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  1. Non-histone lysine acetylation is a widespread protein post-translational modification that regulates almost all key cellular processes, and its dysregulation is closely associated with various human diseases....

    Authors: Yuqing Geng, Hao Luo and Feng Gao
    Citation: BMC Biology 2025 23:311
    Content type: Research Published on:

  2. Serial dependencies in perceptual tasks have been suggested to reflect implicit perceptual priors derived from short-term perceptual history. A reduced weighting of perceptual priors has been proposed as a mec...

    Authors: Anna-Chiara Schaub, Anna-Lena Eckert, Stijn A. Nuiten, Veith Weilnhammer and Philipp Sterzer
    Citation: BMC Biology 2025 23:310
    Content type: Research Published on:

  3. Predicting drug-target interactions (DTIs) is essential for accelerating drug discovery, yet traditional experimental methods are time-consuming and costly. Computational approaches, especially those using mac...

    Authors: Youyuan Shui, Xuewen Ge, Chen Cao, Junjie Wang, Jie Hu and Yun Liu
    Citation: BMC Biology 2025 23:309
    Content type: Research Published on:

  4. Entamoeba histolytica, an enteric pathogen, causes disease by adhering to and destroying the host tissues. The interaction between the parasite and host tissue enables the rewiring of gene expression and global m...

    Authors: Navyaka Padavala and Kuldeep Verma
    Citation: BMC Biology 2025 23:308
    Content type: Research Published on:

  5. Bacterial infections rank as the second leading cause of death globally, with virulence factors (VFs) being crucial to their pathogenicity. Predicting VFs accurately can uncover mechanisms of bacterial disease...

    Authors: Yitong Liu, Xin Cao, Jiani Li, Tao Li, Juanjuan Li, Xiang Ma, Xue Chi, Yanqiong Tang, Zhu Liu and Hong Li
    Citation: BMC Biology 2025 23:307
    Content type: Research Published on:

  6. The ability to respond plastically to environmental variation is a key determinant of fitness. Females may use cues to strategically place their eggs, for example adjusting the number or location of eggs accor...

    Authors: Emily R. Churchill, Emily K. Fowler, Lucy A. Friend, Marco Archetti, Douglas W. Yu, Andrew F. G. Bourke, Tracey Chapman and Amanda Bretman
    Citation: BMC Biology 2025 23:306
    Content type: Research Published on:

  9. Novel interventions for mosquito-borne disease control which release modified mosquitoes that are sterilised or genetically modified to cause offspring inviability are progressing towards field applications. C...

    Authors: Penelope A. Hancock, Tin-Yu J. Hui, Patric S. Epopa, Azize Milogo, Andrew R. McKemey, Franck A. Yao, Abdoulaye Diabaté and Austin Burt
    Citation: BMC Biology 2025 23:303
    Content type: Research Published on:

  10. Mitochondria carry out essential functions in eukaryotic cells. The mitochondrial genome encodes factors critical to support oxidative phosphorylation and mitochondrial protein import necessary for these funct...

    Authors: Katie Lin Amberg, Lyrica Hao, Susanne Cranz-Mileva and Mikel Zaratiegui
    Citation: BMC Biology 2025 23:302
    Content type: Research Published on:

  11. Land plants include angiosperms, gymnosperms, bryophytes, lycophytes, and ferns, each of which may deploy distinct strategies to resist pathogens. Here, we investigate fern-pathogen interactions by characteriz...

    Authors: Baptiste Castel, Madeleine Baker, Jean Keller, Yves Martinez, Maxime Bonhomme, Pierre-Marc Delaux and Christophe Jacquet
    Citation: BMC Biology 2025 23:301
    Content type: Research Published on:

  12. Skinks (Scincidae) are one of the most diverse and ecologically versatile lizard families, making them key models for studying major evolutionary transitions including viviparity, limb reduction, and shifts be...

