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 Based on Physicians' Desk
Reference®^ the Nation’s
Leading Drug Handbook

7TH EDITION FULLY REVISED & UPDATED

THE SAME INFORMATION
YOUR DOCTOR DEPENDS ON
THE

Pocket Guide to
PRESCRIPTION TM

DRUGS
A-to-Z listing of more than 1,000 brand-name drugs
and their generic equivalents
• Easy-to-understand drug profiles—treatment,
dosage, side effects, warnings
• A Drug Identification Guide featuring full-color,
actual-size photographs
i$7.99 U.S.
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 WHAT THE EXPERTS
ARE SAYING ABOUT
THE PDR® POCKET GUIDE
TO PRESCRIPTION DRUGS ™

“An easy-to-read guide to medications, side effects, and

efficacy,.. Now one can get understandable medical in¬
formation that can help keep health costs down, yet give
patients a fine comfort level with the medicines they
take.”
—^Leon G. Smith, MD
Chairman of Medicine
St. Michael’s Medical Center
Newark, NJ

“A must for every household where there are concerns

about the safe use of medications. It is an ideal way to
clarify and supplement the information provided by
your healthcare provider.”
—Jack M. Rosenberg, PharmD, PhD
Professor of Pharmacy Practice and Pharmacology
Arnold & Marie Schwartz College of Pharmacy
Long Island University—Brooklyn Campus
Brooklyn, NY
 Digitized by the Internet Archive
in 2018 with funding from
Kahle/Austin Foundation

https://archive.org/details/pdrpocketguidetoOOphys
POCKET GUIDE
TO PRESCRIPTION DRUGS"
7TH EDITION
FULLY REVISED AND UPDATED

Based on Physicians* Desk Reference®,

the Nation’s Leading Drag Handbook

4
POCKET BOOKS
New York London Toronto Sydney
 The sale of this book without its cover is unauthorized. K you purchased
this book without a cover, you should be aware that it was reported to
the publisher as “unsold and destroyed.” Neither the authors nor the
publisher have received payment for the sale of this “stripped book.”

PHYSICIANS’ DESK REFERENCE®, PDR®, Pocket PDR®, The PDR® Family

Guide to Prescription Drugs®, The PDR® Family Guide to Women’s Health and Pre¬
scription Drugs ®, and The PDR® Family Guide to Nutrition and Health are registered
trademarks used herein under license. PDR® for Ophthalmic Medicines, PDR® for
Nonprescription Drugs and Dietary Supplements, PDR® Companion Guide, PDR®
Pharmacopoeia Pocket Dosing Guide, PDR® Monthly Prescribing Guide™, PDR® for
Herbal Medicines, PDR® for Nutritional Supplements, PDR® Medical Dictionary,
PDR® Nurse’s Drug Handbook™, PDR® Nurse’s Dictionary, The PDR® Family Guide
Encyclopedia of Medical Care, The PDR® Family Guide to Natural Medicines and
Healing Therapies, The PDR® Family Guide to Common Ailments, The PDR® Family
Guide to Over-the-Counter Drugs, The PDR® Family Guide to Nutritional Supple¬
ments, and PDR® Electronic Library are trademarks used herein under license.

Officers (rf Thomson Healthcare, Inc.: President and Chief Executive Officer: Kevin
King; Chief Financial Officer: Paul HUger; Chief Technology Officer: Frank Licata; Ex¬
ecutive Vice President, Medical Education: Jeff MacDonald; Executive Vice President,
Medstat: Carol Diephuis; Executive Vice President, Micromedex: Jeff Reihl; Senior
Vice President, Marketing: Timothy Murray; Vice President,'Finance: Joseph Scar-
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POCKET BOOKS, a division of Simon & Schuster, Inc.

