PENGUIN (PolygENic Genetic confoUnding INference) is a variance component analytical framework to control for genome-wide confounding effects in epidemiologic association studies.

Please see the wiki for the detailed manual of PENGUIN.

• January 18, 2024: Initial release.

If you use PENGUIN, please cite:
Zhao Z., Yang X., Dorn S., Miao J., Barcellos S., Fletcher J., Lu Q. (2024). Controlling for polygenic genetic confounding in epidemiologic association studies. PNAS, 121(44): e2408715121.

For questions and comments, please open a Github issue (preferred) or contact Zijie Zhao at [email protected] or Stephen Dorn at [email protected].