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  1. Clinical epigenetics as a field has experienced rapid advancement over recent decades. Complexities of fundamental epigenetic regulation in health and disease continue to be uncovered, alongside developments i...

    Authors: Jim Smith, Aniruddha Chatterjee and Euan J. Rodger
    Citation: Epigenetics Communications 2025 5:7
    Content type: Meeting Report Published on:

  2. Cholangiocarcinoma (CCA) is an aggressive cancer characterized by high metastatic potential and poor prognosis. Recent advances in understanding the molecular biology of CCA have led to the development of nove...

    Authors: Elsa Hallab, Jennifer N. Durham, Rosalind Walker, Leslie Cope, Soren Charmsaz, Nicole E. Gross, Dimitrios N. Sidiropoulos, Alexei Hernandez, James Leatherman, Sarah Mitchell, Mark Yarchoan, Won Jin Ho, Nilofer S. Azad and Marina Baretti
    Citation: Epigenetics Communications 2025 5:6
    Content type: Research Published on:

  3. Oxidative stress has been associated with the development and progression of cancer by accelerating DNA mutations or causing DNA damage, genomic instability, and cell proliferation. Conventional radio-/chemoth...

    Authors: Ritu Raina, Ravinder Bhatt, Atiya Hussain, Nazia Afroze and Arif Hussain
    Citation: Epigenetics Communications 2025 5:5
    Content type: Review Published on:

  5. “We have never been individuals.” This shady statement obscures the complexity of defining biological individuals. Some authors, departing from ecological developmental biology, have argued that humans are hol...

    Authors: Franlu Vulliermet
    Citation: Epigenetics Communications 2025 5:3
    Content type: Hypothesis Published on:

  6. Human DNA methylation profiling offers great promises in various biomedical applications, including ageing, cancer and even forensics. So far, most DNA methylation techniques are based on a chemical process ca...

    Authors: Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser and Athina Vidaki
    Citation: Epigenetics Communications 2025 5:2
    Content type: Methodology Published on:

  7. Cardiovascular disease (CVD) is the primary cause of mortality globally with a multifactorial etiology that involves epigenetics. Chromobox 3 (CBX3), the major isoform of heterochromatin protein 1, is involved...

    Authors: Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Michele Grieco, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci and Mariarosaria Conte
    Citation: Epigenetics Communications 2025 5:1
    Content type: Review Published on:

  8. The 7th International Conference on Epigenetics & Bioengineering held in Amsterdam, The Netherlands was a successful event covering cutting-edge research utilizing innovative technologies from multidisciplinar...

    Authors: Jim Jacob, Quint C. van Loosen, Anna C. H. van den Berg van Saparoea, Federica Sarno and Pernette J. Verschure
    Citation: Epigenetics Communications 2024 4:8
    Content type: Meeting Report Published on:

  9. Polycomb group proteins, known for their role in epigenetic gene silencing, are critical regulators of cell fate and tissue development across species. These highly conserved proteins are assembled into two mu...

    Authors: Pratiksha S. Kavade, Saili S. Parab, Vincenza Capone, Daniela Carannante, Concetta Ambrosino, Lucia Altucci and Vincenzo Carafa
    Citation: Epigenetics Communications 2024 4:7
    Content type: Review Published on:

  10. Atrial natriuretic peptide (ANP) has been associated with ischemic stroke (IS), but the underlying molecular mechanisms are not clear. The objective of this study was to examine whether DNA methylation and hyd...

    Authors: Jialing Yao, Linghua Song, Jun Jiang, Jianan Zhang, Linan Chen, Wenxiu Fan, Ying Lu, Xiaolong Zhang, Jiexiang Jing, Yibing Jin, Mingzhi Zhang, Yongang Hao and Hao Peng
    Citation: Epigenetics Communications 2024 4:6
    Content type: Research Published on:

  11. Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formati...

    Authors: Natalia Carreras-Gallo, Varun B. Dwaraka, Dereje D. Jima, David A. Skaar, Tavis L. Mendez, Antonio Planchart, Wanding Zhou, Randy L. Jirtle, Ryan Smith and Cathrine Hoyo
    Citation: Epigenetics Communications 2024 4:5
    Content type: Research Published on:

  12. Exposure to environmental chemicals such as phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs) during pregnancy can increase the risk of adverse newborn outcomes. We explored the associations bet...

