Science 2.0

Actors, artists, and musicians are rightly worried about the impact of AI on their incomes but doctors and scientists welcome the help. They know typewriters didn't make literature worse than writing in longhand and "AI" - LLMs - likewise removes the 'how' of information access so thinkers can get to the 'why.'

In modern government-controlled healthcare, doctors are more pressed for time per patient than ever. Often while relying on incomplete information. Electronic health records contain vast amounts of patient data but much of it remains difficult to interpret quickly, and that is even more challenging for patients with rare diseases or unusual symptoms.

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In the early days of Science 2.0, blogging did not get a lot of institutional respect. Public outreach was a waste of time, academics were often told, leave that to science journalists and the PIOs at schools who write press releases.

It seemed archaic. Anyone who knows how much of science is government-funded, about a third of basic research, knows that means it is political. Which means you cannot and should not let someone else write your narrative. It's too easy to manipulate. A decade ago, when a group wrote to Columbia University and asked them to remove Dr. Oz from the faculty because of his claims about supplements and that medicine was a corporate conspiracy, he got allies in corporate journalism to dismiss us as Big Pharma shills.(1)

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Due to President Clinton's 1994 DSHEA law (Dietary Supplement Health and Education Act of 1994), and diverting science funding to the National Center for Complementary and Alternative Medicine, a large number of people believe acupuncture works and that supplements can be alternatives to medicine.

Acupuncture is the placebo effect but some natural products can work - the problem is that if they work they may do something bad. Kratom is an example of a product banned in countries that grow it; unless it is for export to the United States. They know that it works, and also that it can kill Godzilla.

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From Los Angeles to Portland to New York City, political protests have become common. That provides data for what may be happening in brains and how engaged people can avoid becoming a Tyler Robinson or Luigi Mangione or Antifa in Oregon.

The US is not special when it comes to protests, the Carnegie Endowment for International Peace says there have been over 140 mass demonstrations globally in the past year, with 30 ongoing.

A new paper(1) says  up to 80% of activists experience moderate to severe anxiety or depression. Are they protesting because they are anxious or are they anxious because they spend time in a group of protesters? 

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When you picture a black hole, you probably picture in the center of a galaxy with matter swirling toward it. You're not wrong but that is why the exception proves the rule.

A recent study detected a surprising tidal disruption event where a black hole outside the center of a galaxy is tearing apart a star. Even stranger and defiance of black hole lore, the delayed and powerful radio outbursts suggest previously unknown processes in how black holes eject material over time. Designated AT 2024tvd, it is to-date the fastest-evolving radio emission ever observed from a black-hole-driven stellar disruption.

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The process by which the nervous system continuously receives and interprets the body’s physiological signals to keep vital functions running smoothly, a "sixth sense" called interoception that tells your brain when you need to breathe, when your blood pressure declines or when you have an infection, is getting some star power; a Nobel laureate neuroscientist,

And an NIH grant.

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A cross-sectional analysis of emergency Medicaid expenditures from data in the 2022 Medicaid Budget and Expenditure System found that of the 38 states plus Washington, DC, was nominal compared to overall spending.

There are confounders. Not all states allow it and 11 did not report emergency Medicaid spending on illegal immigrants and some, like California, now give health care for free to anyone regardless of their legal status, which means the $9 billion on emergency room care for illegal immigrants in 2024 is 70% due to that one state. Total Medicaid costs for illegal immigrants during 2021-2024 were $16 billion but this paper did not include other public spending.

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Everybody wonders what will happen with artificial intelligence (AI). Truly, it could go in any of several ways. This column lays out possible scenarios.

Scenario-building is usually a group activity, however. So I invite your views on the driving forces and possible additional scenarios.

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The next time someone tries to tell you ancient folk medicine was equivalent to modern science, remind them that people once consumed other humans as part of legal trade. Apothecaries sold powdered mummies, or at least what they claimed were powdered mummies, because of belief in medical cannibalism and that it cured everything from headaches to the plague.

Take that, antibiotics, your job could have been done by ground-up skulls.

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Samhain, All Hallows Evening. Hallowe'en, Halloween. The name has changed but the world’s fascination with a day of spooks and scares has never wavered. Except it has also always been about harvests and farming and food.

