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Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies

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Abstract

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies.

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References

  • Ali, N.N., Edgar, A.J., Samadikuchaksaraei, A., Timson, C.M., Romanska, H.M., Polak, J.M., Bishop, A.E., 2002. Derivation of type II alveolar epithelial cells from murine embryonic stem cells. Tissue Eng., 8(4):541–550. [doi:10.1089/107632702760240463]

    Article  PubMed  CAS  Google Scholar 

  • Archer, S., Rich, S., 2000. Primary pulmonary hypertension: a vascular biology and translational research “work in progress”. Circulation, 102(22):2781–2791.

    PubMed  CAS  Google Scholar 

  • Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., Isner, J.M., 1997. Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275(5302):964–967. [doi:10.1126/science.275.5302.964]

    Article  PubMed  CAS  Google Scholar 

  • Avery, R.K., 1999. Special considerations regarding CMV in lung transplantation. Transpl. Infect. Dis., 1(Suppl. 1):13–18.

    PubMed  Google Scholar 

  • Bernard, G.R., Artigas, A., Brigham, K.L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J.R., Morris, A., Spragg, R., 1994. The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am. J. Respir. Crit. Care Med., 149(3 Pt 1):818–824.

    PubMed  CAS  Google Scholar 

  • Brazelton, T.R., Rossi, F.M., Keshet, G.I., Blau, H.M., 2000. From marrow to brain: expression of neuronal phenotypes in adult mice. Science, 290(5497):1775–1779. [doi:10.1126/science.290.5497.1775]

    Article  PubMed  CAS  Google Scholar 

  • Breen, P.H., Schumacker, P.T., Hedenstierna, G., Ali, J., Wagner, P.D., Wood, L.D., 1982. How does increased cardiac output increase shunt in pulmonary edema? J. Appl. Physiol., 53(5):1273–1280.

    PubMed  CAS  Google Scholar 

  • Brown, L.M., Rannels, S.R., Rannels, D.E., 2001. Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease. Respir. Res., 2(6):340–347. [doi:10.1186/rr84]

    Article  PubMed  CAS  Google Scholar 

  • Brun-Buisson, C., Doyon, F., Carlet, J., Dellamonica, P., Gouin, F., Lepoutre, A., Mercier, J.C., Offenstadt, G., Regnier, B., 1995. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA, 274(12):968–974. [doi:10.1001/jama.274.12.968]

    Article  PubMed  CAS  Google Scholar 

  • Burnham, E.L., Taylor, W.R., Quyyumi, A.A., Rojas, M., Brigham, K.L., Moss, M., 2005. Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am. J. Respir. Crit. Care Med., 172(7):854–860. [doi:10.1164/rccm.200410-1325OC]

    Article  PubMed  Google Scholar 

  • Campbell, A.I., Kuliszewski, M.A., Stewart, D.J., 1999. Cell-based gene transfer to the pulmonary vasculature: endothelial nitric oxide synthase overexpression inhibits moncrotaline-induced pulmonary hypertension. Am. J. Respir. Cell Mol. Biol., 21(5):567–575.

    PubMed  CAS  Google Scholar 

  • Campbell, A.I., Zhao, Y., Sandhu, R., Stewart, D.J., 2001. Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotamine-induced pulmonary hypertension. Circulation, 104(18):2242–2248.

    PubMed  CAS  Google Scholar 

  • Chan, A., Allen, R., 2004. Bronchiolitis obliterans: an update. Curr. Opin. Pulm. Med., 10(2):133–141. [doi:10.1097/00063198-200403000-00008]

    Article  PubMed  Google Scholar 

  • Chaparro, C., Kesten, S., 1997. Infections in lung transplant recipients. Clin. Chest Med., 18(2):339–351. [doi:10.1016/S0272-5231(05)70383-X]

