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41 Commits
001 Clusters
001 Clusters
 
 
002 Progression
002 Progression
 
 
999 Utils
999 Utils
 
 
README.Rmd
README.Rmd
 
 
README.md
README.md
 
 

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Clusters

Analyses were performed on individual federated nodes. Hereafter, results were meta-analysed. Scripts are organized as such: first for each molecular outcome and cohort the individual analyses and next the meta-analysis.

1.Metabolomics

Unadjusted

DCS unadjusted

GoDARTS unadjusted

ANDIS unadjusted

Unadjusted

DCS adjusted

GoDARTS adjusted

ANDIS adjusted

Meta-analysis

Metabolomics unadjusted

Metabolomics adjusted

2.Lipidomics

Unadjusted

DCS unadjusted

GoDARTS unadjusted

ANDIS unadjusted

Adjusted

DCS adjusted

GoDARTS adjusted

ANDIS adjusted

Meta-analysis

Lipidomics unadjusted

Lipidomics adjusted

3. Proteomics

Unadjusted

DCS unadjusted

GoDARTS unadjusted

Adjusted

DCS adjusted

GoDARTS adjusted

Meta-analysis

Proteomics unadjusted

Proteomics adjusted

4. Combine Genetic risk scores

GRSs meta-analysis

5. Compare protein data with Yang et al.

Yang et al. comparison

6. Compare effect sizes TAG with acyl chain carbon and double bonds

Lipid effect sizes vs acyl chains

Progression paper

Metabolomics

DCS Metabolites

GoDARTS Metabolites discovery

GoDARTS Metabolites validation

ANDIS Metabolites discovery

ANDIS Metabolites validation

Combine metabolites

Lipids

DCS Lipids

GoDARTS Lipids

ANDIS Lipids

Combine Lipids

Acyl chains / double bonds

Acyl chains from Source Data 1

Proteins

DCS Proteins

GoDARTS Proteins

Combine proteins

Interaction models

DCS

GODARTS

ANDIS

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RHAPSODY

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Main code RHAPSODY papers Latest
Jan 12, 2023

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