It may seem odd to lump together food and ghosts but that is Halloween in a cultural nutshell; a confusing mash-up of cultures and beliefs. That is actually a good thing. It is evidence for how creating melting pots of people who become one community is better than a salad bowl where no one wants to include outside groups in their customs.

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In 1956, prize-winning puppeteer Shari Lewis appeared on the Captain Kangaroo children's show and debuted a new...well, it was basically a sock with eyes.(1) She called it Lamb Chop, though, and her ventriloquism was a big hit with kids.

Imagine what she would think if she knew Lamb Chop toys were a big hit with dogs.

It's a science mystery why, but dogs love them. Dogs who like to cuddle are obsessed with it, as are dogs who want to destroy things. They like the squeaks, the softs, and perhaps that it almost resembles an animal. Dogs get obsessive-compulsive a lot, according to a new paper.

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Are kids walking at night on Halloween safe? What's the physics of ghosts? How many toxic chemicals are in that organic pumpkin I bought? Is there a Secret Sadist out there putting razor blades in candy?

You can find out the answers to all those questions and more in Halloween Science 2.0. It covers the history of the holiday, of course, this is Science 2.0, not a textbook, through the lens of biology, anthropology and more!

Conventional genetic analysis methods for genotyping of brain tumors usually require one or two days to obtain results but a new method can determine optimal resection margins during surgery in just a few minutes.

The ability to accurately detect genetic mutations in a brain tumor was demonstrated with isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase (TERT) promoters, which are markers for diagnosis of diffuse glioma—the most common type of brain tumor. Their system uses a Polymerase Chain Reaction device in combination with their own protocol and it enables DNA extraction using only heat incubation. 

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With this post I would like to present a short update of my personal life to the few readers who are interested in that topic. You know, when I started writing online (over 20 years ago!), blogs used to contain a much more personal, sometimes introspective, description of the owner's private life and actions. Since long, they have been substituted by much more agile, quick-to-consume videos. But the old-fashioned bloggers who stuck with that medium continue to have a life - albeit certainly a less glamorous one than that of today's influencers; so some reporting of personal affairs is not out of place here. 

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A recent study found the first evidence that sperm microRNAs act as carriers of epigenetic information, enabling the intergenerational transmission of paternal exercise capacity and metabolic health, thereby exerting profound effects on offspring development.

The bad news if you want an excuse for your poor fitness is this is epigenetics and only in mice, which means it is only EXPLORATORY. Mice are not little people and epigenetics lacks the same biological foundation as actual evolution and genetics.

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A new cross-sectional analysis estimates that asthma inhalers contribute the same carbon emissions as 530,000 cars each year. That's over over 2 million metric tons of greenhouse gases annually from the three types of inhalers approved for asthma or COPD during the years 2014 to 2024. 

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Surely you’ve noticed that many countries are subsidizing births – and others are banning abortions – even as tech lords lament the number of “useless people” in the world. You’ve noted the contradiction, and you’ve asked yourself, “What’s going on here?” Cool Hand Luke might say, “What we have here is a failure (of the two factions) to communicate.”

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We definitely need to DOGE nonsense like acupuncture out of the NIH and use that money for science but I don't want to live in a culture where children's theater doesn't want to have a play about "the ups-and-downs of a lovesick zombie who can’t find a date inthe land of the living."

It may not sound all that kid-friendly but this was a children's theater in Oregon and a stroll down any street in Portland exposes children to a lot worse things than lonely zombies.

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Information freedom is a good thing but there is no question it has been weaponized. Many scientists have been ruined by activists and their trade groups who use Freedom of Information Act rules to find a sentence in correspondence with corporations or trade groups, remove it from context, and claim science is a corporate conspiracy. Then they publish it thanks to politically aligned schools like UC San Fransisco, where Tracey Woodruff, PhD, MPH, will help any attorney wanting to sue companies.

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Ιf you asked a multilingual friend which language they find more emotional, the answer would usually be their mother tongue – the one they used while growing up and probably still use at home. This does not mean they are incapable of expressing emotion in another language, but there is a clear link between first languages and stronger emotional expression.

This has a lot to do with where and how we learn a language. Our first language, which linguists call L1, is usually acquired in the emotionally charged settings of childhood and family. Second languages, known as L2, are often learned in more neutral contexts, such as schools and institutions, making them less emotionally intense.

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