    Article  PubMed  CAS  Google Scholar 

  • Coraux, C., Hilmi, C., Rouleau, M., Spadafora, A., Hinnrasky, J., Ortonne, J.P., Dani, C., Aberdam, D., 2003. Reconstituted skin from murine embryonic stem cells. Curr. Biol., 13(10):849–853. [doi:10.1016/S0960-9822(03)00296-3]

    Article  PubMed  CAS  Google Scholar 

  • Coraux, C., Nawrocki-Raby, B., Hinnrasky, J., Kileztky, C., Gaillard, D., Dani, C., Puchelle, E., 2004. Embryonic stem cells generate airway epithelial tissue. Am. J. Respir. Cell Mol. Biol., 32(2):87–95. [doi:10.1165/rcmb.2004-0079RC]

    Article  PubMed  CAS  Google Scholar 

  • Crouser, E.D., Dorinsky, P.M., 1994. Gastrointestinal tract dysfunction in critical illness: pathophysiology and interaction with acute lung injury in adult respiratory distress syndrome/multiple organ dysfunction syndrome. N. Horiz., 2(4):476–487.

    CAS  Google Scholar 

  • Davidson, T.A., Caldwell, E.S., Curtis, J.R., Hudson, L.D., Steinberg, K.P., 1999. Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients. JAMA, 281(4):354–360. [doi:10.1001/jama.281.4.354]

    Article  PubMed  CAS  Google Scholar 

  • Deitch, E.A., 1992. Multiple organ failure: pathogenesis and potential future therapy. Ann. Surg., 216(2):117–134. [doi:10.1097/00000658-199208000-00002]

    Article  PubMed  CAS  Google Scholar 

  • Dupont, H., LeCorre, R., Fierobe, L., Cheval, C., Moine, P., Timsit, J.F., 1999. Efficacy of inhaled nitric oxide as rescue therapy during severe ARDS: survival and factors associated with the first responses. J. Crit. Care, 14(3):107–113. [doi:10.1016/S0883-9441(99)90022-9]

    Article  PubMed  CAS  Google Scholar 

  • Eglitis, M.A., Mezey, E., 1997. Hematopoietic cells differentiate into both microglia in the brains of adult mice. Proc. Natl. Acad. Sci. USA, 94(8):4080–4085. [doi:10.1073/pnas.94.8.4080]

    Article  PubMed  CAS  Google Scholar 

  • Evans, M.J., Kaufman, M.H., 1981. Establishment in culture of pluripotential cells from mouse embryos. Nature, 292(5819):154–156. [doi:10.1038/292154a0]

    Article  PubMed  CAS  Google Scholar 

  • Ezri, T., Kunichezky, S., Eliraz, A., Soroker, D., Halperin, D., Schattner, A., 1994. Bronchiolitis obliterans-current concepts. Q. J. Med., 87(1):1–10.

    PubMed  CAS  Google Scholar 

  • Ferrari, G., Cusella-De Angelis, G., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., Mavilio, F., 1998. Muscle regeneration by bone marrow derived myogenic progenitors. Science, 279(5356):1528–1530. [doi:10.1126/science.279.5356.1528]

    Article  PubMed  CAS  Google Scholar 

  • Fowler, A.A., Hamman, R.F., Good, J.T., Benson, K.N., Baird, M., Eberle, D.J., Petty, T.L., Hyers, T.M., 1983. Adult respiratory distress syndrome: risk with common predisposition. Ann. Intern. Med., 98(5 Pt 1):593–597.

    PubMed  CAS  Google Scholar 

  • Frost, A.E., 2002. Bronchiolitis obliterans: the Achilles heel of lung transplantation. Veth. K. Acad. Geneeskd. Belg., 64(5):303–319.