    Authors: Jagadeesh Puvvula, Joseph M. Braun, Emily A. DeFranco, Shuk-Mei Ho, Yuet-Kin Leung, Shouxiong Huang, Xiang Zhang, Ann M. Vuong, Stephani S. Kim, Zana Percy, Antonia M. Calafat, Julianne C. Botelho and Aimin Chen
    Citation: Epigenetics Communications 2024 4:4
    Content type: Research Published on:

  14. Pregnancy and childbirth have been connected to modified risk of a wide variety of conditions in later life, including neurodegenerative disorders and cancers. The presence, extent, and direction of the effect...

    Authors: Su Chen, Miranda Johs, Wilfried Karmaus, John W. Holloway, Parnian Kheirkhah Rahimabad, Jaclyn M. Goodrich, Karen E. Peterson, Dana C. Dolinoy, S. Hasan Arshad and Susan Ewart
    Citation: Epigenetics Communications 2024 4:2
    Content type: Research Published on:

  15. Hibernation (torpor) is a strategy to survive extreme environmental conditions, associated with a significant decrease in metabolism and body temperature. The inducibility by the environment of torpor for facu...

    Authors: Marloes M. Oosterhof, Louis Coussement, Alienke van Pijkeren, Marcel Kwiatkowski, Martijn R. H. Zwinderman, Frank J. Dekker, Tim de Meyer, Vera A. Reitsema, Rainer Bischoff, Victor Guryev, Hjalmar R. Bouma, Rob H. Henning and Marianne G. Rots
    Citation: Epigenetics Communications 2024 4:1
    Content type: Research Published on:

  18. Infinium Methylation BeadChips are widely used to profile DNA cytosine modifications in large cohort studies for reasons of cost-effectiveness, accurate quantification, and user-friendly data analysis in chara...

    Authors: Diljeet Kaur, Sol Moe Lee, David Goldberg, Nathan J. Spix, Toshinori Hinoue, Hong-Tao Li, Varun B. Dwaraka, Ryan Smith, Hui Shen, Gangning Liang, Nicole Renke, Peter W. Laird and Wanding Zhou
    Citation: Epigenetics Communications 2023 3:6
    Content type: Research Published on:

  22. The recent correspondence article by Chiapperino and Paneni in Clinical Epigenetics correctly points to the inability of epigenetics to incorporate fine-grained mapping data of the individual’s surrounding milieu...

    Authors: Silvio Zaina
    Citation: Epigenetics Communications 2023 3:2
    Content type: Correspondence Published on:

    The original article was published in Clinical Epigenetics 2022 14:144

    The Correspondence to this article has been published in Epigenetics Communications 2023 3:3

  23. While preeclampsia (PE) is a leading cause of pregnancy-related morbidity/mortality, its underlying mechanisms are not fully understood. DNA methylation (DNAm) is a dynamic regulator of gene expression that ma...

    Authors: Shuwei Liu, Haoyi Fu, Mitali Ray, Lacey W. Heinsberg, Yvette P. Conley, Cindy M. Anderson, Carl A. Hubel, James M. Roberts, Arun Jeyabalan, Daniel E. Weeks and Mandy J. Schmella
    Citation: Epigenetics Communications 2023 3:1
    Content type: Research Published on:

  24. The Illumina EPIC array is widely used for high-throughput profiling of DNA cytosine modifications in human samples, covering more than 850,000 modification sites across various genomic features. The applicati...

    Authors: Zhou Zhang, Chang Zeng and Wei Zhang
    Citation: Epigenetics Communications 2022 2:7
    Content type: Correspondence Published on:

  26. Distinct cell types can be identified by their DNA methylation patterns. Much research over the last decade has focused on DNA methylation changes in cancer or the use of cell-free circulating DNA in plasma to...

    Authors: M. J. Dunnet, O. J. Ortega-Recalde, S. A. Waters, R. J. Weeks, I. M. Morison and T. A. Hore
    Citation: Epigenetics Communications 2022 2:5
    Content type: Research Published on:

  27. Carcinogens in cigarette smoke may cause aberrant epigenomic changes. The hypomethylation of long interspersed nucleotide element-1 (LINE-1) in colorectal carcinoma has been associated with genomic instability...

