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  1. The delivery of selective and specific neural stimulation is of paramount importance to enable effective interactions with the nervous system while reducing potential side effects. Neural interfaces play a key...

    Authors: Valentina Galletta, Marta Bonato, Marta Parazzini, Emma Chiaramello and Serena Fiocchi
    Citation: Bioelectronic Medicine 2025 11:25
    Content type: Research Published on:

  2. Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS), have a significant impact on patients, reducing their quality of life and work efficiency. Pharmacological therapy is primar...

    Authors: Kaijie Wang, Md Jahangir Alam, Xinya Lan, Fei Li and Jiande D. Z. Chen
    Citation: Bioelectronic Medicine 2025 11:23
    Content type: Review Published on:

  4. Cervical spinal cord injury (SCI) impairs sensorimotor and autonomic functions. We investigated the effects of lumbosacral transcutaneous spinal cord stimulation (tSCS) on urinary bladder, bowel, and sexual fu...

    Authors: Soshi Samejima, Claire Shackleton, Raza N. Malik, Ali Hosseinzadeh, Lucas Rempel, Anh-Duong Phan, Alison Williams, Tom Nightingale, Amandeep Ghuman, Stacy Elliott, Matthias Walter, Klaus Krogh, Michael Berger, Tania Lam, Rahul Sachdeva and Andrei V. Krassioukov
    Citation: Bioelectronic Medicine 2025 11:20
    Content type: Research Published on:

  6. While there has been rapid progress in research aimed at developing device-based neuromodulation therapies for blood pressure (BP) disorders, there is a paucity of FDA-approved therapies. Currently, the only a...

    Authors: Peter L. Greechan, Ryan G. L. Koh and Paul B. Yoo
    Citation: Bioelectronic Medicine 2025 11:19
    Content type: Review Published on:

  10. One problematic and undertreated consequence of spinal cord injury (SCI) is urinary dysfunction. Treatment is usually conservative, involving regulation of fluid intake and scheduled bladder emptying through i...

    Authors: Mia J. Sargusingh, Juliet J. A. Addo, Margot S. Damaser, Philippe Zimmern, Seth A. Hays and Ana G. Hernandez-Reynoso
    Citation: Bioelectronic Medicine 2025 11:15
    Content type: Perspective Published on:

  11. Metabolic stress during major surgery increases insulin resistance and causes post-operative hyperglycemia (POHG), which may in turn contribute to post-operative morbidity and mortality. Intensive insulin ther...

    Authors: Weiguo Song, Khaled Qanud, Dane A. Thompson, Jared M. Huston and Stavros Zanos
    Citation: Bioelectronic Medicine 2025 11:14
    Content type: Brief Report Published on:

  12. Breast cancer (BC) is still the most diagnosed cancer for females with an increased focus on immunotherapy as a promising precise treatment. Selecting appropriate patients and monitoring patient treatments are...

    Authors: Houda Bendani, Nasma Boumajdi, Lahcen Belyamani and Azeddine Ibrahimi
    Citation: Bioelectronic Medicine 2025 11:13
    Content type: Review Published on:

  13. Epilepsia partialis continua (EPC) is a medication-resistant form of focal status epilepticus (SE), causing significant morbidity. This case series explored whether continuous theta burst stimulation (cTBS) co...

    Authors: Chloé Algoet, Sofie Carrette, Alfred Meurs, Ann Mertens, Dimitri Hemelsoet, Paul Boon and Kristl Vonck
    Citation: Bioelectronic Medicine 2025 11:12
    Content type: Research Published on:

  14. Previous efforts to translate vagus nerve stimulation (VNS) therapies from preclinical studies to human clinical applications (e.g., for stroke, heart failure, and inflammatory diseases) did not account for in...

