.
Q6 Please review the given names (no colouring) and surnames (highlighted in teal colouring) to make
sure that we have identified them correctly and that they are presented in the desired order. Carefully
verify the spelling of all authors’ names as well. If changes are needed, please provide the edits in the
author section.
Q7 Per Journal style, please provide the highest degree obtained by the authors in place of XX.

Please check this box or indicate your approval if

you have no corrections to make to the PDF file.

Thank you for your assistance.

 Letter to the Editor
Letter to the editor regarding “The
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preeclampsia and hypertension target 103
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treatment study: a multicenter prospective 107
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study to evaluate the effectiveness of the 110
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antihypertensive therapy based on maternal 114
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hemodynamic findings”
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23 To the Editor: output, and stroke volume. In addition, a detailed BSA mea- 124
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25 We have reviewed the article entitled “The preeclampsia and surement would improve the accuracy of drug dosage calcula- 125
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26 hypertension target treatment study: a multicenter prospec- tions, allowing treatments to be individualized according to 127
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28 Q1 tive study to evaluate the effectiveness of the antihypertensive body size, resulting in more effective and safer interventions. 129
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30 therapy based on maternal hemodynamic findings” by di Pas- In conclusion, to improve the effectiveness and wider applicabil- Q4 131
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32 quo et al.1 We enjoyed reading this article and admire the ity of hypertension management in pregnancy, rectification of 133
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34 authors for their remarkable work. We agree with the primary these deficiencies by using an enhanced study design inclusive 135
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36 conclusion of the article that, for women with newly devel- of varied populations, reporting biochemical assessments when 137
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38 oped hypertensive disorders, a reduced incidence of severe available, and applying valid measures for body metrics toward 139
39 hypertension was noted when the initial hypertensive treat- individualizing treatment can serve as an indispensable key. 140
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41 ment was given. However, although the study provides mean- 142
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ingful information, it is important to consider several ETHICAL STATEMENT : We hereby declare that the manu- Q5 144
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45 limitations to fully comprehend the implications of the find- script entitled “Letter to the editor regarding ‘The pre- 146
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47 ings, which would add more value to the study. eclampsia and hypertension target treatment study: a 148
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49 First, the study remained short in discussing diverse racial multicenter prospective study to evaluate the effectiveness 150
50 and ethnic groups, which limits the generalizability of the 151
51 of the antihypertensive therapy based on maternal hemo- 152
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findings beyond the Italian population. Given that African dynamic findings’”1 submitted to the American Journal of 153
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American women have a higher risk of mortality from hyper- Obstetrics & Gynecology MFM adheres to the highest ethi- 155
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56 tensive disorders of pregnancy than Hispanic, American cal standards and principles of academic integrity. We 157
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58 Q2 Indian/Alaska Native, Asian/Pacific Islander, and White affirm that the content of this publication is original, and 159
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60 women,2 this discussion could have provided a valuable per- any sources or references used have been appropriately 161
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62 spective on maternal hemodynamic patterns, leading to more cited. 163
63 appropriate strategies. Second, the article of our concern 164
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65 failed to mention the assessment of biochemical markers, spe- Plagiarism: We affirm that the manuscript is a result of 166
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67 cifically N-terminal pro−B-type natriuretic peptide in preg- our original work, and any information, ideas, or wording 168
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69 nant women with hypertensive disorders. The evaluation of taken from other sources have been properly acknowledged 170
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71 this marker is significant as it helps rule out heart failure in through appropriate citations and references. 172
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73 particular and allows an in-depth understanding of the patho- 174
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physiology behind hypertensive disorders.3 This is relevant Authorship: We confirm that all individuals who have sig- 175
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76 because it involves hemodynamic changes and biochemical 177
77 nificantly contributed to the content and findings of this man- 178
78 alterations that can influence disease progression and can be 179
79 uscript have been included as authors. 180
80 a valuable predictor of disease severity. 181
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82 Q3 Furthermore, the article provided no method to evaluate the Data and research integrity: We affirm that the data pre- 183
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84 pregestational body surface area (BSA) using the Boyd for- sented in the manuscript is accurate and authentic. 185
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86 mula compared with another study by Ornaghi et al.4 A thor- 186
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87 ough assessment of the BSA would greatly enhance the 188
88 Informed consent and privacy: Not applicable on this 189
89 evaluation of the hemodynamic profile as the BSA has a major 190
90 study. 191
91 effect on the results of systemic vascular resistance, cardiac 192
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94 Ethical approval: Not applicable on this study. 195
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97 Cite this article as: Jawaid M, Tanveer L, Maaz M. Letter to the editor regarding “The 198
98 preeclampsia and hypertension target treatment study: a multicenter prospective study
Ethical guidelines: We have followed the ethical guide- 199
99 200
100 to evaluate the effectiveness of the antihypertensive therapy based on maternal hemody- lines and principles outlined by the International Committee 201
101 namic findings”. Am J Obstet Gynecol MFM 2025;xxx:101600. of Medical Journal Editors and any other relevant 202

& 2025 AJOG MFM 1

 ARTICLE IN PRESS
Letter to the Editor

203 professional organizations for the conduct and reporting of CREDIT AUTHORSHIP CONTRIBUTION STATEMENT: Marium 305
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205 research. Jawaid: Writing − original draft. Laiba Tanveer: Writing − 307
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207 By submitting this manuscript, we acknowledge that we are original draft. Muhammad Maaz: Writing − review & 309
208 responsible for the content presented and that we have com- editing. 310
209 311
210 plied with the ethical standards and guidelines mentioned 312
211 313
212 above. We understand that any violation of these ethical prin- REFERENCES 314
213 315
214 ciples may result in the rejection or retraction of the manu- 1. di Pasquo E, Giannubilo SR, Valentini B, et al. The “Preeclampsia and
316
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216 script. hypertension Target Treatment” study: a multicenter prospective study to 318
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218 & evaluate the effectiveness of the antihypertensive therapy based on maternal 320
219 hemodynamic findings. Am J Obstet Gynecol MFM 2024;6:101368. 321
220 322
221 2. Lo JO, Mission JF, Caughey AB. Hypertensive disease of pregnancy 323
222 Q6 Marium Jawaid, XX and maternal mortality. Curr Opin Obstet Gynecol 2013;25:124–32. 324
223 325
224 Q7 Laiba Tanveer, XX 3. McLaughlin K, Scholten RR, Kingdom JC, Floras JS, Parker JD. 326
225 Should maternal hemodynamics guide antihypertensive therapy in pre- 327
226 Jinnah Sindh Medical University 328
227 eclampsia? Hypertension 2018;71:550–6. 329
228 Karachi, Pakistan 330
229
4. Ornaghi S, Caricati A, Di Martino DD, et al. Non-invasive maternal 331
[email protected]
230 hemodynamic assessment to classify high-risk pregnancies complicated 332
231 333
232 Muhammad Maaz, XX by fetal growth restriction. Front Clin Diabetes Healthc 2022;3:851971. 334
233 Shaheed Mohtarma Benazir Bhutto Medical College Lyari 335
234 © 2025 Elsevier Inc. All rights are reserved, including those for text and 336
235 Karachi, Pakistan 337
236 data mining, AI training, and similar technologies. https://doi.org/ 338
237 The authors report no conflict of interest. 10.1016/j.ajogmf.2025.101600 339
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