OB Comprehensive
OB Comprehensive
Signs of Ovulation
1. Mittelschmerz = mid-cycle pain (ovulation)
2. ↑BBT (sudden)
1. Dispermy + ovum = abnormal = partial H-
Luteal Phase (15-28) mole (paternal)
After ovulation, ↑LH + ↑Progesterone 2. Sperm + empty ovum = complete H-mole
(maternal)
Secretory: twisted and spongy o 40+ is at risk because follicles are
Day 15-26 = corpus luteum (↑Progesterone, damaged
↓Estrogen)
Pregestational post-ovulation pre-menstruation Multifetal Pregnancy
Dizygotic Twins (Fraternal twins; same/different
6-8 days after fertilization implantation (fundus) sex)
hCG production maintains corpus luteum for More common than monozygotic
the first trimester corpus luteum produces 2 Placentas + 2 bags of water = bigger
↑Estrogen ↑Progesterone (maintains endometrium uterus
= amenorrhea = pregnancy) Multiple ovulation
Taking ovulatory drug
Ischemic: vasoconstriction o Clomid: stimulates FSH & LH
Day 27-28 = corpus albicans (white) no o Could be a factor for complete H-
production of progesterone (to maintain mole
endometrial lining) in preparation for next menses
Monozygotic Twins (identical)
Related terminologies Only one ovum is present, splitting/division
Menarche (first menstruation) happens
9 y.o., 12-13 y.o., 17 y.o. Same sex, identical
Pregnancy is possible 2 years after Dichorionic Diamniotic
menarche o Splitting: 1st - 3rd day after
Dysmenorrhea (excessive menstrual pain) fertilization
Primary = idiopathic o 2 placentas, 2 BOW, 2 fetuses
Secondary = due to pelvic pathology Monochorionic Diamniotic
Endometriosis = growth of endometrium o Splitting: 4th - 7th day after
outside the uterus fertilization
Pain: sex, urination, menstruation o 1 placenta, 2 BOW, 2 fetuses
Amenorrhea (absence of menstruation) Monochorionic monoamniotic
Primary: menses have never occurred o Splitting: 8th - 13th day after
>17y.o.
fertilization
Secondary: previously menstrual bleeding
o 1 placenta, 1 BOW, 2 fetuses
has occurred
Conjoined twins
Regular cycles = 3 missed cycles
o Splitting: > 13 days after fertilization
Irregular cycles = 6 missed cycles
o Cleavage is incomplete
Metrorrhagia (bleeding in between menses)
Bleeding at irregular intervals o Rare
IUD / Depo Povera [injectable] / Implanon
[implant]
External version: abdominal manipulation to
change the presentation especially in cephalic-
breech fetuses
Trophobla
Amnio st
n
Complications of Multifetal Gestations
Pre-eclampsia
Polyhydramnios
Overdistension of uterus
o Uterine atony PPH
Prematurity and low birth weight
o < 37 weeks
o Low BW: < 2500g
o Very low BW: < 1500g
Postpartum hemorrhage
Malpresentation
Cord prolapse
Dystocia
o The number of fetuses and
malpresentation
o Shoulder: most common in GDM
Placenta previa Treat syphilis ASAP during 1st trimester =
Maternal anemia Benzathine Penicillin G
Structural abnormalities
Inner cell mass:
Fetal Growth Amnion (inner and thinner membrane)
4 to 40 weeks, 10 lunar months BOW and umbilical cord
20-36: pre-term o Facing the fetus
37-42: term Embryo fetus
40: full-term
>43 weeks: post-term Embryo (2-8 weeks): production of organogenesis
Age of viability: 20 weeks / 5 months (most critical stage)
Month 2
Head is large
o At birth: head is largest
o CC & AC: 31-33cm
Report if abnormal
The neural tube: brain, spinal cord and
other neural tissues in the CNS is well- Month 4
formed Quickening: 1st fetal movement felt by
Folic Acid to prevent neural tube defects multigravida (primi is for 5th month)
o B9, Folate Formed eyes ears nose
NTDs: anencephaly (no brain), spinal bifida Scalp hair develops
o Delivery via cesarean section FHT by Fetoscope
o Can be detected through
Lanugo begins to appear (fine hair =
amniocentesis
Alpha fetoprotein (16-20wks) warmth)
>20wks = false high Meconium in bowels (green, intestinal
result secretions, 1st stool)
Bloody tap = false o Day 1 newborn stool: dark green,
high result thick and tarry
↑= Neural tube defect o Day 2-3 transitional stool: watery
(may butas: AFP is
lumalabas) and thin, green
↓= Down syndrome o Day 4+ BF stool: yellow, soft, sweet-
External genitalia is formed smelling
Sonogram shows a gestational sac o Meconium staining: post-term is at
Pregnancy Diagnostic: 6 weeks risk, suffers from uteroplacental
End of the 2nd month insufficiency chronic hypoxia
o Fetus is 2.5cm, weighs 20g
meconium staining
Organogenesis is ongoing critical!