    Authors: Eric D. Musselman, Ishani Raha, Nicole A. Pelot and Warren M. Grill
    Citation: Bioelectronic Medicine 2025 11:11
    Content type: Research Published on:

  15. Over a third of the global population is affected by obesity, fatty liver disease (Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD), and its severe form, MASH (Metabolic Dysfunction-Associated ...

    Authors: Sahara John, Krishanu Bhowmick, Andrew Park, Hai Huang, Xiaochun Yang and Lopa Mishra
    Citation: Bioelectronic Medicine 2025 11:10
    Content type: Review Published on:

  16. Preclinical and early clinical evidence demonstrates that electrical stimulation (ES) applied for one hour following surgical nerve intervention enhances axonal regeneration and functional outcomes. Wide clini...

    Authors: Christopher J Coroneos, Carolyn Levis, Michael P Willand, Katelyn JW So and James R Bain
    Citation: Bioelectronic Medicine 2025 11:9
    Content type: Research Published on:

    The Correction to this article has been published in Bioelectronic Medicine 2025 11:21

  17. Low intensity, trans-spinal focused ultrasound (tsFUS) is a noninvasive neuromodulation approach that has been shown to modulate spinal circuit excitability in healthy rats. Here, we evaluated the potential of...

    Authors: Weiguo Song, Alice Giannotti, Alexandra Bekiaridou, Ona Bloom and Stavros Zanos
    Citation: Bioelectronic Medicine 2025 11:8
    Content type: Brief Report Published on:

  18. Temporal interference (TI) is a method of non-invasive brain stimulation using transcutaneous electrodes which allows the targeting and modulation of deeper brain structures, not normally associated with non-i...

    Authors: Boris Botzanowski, Emma Acerbo, Sebastian Lehmann, Sarah L. Kearsley, Melanie Steiner, Esra Neufeld, Florian Missey, Lyle Muller, Viktor Jirsa, Brian D. Corneil and Adam Williamson
    Citation: Bioelectronic Medicine 2025 11:7
    Content type: Research Published on:

  19. Implanted neural interfaces are electronic devices that stimulate or record from neurons with the purpose of improving the quality of life of people who suffer from neural injury or disease. Devices have been ...

    Authors: Ashley N. Dalrymple, Sonny T. Jones, James B. Fallon, Robert K. Shepherd and Douglas J. Weber
    Citation: Bioelectronic Medicine 2025 11:6
    Content type: Review Published on:

  20. Following the COVID-19 pandemic, there are many chronically ill Long COVID (LC) patients with different symptoms of varying degrees of severity. The pathological pathways of LC remain unclear until recently an...

    Authors: Marco Leitzke, Donald Troy Roach, Swen Hesse, Peter Schönknecht, Georg-Alexander Becker, Michael Rullmann, Bernhardt Sattler and Osama Sabri
    Citation: Bioelectronic Medicine 2025 11:5
    Content type: Review Published on:

  21. The octopus has many features that make it advantageous for revealing principles of motor circuits and control and predicting behavior. Here, an array of carbon electrodes providing single-unit electrophysiolo...

    Authors: Nitish Satya Sai Gedela, Ryan D. Radawiec, Sachin Salim, Julianna Richie, Cynthia Chestek, Anne Draelos and Galit Pelled
    Citation: Bioelectronic Medicine 2025 11:4
    Content type: Research Published on:

  23. In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocureâ„¢, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they...

    Authors: Isobel Jobson, Nguyen T. N. Vo, Edward Kujawinski, Chris Denning, Snow Stolnik, Veeren M. Chauhan and Frankie Rawson
    Citation: Bioelectronic Medicine 2025 11:2
    Content type: Research Published on:

  24. The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulatio...

    Authors: Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A. Silverman, Anuj Bhardwaj, Alex J. Mann, Alik Widge, Joseph Palin, Christopher Puleo and Hubert Lim
    Citation: Bioelectronic Medicine 2025 11:1
    Content type: Mini Review Published on:

  25. Current inflammatory bowel disease (IBD) treatments often fail to achieve lasting remission and have adverse effects. Vagus nerve stimulation (VNS) offers a promising therapy due to its anti-inflammatory effec...

