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PRP: Pathogenic Risk Prediction for Rare Nonsynonymous Single Nucleotide Variants

Notes

  • The training dataset and three test datasets associated with the publication are available under the '00.dataset'
    OR get it from Zenodo.
  • PRP model are available under the '02.code' folders, with names PRP_model.pkl.
  • The PRP performance comparison associated with the publication is available under the '02.code' folders, with names 02.performance.ipynb.
  • The PRP scores are available under the '03.PRP_score' folders.
  • For user convenience, a web interface will be provided, offering access to the PRP scores, biological annotations for variants, and decision plots for prediction interpretation

library

library version library version library version library version
CatBoost v1.2.5 LightGBM v4.1.0 Optuna v3.6.1 scikit-learn v1.2.2
Shap v0.45.0 Tabnet v4.1.0 Torch v2.3.0 XGBoost v2.0.3

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[email protected]

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PRP: Pathogenic Risk Prediction for Rare Nonsynonymous Single Nucleotide Variants

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