1230 Avenue of the Americas, New York, NY 10020

Copyright © 1996, 1997, 1999, 2000, 2002, 2003, 2005 by Thomson PDR

Published by arrangement with Thomson PDR

All rights reserved, including the right to reproduce this book or portions thereof in
any form whatsoever. For information address Thomson PDR, 5 Paragon Drive,
Montvale, NJ 07645

ISBN-13: 978-1-4165-1085-7
ISBN-10: 1-4165-1085-0
ISBN-13: 978-1-4165-2331-4
ISBN-10: 1-4165-2331-6

This Pocket Books paperback edition December 2005

10 987654321

POCKET and colophon are registered trademarks of Simon & Schuster, Inc.

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Manufactured in the United States of America

For information regarding special discounts for bulk purchases,

please contact Simon & Schuster Special Sales
at 1-800-456-6798 or [email protected].
Publisher’s Note

The drug information contained in this book is based on product label¬

ing published in the 2005 edition of Physicians' Desk Reference®, sup¬
plemented with facts from other sources the publisher believes reliable.
While diligent efforts have been made to ensure the accuracy of this in¬
formation, the book does not list every possible action, adverse reaction,
interaction, and precaution; and all information is presented without
guarantees by the authors, consultants, and publisher, who disclaim all
liability in connection with its use.
This book is intended only as a reference for use in an ongoing part¬
nership between doctor and patient in the management of the patient’s
health. It is not a substitute for a doctor’s professional judgment, and
serves only as a reminder of concerns that may need discussion. All
readers are urged to consult with a physician before beginning or dis¬
continuing use of any prescription drug or undertaking any form of self-
treatment. Brand names listed in this book are intended to represent only
the more commonly used products. Inclusion of a brand name does not
signify endorsement of the product; absence of a name does not imply a
criticism or rejection of the product. The publisher is not advocating the
use of any product described in this book, does not warrant or guarantee
any of these products, and has not performed any independent analysis
in connection with the product information contained herein.
Contents

Contributors and Consultants ix

Foreword xiii

How to Use This Book xv

Drug Identification Guide (see 'insert)

Drug Profiles 1

Disease and Disorder Index 1683

Appendix 1: Safe Medication Use 1717

Appendix 2: Poison Control Centers 1719

Appendix 3: Top 200 Brand-Name Drugs 1731

yt'i c.
The PDR ® Pocket Guide
to Prescription Drugs’^”,
based on the 2005 edition of PDR ®
Editor-in-Chief: Bette LaGow

Director, Clinical Content: Thomas Fleming, PharmD

Senior Editor: Lori Murray

Production Editor: Gwynned Kelly

Drug Information Specialist: Gregory Tallis, RPh

Writers: Nancy K. Bannon; Rebecca Bowers; Janette

Carlucci; Neil Chesanow; Mary Lou Hurley; Eileen
McCaffrey; Leah E. Perry; Kathleen Rodgers, RPh; Marissa J.
Ventura

Editorial Production: Vice President, PDR Services: Brian

Holland; Director, Operations: Robert Klein; Production
Specialist: Christina Klinger; Digital Imaging Manager:
Christopher Husted; Digital Imaging Coordinator: Michael
Labruyere; Production Design Supervisor: Adeline Rich;
Senior Electronic Publishing Designer: Livio Udina

Thomson PDR
Senior Vice President, Sales & Marketing: Dikran M.
Barsamian

Senior Director, Brand & Product Management: Valerie E.