    Authors: Fatemeh Hesampour, Diane M Tshikudi, Charles N Bernstein and Jean-Eric Ghia
    Citation: Bioelectronic Medicine 2024 10:29
    Content type: Research Published on:

  26. Drug-resistant hypertension affects approximately 9–18% of the United States hypertensive population. Recognized as hypertension that is resistant to three or more medications, drug-resistant hypertension can ...

    Authors: Garrett W. Thrash, Elijah Wang, Yifei Sun, Harrison C. Walker, Prasad Shirvalkar, Bryan K. Becker and Marshall T. Holland
    Citation: Bioelectronic Medicine 2024 10:28
    Content type: Review Published on:

  27. The purpose of this study was to investigate the effects of different electrical stimulation methods (bilateral electroacupuncture (BEA), unilateral EA (UEA), transcutaneous electrical acustimulation (TEA, sti...

    Authors: Md Jahangir Alam, Tingting Zhao, John W. Wiley and Jiande D. Z. Chen
    Citation: Bioelectronic Medicine 2024 10:27
    Content type: Research Published on:

  28. The protective effects of time spent outdoors emphasize the major role of daylight in myopia. Based on the pathophysiology of myopia, the impact of blue light stimulation on the signaling cascade, from melanop...

    Authors: Ana Amorim-de-Sousa, Ranjay Chakraborty, Michael J. Collins, Paulo Fernandes, José González‑Méijome, Jens Hannibal, Hosein Hoseini-Yazdi, Scott A. Read, Jens Ellrich and Tim Schilling
    Citation: Bioelectronic Medicine 2024 10:26
    Content type: Mini Review Published on:

  29. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention that shows promise as a potential treatment for depression. However, the clinical efficacy of tDCS varies, possib...

    Authors: Alejandro Albizu, Aprinda Indahlastari, Paulo Suen, Ziqian Huang, Jori L. Waner, Skylar E. Stolte, Ruogu Fang, Andre R. Brunoni and Adam J. Woods
    Citation: Bioelectronic Medicine 2024 10:25
    Content type: Research Published on:

  30. Integrating advanced machine-learning (ML) algorithms into clinical practice is challenging and requires interdisciplinary collaboration to develop transparent, interpretable, and ethically sound clinical deci...

    Authors: Khoa Nguyen, Debbie L. Wilson, Julie Diiulio, Bradley Hall, Laura Militello, Walid F. Gellad, Christopher A. Harle, Motomori Lewis, Siegfried Schmidt, Eric I. Rosenberg, Danielle Nelson, Xing He, Yonghui Wu, Jiang Bian, Stephanie A. S. Staras, Adam J. Gordon…
    Citation: Bioelectronic Medicine 2024 10:24
    Content type: Methodology Published on:

  31. Virtual Reality (VR) is an emerging technology in post stroke recovery. However, its precise role in stroke rehabilitation is not well defined. The aim of this paper is to conduct an overview of systematic rev...

    Authors: Ammar Khan, Yahia Z. Imam, Mohamed Muneer, Salman Al Jerdi and Sumanjit K. Gill
    Citation: Bioelectronic Medicine 2024 10:23
    Content type: Review Published on:

  32. The identification of acute cardioprotective strategies against myocardial ischemia/reperfusion (I/R) injury that can be applied in the catheterization room is currently an unmet clinical need and several inte...

    Authors: Giuseppe Giannino, Lorenzo Nocera, Maria Andolfatto, Valentina Braia, Federico Giacobbe, Francesco Bruno, Andrea Saglietto, Filippo Angelini, Ovidio De Filippo, Fabrizio D’Ascenzo, Gaetano Maria De Ferrari and Veronica Dusi
    Citation: Bioelectronic Medicine 2024 10:22
    Content type: Review Published on:

  33. Nearly all geriatric surgical complications are studied in the context of a single organ system, e.g., cardiac complications and the heart; delirium and the brain; infections and the immune system. Yet, we kno...

