Research articles

Allergic inflammation is linked to asthma immunopathology and disease onset. Here the authors explore the use of a mucosal vaccine and show reduced immunopathology and asthma prevention in a murine model of allergic airway disease.

Voltage sensors in hERG potassium channels regulate heartbeat, and their mutations can cause arrhythmias. Here, authors combine fluorescence lifetime imaging and computational modeling to reveal impaired sensor movements in disease, uncovering a detailed structural mechanism.

Here, the authors show that task-focused brain activity builds on background activity during rest, supporting the Active Cortex Model—the idea that the brain is surprisingly always active, and tasks boost specific resting processes.

Madruga and colleagues present an open-source, miniature 2-photon microscope that can fit on a mouse’s head. Using this system, the authors perform high-resolution brain activity measurements in fine neuronal structures, which they can achieve even in conditions where the mouse is freely-moving within its cage.

Lightweight electromagnetic shielding materials are of interest, though it is challenging to balance performance and processability with conventional materials. Here, the authors report, an ordered melanin-like polymer, using π–π stacking, for a microwave shielding material.

Non-Abelian integrated photonics exploits the non-Abelian holonomy principle, giving rise to robust and broadband on-chip photonic devices. Here, authors propose a reconfigurable non-Abelian photonic chip where the non-Abelian functionality can be reprogrammed by employing the thermal-optic effect.

The authors present a frequency-adjustable ferroelectric heterojunction based on K_0.5Na_0.5NbO₃ piezoelectric ceramic, which enabling therapeutic effects in a myocardial infarction animal model by long-term and high-precision transcranial neuromodulation.

Multipolarons provide a potential platform for manipulating electrons. Here, the authors demonstrate the creation and manipulation of multipolarons in CrBr₃ via the tip of a scanning tunneling microscope.

Portable robots may assist subjects with disabilities. However, upper limb movements are hard to fine-tune. Here, the authors design a personalized AI intention detection model to decode user’s motion intention from IMU and compression sensors.

The present main-stream medical ultrasonic nebulizers contain a usually overlooked health risk of lead exposure as their key components are made of lead-containing piezoceramics. Here the authors introduce a lead-free medical ultrasonic nebulizer, which eliminates lead exposure risk in nebulization therapy and offers a healthy solution for patients.

In the pre-synapse, vesicle fusion is a key process for neurotransmitter release in the nervous system. Here authors demonstrate under pathological condition, synaptotagmin1 with Zn²⁺ adopts an alternative mode to regulate spontaneous neurotransmitter release.

Triple-negative breast cancer immunotherapeutic efficacy is greatly affected by oxidative imbalance within the lymph nodes, driving dendritic cell dysfunction. Here, this group presents a chimeric exosome-derived immunomodulator involving ROS scavenger mesoporous silica and lipid modulator toyocamycin coated with dendritic cell-derived exosomes to restore the lymph node immuno-microenvironment in triple-negative breast cancer.

This study presents BERT, an algorithm for high-performance integration of incomplete omics data with robustness to unequal phenotype distribution. It validates the method on simulated and experimental data from proteomics, metabolomics and transcriptomics.

Orsay virus establishes a latent infection in C. elegans, triggering age-dependent immunity and RNAi based cross-protection that limits secondary infections and reveals parallels to adaptive antiviral responses.

Tumor pericytes are located surrounding blood vessels, and can regulate tumor vascular structure. Here, the authors discover that a subpopulation of NKX2-3 high tumor pericytes modulates vasodilation and hemodynamics to promote metastasis.

Myelin abnormalities in ASD remain poorly understood. Here authors investigate Scn2a deletion in oligodendrocytes, and report disruptions in myelin, ion channel distribution, and axonal conduction lead to abnormal synaptic plasticity and auditory hypersensitivity.

Altermagnets, unlike their conventional collinear antiferromagnetic counterparts, allow for an anomalous Nernst response despite their collinear compensated magnetic ordering. Here, Badura et al find such an anomalous Nernst effect at zero magnetic field in the altermagnetic candidate, Mn₅Si₃.

In this study, the authors analyzed iPSC-derived neurons from 180 ALS patients and controls, finding that TDP-43 dysfunction is variable and mirrors changes seen in postmortem brain and repairing nuclear pore damage is sufficient to reverse TDP-43 proteinopathy.

The nervous system can influence cancer progression. Here, authors show in mouse models that Netrin-1 promotes sympathetic nerve remodeling in early pancreatic cancer lesions and has a protective effect against their progression.

Group 2 Innate lymphoid cells (ILC2) have been shown to promote type 2 immune responses. Here the authors show a TLR4⁺ILC2 population in type 2 airway diseases and that this population responds more vigorously to type 2 stimuli and contributes to persistence of type 2 immunity.