Gene regulation articles from across Nature Portfolio

We show that alternative DNA structures, called G-quadruplexes, behave as elements of eukaryotic promoters. Our data suggest that they function to support intrinsic nucleosome exclusion and to facilitate transcriptional pause release by RNA polymerase II.

A newly uncovered mechanism shows how a single transposable element of retroviral origin can adopt the expression pattern of a neighboring gene. This leads to the production of viral-like particles that disrupt organ formation when epigenetic silencing is compromised.

This Perspective proposes a human rights-based governance framework for cross-border genomic data sharing, addressing limitations of data sovereignty approaches while balancing privacy, security and global research collaboration.

CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.

Integrative multi-omics analysis revealed potential key genes and their regulatory mechanisms underlying milk composition traits.

Engineering genetic circuits to control gene expression in response to complex signal inputs remains a challenge due to limited precision. This study introduces operational amplifiers that decode complex signals, enabling scalable dynamic regulation and resolving multi-channel crosstalk.

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and single cells, and apply it to assess changes in TF activity in SCLC tumours following chemotherapy.

We show that alternative DNA structures, called G-quadruplexes, behave as elements of eukaryotic promoters. Our data suggest that they function to support intrinsic nucleosome exclusion and to facilitate transcriptional pause release by RNA polymerase II.

Samira Musah highlights a recent study by Ward et al., who generated isogenic human induced pluripotent stem cell lines to analyse the transcriptional and epigenetic effects of SMAD2 variants identified in patients with congenital heart disease.

A newly uncovered mechanism shows how a single transposable element of retroviral origin can adopt the expression pattern of a neighboring gene. This leads to the production of viral-like particles that disrupt organ formation when epigenetic silencing is compromised.

We created a population-scale functional genomic dataset that maps whole blood regulatory variation in three South African groups. This resource supports the interpretation of genome-wide association studies in African-ancestry individuals, enabling translation to actionable discoveries.