    Authors: Paul A. Saunders, Francisco M. C. Sassi, Marcelo B. Cioffi, Oleg Simakov, Christopher P. Burridge, Tariq Ezaz and Erik Wapstra
    Citation: BMC Biology 2025 23:300
    Content type: Research Published on:

  13. The genus Beta encompasses important crops such as sugar, table, fodder, and leaf beets. All cultivated beets are believed to have originated from the wild sea beet, B. vulgaris subsp. maritima. Sugar beet, a rec...

    Authors: Amar Singh Dhiman, Demetris Taliadoros, Eva H. Stukenbrock, J. Mitchell McGrath, Nazgol Emrani and Christian Jung
    Citation: BMC Biology 2025 23:299
    Content type: Research Published on:

  14. The wing veins of known fossil and living phorids are reduced, making them difficult to homologise. Consequently, different interpretations have led to much confusion over the years. However, veins are crucial...

    Authors: Mélanie C. M. Herbert, André Nel, Brian V. Brown, Antonio Arillo, Brendon E. Boudinot and Mónica M. Solórzano-Kraemer
    Citation: BMC Biology 2025 23:298
    Content type: Research Published on:

  15. Cotton (Gossypium spp.) cultivation is significantly challenged by high temperatures (HT), especially during reproductive stages, leading to male abortion and yield losses.

    Authors: Aamir Hamid Khan, Qingyuan Li, Anyu Luo, Huanhuan Ma, Marcin Kiedrzyński, Abdullah Shalmani, Adnan Akbar, Adnan Iqbal, Jing Cao, Longfu Zhu, Xianlong Zhang and Ling Min
    Citation: BMC Biology 2025 23:297
    Content type: Research Published on:

  16. Curvature is a ubiquitous feature in biology, shaping structures at every scale and playing diverse roles in processes ranging from membrane dynamics to tissue organization. In this review, we first introduce ...

    Authors: Carole Arnold, Ismail Tahmaz, Marie-Ly Chapon, Hasna Maayouf, Valeriy Luchnikov, Jean-Louis Milan, Fabricio Borghi and Laurent Pieuchot
    Citation: BMC Biology 2025 23:296
    Content type: Review Published on:

  18. The Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae), is a major pest of potato that undergoes diapause (hibernation) to survive harsh winter conditions. Lipid metabolism plays a cruc...

    Authors: Doga Cedden, Gözde Güney, Şerife Bayram, Doug Baldwin, Cathy Coutu, Dwayne Hegedus, Megan N. Lipke, Cansu Doğan, Russell L. Groves and Umut Toprak
    Citation: BMC Biology 2025 23:294
    Content type: Research Published on:

  19. Many species of lichen-forming fungi exhibit large geographical ranges and broad thermal niches, making them excellent models for investigating the genomics of climate adaptation. In this study, we examined th...

    Authors: Edgar L.Y. Wong, Anjuli Calchera, Jürgen Otte and Imke Schmitt
    Citation: BMC Biology 2025 23:293
    Content type: Research Published on:

  20. Guanylate-binding proteins (GBPs) belong to the large guanosine triphosphatases (GTPases) family and have specialised in host defence in vivo against a broad spectrum of invading pathogens. This ancient evolut...

    Authors: João Vasco Côrte-Real, Ana Pinheiro, Jordan M. Sampson, Kimberly A. Morrissey, João Pedro Marques, Hanna-Mari Baldauf, Robert D. Miller, Joana Abrantes and Pedro José Esteves
    Citation: BMC Biology 2025 23:292
    Content type: Research Published on:

  21. Collective migration is the coordinated movement of a group of cells—a fundamental process in health and disease. Many models have been developed to study the molecular and physical mechanisms of collective mi...

    Authors: Janine Grolleman, Carlijn V. C. Bouten, Vito Conte and Cecilia M. Sahlgren
    Citation: BMC Biology 2025 23:291
    Content type: Research Published on:

  23. The primary signals of sex determination in insects are diverse and evolve erratically. This also appears to be the case with moths and butterflies. In the silkworm Bombyx mori, female development is triggered by...