MS + pink skin = acute
Month 3 hypoxia
Pla-cen-ta is complete MS + green skin = chronic
FHT by electronic Doppler (10-12wks) hypoxia (post-term)
Sex is distinguishable by UTZ A sign of fetal distress except
Kidneys excrete urine = amniotic fluid in breech presentation
Fetus begins to swallow
Absence of meconium stools
Liver produces bile (green)
Circulatory system is working at birth:
Imperforate anus / no The skin is covered with vernix caseosa
anal opening o cheese-like substance responsible
o Check the for thermoregulation, a form of
urine for lubrication
greenish DO NOT REMOVE but spread!
characteristics A newborn’s temp only
(fistula) becomes stable after 6hrs
Hirschsprung’s o thick vernix and lanugo: pre-term
disease: NO peristalsis (compensatory mechanism for
(aganglionic) protection from hypothermia)
Cystic fibrosis: NO o thin vernix and lanugo: term
pancreatic enzyme o absent vernix and lanugo: post-term
hardened meconium Hearing is established (can stimulate fetal
By the end of 4th month, the fetus is about 6 movement)
inches long and weighs 55-120g. Fetus: 28-36cm. long, Weight: 780g
Month 7
Surfactant in the amniotic fluid
o Amniotic fluid = lung expansion
o Insufficient amount = fetal lung
Fetal Alcohol Syndrome has craniofacial deformity collapse
Body is less wrinkled
Hearing fully developed
Testes begin to descend in the scrotal sac
Thin retinal blood vessels (pre-term)
o Will constrict if exposed to ↑O2
retinopathy of prematurity
(retinopathy is reversible through
surgery)
Fetus is 35 to 38cm long, weight: 1200g
Daily counting of fetal movement increases
Month 5
Lanugo completely appears between 28-38 weeks (10-12 FMs/hr)
Quickening for Primigravida o Ways: eat / move / sounds /
FHT by ordinary STETHOSCOPE (Bell) massage
Bones hardening o Time: daytime hours active
Nipples appear over the mammary gland o Position: left-side / reclining
(pre-term babies have little areolas) o Rule: < 10 FMs in 1 hour = extend 1
Fetus actively swallows amniotic fluid: hour (only count the lacking
600mL/day numbers)
Age of Viability: survival is possible if at < 10 FMs in 2 hours =
least 500g BW REPORT (uteroplacental
End of 5th month: fetus 25cm long insufficiency)
Note: In women with a multifetal
Month 6 gestation, daily fetal movements are
Body well proportioned significantly increased.