Berger

Director, Brand & Product Management: Carmen Mazzatta

Senior Director, Publishing Sales & Marketing: Michael-

Bennett

Director, Trade Sales: Bill Gaffney

M / THE PDR POCKET GUIDE TO PRESCRIPTION DRUGS

Board of Medical Consultants

Chair:
Robert W. Hogan, MD
Family and Preventive Medicine
Southern California Permanente Medical Group
San Diego, CA
David J. Anderson, MD
St. Louis, MO
Rudolph £. Angeli, MD
Teaneck, NJ
Donald E. Arnold, MD
Department of Anesthesiology
St. John’s Mercy Medical Center, St. Louis, MO
Gregg J. Berdy, MD
Ophthalmology Associates
Creve Coeur, MO
Susan Schukar Berdy, MD
St. Louis, MO
Ira Bernstein, MD
Department of Obstetrics and Gynecology
Hackensack University Medical Center, Hackensack, NJ
Marc A. Clachko, MD
Associate Director, Department of Obstetrics and Gynecology
Hackensack University Medical Center, Hackensack, NJ
Charles A. Crecelius, MD, PhD
St. Louis, MO
Alan Felsen, MD
Attending Physician, Department of Internal Medicine
Hackensack University Medical Center, Hackensack, NJ
Mortimer S. Greenberg, MD
Cambridge, MA ^
Gary D. Koenig, MD
Florissant, MO
Mitchell R. Lester, MD
Greenwich, CT
Younghee Limb, MD
Assistant Professor of Clinical Medicine
State University of New York, Stony Brook, NY
 THE PDR POCKET GUIDE TO PRESCRIPTION DRUGS /xi

Gardiner Morse, MS
Editor, Harvard Health Publications, Boston, MA
Louis V. Napolitano, MD
Family Practice
Hackensack University Medical Center, Hackensack, NJ
Mark D. Ravenscraft, MD
Creve Coeur, MO
Martin 1. Resnick, MD
Professor and Chairman, Department of Urology
Case Western Reserve University, Cleveland, OH
Frank Simo, MD
St. Louis, MO
Karl Singer, MD
Exeter Family Medicine Associates, Exeter, NH
Eugene W. Sweeney, MD
Department of Dermatology
Columbia Presbyterian Medical Center
New York, NY
Foreword

The PDR® Pocket Guide to Prescription Drugs™ strives to make the

many benefits of modem pharmaceuticals—as v^ell as their undeniable
risks—as clear and simple as can be. The PDR Pocket Guide spells out
exactly why each dmg is prescribed and the most important fact to re¬
member about it, then discloses its most common side effects. As a safe¬
guard against error, it also provides you with information on standard
dosage recommendations. It tells exactly what to do when you miss a
dose of your medication, while alerting you to the warning signs of an
overdose. And to help you find all these facts as quickly as possible, it
lists each medication under its familiar brand name—with a cross-
reference in case the dmg is dispensed generically.
Still, despite the depth and detail of the information you’ll find here.
The PDR Pocket Guide is not a replacement for your doctor’s advice.
Rather, it serves as a reminder of the basic instmctions and caveats that
may be forgotten by the time you leave your doctor’s office, as well as
providing you with a checklist of the problems and conditions that you
must be certain the doctor knows about—facts that might call for a
change in your prescription.
In this way, the book is designed to serve as an aid in an ongoing dia¬
logue between you and your doctor—a collaboration necessary for any
treatment to work. Just as the doctor must tell you how and why to use a
particular dmg, you must tell the doctor how it affects you, reporting
any reactions or dmg interactions you suspect you may have. And while
it’s up to the doctor to devise your treatment strategy, it’s up to you to
make sure that the right doses are administered at the right times, and
that the prescribed course of therapy is completed as planned.
Physicians’ Desk Reference® has been providing doctors with the in¬
formation needed for safe, effective dmg therapy for 60 years. Designed
especially for healthcare professionals, it presents the facts in a detailed,
technical format approved by the Food and Dmg Administration (FDA).
To make the key facts buried in this wealth of data accessible to every¬
one, The PDR Pocket Guide strips away the medical shorthand and tech¬
nical terminology, and presents the core of this information in a simple,
standard format designed for maximum convenience and ease of use by
the consumer. Almost all the information you’ll find in The PDR Pocket
Guide’s consumer dmg profiles has been extracted from PDR itself.
When necessary, however, selected facts have been added from other
authoritative sources—in particular, the databases maintained by
Thomson Micromedex, another company within the Thomson Health¬
care group of respected, authoritative healthcare, medical, and pharma¬
cological content specialists.
xiv/FOREWORD

Modem dmg therapy is a vast and complicated field—so compli¬

cated that, for many questions about medicines, the answer varies with
each patient. The PDR Pocket Guide to Prescription Drugs gives you
general guidelines for safe dmg use. But only your doctor, evaluating
the unique details of your case, can give you the exact instmctions best
suited for you. The goal of this book is simply to alert you to the most
pertinent questions to ask, and to help clarify your doctor’s answers—in
short, to give you the tools you need to supervise your own medical care
as effectively as possible.
We wish you good health.