    Authors: Sander Visser, Atsuo Yoshido, Irena Provazníková, Martina Dalíková, Dagmar Voříšková, Anna Chung Voleníková, Eveline C. Verhulst and František Marec
    Citation: BMC Biology 2025 23:289
    Content type: Research Published on:

  24. Structural variants (SVs) are genetic polymorphisms including deletions, insertions, inversions, and duplications, with potential to influence traits through impacts on gene function and expression. SVs have n...

    Authors: Zexin Jiao, Robert Mukiibi, Manu Kumar Gundappa, Massimiliano Babbucci, James G. D. Prendergast, Diego Robledo, Luca Bargelloni and Daniel J. Macqueen
    Citation: BMC Biology 2025 23:288
    Content type: Research Published on:

  25. Museomics utilizes historical genetic data from museum specimens to inform threatened species conservation. The Yellow-breasted Bunting (Emberiza aureola) and the Jankowski’s Bunting (E. jankowskii), categorized ...

    Authors: Shangyu Wang, Dezhi Zhang, Xiaolu Jiao, Lei Wu, Qiang-Hui Zhu, Hongrui Lv, Haitao Wang, Zheng Han, Shi Li, Peng He, Jun Chen, Shaohong Feng, Urban Olsson, Per Alström and Fumin Lei
    Citation: BMC Biology 2025 23:287
    Content type: Research Published on:

  26. Adipose tissue plays a central role in systemically metabolic regulation. Polymerase I and transcript release factor (PTRF) is responsible for caveolae structure formation and plays a crucial role in lipid met...

    Authors: Yu Zhang, Keren Long, Songling Zhang, Biwei Zhang, Xiaokai Li, Xuemin Li, Zhining Zhong, Ziqi Li, Qiuyue Chen, Penghao Li, Li Chen, Jinwei Zhang, Jianlin Yuan, Anan Jiang, Lu Lu, Haohuan Li…
    Citation: BMC Biology 2025 23:286
    Content type: Research Published on:

  27. Bellamya aeruginosa belongs to the family Viviparidae and is widely distributed in freshwater ecosystems in Asia. This species is resilient to thermal stress and can survive in polluted waters and consequently ha...

    Authors: Gang Wang, Lianfu Chen, Haoran Pan, Aobo Pang, Yanxia Shi, Sisi Chen, Zhijuan Bian, Chijie Yin, Rongchen Liu, Xiaoli Sun, Xiaoxiao Wu, Sheng Tang, Fujun Xuan, Qiuning Liu, Shouquan Hou, Boping Tang…
    Citation: BMC Biology 2025 23:285
    Content type: Research Published on:

  28. Streptococcus suis poses a significant threat to both humans and pigs, causing severe disease such as meningitis, septicaemia, and sudden death. The type VII secretion system (T7SS) plays a crucial role in export...

    Authors: Huizhen Wu, Yifan Wu, Qiankun Bai, Zijing Liang, Xinchi Zhu, Xinming Pan, Minghui Liu, Huochun Yao, Jiale Ma and Zongfu Wu
    Citation: BMC Biology 2025 23:284
    Content type: Research Published on:

  29. This study aimed to develop and evaluate a bispecific single-chain variable fragment (bsscFv) targeting B-cell activating factor (BAFF) and interleukin-17 (IL-17) for the treatment of systemic lupus erythemato...

    Authors: Cheng Xin, Jingming Zhou, Yumei Chen, Yankai Liu, Hongliang Liu, Chao Liang, Xifang Zhu, Yanhua Qi, Gaiping Zhang and Aiping Wang
    Citation: BMC Biology 2025 23:283
    Content type: Methodology Published on:

  31. Genetic diagnosis is fast and cheap, challenging our capacity to evaluate the functional impact of novel disease-causing variants or identify potential therapeutics. Model organisms including C. elegans present t...