    CAS  Google Scholar 

  • Gao, Z., McAlister, V.C., Williams, G.M., 2001. Repopulation of liver endothelium by bone-marrow-derived cells. Lancet, 357(9260):932–933. [doi:10.1016/S0140-6736(00)04217-3]

    Article  PubMed  CAS  Google Scholar 

  • Gattinoni, L., Pelosi, P., Vitale, G., Pesenti, A., D’Andrea, L., Mascheroni, D., 1991. Body position changes redistribute lung computed tomographic density in patient with acute respiratory failure. Anesthesiology, 74(1):15–23. [doi:10.1097/00000542-199101000-00004]

    Article  PubMed  CAS  Google Scholar 

  • Gill, M., Dias, S., Hattori, K., Rivera, M.L., Hicklin, D., Witte, L., Girardi, L., Yurt, R., Himel, H., Rafii, S., 2001. Vascular trauma induces rapid but transient mobilization of VEGFR2(+) AC133(+) endothelial precursor cells. Circ. Res., 88(2):167–174.

    PubMed  CAS  Google Scholar 

  • Goris, R.J., te Bockhorst, T.P., Nuytinck, J.K., Gimbrere, J.S., 1985. Multiple organ failure: generalized autodestructive inflammation? Arch. Surg., 120(10):1109–1115.

    PubMed  CAS  Google Scholar 

  • Grimm, P.C., Nickerson, P., Jeffery, J., Savani, R.C., Gough, J., McKenna, R.M., Stem, E., Rush, D.N., 2001. Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal allograft rejection. N. Engl. J. Med., 345(2):93–97. [doi:10.1056/NEJM200107123450203]

    Article  PubMed  CAS  Google Scholar 

  • Grove, J.E., Lutzko, C., Poller, J., Hengariu, O., Theise, N.D., Kohn, D.B., Krause, D.S., 2002. Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. Am. J. Respir. Cell Mol. Biol., 27(6):645–651.

    PubMed  CAS  Google Scholar 

  • Harari, A., Zimmerli, S.C., Pantaleo, G., 2004. Cytomegalovirus (CMV) specific cellular immune responses. Hum. Immunol., 65(5):500–506. [doi:10.1016/j.humimm.2004.02.012]

    Article  PubMed  CAS  Google Scholar 

  • Hooper, R.G., 1991. ARDS: inflammation, infections, and corticosteroids. Chest, 100(4):889–890.

    PubMed  CAS  Google Scholar 

  • Jones, E.A., Tosh, D., Wilson, D.I., Lindsay, S., Forrester, L.M., 2002. Hepatic differentiation of murine embryonic stem cells. Exp. Cell Res., 272(1):15–22. [doi:10.1006/excr.2001.5396]

    Article  PubMed  CAS  Google Scholar 

  • Keller, G.M., 1995. In vitro differentiation of embryonic stem cells. Curr. Opin. Cell Biol., 7(6):862–869. [doi:10.1016/0955-0674(95)80071-9]

    Article  PubMed  CAS  Google Scholar 

  • Kitamura, K., Kangawa, K., Kawamoto, M., Ichiki, Y., Nakamura, S., Matsuo, H., Eto, T., 1993. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophy. Res. Commun., 192(2):553–560. [doi:10.1006/bbrc.1993.1451]

    Article  CAS  Google Scholar 

  • Klepetko, W., Laufer, G., Kocher, A., 2004. Thoracic transplantation and stem cell therapy. Eur. J. Cardiothorac. Surg., 26(Suppl. 1):S57–S58.

    PubMed  Google Scholar 

  • Kocher, A.A., Schuster, M.D., Szabolcs, M.J., Takuma, S., Burkhoff, D., Wang, J., Homma, S., Edwards, N.M., Itescu, S., 2001. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med., 7(4):430–436. [doi:10.1038/86498]

    Article  PubMed  CAS  Google Scholar 

  • Kollef, M.H., Schuster, D., 1996. Acute respiratory distress syndrome. DM, 42(5):266–326.