    Authors: Leah Acker, Kevin Xu and J. P. Ginsberg
    Citation: Bioelectronic Medicine 2024 10:21
    Content type: Hypothesis Published on:

  34. Peripheral neural interfaces facilitate bidirectional communication between the nervous system and external devices, enabling precise control for prosthetic limbs, sensory feedback systems, and therapeutic int...

    Authors: Alice Giannotti, Ranieri Santanché, Ciro Zinno, Jacopo Carpaneto, Silvestro Micera and Eugenio Redolfi Riva
    Citation: Bioelectronic Medicine 2024 10:20
    Content type: Research Published on:

  35. Bioelectronic Medicine (BEM), which uses implantable electronic medical devices to interface with electrically active tissues, aspires to revolutionize the way we understand and fight disease. By leveraging kn...

    Authors: Dimitrios A. Koutsouras, George G. Malliaras and Geert Langereis
    Citation: Bioelectronic Medicine 2024 10:19
    Content type: Perspective Published on:

  36. Authors: Danny V. Lam, Justin Chin, Meagan K. Brucker-Hahn, Megan Settell, Ben Romanauski, Nishant Verma, Aniruddha Upadhye, Ashlesha Deshmukh, Aaron Skubal, Yuichiro Nishiyama, Jian Hao, J. Luis Lujan, Simeng Zhang, Bruce Knudsen, Stephan Blanz, Scott F. Lempka…
    Citation: Bioelectronic Medicine 2024 10:18
    Content type: Correction Published on:

    The original article was published in Bioelectronic Medicine 2024 10:17

  37. Spinal cord stimulation (SCS) has demonstrated multiple benefits in treating chronic pain and other clinical disorders related to sensorimotor dysfunctions. However, the underlying mechanisms are still not ful...

    Authors: Danny V. Lam, Justin Chin, Meagan K. Brucker-Hahn, Megan Settell, Ben Romanauski, Nishant Verma, Aniruddha Upadhye, Ashlesha Deshmukh, Aaron Skubal, Yuichiro Nishiyama, Jian Hao, J. Luis Lujan, Simeng Zhang, Bruce Knudsen, Stephan Blanz, Scott F. Lempka…
    Citation: Bioelectronic Medicine 2024 10:17
    Content type: Research article Published on:

    The Correction to this article has been published in Bioelectronic Medicine 2024 10:18

  38. Implantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to de...

    Authors: Fangqi Liu, Maryam Habibollahi, Yu Wu, Nazanin Neshatvar, Jiaxing Zhang, Ciro Zinno, Outman Akouissi, Fabio Bernini, Lisa Alibrandi, Khatia Gabisonia, Vincenzo Lionetti, Jacopo Carpaneto, Henry Lancashire, Dai Jiang, Silvestro Micera and Andreas Demosthenous
    Citation: Bioelectronic Medicine 2024 10:16
    Content type: Research article Published on:

  39. Vagus nerve stimulation (VNS) is an established therapy for treating a variety of chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation. However, lack of precision and side-eff...

    Authors: Antonin Berthon, Lorenz Wernisch, Myrta Stoukidi, Michael Thornton, Olivier Tessier-Lariviere, Pascal Fortier-Poisson, Jorin Mamen, Max Pinkney, Susannah Lee, Elvijs Sarkans, Luca Annecchino, Ben Appleton, Philip Garsed, Bret Patterson, Samuel Gonshaw, Matjaz Jakopec…
    Citation: Bioelectronic Medicine 2024 10:15
    Content type: Research article Published on:

  40. Blue light activates melanopsin, a photopigment that is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs). The axons of ipRGCs converge on the optic disc, which corresponds to the physi...