    Authors: Thomas J. O’Brien, Eneko P. Navarro, Consuelo Barroso, Lara Menzies, Enrique Martinez-Perez, David Carling and André E. X. Brown
    Citation: BMC Biology 2025 23:281
    Content type: Research Published on:

  32. Abdominal aortic aneurysm (AAA) is typically an asymptomatic disease closely associated with immune mechanisms. A deep understanding of cellular responses within AAA tissues, particularly the molecular changes...

    Authors: Demin Li, Ge Zhang, Pengchong Du, Chang Cao, Xuyu He, Yan Lv, Peiyu Yuan, Yujia Wang, Ruhao Wu, Yifan Cao, Yu Yang, Jiamin Gao, Bo Lan, Guo-Ping Shi, Xiaolin Cui, Jinying Zhang…
    Citation: BMC Biology 2025 23:280
    Content type: Research Published on:

  33. Activity cliffs, which refer to pairs of molecules that are structurally similar but show significant differences in their potency, can lead to model representation collapse and make the model challenging to d...

    Authors: Zhixiang Cheng, Hongxin Xiang, Pengsen Ma, Li Zeng, Xin Jin, Xixi Yang, Jianxin Lin, Xinxin Feng, Yang Deng, Changhui Deng, Bosheng Song and Xiangxiang Zeng
    Citation: BMC Biology 2025 23:279
    Content type: Research Published on:

  34. In many animals, survival during infection depends on the ability to coordinate interactions between the host immune system and gut microbiota. These tripartite interactions, in turn, potentially shape pathoge...

    Authors: Maryam Keshavarz, Mathias Franz, Haicheng Xie, Caroline Zanchi, Susan Mbedi, Sarah Sparmann and Jens Rolff
    Citation: BMC Biology 2025 23:278
    Content type: Research Published on:

  35. Modern bony fishes exhibit a considerable variation in the morphology of their hearing structures, and the morphological composition of these has been studied for centuries. However, the precise interaction an...

    Authors: Isabelle P. Maiditsch, Tanja Schulz-Mirbach, Martin Heß, Friedrich Ladich, Marco Stampanoni and Christian M. Schlepütz
    Citation: BMC Biology 2025 23:277
    Content type: Methodology Published on:

  36. The European hamster (Cricetus cricetus) was once a pest on European farmland, but its numbers have declined dramatically in recent decades, making it a critically endangered species throughout Europe and beyond....

    Authors: Tobias Erik Reiners, David Prochotta, Tilman Schell, Carola Greve, Alexander Ben Hamadou, Charlotte Gerheim, Juan-Manuel Ortega, Carsten Nowak, Marcel Nebenführ and Axel Janke
    Citation: BMC Biology 2025 23:276
    Content type: Research Published on:

  37. Mammalian skin exhibits profound cellular and molecular restructuring across lifespan, yet an integrated single-cell mapping from embryogenesis to senescence remains limited. The Chenghua (CH) pig, with except...

    Authors: Ting Zheng, Rong Yuan, Yu Zhang, Qin Zou, Yifei Wang, Yujing Li, Zhengyin Gong, Zhengli Chen and Yanzhi Jiang
    Citation: BMC Biology 2025 23:275
    Content type: Research Published on:

  38. The Pompeii worm Alvinella pompejana, a terebellid annelid, has long been an exemplar of a metazoan that lives in an extreme environment, on the chimney wall of deep-sea hydrothermal vents, but this very environm...

    Authors: Sami El Hilali, Philippe Dru, Alan Le Moan, Yang I Li, Martijn A. Huynen, André Hoelz, Robert C. Robinson, José M. Martín-Durán, Didier Jollivet, Adam Claridge-Chang and Richard R. Copley
    Citation: BMC Biology 2025 23:274
    Content type: Research Published on:

  39. Microplastics, small particles that are released from plastics as they degrade, are ubiquitous and increasing in amount in most environments, including the soil. Here, we review the impacts of microplastics on...

    Authors: Kai Wang, Fayuan Wang, Yongxiang Yu, Side Yang, Yujie Han and Huaiying Yao
    Citation: BMC Biology 2025 23:273
    Content type: Review Published on:

  40. RNA post-transcriptional modifications involve the addition of chemical groups to RNA molecules or alterations to their local structure. These modifications can change RNA base pairing, affect thermal stabilit...