    Google Scholar 

  • Korbling, M., Katz, R.L., Khanna, A., Ruifrok, A.C., Rondon, G., Albitar, M., Champlin, R.E., Estrov, Z., 2002. Hepatocytes and epithelial cells of donor origin in recipients of peripheral blood stem cells. N. Engl. J. Med., 346(10):738–746. [doi:10.1056/NEJMoa3461002]

    Article  PubMed  Google Scholar 

  • Kotton, D.N., Ma, B.Y., Cardoso, W.V., Sanderson, E.A., Summer, R.S., Williams, M.C., Fine, A., 2001. Bone marrow-derived cells progenitors of lung alveolar epithelium. Development, 128(24):5181–5188.

    PubMed  CAS  Google Scholar 

  • Krause, D.S., Theise, N.D., Collector, M.I., Henegariu, O., Hwang, S., Gardner, R., Neutzel, S., Sharkis, S.J., 2001. Multi-organ, multilineage engraftment by a single bone marrow derived stem cells. Cell, 105(3):369–377. [doi:10.1016/S0092-8674(01)00328-2]

    Article  PubMed  CAS  Google Scholar 

  • Kubo, H., 2005. Is cell therapy in acute lung injury a realistic dream? Am. J. Respir. Crit. Care Med., 172(7):794–795. [doi:10.1164/rccm.2507006]

    Article  PubMed  Google Scholar 

  • Kuebler, W.M., Ying, X., Singh, B., Issekutz, A.C., Bhattacharya, J., 1999. Pressure is proinflammatory in lung venular capillaries. J. Clin. Invest., 104(4):495–502.

    PubMed  CAS  Google Scholar 

  • Kuebler, W.M., Parthasarathi, K., Wang, P.M., Bhattacharya, J., 2000. A novel signaling mechanism between gas and blood compartments of the lung. J. Clin. Invest., 105(7):905–913.

    PubMed  CAS  Google Scholar 

  • Kugathasan, L., Duty, A.E., Zhao, Y.D., Deng, Y., Robb, M.J., Keshavjee, S., Stewart, D.J., 2005. Role of angiopoitin-1 in experimental and human pulmonary arterial hypertension. Chest, 128(6_suppl.):633S–642S. [doi:10.1378/chest.128.6_suppl.633S]

    Article  PubMed  CAS  Google Scholar 

  • Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I.L., Grompe, M., 2000. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med., 6(11):1229–1234. [doi:10.1038/81326]

    Article  PubMed  CAS  Google Scholar 

  • Leach, C.L., Fuhrman, B.P., Morin, F.C.3rd, Rath, M.G., 1993. Perfluorocarbon-associated gas exchange (partial liquid ventilation) in respiratory distress syndrome. A prospective randomized, controlled study. Crit. Care Med., 21(9):1270–1278. [doi:10.1097/00003246-199309000-00008]

    Article  PubMed  CAS  Google Scholar 

  • Lessard, M.R., 1996. New concepts in mechanical ventilation for ARDS. Can. J. Anesth., 43(5 Pt 2):R50–R54.

    Google Scholar 

  • Luhr, O.R., Antonsen, K., Karlsson, M., Aardal, S., Thorsteinsson, A., Frostell, C.G., Bonde, J., 1999. Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. The ARF study group. Am. J. Respir. Crit. Care Med., 159(6):1849–1861.

    PubMed  CAS  Google Scholar 

  • Lumelsky, N., Blondel, O., Laeng, P., Belassco, I., Ravin, R., McKay, R., 2001. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science, 292(5520):1389–1394. [doi:10.1126/science.1058866]

    Article  PubMed  CAS  Google Scholar 

  • Martin, G.R., 1981. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA, 78(12):7634–7638. [doi:10.1073/pnas.78.12.7634]

    Article  PubMed  CAS  Google Scholar 

  • Matthay, M.A., Wierner-Kronish, J.P., 1990. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am. Rev. Respir. Dis., 142(6 Pt 1):1250–1257.

    PubMed  CAS  Google Scholar 

  • Matuschak, G.M., 1994. Liver-lung interactions in critical illness. N. Horiz., 2(2):488–504.

