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Clinical and molecular landscape of breast cancer in women of African and South Asian ancestry

An evaluation of genetic ancestry effects in African and South Asian breast cancer patients, compared to European ancestry patients, reveals disparities in diagnosis, mortality, and tumour grade.

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    Our editors highlight articles they see as particularly interesting or important in these new pages spanning all research areas.

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    This Nature Conference examines how energy metabolism in the brain impacts neurological function and disease. Over 20 leading experts investigating brain metabolism across multiple disciplines will convene to share findings and exchange ideas that are advancing this critical field.  Join us at the KAUST campus in Saudi Arabia December 3–5, 2025. The call for abstracts ends October 3, 2025.

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    This Nature Conference, held in Nanjing in October 2025, explores how the integration of AI with biological sciences unlocks immense potential for groundbreaking discoveries. It will cover multi-modal data mining, protein engineering, molecular and cellular engineering, large language models, foundation models for understanding complex biological systems and diseases, and the emergence of life.

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  • Here the authors analyse rare coding variants to identify schizophrenia risk genes. Associations are reported at exome-wide significance for STAG1 and ZNF136, and at a false discovery rate of 5% for SLC6A1, PCLO, ZMYND11, BSCL2, KLC1 and CGREF1.

    • Sophie L. Chick
    • Peter Holmans
    • Elliott Rees
    ArticleOpen Access
  • Portable robots may assist subjects with disabilities. However, upper limb movements are hard to fine-tune. Here, the authors design a personalized AI intention detection model to decode user’s motion intention from IMU and compression sensors.

    • James Arnold
    • Prabhat Pathak
    • Conor J. Walsh
    ArticleOpen Access
  • Triple-negative breast cancer immunotherapeutic efficacy is greatly affected by oxidative imbalance within the lymph nodes, driving dendritic cell dysfunction. Here, this group presents a chimeric exosome-derived immunomodulator involving ROS scavenger mesoporous silica and lipid modulator toyocamycin coated with dendritic cell-derived exosomes to restore the lymph node immuno-microenvironment in triple-negative breast cancer.

    • Mengchi Sun
    • Yuxia Wu
    • Qiuhua Luo
    ArticleOpen Access

Subjects within Health sciences

  • Horses have lived in Iberia since the Ice Age. Using ancient genomes to study their history, Lira Garrido et al. reveal a local wild lineage lasting until Late Iron Age, and highlight the far-reaching influence of Iberian bloodlines across Europe and north Africa during the Iron Age and beyond.

    • Jaime Lira Garrido
    • Gaétan Tressières
    • Ludovic Orlando
    ArticleOpen Access
  • Seed separation ensures only high-quality seeds are used in agriculture. Here, authors present a low-cost system using ultrasonic phased arrays to manipulate, and eject seeds based on characteristics like size and colour, enabling precise, flexible, and contactless sorting.

    • James Hardwick
    • Zak Morgan
    • Ryuji Hirayama
    ArticleOpen Access
  • A cross-national survey in Latin America finds that emotional responses strongly predict climate risk perceptions. Unlike high-income countries, political ideology and socio-demographics have weak effects, suggesting opportunities for cross-party climate collaboration.

    • Guilherme N. Fasolin
    • Matias Spektor
    • Juliana Camargo
    ArticleOpen Access
  • Reducing the size of the nanopesticide delivery system could improve pesticidal efficacy, but achieving unimolecular-sized nanosystems in a water-based process remains challenging. Here, the authors develop a water-based unimolecular platform that enhances cellular uptake, insect-dermis and leaf-cuticle penetration of pesticide, leading to improved field control efficacy against multiple pests.

    • Xingye Li
    • Xinyue Wang
    • Yan Wang
    ArticleOpen Access

Subjects within Scientific community and society

  • We introduce a framework for the design of photonic integrated laser sources for FMCW LiDAR, evaluating trade-offs in key laser metrics such as linewidth, chirp linearity and rate, based on laser-system co-design metrics. We review the main performance requirements for mid-range applications, with the goal of guiding ongoing research and commercial development.

    • Simone Bianconi
    • Pol Ribes-Pleguezuelo
    • Fabrizio Silvestri
    CommentOpen Access
  • The Arctic winters are changing fast. In February 2025, Svalbard endured rain, thawing tundra, and pooling meltwater. The Comment by Bradley and coauthors describes how winter warming is reshaping polar ecosystems—and why this resembles the new Arctic.

    • James A. Bradley
    • Laura Molares Moncayo
    • Donato Giovannelli
    CommentOpen Access
  • Ecologically Unequal Exchange (EUE) theory reframes trade as asymmetric transfers of biophysical resources from South to North, rejecting monetary value metrics. It challenges both mainstream and Marxian economics by emphasizing material flows over money-based interpretations of global inequality.

    • Alf Hornborg
    CommentOpen Access
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Biotechnology and methods

Papers highlighted here represent a snapshot of some of the recent exciting work published in the area of bioengineering, genome engineering, metabolic engineering, synthetic biology, system and computational biology, cellular biotechnology and imaging, and therapeutic biotechnology.
  • Chuanfu An, Ross Cloney, Cara Eldridge, Philip Lössl, Aline Lueckgen, Doaa Megahed, Anne Mirabella and Lorenzo Righetto
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