Robert W. Hogan, MD
Chair, Board of Medical Consultants
How to Use This Book

Although doctors today can often work miracles with advanced tech¬
nology and sophisticated medicines, it’s vital for you to take an active
role in managing your health. Any medicine can prove worthless if
taken improperly. Likewise, you must let your doctor know if you react
badly to a drug or have a condition that makes taking it dangerous.
While no book is a substitute for a visit to the doctor, this guide is
designed to help you use your medications safely and effectively, and
to help you determine things that deserve further discussion with your
doctor.
The book is divided into two major parts. In the first, you’ll find
profiles of the more frequently prescribed medications. The second
section has helpful references and an index of common diseases and dis¬
orders.

THE DRUG PROFILES

The profiles provide detailed information on the most frequently pre¬
scribed prescription drugs, plus a few widely used over-the-counter
medications. Though the section covers more than 1,000 products, don’t
be alarmed if you don’t find a profile for a prescription you’ve received.
There are a number of specialized yet valuable drugs that have been
omitted here due to lack of space.
The products described here are listed alphabetically by the manu¬
facturer’s brand name or the generic name. Full-profile headers appear
in all uppercase letters; cross-references are either boldface upper- and
lowercase (for brand names) or boldface upper- and lowercase italic (for
generics). If there is more than one brand of a drug, you’ll usually find
the profile cross-referenced to the name most Ife^uently prescribed.
Tfie drug profiles begin with correct pronunciation of the name, fol¬
lowed by the generic name for the drug and, if applicable, the other
brand names. The information that follows these names is divided into
10 sections. Here’s what you’ll find in each.

Why is this drug prescribed?

This is an overview of the major conditions for which the drug is gener¬
ally prescribed.

Most important fact about this drug

Highlighted here is one key point about a drug that is especially worth¬
while to know. We’ve placed it here for the sake of emphasis. Never re¬
gard this section as a definitive summary of the drug.
X¥i/HOWTO USE THIS BOOK

How should you take this medication?

This section details special instructions, including how and when to take
the drug, and any dietary restrictions that may apply. Also found here is
advice on what to do if you forget a dose, as well as any special storage
requirements that apply.

What side effects may occur?

Shown here are only the most common side effects listed by the manu¬
facturer in the drug’s FDA-approved product labeling. Any drug will oc¬
casionally cause an unwanted reaction. Even the most common side
effects are seen in only a small percentage of patients. Not included are
side effects that can be detected only by a physician or laboratory. If you
have any questions about side effects-—or if you have any new or con¬
tinuing symptoms—talk to your doctor

Why should this drug not be prescribed?

A few drugs are harmlul under certain conditions, which are detailed
here. The most common contraindication is a hypersensitivity to the
drug itself. If you think one of these restrictions applies to you, alert
your doctor immediately.

Special warnings about this medication

If you recognize any problems or conditions that your doctor may be un¬
aware of, be sure to bring them to his or her attention. Do not change
your dosage or discontinue the drug without first consulting your doc¬
tor, however. Such a change might well do more harm than good.

Possible food and drug interactions when taking this

medication
This section lists specific drugs, classes of drugs, and foods that have
been known to interact with the medicine being profiled. The examples
are not all-inclusive. If you’re not certain whether a medication you’re
taking falls into one of these categories, be sure to check with your doc¬
tor or pharmacist. But never stop taking any drug without first consult¬
ing your doctor.

Special information if you are pregnant or breastfeeding

This section will tell you whether a drug has been confirmed safe for use
during pregnancy or breastfeeding, is known to be dangerous, or is part
of that large group about which scientists are not really sure. With many
of these drugs, the small theoretical risk they pose may be overshad¬
owed by your need for treatment.

Recommended dosage
Shown here are excerpts of the dosage guidelines your doctor uses. The
information is presented as a convenient double check in case you sus-
 HOWTO USE THIS BOOK/xvIl

pect a misunderstanding or a typographical error on your prescription

label. Don’t use it to determine an exact dosage yourself.