    CAS  Google Scholar 

  • Meduri, G.U., Chinn, A.J., Leeper, K.V., Wunderink, R.G., Tolley, E., Winer-Muram, H.T., Khare, V., Eltorky, M., 1994. Corticosteroid rescue treatment of progressive fibroproliferation in late ARDS. Chest, 105(5):1516–1527.

    PubMed  CAS  Google Scholar 

  • Milberg, J.A., Davis, D.R., Steinberg, K.P., Hudson, L.D., 1995. Improved survival of patients with acute respiratory distress syndrome (ARDS). JAMA, 273(4):306–309. [doi:10.1001/jama.273.4.306]

    Article  PubMed  CAS  Google Scholar 

  • Milne, E.N.C., Pistolesi, M., Miniati, M., Giuntini, C., 1985. The radiologic distinction of cardiogenic and non-cardiogenic edema. Am. J. Roentgenol., 144(5):879.

    CAS  Google Scholar 

  • Moss, P., Khan, N., 2004. CD8(+) T cell immunity to cytomegalovirus. Hum. Immunol., 65(5):456–464. [doi:10.1016/j.humimm.2004.02.014]

    Article  PubMed  CAS  Google Scholar 

  • Munford, R.S., Pugin, J., 2001. Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am. J. Respir. Crit. Care Med., 163(2):316–321.

    PubMed  CAS  Google Scholar 

  • Nagaya, N., Kangawa, K., Kanda, M., Uematsu, M., Horio, T., Fukuyama, N., Hino, J., Harada-Shiba, M., Okumura, H., Tabata, Y., et al., 2003a. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of entothelial progenitor cells. Circulation, 108(7):889–895. [doi:10.1161/01.CIR.0000079161.56080.22]

    Article  PubMed  CAS  Google Scholar 

  • Nagaya, N., Kanda, M., Horio, T., Kangawa, K., Uematsu, M., Fukuyama, N., Hino, J., Harada-Shiba, M., Okumura, H., Tabata, Y., et al., 2003b. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytoing action of endothelial progenitor cells. Circulation, 108(7):889–896. [doi:10.1161/01.CIR.0000079161.56080.22]

    Article  PubMed  CAS  Google Scholar 

  • Odorico, J.S., Kaufman, D.S., Thomson, J.A., 2001. Multi-lineage differentiation from human embryonic stem cell lines. Stem Cells, 19(3):193–204. [doi:10.1634/stemcells.19-3-193]

    Article  PubMed  CAS  Google Scholar 

  • Otto, W.R., 2002. Lung epithelial stem cells. J. Pathol., 197(4):527–535. [doi:10.1002/path.1160]

    Article  PubMed  CAS  Google Scholar 

  • Paradis, I., Yousem, S., Griffith, B., 1993. Airway obstruction and bronchiolitis obliterans after lung transplantation. Clin. Chest Med., 14(4):751–763.

    PubMed  CAS  Google Scholar 

  • Paulson, T.E., Spear, R.M., Silva, P.D., Peterson, B.M., 1996. High-frequency pressure-control ventilation with high positive end-expiratory pressure in children with acute respiratory distress syndrome. J. Pediatr., 129(4):566–578. [doi:10.1016/S0022-3476(96)70122-1]

    Article  PubMed  CAS  Google Scholar 

  • Petersen, B.E., Bowen, W.C., Patrene, K.D., Mars, W.M., Sullivan, A.K., Murase, N., Boggs, S.S., Greengerger, J.S., Goff, J.P., 1999. Bone marrow as a potential source of hepatic oval cells. Science, 284(5417):1168–1170. [doi:10.1126/science.284.5417.1168]

    Article  PubMed  CAS  Google Scholar 

  • Pistolesi, M., Milne, E.W.C., Miniati, M., Giuntini, C., 1984. The vascular pedicle of the heart and the vena azygos. Part II: Acquired heart disease. Radiology, 152(1):9.

