Supplementary Training Modules on GMP
Air Handling Systems Heating Ventilation and Air Conditioning (HVAC) Part 2: Components
Module 3, Part 2: Components
Slide 1 of 20
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Air Handling Systems
Purpose of an air handling system
Air Handling System
Supply Air
Production Room With Defined Requirements
Outlet Air
Module 3, Part 2: Components
Slide 2 of 20
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Air Handling Systems
Objectives In the following slides, we will study the components of air handling systems in order to:
1.
2.
become familiar with the components
know their functions
3.
become aware of possible problems
Module 3, Part 2: Components
Slide 3 of 20
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Air Handling Systems
Main subsystems
Exhaust air treatment
Fresh air treatment (make-up air)
Terminal air treatment at production room level
Production Room Central air handling unit
Module 3, Part 2: Components
Slide 4 of 20
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Air Handling Systems
Overview components
Exhaust Air Grille
Silencer Flow rate controller Fan Filter
Weather louvre
Control damper Heater
+
Prefilter Humidifier Terminal filter
Heating coil
Cooling coil with droplet separator
Secondary Filter
Production Room
Re-circulated air
Module 3, Part 2: Components
Slide 5 of 20
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Air Handling Systems
Components (1)
Weather louvre Silencer Flow rate controller Control damper
To prevent insects, leaves, dirt and rain from entering To reduce noise caused by air circulation Automated adjustment of volume of air (night and day, pressure control) Fixed adjustment of volume of air
Module 3, Part 2: Components
Slide 6 of 20
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Air Handling Systems
Components (2)
Heating unit
Cooling unit /dehumidifier
To heat the air to the proper temperature
To cool the air to the required temperature or to remove moisture from the air
Humidifier
Filters Ducts
To bring the air to the proper humidity, if too low
To eliminate particles of pre-determined dimensions and/or micro-organisms To transport the air
Slide 7 of 20
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Module 3, Part 2: Components
Air Handling Systems
Problems with components
Flow rate controller
Control damper Humidifier Cooling battery Filters
Blocked
Poorly adjusted, bad pressure differential system Bad water/steam quality/poor drainage No elimination of condensed water/poor drainage Incorrect retention rate/damaged/badly installed
Ducts
Inappropriate material/internal insulator leaking
Module 3, Part 2: Components
Slide 8 of 20
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Air Handling Systems
Air types
Fresh air (make-up air)
Supply air
Exhaust air
Production Room
Return air (re-circulated)
Module 3, Part 2: Components
Slide 9 of 20
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Air Handling Systems
Comparing International Cleanroom Classifications
Particles / m3
0.5m 1 3,5 10 35 100 353 1.000 3.530 10.000 35.300 100.000 353.000 1.000.000 3.530.000 10.000.000
US 209D nonmetric
US 209E 1992 metric
EC cGMP Annex I 1997
Germany VDI 2083 1990 0
UK BS 5295 1989
Japan ISO 14644JIS B 9920 1 1989 2 3 4 2 3 4 5
1 10 100
M1 M 1.5 M2 M 2.5 M3 M 3.5 M4 M 4.5 M5 M 5.5 M6 M 6.5 M7
1 2 A, B
A= unidirectional B= turbulent
E or F
1.000 10.000 100.000
4 C D 5 6
G or H J K
6 7 8
6 7 8
Module 3, Part 2: Components
Slide 10 of 20
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Air Handling Systems
Filter classes
Standard Dust filters
Aerosol
Coarse
Dp > 10 m
Fine
10 m > Dp > 1 m
HEPA
Dp < 1 m
ULPA
G1 - G4
EN 779 Standard
F5 - F9
H 11 - 13
EN 1822 Standard
U 14- 17
Module 3, Part 2: Components
Slide 11 of 20
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Air Handling Systems
Classification of filters according to their efficiency
Average Efficiency Integral Value Retention in Penetration % 85 0.15 95 99.5 99.95 99.995 0.05 5x10 5x10 5x10
-3 -4 -5
Peak Arrestance Local Value Efficiency Penetration
F9 H11 H12 H13 U14
97.5 99.75 99.975
25x10 25x10 25x10
-3 -4 -5
Module 3, Part 2: Components
Slide 12 of 20
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Air Handling Systems
HEPA or tertiaary filter
Primary panel filter
Secondary filter
Module 3, Part 2: Components Slide 13 of 20
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Air Handling Systems
Humidifier Silencer Heating and cooling units
Module 3, Part 2: Components
Slide 14 of 20
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Air Handling Systems
Control damper for air flow
Humid room air Adsorber wheel Dry air
AHU with fan Variable Speed Controller
Regeneration air
Humid room air Air heater
Filter Pressure Gauges
De-humidification
Air handling unit
Slide 15 of 20
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Module 3, Part 2: Components
Air Handling Systems
1
2
3 4
1 2 3 4
Filter Swirl Tightening frame Register outlet Screw fixation for register
Type air diffusors with terminal filters
Slide 16 of 20
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Module 3, Part 2: Components
Air Handling Systems
High induction office type diffusor (avoid)
Module 3, Part 2: Components Slide 17 of 20
Low induction swirl diffusor (preferred)
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Air Handling Systems
Regulation of room pressure pressure differentials concept
Room pressure gauges Room pressure indication panel
Annex 1, 17.26
Module 3, Part 2: Components Slide 18 of 20
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Air Handling Systems
Pressure cascade injectables Protection from micro-organisms and particles
Room 1
30 Pa 60 Pa
Room 2 A LF
Room 3
45 Pa
D Air Lock
45 Pa
Air Lock B C
15 Pa 30 Pa
Passage
Air Lock
0 Pa
Annex 1, 17.24, 17.25
Note : Direction of door opening relative to room pressure
Module 3, Part 2: Components
Slide 19 of 20
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Air Handling Systems
Pressure cascade solids Protection from cross-contamination
Room 1
15 Pa
Room 2
15 Pa
Room 1
15 Pa
Room 3
15 Pa
Room 2
15 Pa
Room 3
15 Pa
Air Lock
Air Lock Air
30 Pa
Lock
E
0 Pa
Passage
15 Pa
Note : Direction of door opening relative to room pressure
Air Lock
Air Lock Air
30 Pa
Lock E Passage
15 Pa
0 Pa
Note : Direction of door opening relative to room pressure
Module 3, Part 2: Components
Slide 20 of 20
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