Skin is red and wrinkled
At birth: Month 8 (& above focus: fetal weight gaining)
o Preterm: wrinkled skin 1st Tri: Organogenesis
o Term: smooth 2nd Tri: Fetal length
Subcu8taneous fats begin to deposit (brown
o Post-term: dry and desquamating
fats = heat insulators); pre-terms lack fat
(peeling) due to fetal malnutrition
depositions difficulty producing body
Eyebrows and eyelashes are well defined
heat at risk for hypothermia
Eyelids are open
Dexamethasone: 6mg IM
q12x2
Fetus: 42-48 cm. long, weight: 1800grams-
2700grams
Amniotic Fluid
Major sources of AF after 20 weeks: fetal
kidney
o In pre-term, fetus is at risk for Normal volume: 500 to 1000mL / 800 to
breech presentation 1200 mL
Lecithin and sphingomyelin ratio (L/S) is 2:1 o Assessed via ultrasound
= 35 weeks: mature lungs pH: 7 – 7.25 (neutral to slightly alkaline)
Presence of phosphatidyl glycerol (PG) o Nitrazine paper, a pH paper
confirms lung maturity (36 weeks) Yellow = acidic = urine
o Pre-terms are at risk for ARDS Blue/Green = alkaline = BOW
o Antenatal Corticosteroids to increase Normal color: clear
lung surfactant (will be prone to If BOW ruptures + unengaged head
infection) o At risk for cord prolapse
Betamethasone: 12mg IM o Check FHR (priority)
q24hx2 o Time of rupture
o Delivery within 24hrs risk for
infection
o If ruptures < 20 weeks = fetus is not
viable
If cord is exposed = cover with wet gauze
to prevent drying
o Dry cord atrophy of umbilical
vessels
o DO NOT re-insert
o Reposition: Trendelenburg, Knee-
Chest, Hands and knees, Sims
To decompress the cord
Push the head and
accompany the mother to the
OR
PIH Management
Criteria for home management:
Abnormal colors Blood pressure is less than 150/100,
Green proteinuria less than 1g/24 hours,
o Meconium staining Normal platelet count, and no fetal growth
Golden yellow byproduct: Bilirubin restrictions.
o Due to destruction of fetal RBCs /
Hospital care for Pre-Eclampsia. The woman is
Hemolytic disease
placed in bed rest
o Related to Rh Incompatibility
Rh(-) mother & Rh(+) fetus POSITION: left lateral recumbent (↑venous
Mgmt: RHOGAM/RhIg/Anti-D return)
Given 28 weeks, repeat 48-72 DIET: high protein (70-80g/day, to replace
hrs after delivery protein loss), moderate sodium (3g/day, for
Check indirect comb’s test electrolyte balance)
(mother’s blood) = result ROOM: dim and quiet, non-stimulating
should be negative (reduce visual and auditory stimulation)
Methods of Abortion
Medical termination
o Avoids an anesthesia
o More effective at earlier gestation
(49 days or less)
GDM first therapy: Diet (calory-deficit, 1800- o Mifepristone (Anti-Progesterone)
2400 calories/day) after 3 days Misoprostol (Cervical
If diet is inadequate: Insulin (safe) ripener, Prostaglandin)
Oral hypoglycemics are never used during Surgical Termination
pregnancy o Requires anesthesia
o >49 days
Perinatal Insulin Requirements (varies
o Suction evacuation (menstrual
throughout)
extraction)
1st tri: decreased (fetal organogenesis, brain
5-7 weeks after LMP
development, ↓appetite)
Prior to dilatation, Misoprostol is given to
2nd tri: increased (↑placental hormones =
ripen the cervix
insulin antagonist)
o Dilatation and curettage
3rd tri: increased
< 13 weeks
o By 36 weeks, insulin may be
o Dilatation and vacuum extraction
decreased because placental
Between 12-16 weeks
hormones are decreased
TYPES DESCRIPTION
Labor and delivery: decreased because we
THREATENED Possible loss/ foundation of all
need energy -Closed cervix types of abortions/
o Regular insulin IV (only) -Mild bleeding painless/ mild cramps/ mild
Immediate postpartum: rapid return to pre- bleeding/vaginal spotting/non-
pregnant levels tender uterus
o Due to the delivery of placenta No sex for 2 weeks / no lifting
NO antagonist heavy objects / bed rest until
Breastfeeding: decreased (to decrease bleeding subsides / observe for
increasing blood loss.
insulin dose)
INEVITABLE Imminent, loss cannot be
o Carbohydrates are needed for milk -Dilated cervix prevented, moderate bleeding. Mild
production -Moderate to painful uterine contractions,
bleeding membranes may rupture. No
Timing of birth passage of abortus yet.
