Q4.
Exophthalmos is commonly associated with:
a. Cretinism
b. Myxedema
c. Grave's disease
d. Hashimotos' thyroiditis
Q5. The cell of origin of meningioma is
a.Arachnoid
b.Dura
c. Pia
d. Choroid plexus
Q6. Which among the following cyst layers is the host reaction to Hydatid
cyst disease?
a. Endocyst
b. Ectocyst
c. Pericyst
d. Mesocyst
Q7. In IgA nephropathy the immune deposits are seen in:
a. Subepithelial region
b. Basement membrane
c. Subendothelial region
d. Mesangial region
Q8. Most common cause of Cushing syndrome is:
a. latrogenic corticosteroids
b. Adrenal adenoma
c. Adrenal carcinoma
d. Pituitary adenoma
Q9. Glucose content of cerebrospinal fluid (CSF) is unaltered in the following
type of meningitis:
a. Acute pyogenic meningitis
b. Acute viral meningitis
c. Cryptococcal meningitis
d. Tuberculous meningitis
Q10.
Hypofunction of the anterior pituitary results in the following EXCEPT
a. Sheehan syndrome
b. Pituitary dwarfism
c. Diabetes insipidus
d. Empty-sella syndrome
Q11.
The most common astrocytoma in children is:
a. Fibrillary
b. Pilocytic
c. Anaplastic
d. Glioblastoma multiforme
Q12.
Fungi in general can be identified by the following stains EXCEPT:
a. Silver methenamine
b. Giemsa
c. Mucicarmine
d. Periodic acid Schiff
Q13.
All of the following are pediatric malignant tumours EXCEPT:
a. Carcinoma lung
b. Acute lymphoblastic leukemia
c. Neuroblastoma
d. Rhabdomyosarcoma
Q14.
Which of the following organs have tumours in patients with MEN syndrome
type 1?
a. Adrenal, thyroid and parathyroid
b. Kidneys, adrenal and liver
Pituitary, parathyroid and pancreas
d. Parathyroid, pineal and pancreas
Q15.
Which among the following tumours rarely metastasizes to the brain?
a. Carcinoma lung
b. Carcinoma breast
c. Carcinoma prostate
d. Melanoma
Q16.
A 45-year-old gentleman presented to the emergency department with high
grade fever, chills and severe body aches since 1 day. His peripheral smear
showed anemia, leukocytosis and thrombocytopenia. Some of the RBCs
showed small ring forms, with occasional RBCs showing multiple rings in
them. On careful search, few banana-shaped gametocytes were also
identified. Which RBCs are preferentially involved in this disease?
A. Older RBCS
0
b. All stages of RBCS
c. Reticulocytes
e. None of the above
Q17.
An 11 month-old-male infant presented with failure to thrive. He has
experienced recurring infections and regression of neurological milestones
starting from the age of seven months. Two other siblings have died of a
similar illness. On examination, he is below the 5 th percentile for weight, his
heart and lung sounds are normal and hepatosplenomegaly is present. On
ophthalmoscopic exam there is a relative paleness of the retina compared
with the central macula (cherry red spot). Despite heroic care, the infant dies
at age of 15 months. At autopsy, lipid vacuolation of neurons is observed
with prominent lysosomes filled with whorled membranes on electron
microscopy. What is the most likely diagnosis?
A. Nieman Pick disease
b. Tay-Sachs disease
Gaucher’s disease
e. Hunter syndrome
Q18.
A 35-year-old man presented with whitish pale patches on his fingers, toes
and face. On examination, the patches were slightly depressed and
anaesthetic. Ulnar and median nerve thickening was also noted. On biopsy of
the skin lesion, many granulomas were found around neurovascular bundles,
along with Langhan’s giant cells. No Grenz zone or organisms were identified
on special stains. What is your most likely diagnosis?
f. Tuberculosis
g. Cat scratch disease
h. Tuberculoid leprosy
i. Cutaneous sarcoidosis
Q19.
A 19-year-old young adult presented with massive splenomegaly,
pancytopenia and bone pains. Bone marrow showed many large phagocytic
cells of size 60-80 microns with fibrillary type of cytoplasm resembling
crumpled tissue paper. The cells were positive with PAS stain.
Glucocerebrosidase activity was found to be reduced in the peripheral blood
leukocytes. What is your most likely diagnosis?
0
a. Tay-Sach’s disease
b. Glycogenoses
c. Gaucher’s disease
d. Niemann Pick disease
Q20.
A 3-year-old boy was brought to the OPD after his mother noticed abdominal
distension and passage of reddish urine, on and off since 5 days. On
examination, the child had pallor. A large mass was palpable in the right
lumbar region. CT abdomen revealed a large solid mass involving the right
kidney. Incision biopsy from the mass revealed a small round cell tumour
with triphasic appearance, containing small blastemal, immature epithelial
tubules and focal mesenchymal component. What is your most likely
diagnosis?
a. Renal cell carcinoma
b. Nephroblastoma
c. Teratoma
d. Triton tumour
Q21.
40 year old lady with an underlying thyroid disorder presented to the
casualty with fever, tachycardia, restlessness, sweating and confused state
of mind. What is the most likely diagnosis in this patient?
A. Myocardial infarction
3. Reidel’s thyroiditis
c. Sepsis
Thyroid storm
Q22.
A 60-year-old obese gentleman presented with abdominal mass and weight
loss since 3 weeks. On examination a large left-sided renal mass was
palpable. Investigations revealed hemoglobin of 19 gm/dl. Gross examination
of nephrectomy specimen showed a large tumour involving the upper renal
pole, and showing variegated cut surface. Microscopic examination showed
clear cells arranged in nests and acini, with areas of hemorrhage and
necrosis. Which among the following is the most likely site to which this
tumour can spread?
a. Skin
b. Brain
+
Lungs
c. Urinary bladder
Q23.
A 35-year-old gentleman presents to the emergency department with
complains of severe flank pain that radiates into his groin and is associated
with nausea and vomiting. He has also noticed blood in his urine. He has no
significant past medical history. His vital signs reveal a temperature of
99.7°F. Physical examination reveals costovertebral angle tenderness. Of the
following, what is the most likely diagnosis?
A. Nephrolithiasis
b. Aortic dissection
Acute prostatitis
d. Ruptured abdominal aortic aneurysm
Q24.
The following physical features are characteristic of which disease? Tall
stature, long fingers, lax ligaments, hyperextendible thumb, dolichocephaly,
bilateral subluxation of lens, mitral valve prolapse, kyphoscoliosis and
pigeon-breast deformity.
A. Down’s syndrome
+ Marfan syndrome
c. Ehler Danlos syndrome
e. Osteogenesis imperfecta
Q25.
A 35-year-old male presented with fever and signs of meningitis.
Seropositivity for HIV was detected.
CSF examination revealed high concentration of protein with few cells. Also
seen were scattered yeasts having thick mucoid capsules and showing
budding. What is your most likely diagnosis?
A. Tubercular meningitis
+1
b. Candidal meningitis
Cryptococcal meningitis
e. HIV-associated aseptic meningitis
