Cristina Sena, PhD, University of Coimbra, Portugal
Cardiovascular Diabetology is calling for submissions to our Collection on Perivascular adipose tissue: friend or foe in cardiometabolic disorders.
Image credit: Cristina Sena
This Collection supports and amplifies research related to SDG 3: Good health and well-being.
Plozasiran (VSA001, ARO-APOC3) is an RNA interference therapy that targets Apolipoprotein C3 (APOC3), a key regulator of lipoprotein metabolism. The study aimed at assessing the safety, tolerability, pharmacok...
Pericoronary adipose tissue (PCAT) radiomics derived from coronary computed tomography angiography (CCTA) for predicting major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS...
Diabetic cardiomyopathy (DCM) is a prevalent complication in diabetic patients, and its pathogenic mechanism involves multiple endocrine and metabolic factors, with dyslipidemia playing a pivotal role in the p...
Epicardial adipose tissue volume (EATV) has been linked to cardiac dysfunction in metabolic syndrome (MetS), but the underlying mechanisms remain unclear. The aim of this study was to investigate whether myoca...
Aging is associated with adipose tissue alterations, oxidative stress, and fibrosis and the onset of cardiometabolic complications. While it has been shown that perivascular adipose tissue (PVAT) contributes t...
Perivascular adipose tissue (PVAT) is a unique and metabolically active adipose tissue that is adjacent to most systemic blood vessels. Healthy PVAT exerts anticontractile and anti-inflammatory effects, contri...
Thoracic aortic aneurysm (TAA) is a life-threatening disease with high morbidity and mortality rates due to fatal complications such as aortic rupture. However, molecular mechanisms underlying TAA pathogenesis...
Epicardial adipose tissue (EAT) comprises three distinct lipid components, each exerting differential effects on cardiovascular diseases. During disease progression, dynamic alterations in lipid composition an...
Pericoronary adipose tissue attenuation (PCATa), derived from coronary computed tomography angiography (CCTA), is a novel marker of inflammation in the coronary arteries. Patients with type 2 diabetes mellitus...
The stress hyperglycemia ratio (SHR) is an emerging biomarker used to assess blood glucose levels under acute stress conditions and has been linked to the incidence of adverse clinical outcomes. However, the p...
Obesity, a major risk factor for cardiovascular disease (CVD), is associated with hypertension and vascular dysfunction. Perivascular adipose tissue (PVAT), a metabolically active tissue surrounding blood vess...
Perivascular adipose tissue (PVAT) is a dynamic tissue that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, and vascular disease is complex and pla...
This study aimed to explore the correlation between radiomics features of pericoronary adipose tissue (PCAT) and gene expression in patients with coronary artery disease (CAD), with the goal of identifying nov...
The aim of this study (EPIDIAB) was to assess the relationship between epicardial adipose tissue (EAT) and the micro and macrovascular complications (MVC) of type 2 diabetes (T2D).
Cardiovascular Diabetology is calling for submissions to our Collection on Perivascular adipose tissue: friend or foe in cardiometabolic disorders. Perivascular adipose tissue (PVAT) has been identified as a key mediator in the maintenance of vascular homeostasis since the groundbreaking work of Soltis and Cassis (1991). PVAT present in the majority of blood vessels throughout the body (with the exception of cerebral and pulmonary arteries), demonstrates regional variations and heterogeneity along the vascular network. Furthermore, PVAT comprises diverse cell types beyond adipocytes. The interconnection between PVAT and blood vessel wall cells is vital for normal vascular function. Recently considered a biomarker and target in pathologic conditions such as atherosclerosis PVAT changes its phenotype under pathologic conditions such as obesity and diabetes. Aging is another factor that modifies this tissue.
Hence, the aims of this collection are to highlight:
1) The importance of PVAT in cardiovascular disease, whether in the presence or absence of diabetes.
2) The involvement of PVAT and its heightened impact on arterial stiffness during aging and various diseases.
3) The translational potential of PVAT as an innovative therapeutic target in clinical contexts.
For this collection, papers on diabetes, cardiovascular disease, aging, perivascular adipose tissue, obesity, arterial stiffness, gut microbiome, hypercholesterolemia, cholesterol, heart failure, exercise, nutraceuticals, diet, ketogenic diet, oxidative stress, and inflammation are welcome. Along these lines reinforcing the role and mechanisms of PVAT in cardiometabolic diseases is imperative and will help to explain heterogeneity in different vascular beds.
Furthermore, exploration into the impact of perivascular adipose tissue (PVAT) on arterial stiffening remains in its early stages, providing limited understanding of this aspect of arterial health. Studies conducted on aging, obesity, and heart failure in preclinical models have directly shown that PVAT promotes or contributes to arterial stiffness. These findings also offer preliminary insights into potential novel targets for intervention. However, there are few interventions that effectively modify the PVAT phenotype to reduce arterial stiffness. A practical approach to bridging preclinical discoveries with clinical applications and establishing PVAT as a therapeutic target for arterial de-stiffening and overall arterial health involves utilizing clinical imaging techniques. For this collection all types of articles are welcome (research articles, commentaries, review articles…).
This Collection welcomes submission of research articles, commentaries, review articles etc. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal.
Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Perivascular adipose tissue: friend or foe in cardiometabolic disorders" under the “Details” tab during the submission stage.
Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.
The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.