Thanks to visit codestin.com
Credit goes to www.scribd.com

Scribd
Upload
289 views11 pages

Duolin Inhalers: Rapid Symptom Relief

Duolin Forte offers a combination of levosalbutamol and ipratropium at higher doses than regular Duolin for more effective relief of respiratory symptoms. Studies show the 80 mcg dose of ipratropium in Duolin Forte provides significantly better bronchodilation and lung function improvement than the 40 mcg dose. Using ipratropium at its optimal 80 mcg dose in Duolin Forte may prolong the duration of bronchodilation and maximize its potential bronchodilating effects.

Uploaded by

Aditya Rounak
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
289 views11 pages

Duolin Inhalers: Rapid Symptom Relief

Duolin Forte offers a combination of levosalbutamol and ipratropium at higher doses than regular Duolin for more effective relief of respiratory symptoms. Studies show the 80 mcg dose of ipratropium in Duolin Forte provides significantly better bronchodilation and lung function improvement than the 40 mcg dose. Using ipratropium at its optimal 80 mcg dose in Duolin Forte may prolong the duration of bronchodilation and maximize its potential bronchodilating effects.

Uploaded by

Aditya Rounak
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 11

Duolin

Team 2
Brand Personality

Brand Name: duolin


Year of Launch: 2001, February
Available as: Duolin Inhaler/ Rotacaps/Forte Rotacaps/ Forte Inhaler
By-line for the brand: Rapid Relief from Symptoms
Price and Composition:

No. Name of Brand Composition Dosage Pack MRP


1 Duolin Inhaler Levosalbutamol 50 mcg + Ipratropium 20 mcg 2 puff Q.I.D 200 MD 281.93
2 Duolin Forte Inhaler Levosalbutamol 50 mcg + Ipratropium 40 mcg 2 Puff T.I.D 200 MD 357.0

3 Duolin Rotacap Levosalbutamol 100 mcg + Ipratropium 40 mcg 1-2 Rotacap Q.I.D 200 MD 77.59

4 Duolin Forte Rotacap Levosalbutamol 100 mcg + Ipratropium 80 mcg 1 Rotacap T.I.D 30’s 136.29
Duolin
A combination of Levosalbutamol (ß2 agonist) and Ipratropium
(anticholinergic)

Levosalbutamol Ipratropium
0.8 – 2 min 5-15 mins
Onset of Action

Peak Response 30 minutes 1.5- 2 hours

Duration of Action 6-8 hours * 6-8 hours *

*As mentioned in GOLD 2019


Mode of Action
Levosalbutamol Ipratropium

Sympathetic Nervous Parasympathetic


System Nervous System

Blocks muscarinic
Stimulates ß2 receptors receptors

Prevents
Causes bronchodilation
bronchoconstriction

Prevents airways
Open up airways
from closing

ß2 agonists and anticholinergic achieve bronchodilation by different means,


using the sympathetic and parasympathetic nervous systems respectively
Total Lung Coverage: Deposits in Both Small and Large Airways

Ipratropium Levosalbutamol
Large Airways Small Airways
Why Combination Bronchodilators?
Offers better symptom control & improvement in lung function

1
Why Combination Bronchodilators?
Offers better symptom control & improvement in lung function

Percentage of patients with exacerbations


1 20%
18%
16%
14%
12%
10% Combination
8%
Salbutamol
6%
4%
2%
0%
Combination Salbutamol

• 85 day study, 347 patients received salbutamol, 358 received ipratropium + salbutamol combination

Chest 1999; 115:635-641


Dose response of ipratropium bromide

Objective -- To assess both the peak bronchodilation and the duration of the response, and the dose-response relationships of ipratropium

20 male patients Groups---


Randomised, double-
blind, placebo- Asthmatic 40 mcg ipratropium Efficacy end-points
controlled, parallel- Mean age 65 yrs 80 mcg ipratropium Mean change in FEV1
group study 4 days using MDls

FEV1 (Increase from baseline)

Conclusion : 80mcg 40%


35%
30% 28%
34%

Ipratropium shows 34%


25%
20%
15%
rise in FEV1 from baseline 10%
5%
0%
40 mcg 80 mcg

40 mcg 80 mcg

FEV1 – Forced expiratory volume in 1 sec FVC – Forced vital capacity Thorax, 1979, 34, 137-139
• 80 mcg Ipratropium offers better symptom control and
improvement in lung function
• 80 mcg Ipratropium may prolong the duration of
Summary: bronchodilatation
Duolin Fort • 80 mcg Ipratropium can also be used to optimize its
potential bronchodilating effects
• Significant bronchodilation with optimal doses might translate
into increased exercise capacity
• TID dosing of Duolin Forte Vs QID dosing of Duolin may offer
better patient compliance
Thanks

You might also like