Dose calculation
CONTINUE
Example
How many grams of codiene phosphate and
ammonium chloride will be contained in each dose ?
Rx
Codeine phosphate 0.6 g
Ammonium chloride 6 g
Cherry syrup 120 ml
Sig : Teaspoonful for cough
solution
1 teaspoonful = 5ml .
0.6 g 120 ml
X 5 ml
X = 0.025 g of codiene
6 120 ml
Y 5 ml
Y = 0.25 g of ammonium chloride
There is another solution !!
Example
How many grams of a drug substance are required to
make 120 ml of solution each teaspoonful of which
will contain 3 mg of the drug substance ?
5 ml 3 mg
12o ml X X= 72 mg = 0.72 g
Example
The usual initial dose of chromabucil is 150 ug per kg of
body weight once a day.
How many milligrams should be administered to a person
weighing 154 Ib ?
1 kg 2.2 Ib
X 154 Ib X= 70 kg
150 ug = 0.15 mg
1kg 0.15 mg
70 kg Y Y= 10.5 mg
Calculation of doses for children
Young’s Rule (based on age )
Cowling’s Rule (based on age )
Fried’s Rule ( for infants)
Clark’s Rule ( based on weight )
Examples on Young’s
If the usual dose of phenobarbital is 15 mg . What’s
the dose for a child 8 years old ?
Answer = 6 mg
If the usual adult dose of an injection is 0.1 ml ,
what’s the dose for a child 12 years old ?
Answer = 0.05 ml
Examples on Clark’s
If the usual dose of a drug is 3 gr . What is the dose
expressed in a fraction of a grain , for a child
weighing 40 Ib ?
Answer = 4/5 gr.
Cough syrup
EXPECTORANT MIXTURE
Syrup
Rx
Ammonium chloride 4g
Liquid extract of liquorice 5 ml
Simple syrup 50 ml
Water q.s. 100ml
Fiat : cough syrup
Sig. : 5ml T.d.s.
Term Meaning
m.d.u. To be taken as directed .
t.d.s. To be taken three times daily.
b.d.s. To be taken two times daily.
q.d.s. To be taken four times daily .
q.n. Every night.
q.h. Every hour.
q.d. Every day.