    Authors: Hosein Hoseini-Yazdi, Scott A. Read, Michael J. Collins, Hamed Bahmani, Jens Ellrich and Tim Schilling
    Citation: Bioelectronic Medicine 2024 10:13
    Content type: Research article Published on:

  41. Key to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune function. Sensory neurons (termed nociceptors) recognize harmful stimuli and...

    Authors: Aisling Tynan, Téa Tsaava, Manojkumar Gunasekaran, Carlos E. Bravo Iñiguez, Michael Brines, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Bioelectronic Medicine 2024 10:14
    Content type: Research article Published on:

  42. Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement,...

    Authors: Gerson N. Moreno Romero, Avery R. Twyman, Maria F. Bandres and Jacob Graves McPherson
    Citation: Bioelectronic Medicine 2024 10:12
    Content type: Mini-review Published on:

  44. Glioblastoma (GBM) presents as an aggressive brain cancer, notorious for its recurrence and resistance to conventional treatments. This study aimed to assess the efficacy of the EMulate Therapeutics Voyager®, ...

    Authors: Rajesh Mukthavaram, Pengfei Jiang, Sandra Pastorino, Natsuko Nomura, Feng Lin and Santosh Kesari
    Citation: Bioelectronic Medicine 2024 10:10
    Content type: Research article Published on:

  45. The vagus nerve has an anti-inflammatory effect through the inflammatory reflex, which inhibits the release of proinflammatory cytokines by macrophages. Recent pilot clinical trials, using implantable bioelect...

    Authors: Bruno Bonaz
    Citation: Bioelectronic Medicine 2024 10:9
    Content type: Commentary Published on:

    The original article was published in Bioelectronic Medicine 2024 10:8

  46. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of...

    Authors: Daniel Peterson, Mark Van Poppel, Warren Boling, Perry Santos, Jason Schwalb, Howard Eisenberg, Ashesh Mehta, Heather Spader, James Botros, Frank D. Vrionis, Andrew Ko, P. David Adelson, Bradley Lega, Peter Konrad, Guillermo Calle, Fernando L. Vale…
    Citation: Bioelectronic Medicine 2024 10:8
    Content type: Research article Published on:

    The Commentary to this article has been published in Bioelectronic Medicine 2024 10:9

  47. Wireless power transfer (WPT) within the human body can enable long-lasting medical devices but poses notable challenges, including absorption by biological tissues and weak coupling between the transmitter (T...

    Authors: Sultan Mahmud, Ali Nezaratizadeh, Alfredo Bayu Satriya, Yong-Kyu Yoon, John S. Ho and Adam Khalifa
    Citation: Bioelectronic Medicine 2024 10:7
    Content type: Mini-review Published on:

  48. Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are importan...

    Authors: Gregory Girardi, Danielle Zumpano, Helen Raybould and Erkin Seker
    Citation: Bioelectronic Medicine 2024 10:3
    Content type: Research article Published on:

  49. Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in disc...

    Authors: Valentina Paggi, Florian Fallegger, Ludovic Serex, Olivier Rizzo, Katia Galan, Alice Giannotti, Ivan Furfaro, Ciro Zinno, Fabio Bernini, Silvestro Micera and Stéphanie P. Lacour
    Citation: Bioelectronic Medicine 2024 10:6
    Content type: Research article Published on:

  50. Seizure detection is challenging outside the clinical environment due to the lack of comfortable, reliable, and practical long-term neurophysiological monitoring devices. We developed a novel, discreet, unobst...

    Authors: McGregor Joyner, Sheng-Hsiou Hsu, Stephanie Martin, Jennifer Dwyer, Denise Fay Chen, Reza Sameni, Samuel H. Waters, Konstantin Borodin, Gari D. Clifford, Allan I. Levey, John Hixson, Daniel Winkel and Jonathan Berent
    Citation: Bioelectronic Medicine 2024 10:4
    Content type: Research article Published on:
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Bioelectronic Medicine

ISSN: 2332-8886