    PubMed  CAS  Google Scholar 

  • Poulsom, R., Alison, M.R., Forbes, S.J., Wright, N.A., 2002. Adult stem cell plasticity. J. Pathol., 197(4):441–456. [doi:10.1002/path.1176]

    Article  PubMed  Google Scholar 

  • Ralph, D.D., Robertson, H.T., Weaver, L.J., Hlastala, M.P., Carrico, C.J., Hudson, L.D., 1985. Distribution of ventilation and perfusion during positive end-expiratory pressure in the adult respiratory distress syndrome. Am. Rev. Respir. Dis., 131(1):54.

    PubMed  CAS  Google Scholar 

  • Rossaint, R., Gerlach, H., Schmidt-Ruhnke, H., Pappert, D., Lewandowski, K., Steudel, W., Falke, K., 1995. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest, 107(4):1107–1115.

    PubMed  CAS  Google Scholar 

  • Roupie, E., Dambrosio, M., Servillo, G., Mentec, H., el Atrous, S., Beydon, L., Brun-Buisson, C., Lemaire, F., Brochard, L., 1995. Titration of tidal volume and induced hypercapnia in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med., 152(1):121–128.

    PubMed  CAS  Google Scholar 

  • Sanajder, J.I., 1999. Strategies to increase alveolar epithelial fluid removal in the injured lung. Am. J. Respir. Crit. Care Med., 160(5 Pt 1):1441–1442.

    Google Scholar 

  • Schumacker, P.T., Samsel, R.W., 1990. Oxygen supply and consumption in the adult respiratory distress syndrome. Clin. Chest Med., 11(4):715–722.

    PubMed  CAS  Google Scholar 

  • Sivan, Y., Mor, C., al-Jundi, S., Newth, C.J., 1990. Adult respiratory distress syndrome in severely neutropenic children. Pediatr. Pulmonol., 8(2):104–108.

    PubMed  CAS  Google Scholar 

  • Spencer, H., Jaffe, A., 2004. The potential for stem cell therapy in cystic fibrosis. J. R. Soc. Med., 97(Suppl. 44):52–56.

    PubMed  Google Scholar 

  • Sprung, C.L., Long, W.M., Marcial, E.H., Schein, R.M., Parker, R.E., Schomer, T., Brigham, K.L., 1987. Distribution of proteins in pulmonary edema. The value of fractional concentration. Am. Rev. Respir. Dis., 136(4):957.

    PubMed  CAS  Google Scholar 

  • St. John, R.C., Mizer, L.A., Weisbrode, S.E., Dorinsky, P.M., 1991. Increased protein permeability in the cat ileum after acid aspiration-induced acute lung injury. Evidence for systemic endothelial injury. Am. Rev. Respir. Dis., 143(5):A805.

    Google Scholar 

  • Slutsky, A.S., Tremblay, L.N., 1998. Multiple system organ failure: is mechanical ventilation a contributing factor? Am. J. Respir. Crit. Care Med., 157(6 Pt 1):1721–1725.

    PubMed  CAS  Google Scholar 

  • Suratt, B.T., Cool, C.D., Serls, A., Chen, L., Varella-Garcia, M., Shpall, E.J., Brown, K.K., Worthen, G.S., 2003. Human pulmonary chimerism after hematopoietic stem cell transplantation. Am. J. Respir. Crit. Care Med., 168(3):318–322. [doi:10.1164/rccm.200301-145OC]

    Article  PubMed  Google Scholar 

  • Sydow, M., Burchardi, H., Ephraim, E., Zielmann, S., Crozier, T.A., 1994. Long-term effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ventilation and volume controlled inverse ratio ventilation. Am. J. Respir. Crit. Care Med., 149(6):1550–1556.

    PubMed  CAS  Google Scholar 

  • Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J.M., Asahara, T., 1999. Ischemia-and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med., 5(4):434–438. [doi:10.1038/7434]

    Article  PubMed  CAS  Google Scholar 

  • Tharratt, R.S., Allen, R.P., Albertson, T.E., 1988. Pressure controlled inverse ratio ventilation in severe adult respiratory failure. Chest, 94(4):755–762.