Fetal lung maturity is delayed INCOMPLETE Some products are expelled,
-Dilated cervix severe bleeding due to retained d. Scarring of the fallopian tube due to
-Severe placenta complication
bleeding Dilatation and curettage
Most painful Classic Symptoms
COMPLETE All products are expelled from the BEFORE RUPTURE
-Closed/dilated uterus Lower and unilateral (one-side) abdominal
cervix Bleeding is not severe pain, amenorrhea, abnormal vaginal
(uterus contracts) bleeding on 6-8th week due to low
HABITUAL Recurrent (3 or more consecutive
progesterone
-Dilated cervix pregnancies have ended in
spontaneous abortion) Low HCG, estrogen, progesterone
SEPTIC Abortion complicated by infection: AFTER RUPTURE
incomplete abortion (foul smelling Deep, sharp, stabbing, unilateral, acute
vaginal discharge, fever) lower quadrant ABDOMINAL PAIN
MISSED Retention (dead fetus syndrome), Cullen’s sign: bluish navel /
-Closed cervix the fetus died before 20 weeks but
retained for 4 weeks or more.
hematoperitoneum / indicative of internal
HCG is negative bleeding
All signs of pregnancy Kehr’s sign: referred pain (pain radiating to
disappear shoulders) due to stimulation to phrenic
No FHT. Regression of Breast nerve (diaphragmatic nerve)
changes. No uterine growth. No
fetal movement.
Management
Unruptured Ectopic
Post-Abortion
Oral Methotrexate (Anti-Folic Acid): when HCG
Expect spotting for 2 weeks
becomes negative, followed by Leucovorin
Report heavy bleeding, and signs of
Pre-requisite
infection
1. Ectopic sac is < 3.5cm in diameter
Do not douche, no tampons
No lifting heavy objects in 3 days 2. Serum hCG levels < 5000mIU/mL
Menstruation will return after 6 weeks 3. Liver function test within normal levels,
normal kidney function, no evidence of
ECTOPIC PREGNANCY / TUBAL PREGNANCY thrombocytopenia
Any blastocyst implantation outside the 4. Hysterosalpingogram or Ultrasound is
uterus performed after the therapy
Common site: Ampulla of the fallopian tube
a. Tubal patency
TYPE DURATION Surgical Treatment for unruptured tubal pregnancy:
Ampullar 6-12 weeks Laparoscopic Salpingostomy
Isthmic 6-8 weeks Surgical Treatment for ruptured tubal pregnancy:
(narrowest, rupture Laparoscopic Salpingectomy (50% sterile)
the earliest)
Fimbriated 6-12 weeks HYDATIDIFORM MOLE/GESTATIONAL
Interstitial 12-14 weeks TROPHOBLASTIC PREGNANCY/MOLAR
PREGNANCY
-The chorionic villi develop into avascular
Risk Factors
transparent grapelike vesicles
Previous Pelvic Inflammatory Disease
-Does not last >20 weeks
o Due to scarring ovum cannot
-Cause: UNKNOWN
migrate
o Causes of PID: chlamydia,
Signs and Symptoms
gonorrhea, postpartum endometritis, Big uterus (rapid growth of trophoblastic
post-abortal uterine infections) clusters/vesicles)
Previous ectopic pregnancy, previous Snowstorm pattern in ultrasound
bilateral tubal ligation, previous tubal, No FHT
pelvic surgeries Excessive hCG (1-2 million IU)
Maternal smoking at the time of conception Hyperemesis gravidarum Met. Alkalosis
Hypertension before 20 weeks
Board Question o PIH develops after 20 weeks
Given Bella’s history of gonorrhea, which of the
Ovarian enlargement
flowing might contribute to her sterility?