Overdosage
As another safety measure this section lists, when available, the signs of
an overdose. If the symptoms listed in this section lead you to suspect an
overdose, seek emergency medical attention immediately.

OTHER FEATURES
Drug Identification Guide
This full-color guide includes actual-sized photographs of the leading
products discussed in the book, arranged alphabetically by brand name.
Manufacturers ocpasionally change the color and shape of a product, so
if a prescription does not match the photo shown here, check with your
pharmacist before assuming there’s been a mistake.

The Disease and Disorder Index

This index helps you quickly identify drugs available for a particular
medical condition. Arranged alphabetically by ailment, it lists all the
medications profiled in the book.

The Appendices
This section provides you with two important safeguards that every
home should always have handy: Appendix 1 is a brief guide to safe
medication use and Appendix 2 is a directory of poison control centers
nationwide. Appendix 3, a new addition, lists the 200 drugs most com¬
monly prescribed in the United States.
 PDR

THEUPDK
POCKET GUIDE
TO PRESCRIPTION DRUGS^
 \

'. •,
Drug Profiles
i

I 'X
 ABILIFY/1

Abscavit See Ziagen, page 1633.

Abacam, Lamivudine, and Zidowudine See Thzivir,
page 1505.

ABILIFY
Pronounced: a-BILL-i-fie
Generic name: Aripiprazole

Why Is this drug prescribed?

Ability is used in the treatment of schizophrenia, the psychological disorder
that causes its victims to lose touch with reality, often triggering hallucina¬
tions, delusions (false beliefs), and disorganized thinking. It’s also used to
help control the manic phase of bipolar disorder, including the prevention
of future episodes. The drug is thought to work by modifying sensitivity to
two of the brain’s chief chemical messengers, serotonin and dopamine.

Most Important fact about this drug

Ability can cause tardive dyskinesia, a condition marked by involuntary
movements in the face and body. This condition may be permanent and
appears to be most common among older adults, especially women. Ask
your doctor for more information about this possible risk.
Drugs such as Ability may increase the risk of death in elderly people
with dementia-related psychosis. Ability is not approved for use in such
patients.

How should you take this medication?

Ability should be taken once a day. It may be taken with food or on an
empty stomach. The drug is available in tablet and oral solution forms.

■ If you miss a dose... *

Take the forgotten dose as soon as you remember. However, if it is al¬
most time for your next dose, skip the one you missed and return to
your regular schedule. Do not take 2 doses at once.
■ Storage instructions...
Store the tablets at room temperature. Keep bottles of the oral solution
in the refrigerator and use within 6 months after opening.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity,
tell your doctor as soon as possible. Only your doctor can determine if it
is safe to continue using Ability.
2/ABlLiFY

■ Side effects may include:

Anxiety, blurred vision, constipation, cough, headache, insomnia,
light-headedness, nausea, rash, restlessness, runny nose, sleepiness,
tremors, vomiting, weakness, weight gain

Why should this drug not be prescribed?

It Ability causes an allergic reaction, you’ll be unable to use it.

