MSGMM allows for efficiently fitting a Gaussian mixture models (GMM) to multiple samples simultaniously using the EM algorithm.

MSGMM is installable in R from Github and can be installed via devtools:

devtools::install_github("AUMC-HEMA/MSGMM")

Note that MSGMM also requires installing RTools.

The method implemented in MSGMM is detailed in: Computationally efficient multi-sample flow cytometry data analysis using Gaussian mixture models

Philip Rutten, Tim Robert Mocking, Jacqueline Cloos, Wessel van Wieringen, Costa Bachas