const string code = @"import numpy as np
import pandas as pd

result = pd.DataFrame({
    'StringColumn':		['Pike',	None,	'Amol'],
    'BoolColumn':		[True,		True,	False],
    'FloatColumn':		[123.456,	np.nan,	456.789],
    'IntColumn':		[123456,	456789,	789123],
    'TimeDeltaColumn':	[np.timedelta64(10, 'h'), None, np.timedelta64(12, 'h')],
    'DateTimeColumn':	[np.datetime64(30, 'Y'), None, np.datetime64(50, 'Y')]
})";

// Set python*.dll full path
PythonDataProvider.PythonDllPath = SettingsMain.Default.PythonDllPath;
// Open connection
PythonDataProvider.Open();
// Reset query
PythonDataQuery.Reset();
try
{
    // Get data
    var table = PythonDataQuery.RunScript(code);
}
catch (Exception exception)
{
    // Handle exception
}
finally
{
    // Close connection
    PythonDataProvider.Close();
}

//Python script file for test
const string fileName = @"TestScript01.py";
var scriptFile = new FileInfo(Path.Combine(AppDomain.CurrentDomain.BaseDirectory, SettingsMain.Default.PythonScriptsFolder, fileName));
if (!scriptFile.Exists) throw new FileNotFoundException("Where is the script?", scriptFile.FullName);

//Setup python environment
var pythonDll = new FileInfo(SettingsMain.Default.PythonDllPath);
if (!pythonDll.Exists) throw new FileNotFoundException("Can't find python*.dll file", pythonDll.FullName);
if (pythonDll.DirectoryName == null)
    throw new DirectoryNotFoundException("Directory name of python*.dll file can't be null");

//Compose PATH variable
var lib = Path.Combine(pythonDll.DirectoryName, "Lib");
var dlls = Path.Combine(pythonDll.DirectoryName, "DLLs");
var packages = Path.Combine(lib, "site-packages");
var libraryBin = Path.Combine(pythonDll.DirectoryName, "Library", "bin");

//Create connection string
var stringBuilder = new PythonConnectionStringBuilder
{
    File = scriptFile.FullName,
    PythonDll = pythonDll.FullName,
    PythonPath = string.Join(";", lib, dlls, packages, libraryBin)
};

var datatable = new DataTable();
using (var connection = new PythonConnection())
{
    connection.ConnectionString = stringBuilder.ConnectionString;
    connection.Open();
    using (var command = connection.CreateCommand())
    {
        //Set query command text. It will be passed to python "query" variable
        command.CommandText = "Hello from ADO.Net!";

        //Set query parameters. It will be passed to python "params" variable
        command.Parameters.Add(new PythonParameter { ParameterName = "bool", Value = true });
        command.Parameters.Add(new PythonParameter { ParameterName = "dt", Value = DateTime.Today });
        command.Parameters.Add(new PythonParameter { ParameterName = "double", Value = 1235.0 });
        command.Parameters.Add(new PythonParameter { ParameterName = "int", Value = 789 });
        command.Parameters.Add(new PythonParameter { ParameterName = "long", Value = 1024L });
        command.Parameters.Add(new PythonParameter { ParameterName = "string", Value = "String parameter" });

        /*
            * Python script must have "result" variable of type pandas DataFrame.
            * This variable data will be transferred to DbDataReader
            */
        using (var reader = command.ExecuteReader())
            datatable.Load(reader);
    }
}

//Python script text
const string scriptText = @"import pandas as pd

query_text = globals()['query'] if 'query' in globals() else None
query_params = globals()['params'] if 'params' in globals() else None

result = pd.DataFrame(
[[True, 99.0],
[True, 56.1],
[False, 73.2],
[False, 69.3]])";

//Setup python environment
var pythonDll = new FileInfo(SettingsMain.Default.PythonDllPath);
if (!pythonDll.Exists) throw new FileNotFoundException("Can't find python*.dll file", pythonDll.FullName);
if (pythonDll.DirectoryName == null)
    throw new DirectoryNotFoundException("Directory name of python*.dll file can't be null");

//Compose PATH variable
var lib = Path.Combine(pythonDll.DirectoryName, "Lib");
var dlls = Path.Combine(pythonDll.DirectoryName, "DLLs");
var packages = Path.Combine(lib, "site-packages");
var libraryBin = Path.Combine(pythonDll.DirectoryName, "Library", "bin");

//Create connection string
var stringBuilder = new PythonConnectionStringBuilder
{
    PythonDll = pythonDll.FullName,
    PythonPath = string.Join(";", lib, dlls, packages, libraryBin)
};

var datatable = new DataTable();
using (var connection = new PythonConnection())
{
    connection.ConnectionString = stringBuilder.ConnectionString;
    connection.Open();
    using (var command = connection.CreateCommand())
    {
        //In this case there is no "query" global variable in python
        command.CommandText = scriptText;

        //Set query parameters. It will be passed to python "params" variable
        command.Parameters.Add(new PythonParameter { ParameterName = "bool", Value = true });
        command.Parameters.Add(new PythonParameter { ParameterName = "dt", Value = DateTime.Today });
        command.Parameters.Add(new PythonParameter { ParameterName = "double", Value = 1235.0 });
        command.Parameters.Add(new PythonParameter { ParameterName = "int", Value = 789 });
        command.Parameters.Add(new PythonParameter { ParameterName = "long", Value = 1024L });
        command.Parameters.Add(new PythonParameter { ParameterName = "string", Value = "String parameter" });

        /*
            * Python script must have "result" variable of type pandas DataFrame.
            * This variable data will be transferred to DbDataReader
            */
        using (var reader = command.ExecuteReader())
            datatable.Load(reader);
    }
}