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The Role of Tomato Lycopene in Cancer Prevention

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Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention

Part of the book series: Diet and Cancer ((DICA,volume 2))

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Abstract

The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and the risk of various types of cancer. This is supported by mechanistic studies with various cell culture and animal models. The biochemical processes involved in the chemoprotective effects of lycopene and other carotenoids are not completely understood. In this review we will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors, such as insulin-like growth factor, and sex hormones such as estrogens and androgens.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel

    Joseph Levy

  2. Soroka Medical Center of Kupat Holim, Beer-Sheva, Israel

    Joseph Levy

  3. Department of Clinical Biochemistry and the Colorectal Unit, Faculty of Health Sciences, Ben-Gurion University and Soroka Medical Center of Kupat Holim, Beer-Sheva, Israel

    Shlomo Walfisch, Andrea Atzmon, Keren Hirsch, Marina Khanin, Karin Linnewiel, Yael Morag, Hagar Salman, Anna Veprik, Michael Danilenko & Yoav Sharoni

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  2. Shlomo Walfisch
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Correspondence to Joseph Levy .

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  1. , Department of Food and Environmental Sci, University of Helsinki, Agnes Sjöberginkatu 2, Helsinki, 00014, Finland

    Marja Mutanen

  2. , Department of Food and Environmental Sci, University of Helsinki, Agnes Sjöberginkatu 2, Helsinki, 00014, Finland

    Anne-Maria Pajari

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Levy, J. et al. (2011). The Role of Tomato Lycopene in Cancer Prevention. In: Mutanen, M., Pajari, AM. (eds) Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention. Diet and Cancer, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9800-9_3

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  • DOI: https://doi.org/10.1007/978-90-481-9800-9_3

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