Special warnings about this medication

The risk ot tardive dyskinesia (see Most important fact about this dru^
increases with the total amount ot Ability that you’ve taken. To reduce
the risk, the doctor will prescribe the lowest effective dose and resort to
long-term therapy only it necessary. It you develop symptoms ot tardive
dyskinesia, see your doctor immediately. Therapy with Ability may have
to be discontinued.
In rare cases, Ability has been known to cause a potentially tatal con¬
dition called Neuroleptic Malignant Syndrome (NMS). Symptoms include
high tever, rigid muscles, irregular pulse or blood pressure, rapid heart¬
beat, excessive perspiration, altered mental status, and changes in heart
rhythm. It you develop these symptoms, contact your doctor immedi¬
ately. Ability should be discontinued.
Certain antipsychotic drugs, including Ability, are associated with an
increased risk ot developing high blood sugar, which on rare occasions
has led to coma or death. See your doctor right away it you develop signs
ot high blood sugar, including dry mouth, unusual thirst, increased uri¬
nation, and tiredness. It you have diabetes or have a high risk ot develop¬
ing it, see your doctor regularly tor blood sugar testing. Also be aware
that the oral solution contains 400 milligrams ot sucrose and 200 mil¬
ligrams ot tructose per milliliter.
Because Ability tends to make some people sleepy, you should be cau¬
tious about operating hazardous machinery such as cars until you are
certain the drug will not impair your ability.
In a tew people. Ability can cause an abrupt drop in blood pressure
when they stand up, leading to iight-headedness or even tainting. Use
Ability with caution it you have any kind ot heart or circulatory problem,
take blood pressure medication, or tend to become dehydrated.
Ability has triggered seizures in a very small number ot patients, and
can also interfere with the swallowing mechanism. The risk ot either
problem is greater among older adults. It you’ve ever had a seizure, be
sure to tell the doctor. Ability should be used with caution.
Drugs such as Ability can cause the body to overheat. Be cautious in
hot weather and when exercising strenuously, and be sure to get plenty ot
liquids.
Ability rias not been tested in children orteenagers. The drug should be
used cautiously by older adults, especially those who have dementia-
related psychosis.
 ACAMPROSATE/3

Possible food and drug interactions when taking this medication

The doctor will need to reduce the dosage of Abilify when you take the fol¬
lowing additional drugs:

Fluoxetine (Prozac)
Ketoconazoie (Nizoral)
Paroxetine (Paxil)
Quinidine (Quinidex)
On the other hand, the dosage of Abilify should be increased when you
take carbamazepine (Tegretol).
Be cautious when taking Abilify with blood pressure medications clas¬
sified as alpha-adrenergic blockers, including Hytrin and Cardura. Cau¬
tion is also advised when combining Abilify with drugs that act on the
brain, including tranquilizers, antidepressants, sleeping pills, narcotic
painkillers, and other schizophrenia medications.
Although Abilify does not interact with alcohol, the manufacturer rec¬
ommends avoiding the combination.

Special information if you are pregnant or breastfeeding

The effects of Abilify during pregnancy have not been adequately studied.
The drug is recommended only if its benefits are thought to outweigh the
potential risk to the baby. If you are pregnant or planning to become preg¬
nant, inform your doctor immediately.
Breastfeeding is not recommended during Abilify therapy.

Recommended dosage
ADULTS

Schizophrenia
The usual dose is 10 or 15 milligrams taken once a day. The doctor will
wait at least 2 weeks before prescribing an increased dosage.

Bipolar Disorder
The usual starting dose is 30 milligrams once a.day. If you experience
side effects, the doctor may decrease your dose to 15 milligrams once
a day.

Overdosage
Any medication taken in excess can have serious consequences. If you
suspect an overdose, seek medical attention immediately.

■ Symptoms of Abilify overdose may include:

Sleepiness, vomiting

Acamprosate See Campral, page 234.

4/ACARBOSE

AcaFbOSe See Precose, page 1126.

ACCOLATE
Pronounced: ACK-o-late
Generic name: Zafirlukast

Why is this drug prescribed?

Accolate helps prevent asthma attacks. It is prescribed for long-term
treatment.

Most important fact about this drug

Accolate will not stop an asthma attack once it starts. You will still need to
use an airway-opening medication when an attack occurs.

How should you take this medication?

Accolate should be taken twice every day, whether or not you have had
any recent asthma attacks. Do not take the medication with food. Allow at
least 1 hour to pass before eating, or wait for 2 hours after a meal. You
can continue to take Accolate while using another medication to stop an
attack.

■ If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose,
skip the one you missed and go back to your regular schedule. Do not
take 2 doses at once.
■ Storage instructions...
Store at room temperature in a dark, dry place.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity,
inform your doctor as soon as possible. Only your doctor can determine
if it is safe for you to continue taking Accolate.

■ Side effects may include:

Headache, infection, nausea

Why should this drug not be prescribed?

