Interactive web application for Trial Sequential Analysis - a statistical method for cumulative meta-analysis monitoring boundaries and futility analysis in clinical trials.

• 📊 Interactive TSA Visualization: Real-time rendering of Z-curves with O'Brien-Fleming boundaries
• 📈 Multiple Datasets: Pre-loaded clinical trial datasets for demonstration
• 🎨 Modern UI: Dark theme with responsive design
• 📱 Fully Responsive: Works on desktop, tablet, and mobile
• ♿ Accessible: WCAG compliant with proper ARIA labels
• 🚀 Production Ready: Zero build errors, optimized bundle

[Add your deployment URL here]

• Framework: React 18 + TypeScript
• Build Tool: Vite
• Styling: Tailwind CSS
• Visualization: HTML5 Canvas
• Statistics: Custom TypeScript implementation

• Node.js 18+ and npm

# Clone the repository
git clone https://github.com/YOUR_USERNAME/tsa-tool.git
cd tsa-tool

# Install dependencies
npm install

# Start development server
npm run dev

Visit http://localhost:5173 to see the app.

npm run build

The optimized build will be in the dist/ directory.

The application implements:

• Mantel-Haenszel pooled odds ratio calculation
• O'Brien-Fleming alpha-spending boundaries
• DerSimonian-Laird heterogeneity estimation (I², τ², Q-statistic)
• Normal quantile function (inverse CDF)
• Chi-squared distribution for p-values

npm install -g vercel
vercel

npm run build
# Drag /dist folder to netlify.com/drop

1. Update vite.config.ts with your repo name:

   export default defineConfig({
     base: '/tsa-tool/',
     // ...
   })

2. Build and deploy:

   npm run build
   git add dist -f
   git commit -m "Deploy"
   git subtree push --prefix dist origin gh-pages

├── src/
│   ├── components/
│   │   ├── TSAChart.tsx       # Canvas-based chart component
│   │   └── ErrorBoundary.tsx  # Error handling wrapper
│   ├── lib/
│   │   └── statistics.ts      # Statistical calculations
│   ├── data.ts                # Example datasets
│   ├── types.ts               # TypeScript interfaces
│   ├── App.tsx                # Main application
│   └── main.tsx               # Entry point
├── public/
│   └── favicon.svg            # Custom favicon
└── index.html                 # HTML template

MIT

Contributions are welcome! Please feel free to submit a Pull Request.

• Statistical methods based on Copenhagen Trial Unit methodology
• Inspired by TSA software for meta-analysis