    Authors: Chunyan Ao, Mengting Niu, Quan Zou, Liang Yu and Yansu Wang
    Citation: BMC Biology 2025 23:272
    Content type: Methodology Published on:

  41. Interhemispheric communication of olfactory information is crucial for accurate odor perception and odor source localization in animals. However, the underlying structural basis for this communication in mamma...

    Authors: Li Wang, Anan Li, Sen Jin, Yue Liu, Feilong Yu, Rafi Haddad, Fan Jia, Peng Su, Jiajia Guo, Zhijian Zhang, Qing Liu and Fuqiang Xu
    Citation: BMC Biology 2025 23:271
    Content type: Research Published on:

  42. The lower Yangtze River basin holds a pivotal role in Chinese history. As previous genetic research in this region has primarily focused on modern population datasets, the limited availability of ancient human...

    Authors: Haifeng He, Xinyuan Kong, Le Tao, Liangsai Zhu, Xuanbo Wang, Mengting Xu, Yuanming Chen, Kongyang Zhu, Yu Xu, Haodong Chen, Hao Ma, Rui Wang, Xiaomin Yang, Tianyou Bai, Jianxin Guo, Yang Yang…
    Citation: BMC Biology 2025 23:270
    Content type: Research Published on:

  43. Circular RNAs (circRNAs) and mRNAs are distinct transcripts from the same genes, produced by different splicing mechanisms. This study investigates the behavior of the circular transcriptome relative to the li...

    Authors: María Alonso-García, Laurence Liaubet, Thomas Faraut, Patrice Dehais, Christa Kühn, Julie Demars, Beatriz Gutiérrez-Gil and Annie Robic
    Citation: BMC Biology 2025 23:269
    Content type: Research Published on:

  44. The cranial base develops from multipotent mesenchymal cells through endochondral ossification. Genetic ablation of Sonic hedgehog (Shh) or Smoothened (Smo) leads to early apoptosis of cranial base cells, thus li...

    Authors: Jiangping Chen, Chengyan Ren, Chuanqing Mao, Yongzhen Lai, Meng Lu, Yuanjing Jiang and Weihui Chen
    Citation: BMC Biology 2025 23:268
    Content type: Research article Published on:

  47. Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty a...

    Authors: Shivum Lal, Shreya Gunji, Pankaj Ahluwalia, Ravindra Kolhe, Wendy B. Bollag, William D. Hill, Meghan E. McGee-Lawrence, Carlos M. Isales and Sadanand Fulzele
    Citation: BMC Biology 2025 23:265
    Content type: Review Published on:

  48. Recent studies have demonstrated that prolonged sperm storage adversely affects offspring through epigenetics, yet its broader effects on other molecular levels such as transcription and proteomics in progeny ...

    Authors: Yu Cheng, Songpei Zhang, Sayyed Mohammad Hadi Alavi, Rigolin Nayak, Swapnil Gorakh Waghmare, Nururshopa Eskander Shazada, Deepali Rahi Roy, Zhijun Ma, Otomar Linhart and Zuzana Linhartová
    Citation: BMC Biology 2025 23:264
    Content type: Research Published on:

  49. Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. Dysregulation of iron homeostasis underlies a broad spectrum of biological phenomena and pathological conditions. Nota...

    Authors: Meijuan Zhong, Yuandi Wang, Junxia Min and Fudi Wang
    Citation: BMC Biology 2025 23:263
    Content type: Review Published on:

  50. Intake of glucose and sucrose accelerates the development of dental caries in children. Scardovia wiggsiae (S. wiggsiae) is a potential pathogen of early childhood caries (ECC). Previous research conducted by our...

    Authors: Peiling Wang, Rong Ma, Dandan Ma, Yisha Lin, Yimin Wang, Yuanyuan Zhang and Jinpu Chu
    Citation: BMC Biology 2025 23:262
    Content type: Research Published on:
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