    Authors: Junko Kishikawa, Tomotaka Ugai, Kenji Fujiyoshi, Yang Chen, Koichiro Haruki, Li Liu, Kota Arima, Naohiko Akimoto, Tsuyoshi Hamada, Kentaro Inamura, Keisuke Kosumi, Tyler S. Twombly, Shanshan Shi, Mai Chan Lau, Chunxia Du, Peilong Li…
    Citation: Epigenetics Communications 2022 2:4
    Content type: Short Report Published on:

  28. Advanced maternal age is currently a term defined by chronological age. However, a group of biomarkers known as epigenetic clocks, which can predict morbidity and mortality, has been used to estimate measures ...

    Authors: Elise N. Erickson, Anna K. Knight, Alicia K. Smith and Leslie Myatt
    Citation: Epigenetics Communications 2022 2:3
    Content type: Research Published on:

  29. Renal cell carcinoma (RCC) is the fourteenth most common cancer worldwide, accounting for approximately 4% of all cancers. More than 70% of RCC are clear cell RCC (ccRCC). To date, no reliable biomarkers for t...

    Authors: Hideki Ohmomo, Shohei Komaki, Yoichi Sutoh, Tsuyoshi Hachiya, Kanako Ono, Eri Arai, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai, Koichi Asahi, Makoto Sasaki and Atsushi Shimizu
    Citation: Epigenetics Communications 2022 2:2
    Content type: Research Published on:

  30. Aging populations in Africa face a growing burden of non-communicable diseases (NCDs), contextualized in broad external exposome and weak health systems. These could accelerate aging and shorten lifespan. DNA ...

    Authors: Dafne Sanchez, Ayoung Jeong, Clemence Essé, Fidèle K. Bassa, Siaka Koné, Félix Acka, Véronique Laubhouet-Koffi, Dinard Kouassi, Jürg Utzinger, Eliézer K. N’Goran, Bassirou Bonfoh, Medea Imboden, John W. Holloway and Ikenna C. Eze
    Citation: Epigenetics Communications 2022 2:1
    Content type: Research Published on:

  31. The vast majority of eukaryotic transcription occurs in bursts during discrete periods of promoter activity, separated by periods of deep repression and inactivity. Elucidating the factors responsible for trig...

    Authors: William F. Beckman, Miguel Ángel Lermo Jiménez and Pernette J. Verschure
    Citation: Epigenetics Communications 2021 1:6
    Content type: Review Published on:

  32. Despite the known role of mitosis in colorectal cancer, previous associations of long-term aspirin use with suppressed cancer-related epigenetic aging did not involve epigenetic mitotic clocks. We investigated...

    Authors: Jamaji C. Nwanaji-Enwerem, Chijioke Nze and Andres Cardenas
    Citation: Epigenetics Communications 2021 1:5
    Content type: Short Report Published on:

  33. Following aneurysmal subarachnoid hemorrhage (aSAH), the brain is susceptible to ferroptosis, a type of iron-dependent cell death. Therapeutic intervention targeting the iron homeostasis pathway shows promise ...

    Authors: Lacey W. Heinsberg, Daniel E. Weeks, Sheila A. Alexander, Ryan L. Minster, Paula R. Sherwood, Samuel M. Poloyac, Sandra Deslouches, Elizabeth A. Crago and Yvette P. Conley
    Citation: Epigenetics Communications 2021 1:4
    Content type: Research Published on:

  34. Delayed cerebral ischemia (DCI) is a common secondary complication and an important cause of disability and mortality among patients who survive aneurysmal subarachnoid hemorrhage (aSAH). Knowledge on DCI path...

    Authors: Dongjing Liu, Annie I. Arockiaraj, John R. Shaffer, Samuel M. Poloyac, Paula R. Sherwood, Sheila A. Alexander, Elizabeth A. Crago, Daniel E. Weeks and Yvette P. Conley
    Citation: Epigenetics Communications 2021 1:3
    Content type: Research Published on:

  35. Biological aging may occur at different rates than chronological aging due to genetic, social, and environmental factors. DNA methylation (DNAm) age is thought to be a reliable measure of accelerated biologica...

    Authors: Lacey W. Heinsberg, Dongjing Liu, John R. Shaffer, Daniel E. Weeks and Yvette P. Conley
    Citation: Epigenetics Communications 2021 1:2
    Content type: Research Published on:
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