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What's Involved: Phosphodiester Bond Condensation Reaction

A phosphodiester bond is formed through a condensation reaction between two nucleotides, where the -OH group from the 3′ carbon of one nucleotide reacts with the phosphate group on the 5′ carbon of another, releasing a water molecule. This results in a strong sugar-phosphate backbone that links nucleotides together, with the chain growing by adding nucleotides to the 3′ end. The document emphasizes the strength of the covalent bonds in the backbone compared to the weaker hydrogen bonds between bases.

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17 views3 pages

What's Involved: Phosphodiester Bond Condensation Reaction

A phosphodiester bond is formed through a condensation reaction between two nucleotides, where the -OH group from the 3′ carbon of one nucleotide reacts with the phosphate group on the 5′ carbon of another, releasing a water molecule. This results in a strong sugar-phosphate backbone that links nucleotides together, with the chain growing by adding nucleotides to the 3′ end. The document emphasizes the strength of the covalent bonds in the backbone compared to the weaker hydrogen bonds between bases.

Uploaded by

gs20gs201232
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Exactly — you’ve nailed it 👌 A phosphodiester bond is formed by a condensation

reaction. Let’s break it down step by step:

1. What’s involved

●​ You have two nucleotides:​

○​ One nucleotide has a phosphate group on its 5′ carbon.​

○​ The other has a –OH group (hydroxyl) on its 3′ carbon (of the sugar).​

2. The reaction

●​ The –OH group from the 3′ carbon reacts with the –OH group on the phosphate of
the next nucleotide.​

●​ A molecule of water (H₂O) is released → this is why it’s called a condensation


reaction.​

●​ A strong covalent bond (the phosphodiester bond) is formed between the 3′ carbon
of one nucleotide and the phosphate on the 5′ carbon of the next.​

3. The result

●​ Nucleotides are linked together in a sugar–phosphate backbone.​

●​ This backbone is very strong (covalent bonds), unlike the weak hydrogen bonds
between bases.​

●​ The chain always grows by adding nucleotides to the 3′ end.​

✅ In summary:
●​ Yes → phosphodiester bonds form via a condensation reaction.​

●​ Water is removed.​
●​ The bond is between the phosphate group (5′ carbon) of one nucleotide and the
sugar (3′ carbon) of the next.​

Would you like me to draw the chemical reaction (nucleotide + nucleotide →


phosphodiester bond + water) so you can see exactly which groups react?

👌
Exactly — you’ve nailed it A phosphodiester bond is formed by a condensation
reaction. Let’s break it down step by step:

1. What’s involved

●​ You have two nucleotides:​

○​ One nucleotide has a phosphate group on its 5′ carbon.​

○​ The other has a –OH group (hydroxyl) on its 3′ carbon (of the sugar).​

2. The reaction

●​ The –OH group from the 3′ carbon reacts with the –OH group on the phosphate of
the next nucleotide.​

●​ A molecule of water (H₂O) is released → this is why it’s called a condensation


reaction.​

●​ A strong covalent bond (the phosphodiester bond) is formed between the 3′ carbon
of one nucleotide and the phosphate on the 5′ carbon of the next.​

3. The result

●​ Nucleotides are linked together in a sugar–phosphate backbone.​

●​ This backbone is very strong (covalent bonds), unlike the weak hydrogen bonds
between bases.​

●​ The chain always grows by adding nucleotides to the 3′ end.​


✅ In summary:
●​ Yes → phosphodiester bonds form via a condensation reaction.​

●​ Water is removed.​

●​ The bond is between the phosphate group (5′ carbon) of one nucleotide and the
sugar (3′ carbon) of the next.​

Would you like me to draw the chemical reaction (nucleotide + nucleotide →


phosphodiester bond + water) so you can see exactly which groups react?

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