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Biopython is vulnerable to doctype XML external entity (XXE) injection through Bio.Entrez

Moderate severity GitHub Reviewed Published Dec 18, 2025 to the GitHub Advisory Database • Updated Dec 18, 2025

Package

Codestin Search App biopython (pip)

Affected versions

<= 1.86

Patched versions

None

Description

Bio.Entrez in Biopython through 1.86 allows doctype XXE.

References

Published by the National Vulnerability Database Dec 18, 2025
Published to the GitHub Advisory Database Dec 18, 2025
Reviewed Dec 18, 2025
Last updated Dec 18, 2025

Severity

Moderate

CVSS overall score

This score calculates overall vulnerability severity from 0 to 10 and is based on the Common Vulnerability Scoring System (CVSS).
/ 10

CVSS v3 base metrics

Attack vector
Network
Attack complexity
High
Privileges required
Low
User interaction
None
Scope
Changed
Confidentiality
Low
Integrity
None
Availability
Low

CVSS v3 base metrics

Attack vector: More severe the more the remote (logically and physically) an attacker can be in order to exploit the vulnerability.
Attack complexity: More severe for the least complex attacks.
Privileges required: More severe if no privileges are required.
User interaction: More severe when no user interaction is required.
Scope: More severe when a scope change occurs, e.g. one vulnerable component impacts resources in components beyond its security scope.
Confidentiality: More severe when loss of data confidentiality is highest, measuring the level of data access available to an unauthorized user.
Integrity: More severe when loss of data integrity is the highest, measuring the consequence of data modification possible by an unauthorized user.
Availability: More severe when the loss of impacted component availability is highest.
CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L

EPSS score

Exploit Prediction Scoring System (EPSS)

This score estimates the probability of this vulnerability being exploited within the next 30 days. Data provided by FIRST.
(10th percentile)

Weaknesses

Improper Restriction of XML External Entity Reference

The product processes an XML document that can contain XML entities with URIs that resolve to documents outside of the intended sphere of control, causing the product to embed incorrect documents into its output. Learn more on MITRE.

CVE ID

CVE-2025-68463

GHSA ID

GHSA-x3vf-39hj-gxr4

Source code

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