Dark brown vaginal discharge
a. Infection of the cervix
Passage of clear fluid-filled vesicles
b. Infection of the uterus
o 16 weeks
c. Infection of the uterus and cervix
o G1, A1 -1st symptom: bloody show < 20 weeks (pinkish
vaginal discharge due to mixture of tuberculum
[white] and blood) = sign of cervical dilatation
-To detect: Transvaginal UTZ
Management
Cervical Cerclage
Performed at 12-14 weeks under regional
anesthesia
Success rate is 85-90%
Types of H-Mole Types
Partial H-Mole o Mc Donald: simple procedure
1 set of chromosomes of maternal in origin Hospitalized for 48hrs
and 2 sets of paternal in origin (Dispermy) Temporary - NSD
69, (XXX, YXX, YYX) Triploid karyotype o Shirodkar: complicated operation
Done if Mc Donald procedure
fails
Hospitalized for 5-7 days
May be left in place - CS
Removal of the cerclage: 37-38 weeks
NSD
After Cerclage
Position in modified/slight trendelenburg for
Complete H-Mole a few days to reduce pressure
A sperm fertilizes an EMPTY ovum Observe: rupture of membranes,
Androgenesis (duplication of paternal set) contraction, V/S, infections
o Ovum never participated No sex, no heavy lifting
46, Diploid karyotype No prolonged sitting and standing
20% risk for developing cancer (>90mins)
Prolonged Labor
Complications of Abruptio Placenta
Fetal distress
Prematurity
Uterine atony
Hemorrhage (bleeding in myometrium
uterus is very rigid)
Signs of True and False Labor
Couvelaire uterus / Uteroplacental apoplexy
CRITERIA TRUE LABOR FALSE
Infection LABOR
DIC CONTRACTIO 3 contractions in 10 Decreasi
N minutes. Regular ng and
Irregular
INTRAPARTAL PERIOD DISCOMFORT Starts from the back Confined
Real cause: UNKNOWN at the
abdomen
CERVIX with changes No
Dilated (active changes
phase) DILATATION: widening of
external os
Primi: 1cm/hr
Multi: 1.5 EFFACEMENT: thinning
cm/hr of the cervical canal.
-Primi: ED
-Multi: DE/sabay
Do IE q 4hrs +3, +4, +5 Crowning = 2nd stage of labor
only to
prevent
infection DECELERATION
WALKING Increases the pain Relieves
the
discomfo
rt
SHOW Increasing Decreasi
ng
Pinkish
discharge =
cervical
dilatation is
increasing
DURATION of Increasing Decreasi
contraction ng Do not check FHR during contractions =
FREQUENCY Increasing Decreasi false result
of contraction ng
INTENSITY of Increasing Decreasi CAUSES OF FETAL DISTRESS Fetal Hypoxia
contraction ng Prolonged cord compression
INTERVAL of Decreasing Increasin
Antepartal and intrapartal hemorrhage
contraction; g
in-between Preeclampsia and eclampsia
contractions Induction or augmentation of labor
Heart conditions complicating pregnancy
Tocolytic Agents and labor
-Muscle relaxant Hypotensive effects of anesthesia
-Use to halt/stop labor temporarily (48hrs) to
provide window for administration of antenatal SIGNS OF FETAL DISTRESS
corticosteroid (Betamethasone, Dexamethosone) Hyperactive fetus
-For preterm labor Fetal tachycardia and bradycardia
IT’S- Indomethacin Severe variable deceleration in electronic
o Least used fetal monitoring
o With fetal side effect (closes ductus Persistent late deceleration in electronic
arteriosus of the fetus) fetal monitoring
NOT- Nifedipine (Procardia) Meconium staining, except for breech
YET- Yutopar (Ritodrine) presentation
MY- MgSO4
TIME- Terbutaline (Brethine) COMPLICATIONS OF FETAL DISTRESS
Mental Retardation / Intellectual Disability
CONTRAINDICATIONS (new term)
1. Dilatation is more than 3 cm Seizures
2. Cardiac disease (rule: >115bpm = do not Cerebral palsy
give) Intrauterine Fetal Death
3. Fetal distress
4. Abruption placenta STAGES OF LABOR
5. PROM (BOW must be intact) 1st Stage of Labor / Cervical Dilatation Stage
6. Chorioamnionitis LATENT ACTIVE TRANSITIO
(6 hrs. (3 hrs. N
FETAL STATION / FETAL DESCENT for primi for
Relationship of presenting part to ischial spine 4.5 hrs. primi
for 2 hrs.
Most important criterion for walking
multi) for
multi) umbilicus