If you have had an allergic reaction to Accolate or to any of its ingredients,
avoid this drug.

Special warnings about this medication

While taking Accolate, you should not stop—or even cut down on—any
other asthma medication you are using unless your doctor recommends
it. Remember that Accolate is notan airway-opening medication. You will
still need an inhaler to stop an attack.
If you have been taking an oral steroid drug and your doctor does de-
 ACCOLATE/5

cide to cut back the dosage, there is a remote chance that complications
will follow. Inform your doctor of any new symptoms.
Also call your doctor if you develop any of the following: pain in the
upper right abdomen, nausea, fatigue, lethargy, loss of appetite, itching,
flu-like symptoms, or jaundice (yellowing of the skin and eyes). These are
signs of a'liver problem—^a rare side effect of Accolate that tends to de¬
velop more often in women. If tests showthe problem to be serious, you’ll
have to stop using the drug. The symptoms will disappear once you stop.

Possible food and drug interactions when taking this medication

A full stomach can reduce Accolate’s effectiveness. Do not take with
meals.
If Accolate is taken with certain other drugs, the effects of either could
be increased, decreased, or altered. It is especially important to check
with your doctor before combining Accolate with the following:

Aspirin (Ecotrin, Genuine Bayer, others)

Astemizole (Hismanal)
Blood-thinning drugs such as Coumadin
Carbamazepine (Tegretol)
Cyclosporine (Sandimmune, Neoral)
Erythromycin (E.E.S., E-Mycin, others)
Heart and blood pressure medications called calcium channel
blockers, including Calan, Cardizem, and Procardia
Phenytoin (Dilantin)
Terfenadine (Seldane)
Theophylline (Theo-Dur, others)
Tolbutamide (Orinase)

Special information if you are pregnant or breastfeeding

Accolate should be taken during pregnancy only if clearly needed". If you
are pregnant or plan to become pregnant, inform your doctor immedi¬
ately.
Accolate does find its way into breast milk and should not be taken by
nursing mothers.

Recommended dosage
ADULTS_
The usual dose for adults and children 12 years of age and over is 20 mil¬
ligrams twice a day.

CHILDREN _
The usual dose for children 5 to 11 years of age is 10 milligrams twice a
day. Safety and effectiveness in children under 5 years of age have not
been established.
6/AGCOLATE

Overdosage
Any medication taken in excess can have serious consequences. If you
suspect an overdose, seek medical attention immediately.

■ Symptoms of Accolate overdose may include:

Rash, upset stomach

AccilNeb See Proventil, page 1185.

ACCUPRIL
Pronounced: AK-you-prill
Generic name: Quinapril hydrochloride

Why is this drug prescribed?

Accupril is used in the treatment of high blood pressure. It can be taken
alone or in combination with a thiazide type of water pill such as
HydroDIURIL. Accupril is in a family of drugs known as ACE inhibitors. It
works by preventing a chemical in your blood called angiotensin I from
converting into a more potent form that increases salt and water retention
in your body. Accupril also enhances blood flow throughout your blood
vessels. Along with other drugs, Accupril is also prescribed in the treat¬
ment of congestive heart failure.

Most Important fact about this drug

You must take Accupril regularly for it to be effective. Since blood pres¬
sure declines gradually, it may be several weeks before you get the full
benefit of Accupril; and you must continue taking it even if you are feeling
well. Accupril does not cure high blood pressure; it merely keeps it under
control.

How should you take this medication?

You can take Accupril with or without meals.
Alcohol may increase the effect of Accupril, and could cause dizziness
or fainting. Avoid alcoholic beverages until you have checked with your
doctor.
Take Accupril exactly as prescribed, and see your doctor regularly to
make sure the drug is working properly, without unwanted side effects.
Do not stop taking this drug without first consulting your doctor.

■ If you miss a dose...

Take the forgotten dose as soon as you remember. However, if it is al¬
most time for your next dose, skip the one you missed and go back to
your regular schedule. Never try to catch up by doubling the dose.
■ Storage instructions...
Accupril can be stored at room temperature. Protect from light.
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