    PubMed  CAS  Google Scholar 

  • Theise, N.D., Nimmakayalu, M., Cardner, R., Illei, P.B., Morgan, G., Teperman, L., Henegariu, O., Krause, D.S., 2000. Liver form bone marrow in humans. Hepatology, 32(1):11–16. [doi:10.1053/jhep.2000.9124]

    Article  PubMed  CAS  Google Scholar 

  • Tomashefsk, J.F., 1990. Pulmonary pathology of the adult respiratory distress syndrome. Clin. Chest Med., 11(4):593–619.

    Google Scholar 

  • Tuchschmidt, J., Fried, J., Astiz, M., Rackow, E., 1992. Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest, 102(1):216–220.

    PubMed  CAS  Google Scholar 

  • Walmrath, D., Gunther, A., Ghofrani, H.A., Schermuly, R., Schneider, T., Grimminger, F., Seeger, W., 1996. Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome. Am. J. Respir. Crit. Care Med., 154(1):57–62.

    PubMed  CAS  Google Scholar 

  • Ware, L.B., Matthay, M.A., 2000. The acute respiratory distress syndrome. N. Engl. J. Med., 342(18):1334–1349. [doi:10.1056/NEJM200005043421806]

    Article  PubMed  CAS  Google Scholar 

  • Ware, L.B., Matthay, M.A., 2002. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation and repair. Am. J. Physiol. Lung. Cell Mol. Physiol., 282(5):L924–L940.

    PubMed  CAS  Google Scholar 

  • Windsor, A.C., Walsh, C.J., Mullen, P.G., Cook, D.J., Fisher, B.J., Blocher, C.R., Leeper-Woodford, S.K., Sugerman, H.J., Fowler, A.A.3rd, 1993. Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation. J. Clin. Invest., 91(4):1459–1468.

    PubMed  CAS  Google Scholar 

  • Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., Suzuki, T., Sasaki, H., 2004. Bone marrow derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J. Immunol., 172(2):1266–1272.

    PubMed  CAS  Google Scholar 

  • Zapol, W.M., Trelstad, R.L., Coffey, J.W., Tsai, I., Salvador, R.A., 1979a. Pulmonary fibrosis in severe acute respiratory failure. Am. Rev. Respir. Dis., 119(4):547–554.

    PubMed  CAS  Google Scholar 

  • Zapol, W.M., Snider, M.T., Hill, J.D., Fallat, R.J., Bartlett, R.H., Edmunds, L.H., Morris, A.H., Peirce, E.C.2nd, Thomas, A.N., Proctor, H.J., et al., 1979b. Extracorporeal membrane oxygenation in severe acute respiratory failure. JAMA, 242(20):2193–2196. [doi:10.1001/jama.242.20.2193].

    Article  PubMed  CAS  Google Scholar 

  • Zhao, Y.D., Campbell, A.I., Robb, M., Ng, D., Stewart, D.J., 2003. Protective role of angiopoitin-1 in experimental pulmonary hypertension. Circ. Res., 92(9):984–991. [doi:10.1161/01.RES.0000070587.79937.F0]

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman, G.A., McIntyre, T.M., Prescott, S.M., 1996. Adhesion and signaling in vascular cell-cell interactions. J. Clin. Invest., 98(8):1699–1702.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Chung-Shan Medical University Hospital, 402, Taichung, Taiwan, China

    Luh Shi-ping

  2. Division of Pulmonary Immunology and Infectious Diseases, Taipei Veterans General Hospital, 112, Taipei, Taiwan, China

    Chiang Chi-huei

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  1. Luh Shi-ping
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  2. Chiang Chi-huei
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Luh, Sp., Chiang, Ch. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies. J. Zhejiang Univ. - Sci. B 8, 60–69 (2007). https://doi.org/10.1631/jzus.2007.B0060

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  • DOI: https://doi.org/10.1631/jzus.2007.B0060

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